GO:0016491

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Name oxidoreductase activity
Categary Function
Go Slim Yes
Go Link GO:0016491
Unique Molecular Interactions 2555
Total Molecular Interactions 3269
Total Single Events 43679
Pain Genes Associated 307

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
3 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
4 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
5 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
8 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
9 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
10 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
11 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
12 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
13 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
14 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
15 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
16 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
17 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
18 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
19 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
20 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2
21 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
22 INT18593 Binding of Sst and Fdft1 2 0.11 0.08 2.12
23 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
24 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
25 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
26 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
27 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
28 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
29 INT125348 Decr1 Regulation of Gene_expression of Fos 1 0.00 0.1 1.92
30 INT14991 SFTPA1 Positive_regulation of Localization of MPO 1 0.11 1.65 1.92
31 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
32 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
33 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83
34 INT115443 Regulation of Binding of Cpox and Defb40 1 0.00 1.28 1.76
35 INT115442 Binding of Cpox and Defb40 1 0.00 1.28 1.76
36 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
37 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
38 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
39 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
40 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
41 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64
42 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
43 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
44 INT33759 Hmmr Positive_regulation of Akr1d1 1 0.00 0 1.58
45 INT7791 Akr1d1 Regulation of Nts 1 0.03 0 1.58
46 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
47 INT7796 Akr1d1 Regulation of Npy 1 0.03 0 1.57
48 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
49 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
50 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
51 INT7797 Akr1d1 Regulation of Sst 1 0.02 0 1.54
52 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
53 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
54 INT63489 Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
55 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
56 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
57 INT61443 Binding of KNG1 and Tyr 1 0.00 0 1.46
58 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
59 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
60 INT351246 Binding of OPN1LW and NNT 1 0.03 0.53 1.45
61 INT150392 Binding of MEFV and PSTPIP1 2 0.51 10.49 1.44
62 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
63 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
64 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
65 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
66 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4
67 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38
68 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
69 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
70 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
71 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
72 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
73 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
74 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
75 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
76 INT153923 Msr1 Positive_regulation of Gene_expression of Tdo2 1 0.00 0.89 1.28
77 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
78 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
79 INT86518 Ass1 Positive_regulation of Hmox2 1 0.03 0.08 1.27
80 INT142431 Cp Positive_regulation of Crh 1 0.31 1.49 1.26
81 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26
82 INT114635 Hmox2 Positive_regulation of Gene_expression of Fos 1 0.47 0.88 1.26
83 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
84 INT21858 Maoa Regulation of Gene_expression of Spna1 1 0.12 0.18 1.24
85 INT21859 Maoa Regulation of Spna1 1 0.12 0.18 1.23
86 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23
87 INT21857 Maoa Regulation of Ap3d1 1 0.12 0.18 1.23
88 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
89 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
90 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2
91 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
92 INT81097 Akr1d1 Regulation of Localization of Abat 1 0.00 0 1.2
93 INT142075 IL4 Negative_regulation of Binding of IDO1 1 0.02 2.07 1.19
94 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
95 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
96 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
97 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
98 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
99 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
100 INT107029 Cpox Regulation of Pag1 1 0.01 1.24 1.15
101 INT18596 Fdft1 Regulation of Localization of Acot1 1 0.06 0 1.14
102 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
103 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
104 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
105 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
106 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
107 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
108 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
109 INT110669 Binding of Alox5 and Trpv1 1 0.07 0.2 1.13
110 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
111 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
112 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
113 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
114 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
115 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 0.11 0 1.11
116 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
117 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
118 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
119 INT75806 Cyp2a5 Negative_regulation of Cyp2g1 1 0.48 0.08 1.09
120 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
121 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
122 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
123 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
124 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05
125 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
126 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
127 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
128 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
129 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
130 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03
131 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02
132 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
133 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01
134 INT250085 Coq7 Positive_regulation of Ltp 1 0.00 0.52 1
135 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
136 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
137 INT70105 SCD Positive_regulation of Oprm1 1 0.01 0 1
138 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
139 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
140 INT52435 Positive_regulation of Binding of Sst and Fdft1 1 0.09 0.08 0.98
141 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
142 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
143 INT97721 Akr1d1 Regulation of Gene_expression of Penk 1 0.00 0 0.98
144 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
145 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98
146 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
147 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
148 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
149 INT18595 Fdft1 Positive_regulation of Localization of Acot1 1 0.08 0 0.96
150 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
151 INT303690 KNG1 Positive_regulation of CPOX 1 0.01 0.76 0.96
152 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
153 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
154 INT155985 Nfkb1 Negative_regulation of Gene_expression of Cyp11a1 1 0.10 0.53 0.95
155 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
156 INT163265 Sst Negative_regulation of Tyr 1 0.00 0.22 0.95
157 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
158 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
159 INT80601 Akr1d1 Regulation of Positive_regulation of Fos 1 0.06 0 0.94
160 INT33976 Trmt2a Negative_regulation of Binding of Fads1 1 0.00 0 0.94
161 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
162 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
163 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
164 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
165 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9
166 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
167 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
168 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
169 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
170 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
171 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
172 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89
173 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
174 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
175 INT75920 Slc8a1 Negative_regulation of Cpox 1 0.03 0.85 0.89
176 INT48455 Scd1 Regulation of Penk 1 0.06 0 0.88
177 INT199189 Binding of Aldh2 and Ros1 1 0.06 0.3 0.88
178 INT168019 Ldha Regulation of Gpt 1 0.01 0.15 0.88
179 INT168018 Positive_regulation of Ldha Regulation of Gpt 1 0.01 0.15 0.88
180 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
181 INT184916 Binding of da and Th 1 0.09 1.22 0.87
182 INT115444 Cpox Positive_regulation of Localization of Defb42 1 0.00 0.64 0.87
183 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
184 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
185 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
186 INT7799 Akr1d1 Regulation of Positive_regulation of Ptgdr 1 0.01 0 0.86
187 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
188 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
189 INT59497 Adh1 Regulation of POMC 1 0.03 0 0.86
190 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
191 INT261461 Positive_regulation of Akr1d1 Regulation of Sftpd 1 0.01 0 0.86
192 INT70670 Scd1 Positive_regulation of Gene_expression of Penk 1 0.11 0.1 0.86
193 INT271780 Zfp560 Negative_regulation of Cpox 1 0.00 0.62 0.86
194 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
195 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
