GO:0016442

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Name RNA-induced silencing complex
Categary Component
Go Slim No
Go Link GO:0016442
Unique Molecular Interactions 41
Total Molecular Interactions 63
Total Single Events 141
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RNA-induced silencing complex. They are ordered first by their pain relevance and then by number of times they were reported for RNA-induced silencing complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT341218 Binding of Eif4e and Eif4ebp1 1 0.19 2.65 1.23
2 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
3 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
4 INT224853 Binding of Bdnf and Eif4e 1 0.10 0 0.5
5 INT330519 Binding of CD8A and DICER1 1 0.08 0.99 0.38
6 INT341215 Binding of Eif4e and Eif4g3 1 0.10 0.41 0.33
7 INT350711 Ifnb1 Negative_regulation of Gene_expression of DICER1 1 0.03 0.15 0.14
8 INT273901 Mtor Positive_regulation of Eif4e 1 0.50 0.54 0.14
9 INT341239 Binding of EIF4E and Eif4e 1 0.08 0.23 0.12
10 INT341238 Binding of EIF4E and Eif4g3 1 0.03 0.23 0.12
11 INT190246 TARBP2 Positive_regulation of PKLR 1 0.01 0.41 0.1
12 INT322560 Binding of TNFSF10 and DICER1 1 0.07 1.76 0.07
13 INT341220 Eif4e Positive_regulation of Eif4ebp1 1 0.20 0.42 0.06
14 INT257879 Negative_regulation of Eif4e Positive_regulation of Cdkn1b 1 0.28 0.54 0.06
15 INT257867 Negative_regulation of Eif4e Positive_regulation of Rb1 1 0.05 0.54 0.06
16 INT190247 TARBP2 Negative_regulation of PKLR 1 0.01 0.2 0.05
17 INT341225 Negative_regulation of Binding of Eif4e and Eif4ebp1 1 0.17 0.14 0.03
18 INT222259 EIF4E Regulation of Negative_regulation of NOD2 1 0.13 0.1 0
19 INT341232 Binding of EIF4A2 and Eif4e 1 0.06 0 0
20 INT225644 Binding of TARBP2 and Acp5 1 0.04 0.15 0
21 INT341240 Binding of EIF4E and Eif4ebp1 1 0.04 0.5 0
22 INT225613 TARBP2 Positive_regulation of Prkdc 1 0.00 0 0
23 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0
24 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0
25 INT307284 DCP2 Positive_regulation of HAL 1 0.00 0 0
26 INT225643 Binding of TARBP2 and Acsl1 1 0.00 0 0
27 INT341221 Eif4e Regulation of Binding of Eif4ebp1 1 0.18 0 0
28 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
29 INT217777 EIF4E Regulation of Gene_expression of MAP3K3 1 0.05 0.19 0
30 INT341234 Eif4g3 Positive_regulation of Binding of EIF4E 1 0.04 0 0
31 INT341216 Regulation of Binding of Eif4e and Eif4ebp1 1 0.11 0 0
32 INT217790 EIF4E Regulation of Gene_expression of RASGRP1 1 0.01 0.19 0
33 INT272524 DICER1 Negative_regulation of Dmpk 1 0.04 0.07 0
34 INT293811 Negative_regulation of EIF4E Negative_regulation of Gene_expression of CCND3 1 0.02 0.32 0
35 INT341230 Eif4g3 Positive_regulation of EIF4E 1 0.04 0 0
36 INT225634 Binding of TARBP2 and MED23 1 0.04 0.15 0
37 INT341233 Positive_regulation of Binding of EIF4E and Eif4ebp1 1 0.06 0.5 0
38 INT341224 Eif4g3 Positive_regulation of Eif4e 1 0.14 0 0
39 INT307286 Binding of PMP2 and DCP2 1 0.04 0 0
40 INT225618 TARBP2 Positive_regulation of gr 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for RNA-induced silencing complex. They are ordered first by their pain relevance and then by number of times they were reported in RNA-induced silencing complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190280 Gene_expression of DICER1 12 0.65 9.54 2.67
