GO:0016265

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Name death
Categary Process
Go Slim No
Go Link GO:0016265
Unique Molecular Interactions 105
Total Molecular Interactions 159
Total Single Events 1239
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for death. They are ordered first by their pain relevance and then by number of times they were reported for death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
2 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
3 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
4 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
5 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
6 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
7 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
8 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99
9 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
10 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
11 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
12 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
13 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
14 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66
15 INT151783 Regulation of Binding of Calca and P2rx1 1 0.42 0.51 0.64
16 INT151778 Binding of Calca and P2rx1 1 0.35 0.5 0.64
17 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59
18 INT170446 Pax3 Positive_regulation of Gene_expression of Spr 1 0.01 0 0.58
19 INT167907 Binding of F2r and ITS 1 0.01 0.7 0.55
20 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
21 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
22 INT152281 Binding of P2rx1 and Trpv1 1 0.15 0.42 0.49
23 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
24 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 0.50 0.07 0.44
25 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
26 INT217034 P2RX1 Regulation of Gene_expression of Ik 1 0.00 0.34 0.42
27 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41
28 INT161082 asp3 Regulation of Gpt 1 0.23 0.67 0.4
29 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
30 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
31 INT90723 Nr4a2 Positive_regulation of Egr1 1 0.22 0.49 0.35
32 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
33 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
34 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
35 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
36 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
37 INT99599 ZNF398 Negative_regulation of NR4A2 1 0.05 0.41 0.3
38 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3
39 INT99600 ZNF398 Negative_regulation of Transcription of NR4A2 1 0.10 0.41 0.3
40 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
41 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
42 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
43 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
44 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
45 INT305686 Binding of Gfap and F2r 1 0.01 0 0.25
46 INT114818 Try4 Positive_regulation of Afg3l2 1 0.04 0.39 0.25
47 INT114820 TPSG1 Positive_regulation of Afg3l2 1 0.06 0.39 0.24
48 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24
49 INT114819 Proc Positive_regulation of Afg3l2 1 0.07 0.39 0.24
50 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
51 INT123660 F2R Positive_regulation of PAR1 2 0.10 1.96 0.22
52 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
53 INT123664 F2R Positive_regulation of PAR4 1 0.03 0.51 0.19
