GO:0016301

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Name kinase activity
Categary Function
Go Slim Yes
Go Link GO:0016301
Unique Molecular Interactions 3904
Total Molecular Interactions 5065
Total Single Events 34290
Pain Genes Associated 297

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
2 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
3 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
4 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
5 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
6 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
7 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
8 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
9 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
10 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
11 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
12 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
13 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
14 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
15 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
16 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
17 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
18 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
19 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
20 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
21 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
22 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
23 INT92182 Mir702 Negative_regulation of Adk 1 0.07 1.29 2.47
24 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
25 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
26 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
27 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
28 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
29 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
30 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
31 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
32 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
33 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
34 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
35 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
36 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
37 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
38 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
39 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
40 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
41 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
42 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
43 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
44 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
45 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
46 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
47 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
48 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
49 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
50 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
51 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
52 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
53 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
54 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
55 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
56 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
57 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
58 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
59 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
60 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
61 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
62 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
63 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
64 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
65 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
66 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
67 INT149632 Binding of HK1 and NCOR2 1 0.01 0.13 1.58
68 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
69 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
70 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
71 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
72 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
73 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
74 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
75 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47
76 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
77 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
78 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
79 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
80 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
81 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
82 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
83 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
84 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
85 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
86 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
87 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
88 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
89 INT148451 Gene_expression of Inhbe Positive_regulation of Pik3cd 1 0.04 1.35 1.4
90 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
91 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
92 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
93 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
94 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
95 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
96 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
97 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
98 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
99 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
100 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
101 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
102 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
103 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
104 INT145473 Mastl Positive_regulation of Dnahc8 1 0.07 0.06 1.33
105 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
106 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
107 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31
108 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3
109 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
110 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29
111 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
112 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
113 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
114 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
115 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
116 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
117 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
118 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
119 INT124108 Binding of RYBP and Ccne1 1 0.09 0.34 1.26
120 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
121 INT73710 Mastl Positive_regulation of Localization of Oprl1 1 0.02 0 1.26
122 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
123 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
124 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
125 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
126 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
127 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
128 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
129 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
130 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
131 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
132 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
133 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
134 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
135 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
136 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
137 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
138 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
139 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
140 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
141 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
142 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
143 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
144 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
145 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
146 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
147 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
148 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
149 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
150 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
151 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
152 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
153 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
154 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
155 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
156 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
157 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
158 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
159 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
160 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
161 INT76378 Binding of Cit and Flvcr2 1 0.09 0.17 1.15
162 INT123387 Binding of Camk2a and Gria2 1 0.13 0.32 1.14
163 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
164 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
165 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
166 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
167 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
168 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
169 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
170 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
171 INT104320 Binding of Adk and Ado 1 0.33 0.3 1.12
172 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
173 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
174 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
175 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
176 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
177 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
178 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
179 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
180 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
181 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
182 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
183 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
184 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
185 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
186 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
187 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
188 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
189 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
190 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
191 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
192 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
193 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
194 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
195 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
196 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
197 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
198 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
199 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
200 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06

Single Events

The table below shows the top 100 pain related interactions that have been reported for kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
4 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
5 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
6 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
7 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
8 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
9 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
10 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
11 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
12 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
13 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
14 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
15 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
16 INT4153 Binding of Insrr 109 0.40 17.99 72.15
17 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
18 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
19 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
20 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
21 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
22 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
23 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
24 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
25 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
26 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
27 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
28 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
29 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
30 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
31 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
32 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
33 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
34 INT61925 Negative_regulation of Adk 53 0.59 22.46 40.38
35 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
36 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
37 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
38 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
39 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
40 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
41 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
42 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
43 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
44 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
45 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
46 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
47 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
48 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
49 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
50 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
51 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
52 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
53 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45
54 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
55 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21
56 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
57 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
58 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
59 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
60 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
61 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
62 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
63 INT123386 Negative_regulation of Camk2a 48 0.58 12.57 23.78
64 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
65 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
66 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
67 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
68 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
69 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
70 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39
71 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
72 INT117527 Binding of Prkca 25 0.48 6.43 21.05
73 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
74 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
75 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
76 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
77 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
78 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
79 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
80 INT292049 Gene_expression of Csnk1a1 1 0.59 28.22 19.53
81 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
82 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
83 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
84 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
85 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
86 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
87 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
88 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
89 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
90 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
91 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
92 INT79458 Localization of Prkca 30 0.81 11.13 15.78
93 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73
94 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
95 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
96 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
97 INT38253 Localization of Trib3 35 0.63 10.28 15.42
98 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
99 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
100 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
101 INT79887 Gene_expression of Prkcc 20 0.78 12.59 14.73
102 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
103 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
104 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
105 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
106 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
107 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
108 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
109 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
110 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
111 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
112 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
113 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
114 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
115 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
116 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
117 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
118 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
119 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
120 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
121 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
122 INT100821 Localization of Ros1 59 0.60 45.26 11.92
123 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
124 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
125 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
126 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
127 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
128 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37
129 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
130 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
131 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
132 INT118676 Positive_regulation of Camk4 34 0.70 16.67 10.9
133 INT118678 Phosphorylation of Camk4 22 0.82 9.4 10.7
134 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
135 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
136 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
137 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
138 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
139 INT790 Gene_expression of Mastl 22 0.68 4.56 10.23
140 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14
141 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
142 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
143 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10
144 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
145 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
146 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
147 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
148 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
149 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
150 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
151 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
152 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
153 INT71565 Negative_regulation of Prkcc 11 0.54 4.16 9.31
154 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
155 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2
156 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
157 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17
158 INT123040 Phosphorylation of Grk4 12 0.60 0.31 9.14
159 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09
160 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07
161 INT119527 Regulation of Camk2a 26 0.60 5.55 9.01
162 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
163 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
164 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
165 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
166 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
167 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
168 INT119529 Positive_regulation of Phosphorylation of Camk2a 16 0.60 1.49 8.94
169 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
170 INT141185 Regulation of Ros1 30 0.24 20.73 8.88
171 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
172 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
173 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
174 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
175 INT71590 Gene_expression of Camk2a 17 0.78 2.3 8.63
176 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
177 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45
178 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
179 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
180 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
181 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
182 INT12859 Localization of Insrr 16 0.32 2.68 8.07
183 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
184 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
185 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
186 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
187 INT35307 Regulation of Adk 11 0.35 3.21 7.79
188 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
189 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
190 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
191 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
192 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
193 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38
194 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
195 INT13348 Negative_regulation of Mastl 11 0.36 3.33 7.28
196 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
197 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
198 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
199 INT50779 Positive_regulation of Gene_expression of Adrbk1 9 0.56 2.79 7.23
200 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
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