2 INT136788 Regulation of Eif4e 3 0.61 0 1.61
3 INT330526 Positive_regulation of Gene_expression of DICER1 5 0.30 3.34 1.18
4 INT136783 Regulation of Regulation of Eif4e 1 0.45 0 1.16
5 INT136785 Phosphorylation of Eif4e 2 0.82 0 1.1
6 INT341195 Binding of Eif4e 1 0.38 3.87 0.92
7 INT117547 Gene_expression of SND1 2 0.57 1.27 0.71
8 INT117542 Positive_regulation of SND1 2 0.34 2.19 0.69
9 INT136780 Positive_regulation of Eif4e 1 0.50 0 0.55
10 INT62300 Regulation of SND1 1 0.47 1.07 0.48
11 INT272502 Transcription of DICER1 3 0.08 2.14 0.39
12 INT343811 Positive_regulation of Transcription of DICER1 1 0.06 2.06 0.39
13 INT343810 Binding of DICER1 1 0.05 1.88 0.35
14 INT330525 Positive_regulation of DICER1 2 0.17 1.34 0.34
15 INT341182 Regulation of Eif4e 1 0.35 0.75 0.25
16 INT350691 Localization of DICER1 1 0.08 1.18 0.23
17 INT341163 Positive_regulation of Eif4e 1 0.54 0.56 0.19
18 INT211839 Binding of EIF4E 8 0.36 0.79 0.18
19 INT257859 Negative_regulation of Eif4e 1 0.23 1.07 0.16
20 INT350685 Negative_regulation of Gene_expression of DICER1 1 0.05 0.15 0.14
21 INT350676 Regulation of Gene_expression of DICER1 1 0.07 0.16 0.14
22 INT237845 Localization of DCP2 2 0.43 1.16 0.13
23 INT341192 Phosphorylation of Eif4e 1 0.49 0.36 0.1
24 INT272508 Regulation of DICER1 4 0.11 1.21 0.05
25 INT341167 Negative_regulation of Binding of Eif4e 1 0.33 0.23 0.03
26 INT341200 Negative_regulation of Eif4e 1 0.46 0.14 0.03
27 INT307299 Binding of DCP2 1 0.06 0 0.03
28 INT341189 Positive_regulation of Positive_regulation of Eif4e 1 0.36 0.13 0.03
29 INT227664 Phosphorylation of EIF4E 6 0.46 0.74 0
30 INT217806 Gene_expression of EIF4E 2 0.27 0.68 0
31 INT293778 Positive_regulation of EIF4E 2 0.45 0.42 0
32 INT190271 Negative_regulation of DICER1 2 0.04 0.24 0
33 INT237848 Positive_regulation of Localization of DCP2 1 0.29 0.94 0
34 INT237844 Gene_expression of DCP2 1 0.39 1.1 0
35 INT293768 Regulation of Binding of EIF4E 1 0.18 0.13 0
36 INT341184 Positive_regulation of Localization of Eif4e 1 0.39 0 0
37 INT227668 Positive_regulation of Phosphorylation of EIF4E 1 0.20 0.15 0
38 INT276879 Regulation of Phosphorylation of EIF4E 1 0.25 0.21 0
39 INT225465 Transcription of TARBP2 1 0.08 0.13 0
40 INT237841 Positive_regulation of Gene_expression of DCP2 1 0.29 0.3 0
41 INT293780 Positive_regulation of Binding of EIF4E 1 0.20 0.13 0
42 INT341191 Localization of Eif4e 1 0.63 0 0
43 INT307294 Negative_regulation of Binding of DCP2 1 0.05 0 0
44 INT352844 Protein_catabolism of DICER1 1 0.12 0 0
45 INT225458 Phosphorylation of TARBP2 1 0.09 0 0
46 INT341208 Negative_regulation of Binding of EIF4E 1 0.14 0 0
47 INT337668 Positive_regulation of Gene_expression of SND1 1 0.51 0.99 0
48 INT341188 Positive_regulation of Binding of Eif4e 1 0.34 0.18 0
49 INT293775 Regulation of EIF4E 1 0.24 0.64 0
50 INT307298 Regulation of DCP2 1 0.05 0 0
51 INT225459 Binding of TARBP2 1 0.05 0 0
52 INT225461 Negative_regulation of TARBP2 1 0.06 0 0
53 INT293761 Negative_regulation of EIF4E 1 0.17 0.85 0
54 INT351112 Positive_regulation of Positive_regulation of EIF4E 1 0.45 0.22 0
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