GO:0016324

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Name apical plasma membrane
Categary Component
Go Slim No
Go Link GO:0016324
Unique Molecular Interactions 1764
Total Molecular Interactions 2435
Total Single Events 22093
Pain Genes Associated 240

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apical plasma membrane. They are ordered first by their pain relevance and then by number of times they were reported for apical plasma membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
2 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
3 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
4 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
5 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
6 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
7 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
8 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
9 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
10 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
11 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
12 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
13 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
14 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
15 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
16 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
17 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
18 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
19 INT12327 Igh-Dex Positive_regulation of Plec 1 0.03 0.73 1.57
20 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
21 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
22 INT322812 Binding of SLC12A1 and MOCOS 1 0.00 1.69 1.49
23 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
24 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
25 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
26 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
27 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
28 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
29 INT212662 KCNA1 Regulation of Localization of Cort 1 0.00 1.36 1.37
30 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
31 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
32 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
33 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
34 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
35 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
36 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
37 INT305408 Binding of KCNMA1 and ST8SIA2 1 0.01 0.09 1.24
38 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
39 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
40 INT247924 Slc12a5 Regulation of Gene_expression of Slc12a2 1 0.25 1.43 1.23
41 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
42 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
43 INT247925 Slc12a2 Regulation of Cl 1 0.01 1.44 1.23
44 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
45 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
46 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
47 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
48 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
49 INT105918 Binding of FUT1 and SLC9A3R2 1 0.00 0.14 1.2
50 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
51 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19
52 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
53 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
54 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
55 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
56 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
57 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
58 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
59 INT81582 Plec Positive_regulation of st 1 0.02 0 1.07
60 INT81581 Plec Positive_regulation of Nudt14 1 0.01 0 1.07
61 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
62 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
63 INT116777 Psma5 Positive_regulation of Binding of Fn1 1 0.01 1.24 1.06
64 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
65 INT146496 Snta1 Positive_regulation of Gene_expression of Adrbk1 1 0.13 0.73 1.05
66 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
67 INT212661 KCNA1 Positive_regulation of Scort1 1 0.00 0.91 1.03
68 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02
69 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02
70 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02
71 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
72 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
73 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02
74 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
75 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
76 INT61637 Binding of P2ry2 and Gtpbp4 1 0.02 0.1 0.99
77 INT128602 Binding of Kcnma1 and Gtf2ird2 1 0.00 0 0.97
78 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
79 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
80 INT75200 Umod Positive_regulation of Transcription of Psma4 1 0.02 1.04 0.92
81 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
82 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
83 INT138862 ABCC2 Negative_regulation of ABCC4 1 0.63 0.24 0.9
84 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
85 INT64127 Igfbp2 Regulation of Localization of Avp 1 0.39 0.19 0.9
86 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
87 INT112642 Positive_regulation of Kcnma1 Positive_regulation of Nav1 1 0.02 0 0.89
88 INT210800 Bst2 Positive_regulation of Tnip1 1 0.36 0.54 0.89
89 INT210789 Bst2 Positive_regulation of B2m 1 0.32 0.54 0.89
90 INT210801 Bst2 Positive_regulation of Net1 1 0.35 0.54 0.89
91 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89
92 INT120293 RYBP Positive_regulation of Abcc2 1 0.04 0.14 0.86
93 INT146495 Snta1 Positive_regulation of Adrbk1 1 0.14 0.68 0.85
94 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
95 INT154439 Ufm1 Positive_regulation of Gene_expression of Abcb1a 1 0.00 0 0.85
96 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
