GO:0016175

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Name superoxide-generating NADPH oxidase activity
Categary Function
Go Slim No
Go Link GO:0016175
Unique Molecular Interactions 191
Total Molecular Interactions 222
Total Single Events 1616
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for superoxide-generating NADPH oxidase activity. They are ordered first by their pain relevance and then by number of times they were reported for superoxide-generating NADPH oxidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
2 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
3 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
4 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
5 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
6 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
7 INT330107 Racgap1 Regulation of Positive_regulation of Nox3 1 0.01 0.87 0.49
8 INT330108 Racgap1 Positive_regulation of Cybb 1 0.03 0.86 0.46
9 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
10 INT147445 Pscs Positive_regulation of Gene_expression of CYBB 1 0.02 0.33 0.31
11 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
12 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
13 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
14 INT215273 Siglec1 Regulation of Ncf2 1 0.01 0.73 0.26
15 INT215289 Siglec1 Regulation of Cyba 1 0.01 0.74 0.26
16 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23
17 INT239236 Prkca Regulation of CYBB 1 0.00 0.98 0.2
18 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18
19 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18
20 INT215270 Binding of Ncf1 and Ncf4 1 0.05 0.38 0.17
21 INT215269 Binding of Ncf2 and Ncf4 1 0.02 0.38 0.17
22 INT328004 Binding of CYBB and Gnb5 1 0.00 1.13 0.15
23 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
24 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12
25 INT215283 Tlr4 Positive_regulation of Localization of Ncf1 2 0.05 1.04 0.11
26 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
27 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
28 INT20123 Gtf2e1 Negative_regulation of CYBB 1 0.00 0 0.1
29 INT165507 CRAT Negative_regulation of Gene_expression of CYBB 1 0.00 0.1 0.1
30 INT20122 Cyp2c22 Negative_regulation of CYBB 1 0.00 0 0.1
31 INT42224 ABCA1 Positive_regulation of CYBB 1 0.01 0 0.09
32 INT269069 Binding of Cyba and Cybb 1 0.18 0.18 0.09
33 INT269056 Positive_regulation of Binding of Cyba and Cybb 1 0.24 0.18 0.09
34 INT55502 NDUFC1 Regulation of Nox1 1 0.00 0 0.08
35 INT249162 CYBB Regulation of CA2 1 0.17 0.31 0.08
36 INT249166 Phosphorylation of NCF1 Positive_regulation of Localization of GOPC 1 0.03 0.06 0.08
37 INT257343 Lox Regulation of Cyba 1 0.02 0.37 0.05
38 INT199107 Binding of Akt1 and Ncf2 1 0.04 0.09 0.05
39 INT249201 PRKDC Regulation of Regulation of CYBB 1 0.01 0.09 0.05
40 INT257338 Lox Regulation of Cybb 1 0.00 0.37 0.05
41 INT257339 Lox Regulation of Ncf1 1 0.02 0.37 0.05
42 INT204172 Regulation of Binding of Cs and Nox1 1 0.08 1.01 0.04
43 INT199103 Akt1 Positive_regulation of Ncf2 1 0.05 0.09 0.04
