GO:0016485

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Name protein processing
Categary Process
Go Slim No
Go Link GO:0016485
Unique Molecular Interactions 688
Total Molecular Interactions 900
Total Single Events 8597
Pain Genes Associated 52

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein processing. They are ordered first by their pain relevance and then by number of times they were reported for protein processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
4 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
5 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
6 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
7 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
8 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
9 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
10 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
11 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
12 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
13 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
14 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
15 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
16 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
17 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
18 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
19 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
20 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
21 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
22 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
23 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43
24 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
25 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
26 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
27 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
28 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
29 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
30 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
31 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
32 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
33 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
34 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
35 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
36 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
37 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
38 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
39 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
40 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
41 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
42 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
43 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
44 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
45 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
46 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
47 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
48 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
49 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
50 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
51 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
52 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
53 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
54 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
55 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
56 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
57 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
58 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
59 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
60 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
61 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
62 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
63 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
64 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
65 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
66 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
67 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89
68 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
69 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
70 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
71 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
72 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
73 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
74 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
75 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
76 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
77 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
78 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
79 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84
80 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84
81 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
82 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
83 INT97056 Cpz Regulation of Gene_expression of Bcl2l1 1 0.22 0.57 0.83
84 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
85 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
86 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
87 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
88 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
89 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
90 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
91 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
92 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
93 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
94 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
95 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
96 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
97 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
98 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
99 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
100 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
101 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
102 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
103 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
104 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
105 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
106 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
107 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
108 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
109 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
110 INT70161 Casp1 Regulation of Oprd1 1 0.03 0 0.65
111 INT70162 Casp1 Regulation of Penk 1 0.03 0 0.64
112 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64
113 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
114 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
115 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
116 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
117 INT2700 Binding of App and Cpe 1 0.00 0 0.63
118 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
119 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
120 INT52478 Binding of Adarb1 and Ift172 1 0.00 0 0.62
121 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62
122 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
123 INT128811 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Casp1 1 0.06 0.35 0.61
124 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 0.06 0.19 0.6
125 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
126 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
127 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
128 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
129 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59
130 INT128604 Casp1 Positive_regulation of Gene_expression of Fos 1 0.10 0.55 0.59
131 INT1211 Binding of Kitl and Cpz 1 0.27 0 0.58
