GO:0016290

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Name palmitoyl-CoA hydrolase activity
Categary Function
Go Slim No
Go Link GO:0016290
Unique Molecular Interactions 143
Total Molecular Interactions 180
Total Single Events 2885
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for palmitoyl-CoA hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported for palmitoyl-CoA hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
2 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
3 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
4 INT17299 Prss12 Regulation of Localization of Acot1 3 0.05 0 2.07
5 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
6 INT30743 Cck Regulation of Localization of Acot1 1 0.02 0 1.64
7 INT18592 Sst Regulation of Localization of Acot1 2 0.22 0 1.61
8 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 0.06 0.49 1.39
9 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
10 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
11 INT62018 CSF2 Regulation of ACOT1 1 0.12 0.47 1.21
12 INT18596 Fdft1 Regulation of Localization of Acot1 1 0.06 0 1.14
13 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 0.11 0 1.11
14 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
15 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
16 INT18595 Fdft1 Positive_regulation of Localization of Acot1 1 0.08 0 0.96
17 INT18597 Sst Positive_regulation of Localization of Acot1 1 0.29 0 0.96
18 INT70802 Ngf Regulation of Ppt1 1 0.21 0.39 0.93
19 INT154259 Nts Positive_regulation of Acot1 1 0.04 0 0.91
20 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87
21 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85
22 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84
23 INT128739 Penk Negative_regulation of Acot1 1 0.19 0 0.77
24 INT164713 Binding of Avp and Positive_regulation of Localization of Acot1 1 0.32 0.43 0.69
25 INT164715 Avp Positive_regulation of Localization of Acot1 1 0.28 0.43 0.69
26 INT172698 Ugt1a6 Negative_regulation of Localization of Acot1 1 0.01 0 0.68
27 INT56669 Nts Regulation of Localization of Acot1 2 0.12 0 0.65
28 INT164721 Binding of NT5C and Acot1 1 0.04 0.45 0.65
29 INT164714 Binding of Avp and Acot1 1 0.26 0.45 0.64
30 INT190525 Acot1 Positive_regulation of Localization of S100a8 1 0.00 0.86 0.63
31 INT190526 Acot1 Positive_regulation of Il1 1 0.01 0.87 0.63
32 INT114593 Il1b Positive_regulation of Gene_expression of Ppt1 1 0.05 0.06 0.48
33 INT28032 TNIP3 Negative_regulation of Acot1 1 0.00 0 0.47
34 INT109780 WAS Regulation of Localization of Acot1 1 0.01 0.26 0.46
35 INT53649 Acot1 Positive_regulation of Calca 1 0.25 0 0.44
36 INT63152 Ppt1 Regulation of Gene_expression of Pd 1 0.01 0 0.43
37 INT87009 Acot1 Negative_regulation of Hc3 1 0.19 0.34 0.43
38 INT5531 Binding of Acot1 and Chrna2 1 0.12 0 0.42
39 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42
40 INT171186 Binding of PPFIA4 and ACOT1 1 0.00 0.37 0.42
41 INT171183 Binding of BHLHE23 and ACOT1 1 0.01 0.36 0.42
42 INT114601 Il1b Positive_regulation of Transcription of Ppt1 1 0.35 0.1 0.41
43 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
44 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4
45 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
46 INT49123 Negative_regulation of Nka1 Positive_regulation of Acot1 1 0.06 0 0.38
47 INT49122 Nka1 Positive_regulation of Acot1 1 0.07 0 0.38