44 INT252808 TNF Positive_regulation of NOX1 1 0.06 1.03 0.04
45 INT204173 Binding of Cs and Nox1 1 0.07 1 0.04
46 INT301667 Tlr4 Positive_regulation of Gene_expression of CYBB 1 0.01 0.84 0.03
47 INT301662 Binding of Tlr4 and Positive_regulation of Gene_expression of CYBB 1 0.01 0.84 0.03
48 INT254511 RAC1 Positive_regulation of Positive_regulation of CYBB 1 0.14 0.39 0.03
49 INT324836 Nox4 Regulation of Gene_expression of ROS1 1 0.01 0.13 0.03
50 INT324800 Binding of Tlr4 and Nox4 1 0.12 0.14 0.03
51 INT249188 Binding of CYBA and S100A8 1 0.11 0 0
52 INT165509 CYBB Regulation of Gene_expression of NFKB1 1 0.02 0 0
53 INT249165 Binding of CA2 and Positive_regulation of CYBB 1 0.18 0 0
54 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
55 INT249185 Binding of S100B and Positive_regulation of CYBB 1 0.11 0 0
56 INT249177 Binding of CYBA and S100A9 1 0.10 0 0
57 INT325997 Binding of Cybb and Ncf1 1 0.18 0.77 0
58 INT165506 HSPG2 Negative_regulation of Gene_expression of CYBB 1 0.03 0.06 0
59 INT249184 PRKCA Regulation of CYBB 1 0.09 0 0
60 INT257344 Gene_expression of Cyba Positive_regulation of Nox1 1 0.23 1.15 0
61 INT324877 CYBB Positive_regulation of Ros1 1 0.00 0.26 0
62 INT249179 PLA2G4A Regulation of CYBB 1 0.18 0 0
63 INT254512 Binding of CYBB and NCF1 1 0.07 0.14 0
64 INT249171 Positive_regulation of Binding of CYBA and S100A9 1 0.10 0 0
65 INT249180 Binding of NCF2 and S100B 1 0.05 0 0
66 INT324878 Ncf1 Positive_regulation of CYBB 1 0.01 0.25 0
67 INT249161 CA2 Regulation of CYBB 1 0.23 0 0
68 INT269062 Nox4 Negative_regulation of Localization of Cyba 1 0.17 0 0
69 INT257341 Binding of Neu2 and Cyba 1 0.00 0.29 0
70 INT325999 Binding of Cybb and Ncf2 1 0.18 0.77 0
71 INT257345 Ncf1 Positive_regulation of Gene_expression of Ros1 1 0.08 0.58 0
72 INT326003 Binding of Cyba and Ncf4 1 0.09 0.77 0
73 INT254509 Binding of CYBA and CYBB 1 0.05 0 0
74 INT249155 Binding of CYBA and S100B 1 0.06 0 0
75 INT326002 Binding of Cyba and Ncf1 1 0.09 0.77 0
76 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
77 INT249191 CYBB Positive_regulation of PLA2G4A 1 0.20 0 0
78 INT249187 Binding of CYBB and PLA2G4A 1 0.14 0 0
79 INT257347 Binding of Cyba and Ncf1 1 0.17 0.29 0
80 INT346023 Negative_regulation of HVCN1 Negative_regulation of Gene_expression of CYBA 1 0.24 0.15 0
81 INT249173 Binding of NCF2 and S100A8 1 0.10 0 0
82 INT189021 NOX5 Positive_regulation of ROS1 1 0.26 0.2 0
83 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0
84 INT257346 Gene_expression of Lox Positive_regulation of Nox1 1 0.02 0.57 0
85 INT249194 S100B Positive_regulation of CYBA 1 0.06 0 0
86 INT254510 Binding of CYBB and NCF2 1 0.06 0 0
87 INT269067 Nox4 Negative_regulation of Localization of Ncf1 1 0.17 0 0
88 INT346022 CYBB Positive_regulation of Gene_expression of HVCN1 1 0.42 0.14 0
89 INT249181 Binding of NCF2 and S100A9 1 0.09 0 0
90 INT326000 Binding of Cyba and Ncf2 1 0.10 0.77 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for superoxide-generating NADPH oxidase activity. They are ordered first by their pain relevance and then by number of times they were reported in superoxide-generating NADPH oxidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91