196 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
197 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 0.13 0.26 0.84
198 INT151409 Binding of Cp and Cd8b 1 0.16 0 0.84
199 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
200 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29
2 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
3 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
4 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19
5 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
6 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02
7 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46
8 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81
9 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
10 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17
11 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
12 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85
13 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71
14 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
15 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
16 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
17 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
18 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66
19 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
20 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
21 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4
22 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
23 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
24 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
25 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
26 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06
27 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
28 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
29 INT3920 Localization of Ldha 241 0.81 83.08 58.72
30 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
31 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
32 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
33 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
34 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
35 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
36 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
37 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
38 INT35975 Regulation of Cpox 109 0.39 57.88 49.69
39 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43
40 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
41 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
42 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
43 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
44 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66
45 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
46 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
47 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
48 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03
49 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
50 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
51 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84
52 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77
53 INT64171 Regulation of CPOX 109 0.36 55.36 32.96
54 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
55 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
56 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
57 INT7787 Positive_regulation of Akr1d1 52 0.66 3.55 31.71
58 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
59 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
60 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
61 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
62 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
63 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72
64 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
65 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
66 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
67 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
68 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
69 INT36428 Binding of Chdh 42 0.47 48.04 26.54
70 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93
71 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
72 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
73 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
74 INT48766 Regulation of NOS1 73 0.61 37.01 24.59
75 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
76 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99
77 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96
78 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
79 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07
80 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
81 INT20575 Gene_expression of Akr1d1 48 0.57 6.2 22.5
82 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45
83 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36
84 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
85 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05
86 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
87 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
88 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72
89 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
90 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
91 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
92 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
93 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
94 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
95 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78
96 INT7920 Binding of Akr1d1 26 0.27 3.64 19.73
97 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
98 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51
99 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36
100 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11
101 INT81194 Binding of CPOX 40 0.29 23.7 18.95
102 INT55335 Binding of Cpox 49 0.34 15.48 18.46
103 INT34569 Regulation of Akr1d1 26 0.24 3.06 18.37
104 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
105 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
106 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
107 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22
108 INT78990 Regulation of Cpox 72 0.57 35.22 18.16
109 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
110 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71
111 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
112 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
113 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
114 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26
115 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
116 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
117 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
118 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68
119 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59
120 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
121 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3
122 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
123 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13
124 INT1261 Localization of Adh1 63 0.81 19.36 16.09
125 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
126 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98
127 INT4616 Regulation of Maoa 40 0.62 6.09 15.94
128 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91
129 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
130 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66
131 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
132 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
133 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38
134 INT11034 Negative_regulation of Akr1d1 23 0.18 3.43 14.84
135 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
136 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
137 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
138 INT5904 Localization of MPO 62 0.81 36.37 14.64
139 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
140 INT75918 Negative_regulation of Negative_regulation of Cpox 19 0.23 10.05 14.4
141 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
142 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
143 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25
144 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
145 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87
146 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83
147 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82
148 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
149 INT2396 Regulation of Maoa 25 0.62 6.04 13.27
150 INT6749 Binding of Dio1 25 0.38 4.41 13.07
151 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99
152 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
153 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
154 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66
155 INT879 Localization of Fdft1 16 0.59 1.11 12.59
156 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
157 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
158 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47
159 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
160 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
161 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35
162 INT222660 Phosphorylation of Tyr 2 0.06 5.31 12.33
163 INT90673 Gene_expression of LOX 66 0.65 69.71 12.18
164 INT27507 Positive_regulation of Dio1 23 0.44 3.43 12.11
165 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91
166 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9
167 INT39587 Gene_expression of CP 42 0.65 31.48 11.87
168 INT2415 Binding of MAOA 26 0.47 13.26 11.86
169 INT16870 Negative_regulation of Gsr 27 0.59 10.28 11.81
170 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
171 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
172 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65
173 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
174 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
175 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
176 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
177 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5
178 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5
179 INT373 Regulation of Ldha 37 0.61 17.86 11.41
180 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
181 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37
182 INT2260 Gene_expression of Tyr 30 0.49 7.05 11.31
183 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
184 INT80251 Binding of Nos1 21 0.30 8.24 11.31
185 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19
186 INT6748 Regulation of Dio1 15 0.45 2.63 11.18
187 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
188 INT10384 Positive_regulation of Nqo1 62 0.70 14.27 11.08
189 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
190 INT95341 Gene_expression of NDOR1 17 0.75 4.27 10.98
191 INT48912 Localization of NOS1 52 0.77 24.14 10.92
192 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
193 INT221448 Gene_expression of CREG1 8 0.05 27.44 10.87
194 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84
195 INT27687 Regulation of Cp 20 0.53 9.75 10.8
196 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78
197 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
198 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
199 INT84077 Gene_expression of Hmox2 18 0.77 6.41 10.66
200 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
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