48 INT340850 Binding of IGHE and Baat 1 0.07 0.27 0.37
49 INT87769 Binding of Acot1 and Treh 1 0.00 0 0.35
50 INT343366 Acsf2 Negative_regulation of Acot1 1 0.05 0 0.31
51 INT58898 Adcyap1 Regulation of Localization of Acot1 1 0.17 0 0.28
52 INT58899 Vip Regulation of Localization of Acot1 1 0.17 0 0.28
53 INT272174 Acot1 Regulation of Ca2 1 0.01 0 0.26
54 INT40964 Binding of Eef1a1 and Positive_regulation of Localization of Acot1 1 0.08 0 0.26
55 INT160225 Acot1 Negative_regulation of Ache 1 0.28 2.18 0.25
56 INT97868 Binding of Chrna2 and Regulation of Acot1 1 0.09 0 0.23
57 INT124383 ACOT1 Positive_regulation of MME 1 0.01 0.17 0.22
58 INT167486 Positive_regulation of Binding of CD63 and ACOT1 1 0.01 0 0.21
59 INT167485 Binding of CD63 and ACOT1 1 0.00 0 0.21
60 INT157083 Ghrl Regulation of Gene_expression of Ppt1 1 0.40 0 0.2
61 INT80927 Acot1 Positive_regulation of Car2 1 0.31 0 0.2
62 INT180441 Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19
63 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
64 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
65 INT60417 Chrm1 Regulation of Localization of Acot1 1 0.13 0 0.19
66 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
67 INT159720 Slc5a7 Regulation of Gene_expression of Acot1 1 0.12 0 0.19
68 INT180440 Positive_regulation of Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19
69 INT159722 Slc5a7 Positive_regulation of Gene_expression of Acot1 1 0.12 0 0.19
70 INT159721 Hc3 Negative_regulation of Gene_expression of Acot1 1 0.04 0 0.19
71 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
72 INT60348 Trh Positive_regulation of Positive_regulation of Acot1 1 0.29 0.44 0.17
73 INT254497 GOPC Regulation of Transcription of HNF4A 1 0.02 0.72 0.16
74 INT10197 Dclk2 Positive_regulation of Localization of Acot1 1 0.03 0.26 0.15
75 INT10198 Dclk2 Regulation of Localization of Acot1 1 0.02 0.26 0.15
76 INT141224 Ache Regulation of Acot1 1 0.09 0.29 0.14
77 INT75791 Positive_regulation of Htr3a Regulation of Acot1 1 0.23 0.12 0.14
78 INT278583 Ppt1 Negative_regulation of Gene_expression of Atp6v1e1 1 0.05 0 0.13
79 INT110107 Acot1 Positive_regulation of Localization of Prkce 1 0.11 0 0.12
80 INT104327 Fen1 Negative_regulation of Baat 1 0.31 0.75 0.12
81 INT104325 Regulation of Fen1 Negative_regulation of Baat 1 0.19 0.75 0.12
82 INT50903 Ppt1 Regulation of Tac4 1 0.18 0 0.11
83 INT50901 Ppt1 Regulation of Transcription of Tac4 1 0.18 0 0.11
84 INT141223 Bche Regulation of Gene_expression of Acot1 1 0.09 0 0.1
85 INT141225 Bche Regulation of Acot1 1 0.09 0 0.1
86 INT5529 Acot1 Positive_regulation of Chrna2 1 0.17 0 0.09
87 INT254496 Binding of HNF4A and GOPC 1 0.10 0.34 0.08
88 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08
89 INT227303 Zbp1 Regulation of Transcription of Baat 1 0.09 1.43 0.08
90 INT5530 Positive_regulation of Binding of Acot1 and Chrna2 1 0.15 0 0.07
91 INT291007 Pomc Positive_regulation of Ppt1 1 0.14 0.06 0.06
92 INT291174 Rpa1 Positive_regulation of Baat 1 0.03 0.63 0.04
93 INT266452 Binding of Acot1 and GOPC 1 0.02 1.23 0.04
94 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04
95 INT266039 Binding of Acot1 and Amh-rs5 1 0.00 0.13 0.04
96 INT197616 Ppt1 Negative_regulation of ge 1 0.00 0.05 0.03
97 INT251701 Bche Regulation of Gene_expression of Acot1 1 0.03 0.25 0.03
98 INT197587 Ppt1 Positive_regulation of Rb1 1 0.18 0 0.03
