GO:0016363

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Name nuclear matrix
Categary Component
Go Slim No
Go Link GO:0016363
Unique Molecular Interactions 581
Total Molecular Interactions 713
Total Single Events 6377
Pain Genes Associated 50

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nuclear matrix. They are ordered first by their pain relevance and then by number of times they were reported for nuclear matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
3 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
4 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
5 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
6 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
7 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
8 INT30042 Binding of YY1 and Gnrhr 1 0.18 0 1.47
9 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
10 INT154114 PENK Positive_regulation of YY1 1 0.50 0.06 1.41
11 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
12 INT26893 OGG1 Negative_regulation of Gh1 1 0.12 0 1.37
13 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
14 INT189017 Binding of Pax3 and Lmna 1 0.14 0.42 1.16
15 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
16 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
17 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
18 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
19 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
20 INT110669 Binding of Alox5 and Trpv1 1 0.07 0.2 1.13
21 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
22 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
23 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
24 INT161512 Ppig Negative_regulation of Positive_regulation of S100a8 1 0.02 0.23 1.12
25 INT56882 Binding of YY1 and Ppbp 1 0.01 0 1.11
26 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
27 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
28 INT69011 Binding of Cebpb and Nfkb1 1 0.19 0.75 1.04
29 INT59518 YY1 Positive_regulation of SGCG 1 0.50 0.32 0.99
30 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
31 INT252602 Binding of Cxcl10 and Ppig 1 0.08 1.55 0.96
32 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
33 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
34 INT118204 ST14 Regulation of YY1 1 0.04 0 0.93
35 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93
36 INT82120 IK Positive_regulation of CEBPB 1 0.00 0 0.92
37 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9
38 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
39 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
40 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89
41 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
42 INT30955 YY1 Negative_regulation of Negative_regulation of LH 1 0.23 0.47 0.87
43 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
44 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
45 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
46 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
47 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81
48 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
49 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
50 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78
51 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77
52 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
53 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
54 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
55 INT170369 Binding of Car2 and Nono 1 0.01 0 0.76
56 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
57 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
58 INT166672 YY1 Regulation of Binding of UGT1A6 1 0.48 0 0.76
59 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
60 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
61 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 0.06 0.71 0.74
62 INT150997 Sfpq Positive_regulation of Gene_expression of Il10 1 0.09 0.71 0.74
63 INT7049 Binding of YY1 and Oprd1 1 0.01 0 0.73
64 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72
65 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
66 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
67 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
68 INT166671 YY1 Regulation of Positive_regulation of UGT1A6 1 0.48 0 0.7
69 INT159569 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Fos 1 0.37 0.4 0.7
70 INT252603 Ppig Positive_regulation of Gene_expression of Cx3cl1 1 0.10 1.8 0.69
71 INT133942 Binding of YY1 and ARFGEF1 1 0.05 0 0.69
72 INT252605 Ppig Positive_regulation of Gene_expression of Cx3cr1 1 0.09 1.81 0.69
73 INT133936 Binding of DNM2 and YY1 1 0.29 0 0.69
74 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
75 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
76 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
77 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
