GO:0016239

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Name positive regulation of macroautophagy
Categary Process
Go Slim No
Go Link GO:0016239
Unique Molecular Interactions 84
Total Molecular Interactions 131
Total Single Events 632
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of macroautophagy. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of macroautophagy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
3 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
4 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
5 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
6 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
7 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
8 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
9 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
10 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
11 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
12 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
13 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
14 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
15 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
16 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
17 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05
18 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
19 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
20 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
21 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
22 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
23 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
24 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0
25 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
26 INT283001 Binding of Becn1 and Om 1 0.00 0.1 0
27 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
28 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0
29 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
30 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
31 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
32 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
33 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0
34 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
35 INT283000 Negative_regulation of Binding of Bcl2 and Becn1 1 0.03 0.71 0
36 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
37 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
38 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
39 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
40 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0
41 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
42 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
43 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
44 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
45 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
46 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
47 INT283010 Regulation of Binding of Bcl2 and Becn1 1 0.03 1.45 0
48 INT283004 Binding of Becn1 and Pdss2 1 0.00 0.57 0
49 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
50 INT283008 Igkv1-131 Regulation of Binding of Becn1 1 0.01 0 0
51 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
52 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
53 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
54 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
55 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
56 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
57 INT283014 Becn1 Regulation of Bcl2 1 0.03 0.88 0
58 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
59 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
60 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
61 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
62 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
63 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of macroautophagy. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of macroautophagy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
2 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
3 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
4 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
5 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
6 INT166628 Positive_regulation of Gene_expression of Becn1 2 0.67 1.03 1.23
7 INT166632 Gene_expression of Becn1 2 0.75 1.02 1.22
8 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
9 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
10 INT166630 Negative_regulation of Localization of Becn1 1 0.41 0.51 0.88
11 INT166626 Localization of Becn1 1 0.76 0.5 0.87
12 INT166633 Binding of Becn1 1 0.45 0.5 0.86
13 INT166629 Negative_regulation of Binding of Becn1 1 0.41 0.5 0.86
14 INT166631 Positive_regulation of Becn1 1 0.41 0.52 0.84
15 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
16 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
17 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
18 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
19 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
20 INT312037 Gene_expression of BECN1 2 0.33 1.5 0.37
21 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
22 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31
23 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
24 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
25 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
26 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
27 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
28 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
29 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
30 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
31 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
32 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
33 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
34 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
35 INT282981 Positive_regulation of Gene_expression of Becn1 8 0.13 6.2 0.06
36 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
37 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
38 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
39 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
40 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
41 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04
42 INT282977 Regulation of Becn1 4 0.25 2.29 0.04
43 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
44 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
45 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
46 INT282974 Binding of Becn1 24 0.07 7.43 0
47 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
48 INT204349 Regulation of SIRT1 8 0.61 1.99 0
49 INT282990 Negative_regulation of Binding of Becn1 6 0.08 1.44 0
50 INT256134 Localization of Sirt1 5 0.50 2.99 0
51 INT204353 Transcription of SIRT1 3 0.68 0.67 0
52 INT282967 Negative_regulation of Gene_expression of Becn1 3 0.08 2.04 0
53 INT331187 Positive_regulation of Becn1 2 0.09 1.01 0
54 INT282988 Regulation of Binding of Becn1 2 0.05 0 0
55 INT282978 Positive_regulation of Binding of Becn1 1 0.04 0 0
56 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
57 INT289569 Transcription of Sirt1 1 0.71 0.25 0
58 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
59 INT300287 Localization of Sirt1 1 0.66 1.46 0
60 INT348466 Positive_regulation of Gene_expression of BECN1 1 0.22 0.76 0
61 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
62 INT348470 Binding of BECN1 1 0.11 0.42 0
63 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
64 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
65 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
66 INT325712 Regulation of Gene_expression of Becn1 1 0.03 0.35 0
67 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
68 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
69 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
70 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
71 INT282969 Protein_catabolism of Becn1 1 0.08 0 0
72 INT204331 Binding of SIRT1 1 0.47 0.39 0
73 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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