54 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18
55 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
56 INT264277 Binding of Car2 and P2rx1 1 0.10 0 0.16
57 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
58 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
59 INT207117 Binding of VEGFA and F2r 1 0.02 0.56 0.15
60 INT338040 Ctsg Positive_regulation of F2r 1 0.29 0 0.15
61 INT338052 F2r Positive_regulation of F2rl3 1 0.12 0 0.15
62 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
63 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
64 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
65 INT313486 GOPC Positive_regulation of P2RX1 1 0.13 0 0.1
66 INT262255 Binding of APC and F2R 1 0.05 3 0.1
67 INT313484 Binding of P2RX1 and SST 1 0.04 0 0.09
68 INT304456 Binding of P2rx1 and P2rx4 1 0.14 0 0.07
69 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
70 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
71 INT267093 FGFR1 Positive_regulation of Gene_expression of P2rx1 1 0.03 0.2 0.03
72 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
73 INT313485 MTOR Positive_regulation of Gene_expression of P2RX1 1 0.16 0 0.03
74 INT261729 COL5A2 Regulation of Gene_expression of F2R 1 0.18 0 0
75 INT224024 Binding of P2RX1 and WDTC1 1 0.01 0.71 0
76 INT339800 P2RX1 Regulation of Negative_regulation of GOPC 1 0.04 0 0
77 INT241605 Binding of Tcf15 and SCFV 1 0.07 1 0
78 INT224027 Binding of P2RX1 and P2RY12 1 0.10 0.71 0
79 INT261732 F2 Positive_regulation of F2R 1 0.14 0 0
80 INT338047 Binding of F2r and Pard3 1 0.11 0 0
81 INT142143 F2r Regulation of Plcg1 1 0.02 0.07 0
82 INT261730 ROCK1 Positive_regulation of Positive_regulation of F2R 1 0.37 0 0
83 INT299445 Lhb Positive_regulation of Gene_expression of Nr4a2 1 0.22 0.13 0
84 INT142142 F2r Positive_regulation of Phosphorylation of Plcg1 1 0.03 0.08 0
85 INT353337 F2r Positive_regulation of Gene_expression of Mif 1 0.46 0 0
86 INT261735 Positive_regulation of F2 Positive_regulation of F2R 1 0.14 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for death. They are ordered first by their pain relevance and then by number of times they were reported in death. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
2 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
3 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
4 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
5 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
6 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
7 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
8 INT95172 Localization of P2rx1 14 0.78 6.77 7.81
9 INT90943 Negative_regulation of P2rx1 13 0.42 8.21 7.22
10 INT114014 Positive_regulation of Gene_expression of P2rx1 13 0.69 7.77 7.15
11 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78
12 INT71758 Gene_expression of P2RX1 40 0.75 9.01 6.14
13 INT170443 Gene_expression of Spr 1 0.12 0.07 5.88
14 INT25831 Gene_expression of NR4A2 20 0.74 2.73 4.92
15 INT71759 Positive_regulation of P2RX1 13 0.67 3.53 4.9
16 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
17 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62
18 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23
19 INT95171 Binding of P2rx1 12 0.36 4.69 3.92
20 INT80473 Gene_expression of Spr 5 0.46 2.76 3.86
21 INT46754 Localization of F2r 7 0.78 2.36 3.24
22 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
23 INT101406 Regulation of Spr 3 0.25 1.32 2.95
24 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89
25 INT170439 Positive_regulation of Spr 1 0.10 0.3 2.67