78 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
79 INT114950 YY1 Positive_regulation of Positive_regulation of PPARA 1 0.52 0.25 0.64
80 INT34005 YY1 Regulation of KNG1 1 0.04 0.38 0.63
81 INT135498 Binding of YY1 and MRGPRX4 1 0.00 0.2 0.62
82 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
83 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
84 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
85 INT270100 Negative_regulation of Binding of ALOX5 and PLA2G2A 1 0.01 0.51 0.59
86 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58
87 INT74656 YY1 Positive_regulation of Localization of IL2 1 0.07 0.09 0.58
88 INT149480 CEBPD Positive_regulation of CEBPB 1 0.50 0.15 0.58
89 INT270102 ALOX5 Negative_regulation of PLA2G2A 1 0.01 0.49 0.57
90 INT142868 YY1 Positive_regulation of Oprd1 1 0.01 0.1 0.55
91 INT77098 Nlrp1a Negative_regulation of Positive_regulation of Ppig 1 0.47 0.68 0.53
92 INT57546 Binding of YY1 and GNPTAB 1 0.00 0 0.53
93 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
94 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
95 INT135500 Positive_regulation of YY1 Positive_regulation of MRGPRX4 1 0.01 0.06 0.52
96 INT135501 MRGPRX4 Positive_regulation of YY1 1 0.00 0.06 0.52
97 INT135497 YY1 Positive_regulation of MRGPRX4 1 0.01 0.06 0.52
98 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
99 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
100 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
101 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
102 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
103 INT135503 MRGPRX4 Regulation of YY1 1 0.01 0.05 0.5
104 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
105 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
106 INT251163 Gene_expression of Alox5 Positive_regulation of Trpv1 1 0.02 0.11 0.48
107 INT92802 Binding of PPIG and GRHPR 1 0.03 0.11 0.47
108 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
109 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
110 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
111 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
112 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
113 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
114 INT72203 GH1 Regulation of OGG1 1 0.10 0 0.46
115 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
116 INT128521 Binding of YY1 and IGKV2-26 1 0.12 0 0.45
117 INT297689 Atn1 Regulation of Gene_expression of Il6 1 0.02 1.13 0.44
118 INT115914 AHR Regulation of Gene_expression of PPIG 1 0.25 0.36 0.44
119 INT8356 Binding of YY1 and Smpd1 1 0.32 0 0.43
120 INT158267 Olr1745 Negative_regulation of Alox5 1 0.05 0.94 0.43
121 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
122 INT62066 Binding of YY1 and Pdyn 1 0.00 0 0.42
123 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41
124 INT159571 Trpv1 Positive_regulation of Gene_expression of Alox5 1 0.37 0.58 0.4
125 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
126 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
127 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
128 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
129 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
130 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
131 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37
132 INT6121 Gmcl1 Regulation of Gene_expression of Penk 1 0.03 0 0.36
133 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36
134 INT39208 ALOX5 Regulation of Gene_expression of IL2 1 0.04 0.06 0.34
135 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
136 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
137 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
138 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32
139 INT59189 Negative_regulation of GBE1 Negative_regulation of ALOX5 1 0.00 0.33 0.31
140 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
141 INT159572 Alox5 Regulation of Gene_expression of Fos 1 0.20 0.32 0.31
142 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
143 INT159570 Negative_regulation of Alox5 Regulation of Gene_expression of Fos 1 0.34 0.27 0.31
144 INT26737 Alox5 Regulation of Localization of Ins1 1 0.06 0.09 0.3
145 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
146 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
147 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
148 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29
149 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
150 INT130107 YY1 Positive_regulation of MAPK1 1 0.45 0 0.28
151 INT130106 Regulation of YY1 Positive_regulation of MAPK1 1 0.41 0 0.28
152 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
153 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
154 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
155 INT238632 Binding of EPB41 and Cask 1 0.44 0.78 0.27
156 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