99 INT49894 Acot1 Positive_regulation of Rrsv 1 0.10 0 0
100 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0
101 INT219416 CCNA2 Regulation of HNF4A 1 0.00 0.11 0
102 INT235596 HNF4A Regulation of Gene_expression of TPI1 1 0.00 0.25 0
103 INT182952 KCNIP3 Positive_regulation of HNF4A 1 0.02 0.45 0
104 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0
105 INT266453 SNRNP70 Regulation of Acot1 1 0.00 0.53 0
106 INT182922 FRA8E Positive_regulation of HNF4A 1 0.00 0.2 0
107 INT268013 Binding of Nos3 and Acot1 1 0.02 1.48 0
108 INT307214 Hnf4a Regulation of Ppara 1 0.18 0.35 0
109 INT182926 VDR Positive_regulation of HNF4A 1 0.02 0.09 0
110 INT326836 Binding of HNF4A and PLD2 1 0.03 0.35 0
111 INT104328 Fen1 Positive_regulation of Baat 1 0.33 0.63 0
112 INT219410 CCNF Regulation of HNF4A 1 0.01 0.11 0
113 INT182938 Binding of HNF4A and KCNIP3 1 0.01 0.2 0
114 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
115 INT219420 CCNE2 Regulation of HNF4A 1 0.00 0.11 0
116 INT173123 Binding of HNF4A and PPARA 1 0.10 0.19 0
117 INT183018 Dre Positive_regulation of HNF4A 1 0.00 0.09 0
118 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
119 INT104326 Regulation of Fen1 Positive_regulation of Baat 1 0.19 0.63 0
120 INT182927 Binding of HNF4A and HRES1 1 0.00 0 0
121 INT326902 Binding of HNF4A and Tcf4 1 0.02 0.35 0
122 INT181835 Binding of Baat and Ppara 1 0.09 0.31 0
123 INT291173 Ins1 Regulation of Baat 1 0.12 0.83 0
124 INT192087 Atr Regulation of Localization of Acot1 1 0.04 0 0
125 INT197595 Ppt1 Regulation of Pgr 1 0.08 0.26 0
126 INT49893 Acot1 Positive_regulation of Nrf1 1 0.00 0 0
127 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0
128 INT278574 Ppt1 Positive_regulation of Tac1 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for palmitoyl-CoA hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported in palmitoyl-CoA hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1352 Localization of Acot1 728 0.80 73.01 296.01
2 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35
3 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17
4 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13
5 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56
6 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44
7 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4
8 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68
9 INT605 Regulation of Acot1 61 0.62 10.7 26.34
10 INT45437 Localization of Acot1 84 0.79 17.37 22.18
11 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83
12 INT4894 Transcription of Ppt1 34 0.67 5.93 21.06
13 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52
14 INT20721 Localization of ACOT1 47 0.80 11.37 10.95
15 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46
16 INT24651 Positive_regulation of Transcription of Ppt1 12 0.47 2.88 8.42
17 INT3983 Positive_regulation of Acot1 30 0.68 5.83 8.34
18 INT12757 Negative_regulation of Positive_regulation of Acot1 16 0.42 2.27 8.25
19 INT5774 Regulation of Ppt1 22 0.60 4.97 7.1
20 INT127 Positive_regulation of ACOT1 16 0.32 5.12 6.57
21 INT45101 Positive_regulation of Gene_expression of Acot1 13 0.40 2.2 6.55
22 INT13854 Positive_regulation of Positive_regulation of Acot1 13 0.50 1.78 6.03
23 INT4888 Positive_regulation of Gene_expression of Ppt1 9 0.54 2.78 5.83
24 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43
