GO:0016446

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Name somatic hypermutation of immunoglobulin genes
Categary Process
Go Slim No
Go Link GO:0016446
Unique Molecular Interactions 60
Total Molecular Interactions 75
Total Single Events 371
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for somatic hypermutation of immunoglobulin genes. They are ordered first by their pain relevance and then by number of times they were reported for somatic hypermutation of immunoglobulin genes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113715 Msh3 Positive_regulation of tf 1 0.11 0 2.47
2 INT104709 Msh3 Positive_regulation of Rbm39 1 0.01 0.07 1.76
3 INT145121 Msh3 Positive_regulation of Oprm1 1 0.06 0.15 0.72
4 INT145120 Msh3 Negative_regulation of Positive_regulation of Oprm1 1 0.05 0.15 0.72
5 INT145122 Oprm1 Negative_regulation of Msh3 1 0.06 0.15 0.63
6 INT121186 Binding of Msh3 and Em 1 0.02 0.1 0.3
7 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
8 INT100456 Binding of Gm694 and Ighd 1 0.00 0.78 0.16
9 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
10 INT220639 Binding of Apbb1 and Ighd 1 0.12 0.31 0.12
11 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12
12 INT182607 Binding of MLH1 and MSH3 1 0.04 0.81 0.11
13 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
14 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
15 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04
16 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
17 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0
18 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
19 INT306511 Binding of XRCC6 and Ung 1 0.00 0.78 0
20 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
21 INT300616 Binding of MLH1 and PMS2 1 0.36 0.53 0
22 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 0.01 1.45 0
23 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0
24 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0
25 INT212525 MSH6 Positive_regulation of Binding of C1qa 1 0.00 0.38 0
26 INT190062 Binding of MLH1 and Msh2 1 0.01 0.91 0
27 INT300617 Binding of MSH6 and MLH1 1 0.28 0.53 0
28 INT190047 Binding of Msh2 and Msh3 1 0.24 0.23 0
29 INT212528 Binding of MSH6 and Apcs 1 0.00 0.68 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for somatic hypermutation of immunoglobulin genes. They are ordered first by their pain relevance and then by number of times they were reported in somatic hypermutation of immunoglobulin genes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104705 Regulation of Msh3 4 0.28 0.1 3.51
2 INT104708 Gene_expression of Msh3 6 0.72 0.07 3.17
3 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8
4 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48
5 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
6 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
7 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46
8 INT112597 Positive_regulation of Msh3 2 0.25 0 1.42
9 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12
10 INT113712 Positive_regulation of Gene_expression of Msh3 2 0.43 0 1.04
11 INT24868 Localization of Ighd 7 0.78 2.08 1.01
12 INT92139 Binding of MLH1 12 0.42 15.62 1
13 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
14 INT306520 Negative_regulation of Msh3 2 0.40 0.22 0.76
15 INT92142 Binding of MSH2 5 0.46 5.64 0.75
16 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
17 INT220110 Negative_regulation of Gene_expression of Ighd 1 0.13 2.55 0.57
18 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
19 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
20 INT100455 Binding of Ighd 1 0.37 1.61 0.31
21 INT121185 Binding of Msh3 1 0.10 0.1 0.3
22 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
23 INT57545 Positive_regulation of Positive_regulation of Ighd 1 0.15 1.78 0.24
24 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
25 INT182621 Localization of MLH1 9 0.64 9.31 0.12
26 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12
27 INT147244 Regulation of MLH1 3 0.08 2.64 0.12
28 INT182623 Localization of MSH2 3 0.77 5.49 0.12
29 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
30 INT17473 Negative_regulation of Ighd 1 0.08 0.42 0.11
31 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
32 INT192786 Positive_regulation of Gene_expression of Ighd 2 0.11 2.26 0.05
33 INT211581 Binding of Pms2 2 0.32 2.49 0.04
34 INT190022 Positive_regulation of Mlh1 2 0.38 3.16 0.03
35 INT184442 Protein_catabolism of Ighd 1 0.14 0.16 0.03
36 INT190039 Gene_expression of Mlh1 3 0.68 6.14 0
37 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0
38 INT107993 Gene_expression of PMS2 3 0.05 0.54 0
39 INT190020 Gene_expression of Msh2 2 0.69 0.69 0
40 INT190038 Binding of Mlh1 2 0.28 3.11 0
41 INT212518 Localization of MSH6 2 0.10 2.66 0
42 INT135162 Regulation of Ighd 2 0.26 0.07 0
43 INT190035 Binding of Msh6 2 0.28 2.72 0
44 INT211582 Transcription of Mlh1 1 0.41 0.34 0
45 INT206928 Transcription of MSH2 1 0.52 0.4 0
46 INT306491 Protein_catabolism of Ung 1 0.01 0.8 0
47 INT268375 Positive_regulation of Positive_regulation of MLH1 1 0.12 0.76 0
48 INT306522 Negative_regulation of Gene_expression of Msh3 1 0.40 0 0
49 INT190012 Regulation of Mlh1 1 0.34 0.34 0
50 INT182625 Positive_regulation of Localization of MSH2 1 0.45 2.47 0
51 INT107982 Positive_regulation of Gene_expression of PMS2 1 0.00 0 0
52 INT300619 Negative_regulation of PMS2 1 0.32 0.19 0
53 INT190058 Positive_regulation of Localization of MLH1 1 0.02 0.84 0
54 INT185286 Transcription of MLH1 1 0.06 1.12 0
55 INT350584 Negative_regulation of Gene_expression of Mlh1 1 0.51 2.21 0
56 INT190015 Binding of Msh2 1 0.27 1.41 0
57 INT305347 Negative_regulation of Gene_expression of Msh6 1 0.25 2.22 0
58 INT211715 Negative_regulation of Gene_expression of MSH6 1 0.06 1.09 0
59 INT268369 Positive_regulation of Negative_regulation of MLH1 1 0.11 0.76 0
60 INT268373 Localization of PMS2 1 0.06 2.5 0
61 INT107990 Positive_regulation of Gene_expression of MLH1 1 0.15 0 0
62 INT306497 Gene_expression of Ung 1 0.01 0.98 0
63 INT107984 Positive_regulation of Gene_expression of MSH2 1 0.11 0 0
64 INT182624 Positive_regulation of Positive_regulation of MSH2 1 0.45 1.24 0
65 INT211583 Regulation of Transcription of Mlh1 1 0.27 0.34 0
66 INT306488 Binding of Ung 1 0.00 0.78 0
67 INT268359 Positive_regulation of MLH1 1 0.12 0.76 0
68 INT175425 Negative_regulation of Negative_regulation of MLH1 1 0.19 0.73 0
69 INT306498 Positive_regulation of Ung 1 0.00 0.76 0
70 INT304071 Binding of MSH6 1 0.28 1.11 0
71 INT306519 Regulation of Gene_expression of Msh3 1 0.42 0 0
72 INT350588 Negative_regulation of Mlh1 1 0.38 3.05 0
73 INT305349 Gene_expression of Msh6 1 0.46 2.21 0
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