GO:0016505

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Name apoptotic protease activator activity
Categary Function
Go Slim No
Go Link GO:0016505
Unique Molecular Interactions 14
Total Molecular Interactions 19
Total Single Events 103
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apoptotic protease activator activity. They are ordered first by their pain relevance and then by number of times they were reported for apoptotic protease activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98
2 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
3 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
4 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12
5 INT201770 Binding of CASP9 and Apaf1 1 0.04 0.89 0.03
6 INT345282 Binding of CASP1 and Pycard 1 0.01 0.3 0.03
7 INT342733 Gene_expression of Lrrk2 Positive_regulation of Apaf1 1 0.10 0.74 0.03
8 INT278385 Binding of Pycard and Nlrp3 1 0.06 0 0
9 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0
10 INT278395 Binding of Pycard and Hps5 1 0.04 0 0
11 INT278381 Binding of Akt1 and Pycard 1 0.00 0 0
12 INT278372 Binding of Syk and Pycard 1 0.06 0 0
13 INT178938 Binding of Casp9 and Apaf1 1 0.01 0.74 0
14 INT193341 auditory Positive_regulation of CASP8AP2 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for apoptotic protease activator activity. They are ordered first by their pain relevance and then by number of times they were reported in apoptotic protease activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
2 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
3 INT141179 Negative_regulation of Apaf1 2 0.41 1.53 1.14
4 INT141181 Negative_regulation of Transcription of Apaf1 1 0.40 1.42 1.14
5 INT141182 Transcription of Apaf1 1 0.68 1.41 1.14
6 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04
7 INT36603 Positive_regulation of CTSH 1 0.01 0 0.46
8 INT254317 Negative_regulation of Pycard 5 0.42 3.13 0.45
9 INT209911 Protein_catabolism of Pycard 2 0.11 1.58 0.33
10 INT286753 Negative_regulation of Positive_regulation of Apaf1 1 0.09 2.82 0.31
11 INT193357 Gene_expression of CASP8AP2 3 0.65 1 0.28
12 INT181665 Localization of Apaf1 2 0.49 1.67 0.23
13 INT216978 Binding of Pycard 6 0.25 2.93 0.22
14 INT142708 Gene_expression of CTSH 1 0.75 1.51 0.18
15 INT175518 Positive_regulation of Apaf1 3 0.15 2.37 0.15
16 INT262796 Positive_regulation of Pycard 12 0.22 6.5 0.14
17 INT330036 Binding of Apaf1 2 0.25 2.06 0.11
18 INT190027 Regulation of Apaf1 2 0.16 2.59 0.04
19 INT262801 Regulation of Gene_expression of Pycard 1 0.08 1.8 0.04
20 INT349816 Regulation of Pycard 1 0.26 0.56 0.04
21 INT204291 Gene_expression of Apaf1 3 0.42 3.31 0.03
22 INT201641 Binding of Apaf1 3 0.16 2.36 0.03
23 INT204285 Positive_regulation of Apaf1 2 0.35 1.87 0.03
24 INT204292 Negative_regulation of Apaf1 1 0.18 0.97 0.03
25 INT204288 Negative_regulation of Negative_regulation of Apaf1 1 0.18 0.98 0.03
26 INT204295 Negative_regulation of Gene_expression of Apaf1 1 0.18 0.97 0.03
27 INT262795 Localization of Pycard 2 0.26 1.61 0
28 INT262800 Positive_regulation of Binding of Pycard 1 0.09 0.75 0
29 INT193356 Phosphorylation of CASP8AP2 1 0.06 0.08 0
30 INT193359 Positive_regulation of CASP8AP2 1 0.04 0.09 0
31 INT190011 Negative_regulation of Gene_expression of Apaf1 1 0.23 0.76 0
32 INT270800 Positive_regulation of Gene_expression of Pycard 1 0.04 0.2 0
33 INT330040 Regulation of Apaf1 1 0.19 0.58 0
34 INT330031 Positive_regulation of Positive_regulation of Apaf1 1 0.35 0.85 0
35 INT278333 Phosphorylation of Pycard 1 0.11 0 0
36 INT193365 Positive_regulation of Phosphorylation of CASP8AP2 1 0.04 0.09 0
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