2 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95
3 INT116434 Positive_regulation of Gene_expression of CYBB 27 0.62 16.24 5.42
4 INT20121 Negative_regulation of CYBB 34 0.54 15.5 4.44
5 INT4545 Negative_regulation of Nox1 15 0.53 10.08 3.4
6 INT197030 Gene_expression of Ncf1 16 0.78 11.5 2.58
7 INT131498 Gene_expression of Cybb 15 0.40 8.73 2.34
8 INT130649 Positive_regulation of Cyba 4 0.36 0.38 2.08
9 INT130648 Negative_regulation of Positive_regulation of Cyba 1 0.05 0.05 2
10 INT143460 Negative_regulation of Cybb 2 0.43 3.12 1.86
11 INT116431 Negative_regulation of Gene_expression of CYBB 11 0.39 7.88 1.72
12 INT174656 Binding of NCF1 5 0.37 6.46 1.65
13 INT152567 Positive_regulation of Gene_expression of CYBA 1 0.17 0.67 1.51
14 INT152569 Positive_regulation of Gene_expression of NOX1 1 0.31 0.67 1.51
15 INT152563 Gene_expression of CYBA 3 0.33 0.82 1.5
16 INT152560 Gene_expression of NOX1 3 0.49 0.73 1.49
17 INT154763 Gene_expression of Nox1 3 0.67 1.83 1.48
18 INT154764 Localization of Nox1 1 0.65 1.07 1.47
19 INT21168 Regulation of CYBB 14 0.53 1.99 1.45
20 INT242902 Gene_expression of NCF1 12 0.78 9.34 1.36
21 INT131497 Positive_regulation of Gene_expression of Cybb 4 0.01 2.09 1.3
22 INT29558 Positive_regulation of Positive_regulation of CYBB 16 0.32 2.33 1.25
23 INT21167 Regulation of NCF1 3 0.15 0.75 1.24
24 INT199090 Localization of Ncf1 14 0.41 5.14 1.18
25 INT128970 Localization of Ncf1 6 0.68 4.25 1.1
26 INT42504 Negative_regulation of Nox1 5 0.43 0.55 0.91
27 INT143466 Positive_regulation of Cybb 4 0.34 2.67 0.88
28 INT22057 Negative_regulation of Positive_regulation of CYBB 7 0.52 1.93 0.87
29 INT203739 Negative_regulation of NCF1 2 0.27 1.22 0.82
30 INT197032 Regulation of Ncf1 3 0.45 2.84 0.79
31 INT199874 Binding of CYBB 6 0.32 4.31 0.77
32 INT215261 Negative_regulation of Localization of Ncf1 6 0.30 3.51 0.74
33 INT143464 Positive_regulation of Positive_regulation of Cybb 2 0.13 1.57 0.73
34 INT260352 Positive_regulation of Gene_expression of NCF1 1 0.50 3.34 0.69
35 INT130651 Gene_expression of Cyba 2 0.41 0.99 0.68
36 INT130650 Negative_regulation of Gene_expression of Cyba 1 0.05 0.1 0.68
37 INT66783 Positive_regulation of Negative_regulation of Nox1 1 0.63 0.81 0.66
38 INT199875 Localization of CYBB 16 0.72 5.77 0.62
39 INT66903 Positive_regulation of Nox1 3 0.25 1.1 0.62
40 INT147440 Gene_expression of Nox1 3 0.57 1.61 0.6
41 INT199096 Phosphorylation of Ncf1 8 0.42 1.55 0.53
42 INT249248 Transcription of CYBB 2 0.60 1.05 0.49
43 INT197037 Negative_regulation of Ncf1 1 0.43 1.49 0.49
44 INT330084 Positive_regulation of Nox3 1 0.25 0.86 0.48
45 INT254539 Regulation of Transcription of CYBB 1 0.39 0.85 0.46
46 INT142324 Gene_expression of Ncf1 19 0.75 10.8 0.41
47 INT199078 Gene_expression of Nox4 3 0.59 3.83 0.41
48 INT199064 Phosphorylation of Ncf2 6 0.48 0.27 0.39
49 INT65962 Negative_regulation of NOX1 1 0.07 0.89 0.39
50 INT257334 Gene_expression of Cyba 12 0.53 5.39 0.34
