GO:0016242

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Name negative regulation of macroautophagy
Categary Process
Go Slim No
Go Link GO:0016242
Unique Molecular Interactions 115
Total Molecular Interactions 150
Total Single Events 1061
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of macroautophagy. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of macroautophagy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
2 INT273111 Bdnf Positive_regulation of Positive_regulation of Mtor 1 0.44 0.07 0.42
3 INT277353 VEGFA Regulation of Mtor 1 0.02 1.11 0.37
4 INT277354 Gene_expression of VEGFA Regulation of Mtor 1 0.02 1.1 0.37
5 INT273118 Bdnf Positive_regulation of Mtor 1 0.66 0 0.33
6 INT150050 Mtor Positive_regulation of Rps6kb1 3 0.49 1.44 0.3
7 INT349560 Olr779 Negative_regulation of Mtor 1 0.02 0.5 0.16
8 INT273902 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.56 0.15
9 INT349559 Mtor Regulation of Pdpk1 1 0.03 0.42 0.14
10 INT273901 Mtor Positive_regulation of Eif4e 1 0.50 0.54 0.14
11 INT273103 Binding of Mtor and Rps6kb1 1 0.44 0 0.11
12 INT273112 Positive_regulation of Binding of Mtor and Rps6kb1 1 0.46 0.05 0.11
13 INT313482 Binding of MTOR and SST 1 0.01 0 0.1
14 INT249126 Binding of Ephb1 and Mtor 1 0.02 0 0.08
15 INT273104 Mtor Negative_regulation of Gene_expression of Gria1 1 0.46 0.15 0.08
16 INT273107 Bdnf Regulation of Positive_regulation of Mtor 1 0.26 0.09 0.07
17 INT273098 Binding of Bdnf and Positive_regulation of Mtor 1 0.47 0 0.06
18 INT244641 PDGFA Regulation of MTOR 1 0.07 2.55 0.06
19 INT273096 Mtor Positive_regulation of Gene_expression of Grip2 1 0.05 0.07 0.05
20 INT329216 Prkag1 Regulation of Mtor 1 0.01 0.35 0.04
21 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
22 INT257874 Agt Positive_regulation of Mtor 1 0.04 0.37 0.04
23 INT257881 Ins1 Positive_regulation of Mtor 1 0.05 0.37 0.04
24 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03
25 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03
26 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
27 INT313485 MTOR Positive_regulation of Gene_expression of P2RX1 1 0.16 0 0.03
28 INT273105 Mtor Regulation of Gria1 1 0.29 0.07 0.03
29 INT198009 MTOR Regulation of HCC 1 0.09 1.1 0
30 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0
31 INT292137 Regulation of Mtor Regulation of Gene_expression of VEGFA 1 0.01 0.75 0
32 INT150051 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.46 0
33 INT198024 CDCP1 Negative_regulation of MTOR 1 0.00 0.97 0
34 INT251780 RRAD Negative_regulation of MTOR 1 0.00 0.62 0
35 INT273106 Binding of Mtor and Cby1 1 0.01 0 0
36 INT303331 Mtor Positive_regulation of Rps6kb1 1 0.07 0.07 0
37 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
38 INT223575 AKT1 Regulation of MTOR 1 0.12 0.37 0
39 INT276887 MTOR Regulation of Ppargc1a 1 0.23 0.33 0
40 INT250668 AKT1 Positive_regulation of MTOR 1 0.16 1.26 0
41 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0
42 INT292136 Mtor Regulation of Gene_expression of VEGFA 1 0.01 0.75 0
43 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0
44 INT250663 Phosphorylation of AKT1 Positive_regulation of MTOR 1 0.16 1.26 0
45 INT223582 Negative_regulation of MTOR Positive_regulation of Phosphorylation of ESR1 1 0.31 0.67 0
46 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0
47 INT198007 MTOR Regulation of Gene_expression of GOPC 1 0.08 1.33 0
48 INT341310 Binding of Npc1 and Chdh 1 0.11 7.04 0
49 INT296867 Binding of B4galnt2 and Mtor 1 0.00 0.51 0
50 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0
51 INT198013 MTOR Regulation of Gene_expression of MCL1 1 0.29 1.3 0
