GO:0016486

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Name peptide hormone processing
Categary Process
Go Slim No
Go Link GO:0016486
Unique Molecular Interactions 500
Total Molecular Interactions 794
Total Single Events 7767
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptide hormone processing. They are ordered first by their pain relevance and then by number of times they were reported for peptide hormone processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
5 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
6 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
7 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
8 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
9 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
10 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
11 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
12 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
13 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
14 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
15 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
16 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
17 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
18 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
19 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
20 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
21 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
22 INT57249 GNRH1 Regulation of Regulation of CGA 1 0.20 0 1.74
23 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
24 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
25 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
26 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
27 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
28 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
29 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
30 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
31 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
32 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
33 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
34 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
35 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
36 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
37 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
38 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
39 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
40 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
41 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
42 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4
43 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33
44 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
45 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
46 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
47 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
48 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
49 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
50 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
51 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
52 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
53 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
54 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
55 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
56 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 0.45 0 1.19
57 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
58 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
59 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
60 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
61 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
62 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
63 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
64 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
65 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
66 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02
67 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
68 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
69 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
70 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
71 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
72 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
73 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
74 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
75 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94
76 INT20888 POMC Positive_regulation of Localization of PDYN 1 0.40 0 0.92
77 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
78 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
79 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
80 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
81 INT264944 Binding of POMC and BOC 1 0.07 0.44 0.89