97 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
98 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
99 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
100 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
101 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
102 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
103 INT16438 Atp6v0d2 Regulation of Localization of Lnpep 1 0.01 0 0.81
104 INT144283 ACP1 Positive_regulation of ABCB1 1 0.63 0.6 0.81
105 INT54559 KCNMA1 Positive_regulation of Localization of TBXA2R 1 0.01 0.07 0.81
106 INT16439 Atp6v0d2 Regulation of Localization of Avp 1 0.02 0 0.81
107 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
108 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79
109 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
110 INT172982 Binding of MUC1 and MUC4 1 0.30 2.46 0.78
111 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
112 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
113 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
114 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
115 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
116 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
117 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
118 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
119 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
120 INT244396 Binding of Cl and Slc12a2 1 0.03 0.88 0.76
121 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
122 INT155220 ABCG2 Positive_regulation of Abcc2 1 0.23 0.54 0.76
123 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
124 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
125 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
126 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
127 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
128 INT329120 Binding of KCNA1 and CNTNAP2 1 0.09 1.23 0.75
129 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
130 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
131 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73
132 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
133 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
134 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73
135 INT157063 SLC12A1 Negative_regulation of CALCRL 1 0.00 0.34 0.73
136 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
137 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
138 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
139 INT216654 Binding of P2ry2 and DRGX 1 0.01 1.59 0.71
140 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7
141 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 0.31 0 0.7
142 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7
143 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
144 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
145 INT782 Tf Positive_regulation of Prl 1 0.43 0 0.7
146 INT106601 ZNF398 Negative_regulation of Protein_catabolism of CIB1 1 0.02 0.21 0.7
147 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
148 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69
149 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
150 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
151 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67
152 INT194410 Binding of CALCA and LZTS1 1 0.06 0 0.67
153 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
154 INT132154 PSG7 Positive_regulation of Localization of MUC1 1 0.00 0 0.65
155 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
156 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
157 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
158 INT216644 Binding of P2ry1 and P2ry2 1 0.24 0.55 0.64
159 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64
160 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
161 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
162 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
163 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
164 INT120294 RYBP Positive_regulation of Positive_regulation of Abcc2 1 0.02 0.15 0.61
165 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
166 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
167 INT223865 Enpep Positive_regulation of Ltp 1 0.02 0 0.59
168 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59
169 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59
170 INT166300 Adrbk1 Positive_regulation of Negative_regulation of Gpbar1 1 0.39 0.63 0.58
171 INT299004 Binding of Il18 and Il1 1 0.04 1.16 0.58
172 INT39210 TF Positive_regulation of Gene_expression of IL2 1 0.17 0.07 0.57
173 INT176370 IL18BP Negative_regulation of IL18 1 0.15 0.76 0.56
174 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
175 INT23679 Chrna7 Regulation of Binding of Stx3 1 0.00 0 0.56
176 INT106374 Olr833 Negative_regulation of Abcb1a 1 0.00 0 0.56
177 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
178 INT145726 Binding of Abcb1a and Alms1 1 0.32 0.48 0.56
179 INT170833 Cftr Negative_regulation of Slc10a2 1 0.47 0.31 0.56
180 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
181 INT77508 ST13 Negative_regulation of Gene_expression of CD9 1 0.09 0.5 0.54
182 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54
183 INT335514 NR1I2 Regulation of Gene_expression of ABCB1 1 0.66 2.42 0.54
184 INT226348 IL18 Positive_regulation of Gene_expression of IL13 1 0.03 2.66 0.54
185 INT69178 Binding of SLC3A2 and Adarb1 1 0.00 0.16 0.53
186 INT308894 Adp Regulation of P2ry1 1 0.05 0.49 0.53
187 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
188 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
189 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53
190 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
191 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
192 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
193 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
194 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
195 INT151222 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Adrbk1 1 0.00 0.13 0.51