52 INT341227 Mtor Regulation of Phosphorylation of Eif4ebp1 1 0.02 0.19 0
53 INT290435 Positive_regulation of Binding of Mtor and Utp3 1 0.01 0.26 0
54 INT341308 Negative_regulation of Npc1 Positive_regulation of Gene_expression of Srebf1 1 0.31 1.48 0
55 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0
56 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0
57 INT253373 Binding of Mtor and Prkaa2 1 0.20 0.26 0
58 INT290436 Binding of Mtor and Utp3 1 0.00 0.26 0
59 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0
60 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
61 INT253372 Prkaa2 Regulation of Mtor 1 0.13 0.09 0
62 INT351098 MTOR Regulation of Binding of EPAS1 1 0.08 0.95 0
63 INT295199 Tlr4 Positive_regulation of Positive_regulation of Mtor 1 0.01 0 0
64 INT341309 Binding of Npc1 and Sugt1 1 0.01 1.04 0
65 INT296869 Mtor Positive_regulation of Gene_expression of B4galnt2 1 0.01 1.56 0
66 INT286564 Pkd1 Regulation of Mtor 1 0.00 0.51 0
67 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
68 INT276868 MTOR Regulation of Gene_expression of MTUS1 1 0.01 0.33 0
69 INT341228 Binding of tor and Mtor 1 0.00 0 0
70 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0
71 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0
72 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0
73 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0
74 INT223576 PIK3CG Regulation of MTOR 1 0.15 0.37 0
75 INT198010 KDR Negative_regulation of MTOR 1 0.11 0.95 0
76 INT223580 Positive_regulation of PIK3CG Regulation of MTOR 1 0.25 0.42 0
77 INT256605 FPR1 Positive_regulation of MTOR 1 0.01 2.18 0
78 INT253371 Akt1 Regulation of Mtor 1 0.05 0.19 0
79 INT319026 Binding of Npc1 and Ruvbl1 1 0.00 0.08 0
80 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0
81 INT260264 Binding of MTOR and FKBP7 1 0.26 0.87 0
82 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of macroautophagy. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of macroautophagy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
2 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
3 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
4 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19
5 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02
6 INT3476 Phosphorylation of Npc1 7 0.48 0 4.84
7 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
8 INT228678 Phosphorylation of Mtor 15 0.78 3.18 2.76
9 INT3475 Regulation of Phosphorylation of Npc1 3 0.36 0 2.45
10 INT55470 Regulation of Mtor 16 0.24 12.51 2.07
11 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04
12 INT42585 Positive_regulation of Phosphorylation of Npc1 3 0.19 0 1.59
13 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44
14 INT166764 Localization of Mtor 2 0.75 1.28 1.42
15 INT228671 Negative_regulation of Phosphorylation of Mtor 8 0.50 1.77 1.2
16 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01
17 INT79941 Negative_regulation of Npc1 9 0.59 3.97 0.82
18 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78
19 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7
20 INT15303 Transcription of Mtor 1 0.47 0.17 0.66
21 INT15302 Regulation of Transcription of Mtor 1 0.31 0.17 0.66
22 INT161248 Positive_regulation of Gene_expression of Mtor 2 0.06 6.47 0.51
23 INT223599 Regulation of MTOR 14 0.42 8.52 0.49
24 INT170346 Gene_expression of Npc1 18 0.78 7.69 0.48
25 INT3477 Regulation of Npc1 6 0.45 1.87 0.47
26 INT253391 Positive_regulation of Positive_regulation of Mtor 7 0.48 0.39 0.46
27 INT136180 Binding of MTOR 9 0.35 5.01 0.38
28 INT228668 Positive_regulation of Localization of Mtor 1 0.39 0.62 0.38
29 INT156201 Negative_regulation of Gene_expression of MTOR 6 0.58 7.7 0.36