25 INT55353 Negative_regulation of Positive_regulation of Ppt1 9 0.57 0.31 5.37
26 INT27803 Regulation of ACOT1 16 0.38 5.94 4.64
27 INT45433 Positive_regulation of Localization of Acot1 18 0.45 1.9 4.32
28 INT3722 Negative_regulation of Acot1 19 0.42 4.88 4.21
29 INT94132 Binding of ACOT1 7 0.13 2.62 4.04
30 INT5526 Binding of Acot1 13 0.30 0.67 4
31 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52
32 INT115227 Regulation of Localization of Acot1 12 0.60 0.15 3.51
33 INT55352 Regulation of Gene_expression of Ppt1 9 0.44 0.4 3.51
34 INT41490 Regulation of Acot1 14 0.45 1.59 3.34
35 INT14857 Negative_regulation of Gene_expression of Ppt1 7 0.42 1.16 3.3
36 INT27973 Gene_expression of ACOT1 31 0.65 15.7 3.15
37 INT137961 Localization of Ppt1 1 0.64 2.89 3.09
38 INT20722 Regulation of Localization of ACOT1 5 0.27 1.43 2.86
39 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68
40 INT20060 Protein_catabolism of Acot1 6 0.56 0.22 2.45
41 INT74237 Positive_regulation of Ppt1 3 0.49 2.92 2.32
42 INT70420 Positive_regulation of Localization of ACOT1 11 0.30 1.26 2.25
43 INT20720 Negative_regulation of Localization of ACOT1 6 0.35 2.66 2.25
44 INT22719 Negative_regulation of Negative_regulation of Acot1 5 0.43 0.77 2.2
45 INT42172 Negative_regulation of Gene_expression of Acot1 7 0.38 1.64 1.96
46 INT14862 Negative_regulation of Transcription of Ppt1 3 0.42 0 1.8
47 INT144292 Binding of Ppt1 9 0.37 2.02 1.71
48 INT117024 Negative_regulation of Localization of Acot1 6 0.41 1.56 1.7
49 INT159718 Negative_regulation of Gene_expression of Acot1 4 0.16 1.4 1.56
50 INT56309 Positive_regulation of Baat 9 0.39 8.47 1.51
51 INT110749 Gene_expression of Ppt1 9 0.34 0.51 1.49
52 INT60220 Positive_regulation of Gene_expression of Acot1 6 0.38 0.52 1.49
53 INT340324 Regulation of Ppt1 1 0.13 1.17 1.47
54 INT4889 Regulation of Transcription of Ppt1 3 0.35 0.89 1.34
55 INT53316 Localization of Ppt1 5 0.65 1.59 1.32
56 INT63532 Positive_regulation of Positive_regulation of Ppt1 2 0.67 0 1.29
57 INT62021 Negative_regulation of Positive_regulation of ACOT1 1 0.18 0.51 1.24
58 INT172630 Binding of HNF4A 16 0.05 7.78 1.22
59 INT133112 Regulation of Baat 2 0.61 11.99 1.2
60 INT55351 Positive_regulation of Negative_regulation of Ppt1 3 0.45 0 1.19
61 INT132987 Positive_regulation of Positive_regulation of Acot1 5 0.39 1.43 1.12
62 INT56310 Gene_expression of Baat 15 0.44 15.5 1.11
63 INT75698 Negative_regulation of Negative_regulation of Ppt1 1 0.42 1.01 1.11
64 INT75699 Negative_regulation of Ppt1 2 0.58 1.07 1.08
65 INT20061 Negative_regulation of Protein_catabolism of Acot1 2 0.36 0 1.08
66 INT22720 Regulation of Negative_regulation of Acot1 3 0.24 0.34 1.04
67 INT172616 Regulation of HNF4A 9 0.06 4.25 1.02
68 INT123577 Negative_regulation of Positive_regulation of Baat 2 0.58 1.78 1.02
69 INT87765 Binding of Acot1 4 0.07 2.59 0.95
70 INT45082 Protein_catabolism of Acot1 4 0.20 1.15 0.92
71 INT55350 Regulation of Negative_regulation of Ppt1 2 0.60 0 0.86
72 INT227601 Gene_expression of Acot7 7 0.75 1.54 0.74
73 INT17296 Regulation of Positive_regulation of Acot1 2 0.24 0.29 0.65
74 INT44696 Gene_expression of Baat 5 0.64 3.1 0.59
75 INT63533 Negative_regulation of Negative_regulation of Ppt1 1 0.29 0 0.59
76 INT107422 Positive_regulation of Regulation of Acot1 1 0.37 0 0.59