132 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
133 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
134 INT1210 Negative_regulation of Binding of Kitl and Cpz 1 0.33 0 0.58
135 INT224724 Gm2458 Negative_regulation of Metap2 1 0.02 1.57 0.57
136 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
137 INT84489 Cpe Negative_regulation of Binding of Mif-ps1 1 0.06 0 0.56
138 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
139 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55
140 INT28925 Cpe Regulation of Sh2b3 1 0.04 0.14 0.55
141 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
142 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
143 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
144 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
145 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
146 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
147 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
148 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
149 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
150 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
151 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
152 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
153 INT47225 Asap1 Regulation of Cpe 1 0.04 0.18 0.49
154 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
155 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
156 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 0.09 0 0.46
157 INT222284 Negative_regulation of Casp1 Negative_regulation of Il18 1 0.01 0.79 0.46
158 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
159 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
160 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
161 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
162 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
163 INT90079 Ass1 Positive_regulation of Casp1 1 0.02 0.99 0.43
164 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
165 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
166 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
167 INT157650 Phosphorylation of Prkcc Positive_regulation of Pik3c3 1 0.51 0 0.41
168 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
169 INT157647 Positive_regulation of Oprd1 Positive_regulation of Pik3c3 1 0.01 0 0.4
170 INT157649 Prkcc Regulation of Pik3c3 1 0.30 0 0.39
171 INT90765 Pcsk2 Positive_regulation of Gene_expression of Pdyn 1 0.41 0 0.39
172 INT42847 Binding of Cpe and SLTM 1 0.00 0 0.38
173 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
174 INT80694 Cpe Negative_regulation of Positive_regulation of Fos 1 0.08 0 0.37
175 INT161004 Binding of Cpe and Cpb2 1 0.03 0.53 0.37
176 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
177 INT161000 Binding of Cpe and Gfap 1 0.05 0.53 0.37
178 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
179 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36
180 INT157648 Binding of Prkcc and Pik3c3 1 0.39 0 0.36
181 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
182 INT198970 GAPDH Negative_regulation of ADAMTS3 1 0.47 0 0.35
183 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
184 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
185 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
186 INT75941 Negative_regulation of Binding of Cpe and Frk 1 0.01 1.28 0.34
187 INT75946 Binding of Cpe and Frk 1 0.01 1.28 0.34
188 INT92444 Cpe Negative_regulation of Phosphorylation of Cd3eap 1 0.01 0 0.34
189 INT75942 Positive_regulation of Binding of Cpe and Frk 1 0.02 1.28 0.34
190 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
191 INT75949 Negative_regulation of Binding of Cpe and Ptafr 1 0.03 1.27 0.33
192 INT75953 Binding of Cpe and Ptafr 1 0.03 1.27 0.33
193 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
194 INT33581 Thop1 Positive_regulation of Cpe 1 0.01 0 0.33
195 INT75940 Positive_regulation of Binding of Cpe and Ptafr 1 0.04 1.27 0.33
196 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
197 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
198 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
199 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
200 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein processing. They are ordered first by their pain relevance and then by number of times they were reported in protein processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
5 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
6 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
7 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
8 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
9 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
10 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
11 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
12 INT5214 Localization of Cpe 49 0.73 13.3 44.36
13 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
14 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
15 INT2699 Binding of Cpe 40 0.48 7.07 33.64
16 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
17 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
18 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
19 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
20 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
21 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
22 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
23 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
24 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
25 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
26 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
27 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
28 INT17938 Binding of Cpe 28 0.48 11.17 13.62
29 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
30 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
31 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
32 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
33 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
34 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
35 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
36 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
37 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
38 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
39 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
40 INT20425 Localization of Cpe 23 0.81 5.18 9.14
41 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
42 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
43 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
44 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
45 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
46 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
47 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
48 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
49 INT98178 Localization of Casp3 32 0.65 21.01 7.77
50 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
51 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2
52 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
53 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
54 INT62691 Transcription of Cpe 11 0.40 3.5 6.66
55 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
56 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
57 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
58 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
59 INT57232 Binding of Casp3 22 0.36 9.42 6.2
60 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
61 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
62 INT25822 Negative_regulation of Positive_regulation of Cpe 7 0.29 2.43 6.02
63 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
64 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
65 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