30 INT97859 Localization of Npc1 12 0.75 6.66 0.35
31 INT4133 Binding of Npc1 14 0.47 8.24 0.33
32 INT32509 Positive_regulation of Npc1 6 0.50 2.24 0.33
33 INT249123 Binding of Mtor 9 0.36 0.57 0.3
34 INT41720 Positive_regulation of Gene_expression of MTOR 2 0.49 1.54 0.28
35 INT41722 Positive_regulation of Negative_regulation of MTOR 1 0.45 0.73 0.28
36 INT156207 Negative_regulation of Phosphorylation of MTOR 5 0.58 2.33 0.25
37 INT327033 Negative_regulation of Phosphorylation of Mtor 3 0.07 1.38 0.23
38 INT32508 Positive_regulation of Positive_regulation of Npc1 2 0.47 0.67 0.23
39 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21
40 INT282732 Positive_regulation of Phosphorylation of Mtor 4 0.06 2.09 0.2
41 INT349553 Negative_regulation of Negative_regulation of Mtor 1 0.40 0.67 0.19
42 INT257861 Positive_regulation of Gene_expression of Mtor 5 0.48 0.9 0.18
43 INT332297 Negative_regulation of Binding of MTOR 2 0.40 1.6 0.18
44 INT38976 Positive_regulation of Negative_regulation of Mtor 2 0.48 0 0.17
45 INT249124 Regulation of Regulation of Mtor 1 0.11 0 0.15
46 INT170340 Regulation of Gene_expression of Npc1 2 0.17 0.38 0.14
47 INT253392 Positive_regulation of Phosphorylation of Mtor 2 0.42 0.26 0.13
48 INT277350 Negative_regulation of Localization of Mtor 1 0.03 1.39 0.11
49 INT257855 Regulation of Positive_regulation of Mtor 3 0.35 0.54 0.1
50 INT277345 Localization of Mtor 3 0.08 1.89 0.09
51 INT327035 Regulation of Phosphorylation of Mtor 1 0.07 0.3 0.09
52 INT296856 Negative_regulation of Gene_expression of Mtor 1 0.05 2.08 0.09
53 INT249121 Positive_regulation of Binding of Mtor 1 0.20 0 0.08
54 INT273094 Regulation of Negative_regulation of Mtor 1 0.43 0.15 0.08
55 INT320843 Negative_regulation of Gene_expression of Npc1 2 0.59 5.82 0.07
56 INT290430 Regulation of Positive_regulation of Mtor 1 0.03 0.42 0.05
57 INT257852 Negative_regulation of Positive_regulation of Mtor 2 0.46 0.21 0.04
58 INT217732 Localization of MTOR 11 0.56 3.19 0.03
59 INT212458 Binding of Mtor 8 0.04 6.77 0.03
60 INT319022 Positive_regulation of Binding of Npc1 2 0.50 0.24 0.03
61 INT282729 Regulation of Binding of Mtor 2 0.05 1.48 0.03
62 INT217730 Positive_regulation of Localization of MTOR 4 0.33 0.86 0
63 INT217731 Positive_regulation of Phosphorylation of MTOR 3 0.40 0.54 0
64 INT246194 Regulation of Phosphorylation of MTOR 2 0.34 0.31 0
65 INT319021 Negative_regulation of Transcription of Npc1 2 0.38 1.44 0
66 INT284329 Regulation of Gene_expression of MTOR 2 0.20 1.63 0
67 INT239157 Positive_regulation of Negative_regulation of Mtor 2 0.11 0.89 0
68 INT155583 Negative_regulation of Positive_regulation of Mtor 2 0.37 0.42 0
69 INT319023 Transcription of Npc1 2 0.63 1.44 0
70 INT279178 Negative_regulation of Positive_regulation of MTOR 1 0.24 0.8 0
71 INT246204 Transcription of MTOR 1 0.25 0 0
72 INT313888 Negative_regulation of Binding of Mtor 1 0.14 0.07 0
73 INT296849 Positive_regulation of Positive_regulation of Mtor 1 0.05 1.24 0
74 INT223608 Negative_regulation of Negative_regulation of MTOR 1 0.32 0.74 0
75 INT256614 Positive_regulation of Binding of MTOR 1 0.18 0.07 0
76 INT298932 Negative_regulation of Localization of MTOR 1 0.08 0.42 0
77 INT223613 Regulation of Negative_regulation of MTOR 1 0.34 1.25 0
78 INT319016 Positive_regulation of Gene_expression of Npc1 1 0.17 0 0
79 INT337052 Regulation of Negative_regulation of Mtor 1 0.03 0.37 0
80 INT296858 Regulation of Gene_expression of Mtor 1 0.04 0 0
81 INT320845 Regulation of Localization of Npc1 1 0.39 0.71 0
82 INT319015 Regulation of Binding of Npc1 1 0.16 0 0
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