GO:0016151

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Name nickel cation binding
Categary Function
Go Slim No
Go Link GO:0016151
Unique Molecular Interactions 16
Total Molecular Interactions 18
Total Single Events 614
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nickel cation binding. They are ordered first by their pain relevance and then by number of times they were reported for nickel cation binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
2 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
3 INT158104 Binding of Trpv1 and P2rx2 1 0.03 0.27 0.4
4 INT325701 Aacs Regulation of Car3 1 0.17 0 0.4
5 INT257805 Binding of Car3 and Gopc 1 0.18 0 0.25
6 INT215167 Phosphorylation of Prkaca Positive_regulation of P2rx2 1 0.06 0.13 0.18
7 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
8 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
9 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
10 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
11 INT215169 Ptger2 Regulation of P2rx2 1 0.19 0.31 0.11
12 INT50533 Binding of ADRB3 and Positive_regulation of Gene_expression of CA3 1 0.11 0.61 0.1
13 INT113861 Binding of CA3 and NR1H4 1 0.00 0 0.06
14 INT280950 Inhbe Positive_regulation of Car3 1 0.02 0.26 0.03
15 INT281097 Binding of P2rx3 and P2rx2 1 0.06 0 0
16 INT296725 Binding of P2rx2 and Afm 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nickel cation binding. They are ordered first by their pain relevance and then by number of times they were reported in nickel cation binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
2 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
3 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
4 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
5 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
6 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94
7 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
8 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
9 INT120261 Binding of P2rx2 19 0.28 5.8 6.72
10 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22
11 INT148649 Transcription of P2rx2 8 0.43 8.11 4.79
12 INT128353 Negative_regulation of Car3 16 0.37 4.93 4.61
13 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73
14 INT215163 Phosphorylation of P2rx2 19 0.60 1.43 3.62
15 INT81830 Localization of P2rx2 14 0.73 5.42 3.16
16 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89
17 INT14883 Regulation of Car3 8 0.58 5.57 2.75
18 INT83681 Positive_regulation of CA3 3 0.49 0.06 2.6
19 INT149066 Regulation of CA3 5 0.44 0.89 2.02
20 INT148648 Negative_regulation of Transcription of P2rx2 3 0.29 3.54 1.94
21 INT245669 Negative_regulation of Gene_expression of Car3 7 0.37 1.87 1.9
22 INT168726 Negative_regulation of Positive_regulation of P2rx2 1 0.07 0.09 1.44
23 INT168727 Negative_regulation of Negative_regulation of P2rx2 1 0.07 0.09 1.43
24 INT142815 Regulation of Regulation of P2rx2 4 0.33 0.69 1.33
25 INT154813 Regulation of Transcription of P2rx2 2 0.26 2.38 1.17
26 INT215499 Positive_regulation of Phosphorylation of P2rx2 3 0.37 0.57 1.07
27 INT32693 Positive_regulation of Gene_expression of Car3 6 0.42 2.7 0.89
28 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
29 INT197371 Regulation of Gene_expression of Car3 2 0.39 0.64 0.65
30 INT215501 Positive_regulation of Binding of P2rx2 3 0.37 0.61 0.56
31 INT72294 Binding of CA3 3 0.32 0.54 0.55
32 INT107819 Positive_regulation of Localization of P2rx2 1 0.24 0.66 0.55
33 INT230267 Negative_regulation of CA3 3 0.28 1.4 0.44
34 INT72295 Regulation of Binding of CA3 1 0.39 0.1 0.38
35 INT235342 Localization of Car3 2 0.41 0.43 0.33
36 INT217405 Regulation of Positive_regulation of P2rx2 1 0.32 0 0.33
37 INT215492 Negative_regulation of Phosphorylation of P2rx2 1 0.31 0 0.31
38 INT84919 Localization of CA3 1 0.59 0.4 0.25
39 INT160516 Positive_regulation of Transcription of P2rx2 1 0.13 0.2 0.24
40 INT235354 Regulation of Localization of Car3 1 0.19 0.12 0.21
41 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
42 INT243530 Positive_regulation of Gene_expression of CA3 1 0.10 0.47 0.14
43 INT288681 Regulation of Transcription of Slc11a2 1 0.44 0.37 0.13
44 INT288683 Transcription of Slc11a2 1 0.69 0.37 0.13
45 INT288682 Binding of Slc11a2 1 0.47 0 0.12
46 INT257800 Binding of Car3 1 0.28 0.19 0.12
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