26 INT82653 Regulation of F2r 8 0.36 3.78 2.62
27 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
28 INT50723 Positive_regulation of Nr4a2 7 0.53 0.47 2.46
29 INT99607 Transcription of NR4A2 2 0.68 1.61 2.41
30 INT121435 Negative_regulation of Gene_expression of P2rx1 3 0.43 1.82 2.21
31 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
32 INT52865 Positive_regulation of Spr 2 0.49 0.56 2.06
33 INT215166 Binding of P2rx1 5 0.35 0.41 1.97
34 INT106984 Regulation of P2RX1 12 0.60 2.05 1.75
35 INT146948 Negative_regulation of Positive_regulation of P2rx1 2 0.34 2.23 1.74
36 INT81169 Localization of Nr4a2 1 0.68 0 1.71
37 INT149435 Regulation of Positive_regulation of P2rx1 2 0.30 1.55 1.67
38 INT80469 Negative_regulation of Spr 2 0.30 1.62 1.61
39 INT50724 Positive_regulation of Positive_regulation of Nr4a2 2 0.49 0.17 1.58
40 INT156231 Binding of F2r 9 0.23 3.78 1.57
41 INT101405 Binding of Spr 1 0.20 0.43 1.55
42 INT53008 Gene_expression of Nr4a2 25 0.74 4.89 1.5
43 INT151777 Regulation of Gene_expression of P2rx1 3 0.60 1.97 1.48
44 INT215162 Phosphorylation of P2rx1 2 0.43 0.12 1.34
45 INT244284 Binding of SLC18A2 1 0.23 1.87 1.34
46 INT102200 Gene_expression of Nr4a2 9 0.72 3.69 1.28
47 INT155662 Positive_regulation of Localization of P2rx1 2 0.47 1.92 1.26
48 INT117498 Regulation of Positive_regulation of F2r 1 0.18 0.91 1.24
49 INT98976 Regulation of F2r 7 0.60 0.71 1.22
50 INT71757 Localization of P2RX1 4 0.73 2.11 1.22
51 INT170440 Positive_regulation of Gene_expression of Spr 1 0.10 0 1.21
52 INT132283 Regulation of P2rx1 3 0.13 0 1.2
53 INT338033 Localization of F2r 1 0.41 0.62 1.2
54 INT80471 Negative_regulation of Gene_expression of Spr 1 0.22 1.19 1.16
55 INT160652 Positive_regulation of Binding of P2rx1 1 0.36 0.67 1.15
56 INT161080 Negative_regulation of asp3 1 0.23 1.28 1.03
57 INT107143 Negative_regulation of P2RX1 11 0.56 2.92 1.01
58 INT132574 Positive_regulation of SLC18A2 1 0.12 0.25 0.99
59 INT267071 Positive_regulation of Gene_expression of P2rx1 2 0.49 1.77 0.98
60 INT326601 Gene_expression of SLC18A2 2 0.42 1.31 0.92
61 INT127103 Negative_regulation of Gene_expression of P2rx1 5 0.41 0.46 0.91
62 INT192123 Transcription of P2rx1 4 0.27 1.24 0.91
63 INT195105 Negative_regulation of Gene_expression of F2r 3 0.37 1.41 0.91
64 INT148259 Negative_regulation of Gene_expression of NR4A2 2 0.55 0.71 0.91
65 INT101402 Positive_regulation of Gene_expression of Spr 1 0.27 0.26 0.88
66 INT101403 Transcription of Spr 1 0.29 0.26 0.88
67 INT101400 Positive_regulation of Transcription of Spr 1 0.25 0.26 0.88
68 INT147867 Localization of Spr 1 0.65 1.16 0.84
69 INT148118 Positive_regulation of Gene_expression of P2RX1 4 0.48 0.78 0.83
70 INT101404 Regulation of Gene_expression of Spr 1 0.34 0.28 0.8
71 INT195099 Positive_regulation of Gene_expression of F2r 7 0.57 5.31 0.78
72 INT353325 Positive_regulation of Localization of F2r 1 0.49 1.31 0.76
73 INT148261 Negative_regulation of Transcription of NR4A2 1 0.41 0.31 0.72
74 INT90714 Positive_regulation of Nr4a2 1 0.67 0.97 0.71
75 INT62192 Regulation of Localization of F2r 2 0.60 0.59 0.7
76 INT326602 Negative_regulation of Gene_expression of SLC18A2 1 0.25 0.93 0.67
77 INT207089 Regulation of Negative_regulation of F2r 1 0.17 1.49 0.62
78 INT353321 Regulation of Positive_regulation of F2r 1 0.60 0.6 0.62
79 INT224011 Binding of P2RX1 7 0.45 1.12 0.6
80 INT123672 Positive_regulation of F2R 9 0.47 0.77 0.58
81 INT149974 Positive_regulation of Gene_expression of NR4A2 4 0.41 0.52 0.58