157 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
158 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
159 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
160 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
161 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
162 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
163 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
164 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
165 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
166 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
167 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
168 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
169 INT55901 Negative_regulation of Alox5 Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
170 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
171 INT110061 Binding of Alox5 and Cpox 1 0.28 0.37 0.23
172 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
173 INT151884 Binding of PRLR and YY1 1 0.01 0 0.23
174 INT61346 Positive_regulation of YY1 Positive_regulation of Localization of SST 1 0.54 0 0.22
175 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
176 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
177 INT163863 Binding of MIB1 and Vim 1 0.02 1.06 0.21
178 INT64382 Positive_regulation of Binding of YY1 and Tyr 1 0.11 0 0.21
179 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
180 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
181 INT64383 Binding of YY1 and Tyr 1 0.09 0 0.21
182 INT313498 Binding of ALOX5 and SNRNP70 1 0.05 2.7 0.21
183 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
184 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
185 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
186 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2
187 INT79206 Binding of MGP and YY1 1 0.34 0 0.19
188 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
189 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
190 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18
191 INT252600 Ppig Regulation of Hand1 1 0.06 0.43 0.17
192 INT313554 Binding of ALOX5 and Cor 1 0.02 2.47 0.17
193 INT252598 Ppig Regulation of Gene_expression of Hand1 1 0.06 0.43 0.17
194 INT74600 Negative_regulation of YY1 Negative_regulation of ADCY1 1 0.36 0.25 0.17
195 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
196 INT275461 Binding of Atxn1 and Atxn2 1 0.39 1.1 0.17
197 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
198 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
199 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
200 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16

Single Events

The table below shows the top 100 pain related interactions that have been reported for nuclear matrix. They are ordered first by their pain relevance and then by number of times they were reported in nuclear matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6437 Binding of YY1 154 0.47 26.3 90.46
2 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16
3 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06
4 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
5 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
6 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
7 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8
8 INT3359 Regulation of YY1 32 0.60 8.19 19.2
9 INT54294 Localization of Spnb4 9 0.78 0 18.64
10 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
11 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
12 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
13 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33
14 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
15 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82
16 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54
17 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48
18 INT50580 Binding of PPIG 39 0.36 11.17 12.34
19 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93
20 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05
21 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
22 INT18647 Localization of YY1 16 0.78 4.04 9.77
23 INT9889 Gene_expression of Alox5 34 0.63 20.83 8.85
24 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33
25 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
26 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
27 INT33419 Positive_regulation of Gene_expression of YY1 10 0.67 4.15 7.08
28 INT127037 Gene_expression of Ppig 26 0.65 16.08 6.84
29 INT25647 Negative_regulation of Binding of YY1 10 0.57 1.47 6.77
30 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
31 INT142065 Phosphorylation of CFL1 8 0.78 0.87 6.3
32 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
33 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
34 INT77076 Positive_regulation of Ppig 16 0.49 13.54 5.91
35 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47