82 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
83 INT59497 Adh1 Regulation of POMC 1 0.03 0 0.86
84 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
85 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
86 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
87 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
88 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
89 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
90 INT1582 Binding of PENK and POMC 1 0.16 0 0.83
91 INT79617 Htr1a Positive_regulation of Localization of POMC 1 0.38 0 0.83
92 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
93 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
94 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
95 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
96 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
97 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
98 INT18099 POMC Positive_regulation of Binding of Prl 1 0.00 0 0.76
99 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
100 INT32163 Binding of CALM1 and POMC 4 0.46 0 0.75
101 INT164055 POMC Regulation of Agrp 1 0.29 0.3 0.75
102 INT164057 POMC Regulation of Pomc 1 0.09 0.3 0.75
103 INT124404 Binding of POMC and Oprm1 1 0.00 0.25 0.75
104 INT164056 Agrp Regulation of POMC 1 0.29 0.3 0.75
105 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
106 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
107 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
108 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
109 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
110 INT26872 ABAT Positive_regulation of Localization of POMC 1 0.03 0 0.71
111 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
112 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
113 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 0.31 0 0.7
114 INT12711 POMC Regulation of Prl 1 0.04 1.25 0.7
115 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
116 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
117 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69
118 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
119 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68
120 INT40471 GH1 Positive_regulation of POMC 1 0.25 0 0.67
121 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 0.01 0.1 0.67
122 INT61798 Binding of NDP and POMC 2 0.22 0 0.66
123 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
124 INT28080 POMC Negative_regulation of Gene_expression of ITGAM 1 0.00 0.16 0.65
125 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
126 INT72146 POMC Positive_regulation of Phosphorylation of MYOT 1 0.00 0.25 0.65
127 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
128 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
129 INT23555 POMC Positive_regulation of Penk 1 0.56 0 0.63
130 INT23554 POMC Positive_regulation of Localization of Penk 1 0.56 0 0.63
131 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62
132 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
133 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
134 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
135 INT42269 POMC Negative_regulation of Localization of AVP 1 0.09 0 0.61
136 INT47461 PDYN Regulation of POMC 1 0.01 0 0.6
137 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
138 INT13238 POMC Regulation of Gene_expression of IL2 1 0.09 0.26 0.59
139 INT130288 POMC Regulation of Gene_expression of VTCN1 1 0.01 0.1 0.59
140 INT34311 Regulation of CRH Positive_regulation of POMC 1 0.24 0 0.59
141 INT60538 Gnrh1 Positive_regulation of Localization of LHB 1 0.00 0.19 0.59
142 INT130287 POMC Regulation of Localization of IL10 1 0.12 0.1 0.59
143 INT156557 TRPV6 Positive_regulation of BACE2 1 0.00 0.23 0.58
144 INT156558 TRPV6 Negative_regulation of BACE2 1 0.00 0.23 0.58
145 INT62034 POMC Regulation of Positive_regulation of IL4 1 0.44 0 0.58
146 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
147 INT35181 Binding of STT3A and POMC 1 0.29 0.75 0.57
148 INT93541 Ntsr1 Regulation of POMC 1 0.00 0 0.57
149 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
150 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
151 INT102422 POMC Regulation of Gene_expression of Sst 1 0.14 0.24 0.54
152 INT23486 HBE1 Positive_regulation of Localization of FSHB 1 0.03 0 0.54
153 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
154 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
155 INT70244 POMC Positive_regulation of Localization of PLOD1 1 0.21 0 0.53
156 INT23483 HBE1 Positive_regulation of FSHB 1 0.01 0 0.53
157 INT56390 CCK Positive_regulation of Localization of POMC 1 0.14 0.06 0.52
158 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
159 INT119030 Binding of POMC and Ighg1 1 0.06 0 0.52
160 INT18248 Binding of CGA and GNRH1 1 0.15 0.92 0.52