51 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
52 INT199073 Positive_regulation of Ncf1 7 0.27 3.64 0.31
53 INT330088 Binding of Cybb 1 0.26 0.7 0.31
54 INT309354 Regulation of Pax2 1 0.10 0 0.29
55 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
56 INT260350 Negative_regulation of Gene_expression of NCF1 1 0.43 1.47 0.27
57 INT199094 Positive_regulation of Phosphorylation of Ncf1 2 0.36 0.55 0.26
58 INT199079 Localization of Ncf2 3 0.21 1.17 0.25
59 INT257315 Positive_regulation of Gene_expression of Cyba 8 0.47 4.04 0.24
60 INT199085 Binding of Ncf2 3 0.16 0.43 0.24
61 INT199092 Binding of Ncf1 3 0.19 0.43 0.24
62 INT254538 Negative_regulation of Localization of CYBB 3 0.37 1.54 0.22
63 INT345296 Positive_regulation of Localization of CYBB 1 0.02 0.78 0.21
64 INT343013 Positive_regulation of NOX5 1 0.15 2.03 0.2
65 INT249259 Regulation of Regulation of CYBB 1 0.17 0.07 0.19
66 INT234591 Gene_expression of Ncf2 3 0.52 0.17 0.18
67 INT179450 Positive_regulation of NCF1 5 0.50 1.04 0.17
68 INT254544 Regulation of Gene_expression of CYBB 3 0.39 0.85 0.17
69 INT199069 Positive_regulation of Transcription of Ncf1 2 0.19 0.37 0.17
70 INT257316 Transcription of Cybb 4 0.02 1.52 0.16
71 INT254545 Negative_regulation of Binding of CYBB 1 0.37 1.03 0.16
72 INT257331 Positive_regulation of Gene_expression of Ncf1 6 0.33 2.39 0.14
73 INT309352 Localization of Pax2 1 0.27 0 0.14
74 INT249250 Phosphorylation of NCF1 1 0.24 0.14 0.14
75 INT249269 Positive_regulation of Phosphorylation of NCF1 1 0.15 0.14 0.14
76 INT234586 Transcription of Ncf2 1 0.41 0.23 0.14
77 INT257322 Transcription of Ncf1 3 0.33 1.13 0.13
78 INT355656 Positive_regulation of Transcription of Cybb 1 0.01 1.13 0.13
79 INT254552 Positive_regulation of Negative_regulation of CYBB 1 0.44 1.45 0.12
80 INT257314 Positive_regulation of Cyba 1 0.47 1.22 0.11
81 INT189034 Gene_expression of NOX5 5 0.48 1.99 0.1
82 INT234589 Positive_regulation of Ncf2 2 0.36 0.66 0.1
83 INT234592 Positive_regulation of Gene_expression of Ncf2 1 0.36 0.11 0.1
84 INT234584 Positive_regulation of Transcription of Ncf2 1 0.36 0.14 0.1
85 INT322980 Positive_regulation of Localization of Ncf1 2 0.33 0.37 0.09
86 INT249267 Positive_regulation of Localization of NCF1 2 0.14 0.53 0.09
87 INT94000 Positive_regulation of NOX1 1 0.20 0.2 0.09
88 INT199093 Binding of Cyba 5 0.19 0.77 0.08
89 INT199062 Transcription of Ncf1 2 0.19 0.18 0.08
90 INT199075 Positive_regulation of Phosphorylation of Ncf2 1 0.14 0.17 0.08
91 INT71291 Binding of Nox1 1 0.11 0.25 0.08
92 INT254540 Transcription of CYBA 1 0.10 0.86 0.08
93 INT71290 Regulation of Nox1 1 0.08 0.25 0.08
94 INT249265 Localization of NCF1 3 0.21 1.12 0.07
95 INT249243 Negative_regulation of Positive_regulation of NCF1 1 0.13 0.08 0.07
96 INT249253 Negative_regulation of Phosphorylation of NCF1 1 0.13 0.08 0.07
97 INT234593 Positive_regulation of Positive_regulation of Ncf2 1 0.36 0.14 0.07
98 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
99 INT249239 Regulation of Positive_regulation of CYBB 1 0.17 0 0.05
100 INT257323 Regulation of Cyba 1 0.18 0.37 0.05