77 INT356226 Positive_regulation of Transcription of Acot1 1 0.06 0.28 0.54
78 INT356223 Transcription of Acot1 1 0.07 0.28 0.54
79 INT22721 Regulation of Protein_catabolism of Acot1 2 0.23 0.17 0.53
80 INT100099 Regulation of Positive_regulation of Ppt1 1 0.26 0 0.5
81 INT63249 Positive_regulation of Regulation of Ppt1 1 0.49 0 0.5
82 INT340845 Regulation of Baat 1 0.08 0 0.47
83 INT275642 Negative_regulation of HNF4A 4 0.05 2.08 0.44
84 INT166858 Positive_regulation of Protein_catabolism of Acot1 1 0.10 0 0.43
85 INT104324 Negative_regulation of Baat 4 0.38 9.79 0.42
86 INT166857 Negative_regulation of Protein_catabolism of Acot1 1 0.12 0 0.42
87 INT32052 Positive_regulation of Negative_regulation of Acot1 2 0.24 0.73 0.41
88 INT104323 Regulation of Positive_regulation of Baat 2 0.39 1.61 0.38
89 INT106253 Positive_regulation of HNF4A 14 0.29 3.88 0.34
90 INT44695 Binding of Baat 1 0.26 0.67 0.32
91 INT183208 Transcription of HNF4A 7 0.11 3.15 0.28
92 INT45081 Negative_regulation of Negative_regulation of Acot1 1 0.03 0 0.28
93 INT46357 Regulation of Gene_expression of Acot1 4 0.45 1.1 0.26
94 INT45435 Positive_regulation of Negative_regulation of Acot1 2 0.39 0 0.26
95 INT45434 Negative_regulation of Positive_regulation of Acot1 2 0.41 0 0.25
96 INT44697 Positive_regulation of Gene_expression of Baat 1 0.42 0.6 0.24
97 INT133113 Positive_regulation of Positive_regulation of Baat 1 0.46 0.57 0.22
98 INT275639 Positive_regulation of Binding of HNF4A 2 0.04 0.87 0.21
99 INT181826 Transcription of Baat 4 0.35 4.43 0.2
100 INT60751 Positive_regulation of Gene_expression of HNF4A 2 0.49 3.5 0.19
101 INT181819 Binding of Baat 2 0.24 0.96 0.19
102 INT164022 Regulation of Gene_expression of HNF4A 1 0.03 0.82 0.16
103 INT287253 Regulation of Negative_regulation of ACOT1 1 0.06 0.22 0.15
104 INT227280 Regulation of Gene_expression of Baat 4 0.26 3.82 0.14
105 INT73811 Regulation of Regulation of Acot1 1 0.05 0.07 0.14
106 INT287917 Phosphorylation of HNF4A 1 0.08 0.07 0.13
107 INT63907 Regulation of Positive_regulation of Acot1 1 0.20 0.14 0.12
108 INT287252 Positive_regulation of Gene_expression of ACOT1 1 0.05 0.18 0.12
109 INT246312 Regulation of Gene_expression of Acot1 2 0.07 0.15 0.1
110 INT242256 Negative_regulation of Regulation of ACOT1 1 0.26 0.53 0.1
111 INT126667 Localization of HNF4A 2 0.06 0.45 0.08
112 INT220704 Protein_catabolism of ACOT1 1 0.02 1.19 0.08
113 INT227277 Regulation of Transcription of Baat 1 0.19 1.02 0.05
114 INT287925 Regulation of Binding of HNF4A 1 0.06 1.1 0.05
115 INT227263 Negative_regulation of Gene_expression of Baat 2 0.24 2.78 0.03
116 INT181830 Positive_regulation of Transcription of Baat 1 0.18 0.31 0
117 INT180416 Phosphorylation of Acot1 1 0.09 0.19 0
118 INT326868 Positive_regulation of Transcription of HNF4A 1 0.04 0.08 0
119 INT307985 Positive_regulation of Negative_regulation of ACOT1 1 0.01 0.26 0
120 INT49891 Positive_regulation of Regulation of Acot1 1 0.11 0 0
121 INT348051 Transcription of ACOT1 1 0.44 0.58 0
122 INT227264 Localization of Baat 1 0.32 0.46 0
123 INT348050 Negative_regulation of Gene_expression of ACOT1 1 0.27 1.05 0
124 INT180421 Positive_regulation of Phosphorylation of Acot1 1 0.07 0.14 0
125 INT326878 Negative_regulation of Gene_expression of HNF4A 1 0.03 0.43 0
126 INT287915 Positive_regulation of Positive_regulation of HNF4A 1 0.06 0.37 0
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