196 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
197 INT69291 Cftr Positive_regulation of Localization of Slc4a8 1 0.04 0.38 0.51
198 INT117482 CFTR Negative_regulation of THRB 1 0.01 0.15 0.51
199 INT151223 Negative_regulation of SIGMAR1 Negative_regulation of Adrbk1 1 0.00 0.13 0.51
200 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51

Single Events

The table below shows the top 100 pain related interactions that have been reported for apical plasma membrane. They are ordered first by their pain relevance and then by number of times they were reported in apical plasma membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95
2 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
3 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56
4 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
5 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
6 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19
7 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19
8 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8
9 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89
10 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
11 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
12 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
13 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
14 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88
15 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42
16 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81
17 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
18 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48
19 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
20 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86
21 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
22 INT100115 Gene_expression of Slc12a2 34 0.76 39.15 15.69
23 INT83682 Positive_regulation of Abcb1a 22 0.68 3.3 15.6
24 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55
25 INT129 Localization of OXTR 51 0.80 11.08 15.36
26 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32
27 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92
28 INT61635 Positive_regulation of P2ry2 35 0.56 12.08 14.68
29 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73
30 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63
31 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
32 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36
33 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35
34 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3
35 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89
36 INT84307 Binding of Cftr 31 0.47 26.19 12.8
37 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39
38 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23
39 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
40 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
41 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67
42 INT93122 Gene_expression of P2ry1 32 0.75 11.82 11.42
43 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
44 INT13240 Gene_expression of TF 94 0.76 57.81 10.99
45 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82
46 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
47 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69
48 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69
49 INT238920 Positive_regulation of SLC9A3R2 44 0.50 27.86 10.51
50 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4
51 INT54473 Binding of ABCB1 30 0.48 8.65 10.38
52 INT127009 Positive_regulation of Phosphorylation of Slc12a2 5 0.70 5.3 9.9
53 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73
54 INT105816 Gene_expression of P2RY2 53 0.78 16.47 9.67
55 INT127010 Phosphorylation of Slc12a2 6 0.82 4.68 9.66
56 INT104502 Gene_expression of Abcc2 26 0.78 8.37 9.65
57 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65
58 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55
59 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53
60 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
61 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
62 INT54707 Positive_regulation of Adrbk1 14 0.67 0.51 9.51
63 INT78038 Gene_expression of Oxtr 43 0.78 18.72 9.38
64 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
65 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
66 INT71494 Positive_regulation of Hspa1b 14 0.67 8.5 9.19
67 INT163054 Gene_expression of Msn 20 0.66 0.6 9.06
68 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
69 INT62014 Negative_regulation of Slc12a2 17 0.49 12.85 8.99
70 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95
71 INT49802 Localization of MUC1 75 0.81 44.74 8.87
72 INT138889 Positive_regulation of Slc12a2 23 0.65 18.53 8.85
73 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83
74 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
75 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
76 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
77 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
78 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
79 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
80 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
81 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81
82 INT103659 Gene_expression of Muc4 10 0.78 7.2 7.7
83 INT127008 Positive_regulation of Slc12a2 2 0.70 4.73 7.61
84 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
85 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58
86 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
87 INT78320 Gene_expression of EPCAM 57 0.75 50.34 7.53
88 INT94127 Positive_regulation of Il18 14 0.69 14 7.47
89 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
90 INT111680 Gene_expression of P2ry2 20 0.58 9.23 7.39
91 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
92 INT76253 Positive_regulation of P2RY2 29 0.70 13.99 7.33
93 INT98856 Negative_regulation of Gene_expression of Adrbk1 5 0.56 0.43 7.29
94 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24
95 INT50779 Positive_regulation of Gene_expression of Adrbk1 9 0.56 2.79 7.23
96 INT168915 Gene_expression of Oxtr 49 0.75 20.53 7.22