36 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37
37 INT60585 Regulation of TP53 59 0.59 54.55 5.21
38 INT6577 Regulation of Alox5 18 0.47 9.19 5.06
39 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
40 INT30355 Positive_regulation of Gene_expression of Alox5 10 0.67 14.61 4.69
41 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
42 INT15995 Positive_regulation of Alox5 18 0.49 3.94 4.63
43 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
44 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
45 INT54297 Regulation of Localization of Spnb4 3 0.44 0 4.36
46 INT50581 Regulation of PPIG 26 0.55 8.96 4.32
47 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04
48 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
49 INT73750 Regulation of Gene_expression of YY1 7 0.44 0.28 3.91
50 INT127039 Negative_regulation of Ppig 13 0.21 5.29 3.87
51 INT80681 Positive_regulation of Atn1 20 0.49 11.85 3.76
52 INT142066 Positive_regulation of Phosphorylation of CFL1 5 0.48 0.24 3.73
53 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
54 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65
55 INT53891 Positive_regulation of Positive_regulation of YY1 5 0.49 0.24 3.65
56 INT26891 Gene_expression of OGG1 21 0.74 2.08 3.64
57 INT29356 Positive_regulation of Binding of YY1 8 0.67 0.22 3.49
58 INT10476 Binding of ALOX5 26 0.36 7.69 3.2
59 INT53889 Negative_regulation of Positive_regulation of YY1 6 0.41 0.57 3.05
60 INT35448 Negative_regulation of Gene_expression of ALOX5 11 0.57 5.28 3.03
61 INT8103 Binding of TP53 46 0.44 40.2 2.96
62 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
63 INT53890 Transcription of YY1 8 0.67 1.53 2.88
64 INT76342 Positive_regulation of Gene_expression of Alox5 9 0.56 5.29 2.87
65 INT120717 Positive_regulation of TEP1 50 0.63 27.94 2.81
66 INT56589 Positive_regulation of Localization of Spnb4 2 0.49 0 2.81
67 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
68 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62
69 INT27935 Binding of Vim 21 0.36 15.65 2.61
70 INT69007 Binding of Cebpb 10 0.48 2.21 2.6
71 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
72 INT153492 Gene_expression of Gmcl1 44 0.65 15.77 2.56
73 INT59709 Negative_regulation of Negative_regulation of YY1 3 0.57 0.07 2.55
74 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
75 INT34905 Positive_regulation of Gene_expression of ALOX5 18 0.50 7.46 2.46
76 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
77 INT55952 Transcription of TP53 16 0.61 12.14 2.36
78 INT6117 Gene_expression of Gmcl1 4 0.49 2.39 2.33
79 INT217253 Positive_regulation of Positive_regulation of PPIG 2 0.08 0.55 2.33
80 INT56658 Gene_expression of Spnb4 7 0.58 5.6 2.22
81 INT54295 Negative_regulation of Localization of Spnb4 2 0.57 0 2.21
82 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18
83 INT16656 Negative_regulation of Gene_expression of YY1 8 0.57 2.62 2.12
84 INT26736 Localization of Alox5 7 0.49 3.72 2.09
85 INT142064 Negative_regulation of Phosphorylation of CFL1 3 0.56 0.42 2.06
86 INT23955 Regulation of Vim 16 0.25 14.21 2.04
87 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01
88 INT297674 Gene_expression of Atn1 11 0.29 6.69 2
89 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
90 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
91 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
92 INT20251 Binding of Alox5 7 0.32 5.33 1.93
93 INT56656 Positive_regulation of Spnb4 3 0.49 1.09 1.92
94 INT238608 Gene_expression of Cask 1 0.73 2.74 1.9
95 INT65855 Localization of TP53 18 0.76 17.08 1.89
96 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
97 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
98 INT34552 Regulation of Gene_expression of Alox5 3 0.50 5.06 1.75
99 INT39229 Regulation of Alox5 6 0.57 3.2 1.72
100 INT192563 Gene_expression of HAT1 8 0.38 4.47 1.71
101 INT56657 Negative_regulation of Positive_regulation of Spnb4 1 0.41 0 1.71
102 INT104220 Positive_regulation of Gene_expression of PPIG 14 0.49 7.38 1.7
103 INT79802 Phosphorylation of YY1 2 0.80 0.07 1.7
104 INT27608 Localization of Alox5 7 0.61 2.66 1.69
105 INT97062 Binding of PML 10 0.41 11.63 1.65
106 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63
107 INT9885 Negative_regulation of Gene_expression of Alox5 3 0.14 2.28 1.59
108 INT231917 Gene_expression of Cebpb 10 0.25 4.45 1.56
109 INT82122 Positive_regulation of CEBPB 3 0.67 0.51 1.54
110 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
111 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
112 INT73926 Localization of ALOX5 8 0.44 3.14 1.52
113 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
114 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
115 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42
116 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
117 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
118 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