161 INT33505 Oprd1 Regulation of Localization of CGA 1 0.00 0 0.52
162 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52
163 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
164 INT55323 GNRH1 Regulation of POMC 1 0.35 0 0.49
165 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
166 INT48114 GHRH Positive_regulation of Localization of CGB 1 0.05 0 0.48
167 INT72088 IL10 Positive_regulation of POMC 1 0.15 0 0.46
168 INT72087 IL4 Positive_regulation of POMC 1 0.16 0 0.46
169 INT28081 POMC Regulation of Gene_expression of VIM 1 0.13 0.09 0.46
170 INT72089 TGFB2 Positive_regulation of POMC 1 0.11 0 0.46
171 INT32662 Hps1 Negative_regulation of Localization of CGB 1 0.00 0 0.46
172 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 0.06 0 0.45
173 INT69873 ASIP Negative_regulation of Binding of POMC 1 0.35 0 0.45
174 INT28082 POMC Regulation of PDYN 1 0.04 0.09 0.45
175 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
176 INT56132 CALCA Positive_regulation of Localization of POMC 1 0.51 0.16 0.44
177 INT100282 TXN Negative_regulation of Transcription of POMC 1 0.54 0.39 0.43
178 INT23481 POMC Regulation of Localization of PLOD1 1 0.20 0 0.42
179 INT128287 POMC Positive_regulation of RTCA 1 0.04 0.13 0.42
180 INT76153 Binding of NCOR2 and Negative_regulation of Localization of LHB 1 0.00 0 0.42
181 INT47595 Binding of POMC and Pomc 1 0.02 0 0.41
182 INT61799 Negative_regulation of Binding of NDP and POMC 1 0.20 0 0.41
183 INT32550 POMC Positive_regulation of Regulation of Nts 1 0.02 0 0.41
184 INT46225 Binding of ALB and POMC 1 0.36 0 0.4
185 INT44513 PDYN Regulation of Localization of CGA 1 0.00 0 0.4
186 INT188336 IL6 Positive_regulation of Localization of POMC 1 0.01 0.83 0.4
187 INT79618 Htr1a Positive_regulation of POMC 1 0.17 0 0.39
188 INT13097 POMC Negative_regulation of Localization of CGA 1 0.46 0 0.39
189 INT90765 Pcsk2 Positive_regulation of Gene_expression of Pdyn 1 0.41 0 0.39
190 INT81731 POMC Regulation of Gene_expression of TNF 1 0.28 1.07 0.39
191 INT67445 Oprd1 Regulation of Localization of POMC 1 0.00 0 0.39
192 INT48115 GH1 Positive_regulation of CGB 1 0.06 0 0.38
193 INT42847 Binding of Cpe and SLTM 1 0.00 0 0.38
194 INT6657 Binding of POMC and D15Mit108 1 0.03 0.49 0.37
195 INT21828 Binding of POMC and Serpinb1a 1 0.02 0 0.36
196 INT114903 POMC Regulation of Gene_expression of COL7A1 1 0.06 0.2 0.36
197 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
198 INT126123 Cck Positive_regulation of POMC 1 0.08 0.29 0.35
199 INT126122 Cck Regulation of POMC 1 0.04 0.29 0.35
200 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptide hormone processing. They are ordered first by their pain relevance and then by number of times they were reported in peptide hormone processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT738 Regulation of POMC 459 0.62 111.19 243.74
5 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
6 INT695 Binding of POMC 304 0.48 56.66 126.85
7 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
8 INT1793 Localization of CGA 379 0.81 67.38 114.69
9 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
10 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
11 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
12 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
13 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
14 INT7035 Regulation of CGA 87 0.45 29.04 28.45
15 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
16 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
17 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
18 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
19 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
20 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
21 INT5372 Localization of LHB 55 0.68 9.47 19
22 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
23 INT1416 Transcription of POMC 40 0.72 10.71 15.38
24 INT11918 Localization of CGB 35 0.51 8.21 15.01
25 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
26 INT17938 Binding of Cpe 28 0.48 11.17 13.62
27 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
28 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
29 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
30 INT9946 Regulation of Localization of LHB 27 0.52 2.47 11.08
31 INT1648 Regulation of LHB 21 0.61 3.32 9.6
32 INT20425 Localization of Cpe 23 0.81 5.18 9.14
33 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
34 INT13346 Regulation of Localization of CGB 18 0.30 1.29 8.32
35 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
36 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
37 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
38 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
39 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
40 INT9729 Negative_regulation of LHB 14 0.42 1.86 4.63
41 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