101 INT257337 Regulation of Cybb 1 0.01 0.37 0.05
102 INT269043 Localization of Cyba 2 0.33 0.73 0.04
103 INT336597 Regulation of Ncf1 1 0.12 0.52 0.04
104 INT336595 Negative_regulation of Localization of Ncf2 1 0.08 0.7 0.04
105 INT204169 Regulation of Nox1 1 0.16 1 0.04
106 INT260351 Regulation of Gene_expression of NCF1 1 0.27 0.84 0.04
107 INT336603 Regulation of Ncf2 1 0.12 0.52 0.04
108 INT257326 Positive_regulation of Ncf1 3 0.33 1.21 0.03
109 INT199100 Positive_regulation of Gene_expression of Ncf1 2 0.19 0.83 0.03
110 INT249247 Binding of NCF2 1 0.10 0.34 0.03
111 INT254554 Positive_regulation of Localization of NCF2 1 0.09 0.45 0.03
112 INT204164 Negative_regulation of Positive_regulation of Nox1 1 0.17 1.02 0.03
113 INT257318 Transcription of Cyba 1 0.49 0.87 0.03
114 INT354470 Negative_regulation of Localization of Ncf1 1 0.28 0.77 0.03
115 INT257324 Negative_regulation of Gene_expression of Ncf1 1 0.26 0.13 0.03
116 INT199091 Negative_regulation of Gene_expression of Ncf1 1 0.12 0.09 0.03
117 INT249264 Positive_regulation of CYBA 3 0.27 0.15 0
118 INT249237 Localization of NCF2 2 0.21 0.35 0
119 INT249233 Phosphorylation of NCF2 1 0.24 0 0
120 INT254553 Regulation of Negative_regulation of CYBB 1 0.39 0.47 0
121 INT257333 Negative_regulation of Transcription of Cyba 1 0.40 0.49 0
122 INT324858 Phosphorylation of CYBB 1 0.02 0.25 0
123 INT197033 Binding of Ncf1 1 0.32 0.06 0
124 INT249291 Regulation of CYBA 1 0.09 0 0
125 INT244782 Negative_regulation of Pax2 1 0.44 0 0
126 INT204167 Positive_regulation of Nox1 1 0.19 1 0
127 INT254549 Negative_regulation of Localization of NCF1 1 0.12 0.69 0
128 INT197029 Protein_catabolism of Ncf1 1 0.77 0.08 0
129 INT257325 Negative_regulation of Transcription of Cybb 1 0.01 0 0
130 INT249290 Positive_regulation of Phosphorylation of NCF2 1 0.15 0 0
131 INT249255 Positive_regulation of Regulation of CYBB 1 0.44 0 0
132 INT204162 Negative_regulation of Binding of Nox1 1 0.17 0.06 0
133 INT204166 Regulation of Negative_regulation of Nox1 1 0.11 0.96 0
134 INT257320 Negative_regulation of Gene_expression of Nox1 1 0.22 0.58 0
135 INT298775 Regulation of NOX1 1 0.00 0.67 0
136 INT257330 Negative_regulation of Gene_expression of Cyba 1 0.29 0.32 0
137 INT249256 Positive_regulation of Positive_regulation of NCF1 1 0.15 0 0
138 INT346041 Protein_catabolism of CYBB 1 0.79 0.09 0
139 INT204163 Binding of Nox1 1 0.15 0.06 0
140 INT249293 Negative_regulation of Negative_regulation of CYBB 1 0.27 0.23 0
141 INT322979 Positive_regulation of Phosphorylation of Ncf1 1 0.33 0.7 0
142 INT235206 Positive_regulation of Localization of Ncf1 1 0.22 0.25 0
143 INT249245 Binding of CYBA 1 0.12 0 0
144 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
145 INT322978 Phosphorylation of Ncf1 1 0.39 0.35 0
146 INT254546 Positive_regulation of Transcription of CYBB 1 0.38 0.15 0
147 INT249249 Regulation of NOX5 1 0.15 0 0
148 INT294982 Regulation of Localization of CYBB 1 0.07 1.22 0
149 INT257332 Regulation of Localization of Ncf1 1 0.17 0.54 0
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