119 INT172953 Binding of Trp53 33 0.37 20.76 1.41
120 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
121 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
122 INT170987 Transcription of ALOX5 4 0.69 2.71 1.41
123 INT145221 Binding of Tp53 10 0.37 8.59 1.37
124 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
125 INT71304 Binding of CEBPB 3 0.36 2.69 1.32
126 INT26890 Negative_regulation of Gene_expression of OGG1 2 0.34 0.13 1.26
127 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
128 INT59708 Regulation of Negative_regulation of YY1 1 0.44 0.07 1.21
129 INT174156 Localization of Trp53 16 0.72 13.52 1.18
130 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
131 INT144843 Regulation of Gmcl1 5 0.37 2.76 1.15
132 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
133 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
134 INT252582 Positive_regulation of Gene_expression of Ppig 3 0.12 2.62 1.13
135 INT250453 Gene_expression of Lmna 3 0.65 0.48 1.13
136 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
137 INT29109 Negative_regulation of Gene_expression of Alox5 6 0.42 2.9 1.07
138 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05
139 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
140 INT34553 Binding of Alox5 3 0.10 0.65 1.03
141 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
142 INT165962 Transcription of Vim 3 0.39 1.47 1.01
143 INT165009 Regulation of Negative_regulation of Alox5 1 0.05 1 1.01
144 INT106023 Localization of PPIG 8 0.57 4.08 0.96
145 INT192564 Binding of HAT1 5 0.15 2.77 0.96
146 INT184896 Negative_regulation of Positive_regulation of ALOX5 2 0.42 0.92 0.96
147 INT169336 Binding of Jak2 2 0.42 1.31 0.93
148 INT297663 Localization of Atn1 1 0.25 1.84 0.93
149 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
150 INT291677 Transcription of Alox5 1 0.58 3.91 0.91
151 INT108012 Regulation of Localization of YY1 1 0.26 0 0.91
152 INT163995 Negative_regulation of Gene_expression of Ppig 4 0.24 2.07 0.89
153 INT54296 Regulation of Spnb4 3 0.44 2.06 0.89
154 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
155 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
156 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
157 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
158 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
159 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
160 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
161 INT317792 Negative_regulation of Binding of HAT1 2 0.07 1.82 0.81
162 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
163 INT142016 Negative_regulation of Gene_expression of CEBPA 1 0.41 0.67 0.8
164 INT142018 Gene_expression of CEBPA 1 0.75 0.66 0.8
165 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
166 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
167 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
168 INT92222 Positive_regulation of Phosphorylation of YY1 1 0.49 0 0.74
169 INT170341 Binding of Nono 1 0.02 0 0.74
170 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
171 INT262726 Localization of PML 6 0.57 7.13 0.72
172 INT29056 Regulation of Gene_expression of Alox5 4 0.60 1.47 0.72
173 INT76005 Regulation of Binding of Vim 1 0.02 0 0.72
174 INT83246 Regulation of Positive_regulation of PPIG 1 0.44 1.61 0.72
175 INT94896 Regulation of TEP1 12 0.39 8.04 0.69
176 INT100542 Regulation of Ppig 6 0.17 11.78 0.69
177 INT142063 Negative_regulation of CFL1 1 0.56 0 0.69
178 INT80680 Negative_regulation of Atn1 3 0.42 1.5 0.64
179 INT196866 Localization of Ppig 2 0.17 0.58 0.64
180 INT238602 Binding of Cask 1 0.40 0.9 0.63
181 INT197832 Localization of MEN1 1 0.80 11.01 0.63
182 INT117899 Positive_regulation of Protein_catabolism of PPIG 1 0.21 0 0.63
183 INT170342 Positive_regulation of Nono 2 0.03 0 0.61
184 INT61506 Localization of Ghrhr 1 0.51 0 0.61
185 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
186 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
187 INT182435 Localization of OGG1 36 0.76 1.66 0.58
188 INT103782 Binding of Ppig 5 0.12 2.57 0.58
189 INT69546 Protein_catabolism of YY1 2 0.64 0.35 0.58
190 INT250455 Localization of Lmna 1 0.68 0.08 0.58
191 INT71306 Gene_expression of CEBPB 7 0.75 4.75 0.57
192 INT100065 Negative_regulation of LMNA 12 0.49 0.12 0.56
193 INT297672 Positive_regulation of Localization of Atn1 1 0.17 0.94 0.55
194 INT71130 Regulation of Positive_regulation of YY1 1 0.44 0 0.55
195 INT16657 Positive_regulation of Negative_regulation of YY1 1 0.49 0.42 0.55
196 INT247258 Positive_regulation of Lmna 1 0.45 0.53 0.55
197 INT172617 Positive_regulation of HAT1 7 0.33 5.47 0.54
198 INT205494 Negative_regulation of Negative_regulation of ALOX5 2 0.32 1.2 0.54
199 INT128549 Positive_regulation of Cebpb 6 0.69 1.56 0.53
200 INT231918 Positive_regulation of Gene_expression of Cebpb 3 0.20 1.48 0.53
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