66 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
67 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
68 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
69 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
70 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16
71 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
72 INT102855 Negative_regulation of Srgn 8 0.57 0.91 4.63
73 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34
74 INT111068 Regulation of Psenen 6 0.35 4.17 4.33
75 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
76 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
77 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
78 INT11872 Protein_catabolism of Rnpep 6 0.87 0 4
79 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
80 INT224723 Negative_regulation of Metap2 1 0.33 11.14 3.76
81 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
82 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
83 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
84 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
85 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
86 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
87 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
88 INT60174 Positive_regulation of Pik3c3 12 0.67 1.05 3.23
89 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
90 INT54364 Negative_regulation of Protein_catabolism of Cpe 4 0.53 0.15 3.14
91 INT76838 Binding of Asprv1 7 0.36 1.42 3.13
92 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
93 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
94 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
95 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
96 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
97 INT36886 Transcription of Myc 6 0.69 3.16 2.86
98 INT21343 Regulation of Localization of Cpe 3 0.21 1.38 2.83
99 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
100 INT107433 Localization of Casp1 6 0.56 2.44 2.64
101 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
102 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
103 INT12051 Negative_regulation of Rnpep 7 0.36 0.42 2.59
104 INT156876 Positive_regulation of Gene_expression of Casp1 10 0.50 10.25 2.58
105 INT102856 Positive_regulation of Srgn 7 0.61 1.27 2.54
106 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
107 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
108 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44
109 INT163544 Binding of Psen1 40 0.36 15.28 2.42
110 INT1488 Negative_regulation of Negative_regulation of Cpe 3 0.42 0.86 2.42
111 INT5958 Positive_regulation of Positive_regulation of Cpe 3 0.38 0.58 2.39
112 INT9386 Transcription of Cpe 7 0.72 0.53 2.31
113 INT31118 Localization of Casp3 17 0.73 11.55 2.3
114 INT9354 Negative_regulation of Binding of Cpe 3 0.21 0.09 2.3
115 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
116 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
117 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
118 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
119 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07
120 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
121 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
122 INT60723 Localization of Psen2 5 0.68 2.11 2.02
123 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
124 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
125 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
126 INT113215 Negative_regulation of Asprv1 1 0.00 0 1.83
127 INT87315 Negative_regulation of Transcription of Cpe 3 0.13 1.76 1.81
128 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
129 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8
130 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8
131 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
132 INT37294 Negative_regulation of Ece1 6 0.54 1.27 1.74
133 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
134 INT58210 Gene_expression of Pcsk1 11 0.70 5.63 1.71
135 INT102857 Phosphorylation of Srgn 1 0.72 0.26 1.71
136 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
137 INT99258 Regulation of Aph1a 3 0.25 2.79 1.68
138 INT91560 Positive_regulation of Negative_regulation of Cpe 2 0.40 0.62 1.67
139 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
140 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
141 INT51984 Localization of Pcsk2 3 0.66 0.37 1.62
142 INT89849 Regulation of Srgn 6 0.30 0.93 1.59
143 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
144 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
145 INT53673 Gene_expression of Furin 6 0.40 1.99 1.54
146 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
147 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
148 INT77164 Binding of F12 8 0.47 2.66 1.48
149 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
150 INT140245 Binding of Gli3 3 0.36 2.65 1.46
151 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
152 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
153 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
154 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
155 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
156 INT94572 Negative_regulation of Pik3c3 5 0.13 1.37 1.41
157 INT125762 Negative_regulation of Pcsk1 4 0.42 3.62 1.37
158 INT111755 Regulation of Positive_regulation of Cpe 1 0.03 0.27 1.37
159 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
160 INT116265 Binding of Myc 9 0.36 4.28 1.36
161 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
162 INT92955 Gene_expression of Ece1 5 0.74 2.2 1.36
163 INT69034 Regulation of Casp1 3 0.27 3.56 1.36
164 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
165 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
166 INT11207 Positive_regulation of Gene_expression of Cpe 3 0.46 0.17 1.33
167 INT92954 Positive_regulation of Gene_expression of Ece1 2 0.48 2.16 1.32
168 INT102852 Negative_regulation of Phosphorylation of Srgn 1 0.52 0.17 1.32
169 INT102853 Positive_regulation of Phosphorylation of Srgn 1 0.61 0.17 1.31
170 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
171 INT95270 Regulation of Ece1 1 0.43 2.08 1.3
172 INT96073 Localization of Casp1 11 0.78 4.91 1.29
173 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
174 INT11871 Gene_expression of Rnpep 4 0.23 1.88 1.29
175 INT20424 Protein_catabolism of Cpe 3 0.52 0 1.28
176 INT73590 Positive_regulation of Positive_regulation of Casp1 2 0.19 1.94 1.28
177 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27
178 INT10133 Negative_regulation of F12 16 0.49 5.21 1.26
179 INT31804 Positive_regulation of Asprv1 5 0.40 1.92 1.26
180 INT53666 Regulation of Furin 4 0.37 0.3 1.24
181 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23
182 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23
183 INT27155 Binding of F12 8 0.36 1.61 1.21
184 INT122783 Regulation of Transcription of Cpe 2 0.20 0.21 1.21
185 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
186 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19
187 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
188 INT148027 Localization of Pik3c3 1 0.24 0.34 1.17
189 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
190 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11
191 INT264244 Gene_expression of Cpz 10 0.58 3.24 1.09
192 INT157642 Gene_expression of Pik3c3 7 0.75 0.68 1.08
193 INT102845 Localization of CASP3 7 0.81 2.81 1.06
194 INT267750 Binding of Casp1 4 0.35 1.53 1.02
195 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
196 INT89853 Gene_expression of Srgn 12 0.44 1.13 1
197 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
198 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
199 INT39012 Positive_regulation of Rnpep 3 0.44 0.09 0.98
200 INT97054 Regulation of Cpz 2 0.37 1.07 0.97
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