42 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
43 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
44 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
45 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
46 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06
47 INT11370 Positive_regulation of LHB 15 0.28 5.45 4.01
48 INT4632 Regulation of CGB 9 0.38 1.81 3.53
49 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
50 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42
51 INT15837 Binding of CGA 31 0.41 12.06 3.17
52 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09
53 INT30077 Positive_regulation of Localization of CGB 5 0.34 0.42 3.07
54 INT11371 Positive_regulation of Localization of LHB 8 0.47 1.4 2.93
55 INT16015 Negative_regulation of Localization of LHB 10 0.37 2.95 2.9
56 INT4147 Gene_expression of LHB 8 0.49 3.94 2.88
57 INT7976 Regulation of Gene_expression of CGA 8 0.19 1.09 2.71
58 INT127552 Gene_expression of Pcsk1n 8 0.78 1.11 2.66
59 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61
60 INT15606 Localization of FSHB 24 0.78 9.16 2.49
61 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45
62 INT9386 Transcription of Cpe 7 0.72 0.53 2.31
63 INT7034 Regulation of Regulation of CGA 5 0.16 0.17 2.29
64 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
65 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07
66 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99
67 INT42497 Regulation of Negative_regulation of POMC 4 0.44 0.63 1.99
68 INT25952 Negative_regulation of Regulation of POMC 4 0.36 0.76 1.96
69 INT68522 Localization of Pcsk1n 2 0.56 1.19 1.85
70 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79
71 INT41580 Negative_regulation of Negative_regulation of POMC 5 0.50 0.46 1.79
72 INT37294 Negative_regulation of Ece1 6 0.54 1.27 1.74
73 INT58210 Gene_expression of Pcsk1 11 0.70 5.63 1.71
74 INT6130 Positive_regulation of Regulation of POMC 6 0.69 3.57 1.7
75 INT51984 Localization of Pcsk2 3 0.66 0.37 1.62
76 INT53673 Gene_expression of Furin 6 0.40 1.99 1.54
77 INT139982 Positive_regulation of BACE2 6 0.42 4.33 1.48
78 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46
79 INT4486 Regulation of TSHB 5 0.28 0.99 1.42
80 INT125762 Negative_regulation of Pcsk1 4 0.42 3.62 1.37
81 INT92955 Gene_expression of Ece1 5 0.74 2.2 1.36
82 INT11207 Positive_regulation of Gene_expression of Cpe 3 0.46 0.17 1.33
83 INT92954 Positive_regulation of Gene_expression of Ece1 2 0.48 2.16 1.32
84 INT40102 Positive_regulation of Phosphorylation of POMC 3 0.44 0.57 1.3
85 INT95270 Regulation of Ece1 1 0.43 2.08 1.3
86 INT9040 Negative_regulation of CGB 9 0.51 2.71 1.29
87 INT20424 Protein_catabolism of Cpe 3 0.52 0 1.28
88 INT53666 Regulation of Furin 4 0.37 0.3 1.24
89 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23
90 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23
91 INT9730 Binding of LHB 4 0.35 2.38 1.19
92 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
93 INT149838 Binding of TSHB 5 0.14 3.27 1.1
94 INT23495 Positive_regulation of Localization of FSHB 7 0.40 0.4 1.07
95 INT2981 Negative_regulation of Gene_expression of CGA 14 0.42 3.41 1.05
96 INT33048 Positive_regulation of Protein_catabolism of POMC 1 0.04 0 1.02
97 INT42210 Positive_regulation of TSHB 6 0.49 3.48 1.01
98 INT91767 Gene_expression of BACE2 5 0.69 2.48 0.96
99 INT330142 Positive_regulation of Pcsk1n 1 0.28 0.3 0.95
100 INT39226 Positive_regulation of Negative_regulation of Cpe 2 0.45 0.17 0.93
101 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92
102 INT72944 Positive_regulation of PCSK1 3 0.49 0 0.89
103 INT137857 Positive_regulation of SCG5 3 0.49 1.01 0.88
104 INT162073 Negative_regulation of Transcription of POMC 1 0.34 0.34 0.88
105 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87
106 INT165345 Localization of PCSK1 2 0.48 0.39 0.87
107 INT53660 Positive_regulation of Pcsk5 2 0.49 0.29 0.85
108 INT53669 Regulation of Transcription of Furin 1 0.16 0.15 0.82
109 INT53670 Transcription of Furin 3 0.50 0.39 0.81
110 INT91561 Regulation of Pcsk2 2 0.52 0.15 0.76
111 INT27546 Positive_regulation of Furin 4 0.40 0.49 0.75
112 INT27545 Gene_expression of Furin 6 0.63 0.75 0.74
113 INT99822 Negative_regulation of Gene_expression of BACE2 1 0.01 0.59 0.7
114 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67
115 INT23492 Negative_regulation of Localization of FSHB 2 0.42 0.73 0.66
116 INT27742 Negative_regulation of Furin 2 0.17 0.22 0.64
117 INT46231 Regulation of Protein_catabolism of POMC 1 0.05 0 0.6
118 INT23039 Positive_regulation of Transcription of Cpe 1 0.46 0.06 0.6
119 INT33926 Negative_regulation of Gene_expression of Cpe 2 0.31 0 0.59
120 INT32612 Negative_regulation of FSHB 3 0.41 2.17 0.58
121 INT29619 Negative_regulation of Gene_expression of FSHB 5 0.05 0.59 0.57
122 INT45778 Negative_regulation of Positive_regulation of CGB 1 0.09 0 0.57