97 INT80981 Regulation of Abcb1a 19 0.62 1.86 7.2
98 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02
99 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97
100 INT95466 Regulation of P2ry2 23 0.56 3.66 6.86
101 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
102 INT94356 Regulation of Slc12a2 11 0.58 12.8 6.59
103 INT91721 Binding of IL18 21 0.48 21.17 6.56
104 INT250050 Gene_expression of Gpr143 1 0.48 5.76 6.53
105 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
106 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
107 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
108 INT163052 Regulation of Msn 11 0.38 1.21 6.31
109 INT120286 Positive_regulation of Abcc2 11 0.70 4.71 6.2
110 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12
111 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1
112 INT73179 Gene_expression of Hspa1b 10 0.73 6.24 6.04
113 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02
114 INT104547 Negative_regulation of Il18 24 0.59 17.89 6.01
115 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
116 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
117 INT86119 Regulation of Cftr 13 0.45 14.08 5.75
118 INT69974 Positive_regulation of Oxtr 30 0.70 2.44 5.73
119 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
120 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
121 INT34742 Gene_expression of Gnat3 44 0.67 6.83 5.65
122 INT95170 Localization of P2ry1 10 0.78 5.08 5.63
123 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
124 INT124705 Binding of Il18 29 0.47 19.02 5.59
125 INT111683 Gene_expression of P2ry1 22 0.74 7.96 5.59
126 INT102836 Binding of LRP2 12 0.38 11.27 5.58
127 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53
128 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34
129 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
130 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
131 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
132 INT50105 Localization of CTSB 29 0.78 10.98 5.21
133 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17
134 INT96198 Positive_regulation of Gene_expression of ABCB1 25 0.68 5.89 5.15
135 INT139238 Positive_regulation of P2ry1 19 0.60 9.22 5.15
136 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12
137 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
138 INT146488 Gene_expression of Slc12a2 16 0.73 4.63 5.11
139 INT119909 Binding of Abcb1a 10 0.36 0.76 5.07
140 INT13051 Regulation of Kcnma1 12 0.12 2.09 5.06
141 INT110202 Positive_regulation of Gene_expression of Abcb1a 13 0.67 2.08 5.01
142 INT89114 Binding of Cftr 13 0.37 11.29 4.99
143 INT109848 Gene_expression of P2RY1 26 0.62 6.71 4.98
144 INT130 Negative_regulation of OXTR 19 0.43 4.63 4.96
145 INT65509 Regulation of P2ry1 13 0.60 2.38 4.96
146 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
147 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91
148 INT21650 Regulation of OXTR 29 0.61 5.99 4.91
149 INT130203 Gene_expression of P2ry4 14 0.50 8.79 4.82
150 INT52952 Binding of Pdpn 8 0.13 3.57 4.79
151 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
152 INT170757 Positive_regulation of Gene_expression of Cftr 3 0.51 11.41 4.75
153 INT75197 Gene_expression of Umod 3 0.75 2.48 4.75
154 INT60957 Negative_regulation of Abcb1b 18 0.57 6 4.73
155 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66
156 INT104549 Localization of Il18 16 0.78 13.01 4.64
157 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56
158 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56
159 INT342801 Negative_regulation of Transcription of Muc4 1 0.04 0.82 4.56
160 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
161 INT169756 Binding of CFTR 9 0.35 9.65 4.55
162 INT139894 Negative_regulation of Msn 11 0.41 0.36 4.52
163 INT244386 Positive_regulation of Gene_expression of Slc12a2 10 0.58 18.39 4.5
164 INT205272 Positive_regulation of Gene_expression of Plec 11 0.43 1.5 4.49
165 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48
166 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
167 INT77148 Gene_expression of Kcna1 20 0.73 4.08 4.46
168 INT125447 Positive_regulation of CLDN4 14 0.70 4.71 4.45
169 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
170 INT112038 Positive_regulation of P2ry2 8 0.45 2.41 4.4
171 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
172 INT165891 Transcription of Il18 5 0.69 7.63 4.37
173 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36
174 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32
175 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
176 INT208287 Binding of Msn 10 0.41 0.33 4.31
177 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3
178 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29
179 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
180 INT173926 Positive_regulation of Atp6v1e1 21 0.27 11.39 4.24
181 INT64157 Positive_regulation of EPCAM 11 0.44 9.09 4.24
182 INT55044 Positive_regulation of Si 15 0.24 1.73 4.2
183 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
184 INT78033 Positive_regulation of Gene_expression of Oxtr 10 0.70 2.5 4.15
185 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
186 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14
187 INT34829 Positive_regulation of Gnat3 27 0.46 5.24 4.14
188 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
189 INT145693 Gene_expression of Slc10a2 5 0.78 2.54 4.13
190 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12
191 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12
192 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
193 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
194 INT182311 Positive_regulation of Birc5 26 0.67 25.32 4.08
195 INT325930 Gene_expression of Ezr 75 0.77 59.77 4.06
196 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
197 INT89113 Regulation of Cftr 11 0.62 6.83 4.01
198 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
199 INT34790 Localization of KCNA1 4 0.43 11.34 3.99
200 INT188449 Gene_expression of ENPEP 12 0.55 11.29 3.96
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