82 INT148260 Negative_regulation of NR4A2 2 0.36 0.68 0.56
83 INT148258 Regulation of Gene_expression of NR4A2 1 0.26 0.39 0.56
84 INT148265 Regulation of Transcription of NR4A2 1 0.58 0.39 0.56
85 INT217018 Regulation of Regulation of P2RX1 3 0.26 0.34 0.54
86 INT215787 Localization of P2rx1 3 0.68 0.49 0.54
87 INT191777 Binding of F2r 2 0.02 0.89 0.54
88 INT338026 Regulation of Localization of F2r 1 0.25 0.05 0.52
89 INT161081 Gene_expression of asp3 1 0.37 0.69 0.49
90 INT114815 Positive_regulation of Afg3l2 1 0.45 0.68 0.47
91 INT313494 Regulation of Gene_expression of P2RX1 3 0.42 0 0.45
92 INT215494 Positive_regulation of Phosphorylation of P2rx1 1 0.26 0 0.42
93 INT147866 Regulation of Localization of Spr 1 0.43 0.49 0.41
94 INT217012 Transcription of P2RX1 1 0.21 0.26 0.39
95 INT239115 Regulation of Binding of P2rx1 1 0.16 0 0.39
96 INT215503 Negative_regulation of Positive_regulation of P2rx1 1 0.23 0 0.38
97 INT341920 Negative_regulation of Binding of P2rx1 1 0.20 0.06 0.36
98 INT144981 Binding of F2R 3 0.36 1.66 0.35
99 INT353324 Negative_regulation of Positive_regulation of F2r 1 0.41 0.24 0.35
100 INT90716 Regulation of Gene_expression of Nr4a2 2 0.43 0.41 0.32
101 INT99609 Localization of NR4A2 2 0.73 0.6 0.3
102 INT99611 Negative_regulation of Localization of NR4A2 1 0.42 0.41 0.3
103 INT246013 Transcription of Nr4a2 4 0.46 1.29 0.27
104 INT148898 Negative_regulation of Gene_expression of Nr4a2 3 0.54 1.13 0.26
105 INT62191 Negative_regulation of Localization of F2r 1 0.35 0 0.26
106 INT276798 Positive_regulation of NR4A2 2 0.16 0.08 0.25
107 INT195091 Negative_regulation of Positive_regulation of F2r 1 0.48 1.69 0.25
108 INT114817 Protein_catabolism of Afg3l2 1 0.64 0.39 0.24
109 INT305682 Positive_regulation of Positive_regulation of F2r 1 0.03 0 0.24
110 INT195112 Positive_regulation of Positive_regulation of F2r 1 0.41 0.97 0.18
111 INT224005 Negative_regulation of Gene_expression of P2RX1 3 0.40 0.48 0.17
112 INT261745 Regulation of F2R 1 0.43 0.22 0.16
113 INT261739 Regulation of Gene_expression of F2R 1 0.26 0.22 0.16
114 INT98700 Regulation of Gene_expression of F2r 1 0.45 0 0.15
115 INT207087 Negative_regulation of Binding of F2r 1 0.27 0.06 0.14
116 INT159223 Binding of NR4A2 2 0.47 0.38 0.12
117 INT197289 Transcription of Nr4a2 1 0.06 0.06 0.12
118 INT341919 Positive_regulation of Binding of P2rx1 1 0.23 0 0.11
119 INT307530 Negative_regulation of Binding of F2R 1 0.03 0 0.09
120 INT84940 Binding of Nr4a2 1 0.35 0.09 0.08
121 INT339811 Regulation of Positive_regulation of P2RX1 1 0.42 0 0.08
122 INT145503 Protein_catabolism of F2r 1 0.66 0.46 0.07
123 INT195082 Regulation of Gene_expression of F2r 1 0.37 0.67 0.07
124 INT261737 Transcription of F2R 1 0.50 0.31 0.05
125 INT246012 Negative_regulation of Gene_expression of Nr4a2 1 0.29 0.06 0.05
126 INT246014 Negative_regulation of Nr4a2 1 0.29 0 0.05
127 INT215817 Transcription of P2rx1 1 0.18 0 0.04
128 INT313493 Positive_regulation of Negative_regulation of P2RX1 1 0.48 0 0.04
129 INT246015 Localization of Nr4a2 1 0.50 0 0.03
130 INT353327 Transcription of F2r 1 0.67 0.21 0.03
131 INT191771 Positive_regulation of Gene_expression of F2r 1 0.01 0.31 0.03
132 INT338031 Transcription of F2r 1 0.39 0 0
133 INT206868 Regulation of NR4A2 1 0.02 0.28 0
134 INT353323 Negative_regulation of Gene_expression of F2r 1 0.41 0 0
135 INT261741 Negative_regulation of Positive_regulation of F2R 1 0.40 0 0
136 INT261743 Positive_regulation of Positive_regulation of F2R 1 0.44 0 0
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