123 INT16251 Negative_regulation of Localization of CGB 2 0.00 0.1 0.56
124 INT132388 Regulation of Regulation of Pcsk1 1 0.13 0.77 0.56
125 INT88705 Localization of Ece1 2 0.22 2.07 0.55
126 INT270969 Regulation of Gene_expression of Cpe 1 0.27 0 0.55
127 INT37938 Localization of Pcsk1 4 0.12 3.74 0.54
128 INT87230 Localization of ECE1 5 0.80 1.51 0.53
129 INT27728 Negative_regulation of Gene_expression of LHB 2 0.04 1.59 0.53
130 INT15608 Regulation of Gene_expression of CGB 2 0.13 0 0.53
131 INT192154 Negative_regulation of Furin 2 0.22 0.94 0.53
132 INT27729 Negative_regulation of Regulation of LHB 1 0.02 0.44 0.53
133 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48
134 INT55850 Negative_regulation of Positive_regulation of CGA 2 0.55 0.08 0.46
135 INT23152 Regulation of Localization of Cpe 1 0.45 0.1 0.46
136 INT105987 Negative_regulation of Protein_catabolism of Cpe 1 0.04 0 0.45
137 INT90764 Positive_regulation of Furin 4 0.32 1.7 0.44
138 INT90762 Regulation of Gene_expression of Pcsk1 2 0.22 0.58 0.44
139 INT330154 Regulation of Pcsk1n 1 0.25 0.45 0.44
140 INT90760 Positive_regulation of Pcsk2 1 0.49 0 0.44
141 INT308493 Positive_regulation of Positive_regulation of Pcsk5 1 0.27 0 0.44
142 INT72196 Transcription of LHB 1 0.02 0.28 0.43
143 INT17581 Regulation of Regulation of LHB 1 0.01 0 0.43
144 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42
145 INT324886 Transcription of Ece1 2 0.37 1.95 0.4
146 INT112327 Positive_regulation of Gene_expression of FSHB 5 0.44 3.64 0.39
147 INT139984 Negative_regulation of BACE2 1 0.39 0.66 0.39
148 INT42846 Regulation of Binding of Cpe 1 0.01 0 0.38
149 INT68523 Negative_regulation of Pcsk1n 2 0.35 0 0.36
150 INT23153 Positive_regulation of Positive_regulation of Cpe 1 0.50 0 0.36
151 INT15836 Positive_regulation of Binding of CGA 1 0.38 0.54 0.34
152 INT330146 Binding of Pcsk1n 1 0.27 0 0.34
153 INT105457 Regulation of Binding of CGA 2 0.45 0.48 0.33
154 INT270972 Phosphorylation of Cpe 1 0.33 0 0.33
155 INT128288 Negative_regulation of Phosphorylation of POMC 1 0.37 0.17 0.33
156 INT61124 Localization of Ece1 1 0.58 0.08 0.32
157 INT79244 Regulation of BACE2 1 0.03 1.21 0.32
158 INT330151 Negative_regulation of Gene_expression of Pcsk1n 1 0.24 0 0.29
159 INT191535 Protein_catabolism of ECE1 1 0.07 1.03 0.28
160 INT39197 Positive_regulation of Regulation of CGA 1 0.02 0.24 0.27
161 INT15792 Regulation of Positive_regulation of CGA 2 0.59 0.4 0.24
162 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24
163 INT55814 Positive_regulation of PCSK7 2 0.03 0.71 0.23
164 INT54039 Positive_regulation of Transcription of POMC 2 0.67 3.24 0.23
165 INT324884 Positive_regulation of Ece1 2 0.37 0.86 0.22
166 INT80306 Localization of Furin 1 0.08 0 0.21
167 INT330152 Positive_regulation of Positive_regulation of Pcsk1n 1 0.28 0 0.21
168 INT59961 Localization of Furin 3 0.76 2.21 0.2
169 INT288255 Protein_catabolism of CGA 5 0.75 1.87 0.19
170 INT324882 Regulation of Transcription of Ece1 1 0.24 0.66 0.19
171 INT295437 Negative_regulation of Protein_catabolism of CGA 1 0.36 0.05 0.19
172 INT97578 Regulation of FSHB 3 0.26 1.41 0.17
173 INT246462 Gene_expression of SCG5 3 0.65 0.78 0.17
174 INT203867 Localization of BACE2 2 0.43 1.38 0.17
175 INT120321 Regulation of Transcription of POMC 1 0.18 0.95 0.17
176 INT87231 Binding of ECE1 4 0.37 0.47 0.16
177 INT330143 Positive_regulation of Localization of Pcsk1n 1 0.28 0.26 0.16
178 INT324723 Transcription of CGA 1 0.07 4.35 0.15
179 INT164161 Regulation of PCSK1 3 0.30 2.09 0.14
180 INT44271 Localization of TSHB 3 0.31 3.34 0.13
181 INT276149 Localization of SCG5 3 0.78 0.56 0.13
182 INT97577 Regulation of Localization of FSHB 1 0.59 0.79 0.13
183 INT161805 Positive_regulation of ECE1 1 0.12 0.61 0.13
184 INT330149 Transcription of Pcsk1n 1 0.39 0 0.12
185 INT91559 Regulation of Gene_expression of Pcsk2 1 0.23 0.15 0.12
186 INT87232 Regulation of ECE1 1 0.45 0.16 0.1
187 INT356496 Phosphorylation of CGA 1 0.42 0.49 0.1
188 INT124295 Positive_regulation of Positive_regulation of CGB 1 0.14 0.55 0.1
189 INT184448 Binding of Furin 2 0.36 0.81 0.09
190 INT70641 Gene_expression of Pcsk5 1 0.21 0.18 0.09
191 INT41112 Negative_regulation of Regulation of CGA 1 0.19 0.25 0.09
192 INT253928 Negative_regulation of Binding of Furin 1 0.41 0.82 0.09
193 INT9388 Regulation of Transcription of Cpe 1 0.45 0.38 0.09
194 INT49260 Negative_regulation of ECE1 7 0.57 0.24 0.08
195 INT330145 Regulation of Binding of Pcsk1n 1 0.25 0 0.08
196 INT330147 Negative_regulation of Regulation of Pcsk1n 1 0.24 0 0.08
197 INT339259 Positive_regulation of Localization of SCG5 1 0.49 0 0.08
198 INT214097 Protein_catabolism of Pcsk2 1 0.12 0 0.07
199 INT209181 Negative_regulation of Binding of CGA 1 0.02 0.07 0.07
200 INT132477 Negative_regulation of TSHB 5 0.45 3.24 0.05
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