GO:0016520

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Name growth hormone-releasing hormone receptor activity
Categary Function
Go Slim No
Go Link GO:0016520
Unique Molecular Interactions 180
Total Molecular Interactions 275
Total Single Events 2162
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for growth hormone-releasing hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for growth hormone-releasing hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
2 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
3 INT30042 Binding of YY1 and Gnrhr 1 0.18 0 1.47
4 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
5 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44
6 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
7 INT3575 Sst Regulation of Localization of Gnrhr 2 0.24 0 1.24
8 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
9 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
10 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 0.11 0.85 1.07
11 INT120318 Gnrhr Negative_regulation of Ngf 1 0.11 0.85 1.07
12 INT775 Nts Positive_regulation of Gnrhr 2 0.18 0 1.02
13 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
14 INT36682 Gh1 Regulation of Gene_expression of Gnrhr 2 0.08 0 0.96
15 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95
16 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
17 INT76062 Gnrhr Positive_regulation of Localization of LH 1 0.10 0 0.9
18 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
19 INT15730 Ghrh Positive_regulation of Gnrhr 2 0.14 0.08 0.84
20 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
21 INT18663 PDYN Negative_regulation of Binding of Gnrhr 1 0.01 0 0.83
22 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
23 INT33995 Ghrh Regulation of Gnrhr 2 0.18 0.43 0.77
24 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
25 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
26 INT40707 Sst Positive_regulation of Localization of Gnrhr 1 0.26 0 0.76
27 INT353718 Binding of Rbm39 and Ghsr 1 0.01 0 0.76
28 INT3570 Trh Regulation of Localization of Gnrhr 2 0.26 0.3 0.75
29 INT31306 Ghrh Regulation of Localization of Gnrhr 2 0.14 1 0.73
30 INT1312 Pomc Positive_regulation of Gnrhr 2 0.11 0.22 0.7
31 INT35920 Penk Positive_regulation of Gnrhr 1 0.29 0 0.67
32 INT74468 Adcyap1 Positive_regulation of Localization of Gnrhr 1 0.27 0 0.67
33 INT42779 Scn4a Positive_regulation of Localization of Gnrhr 1 0.10 0 0.66
34 INT781 Prss12 Positive_regulation of Gene_expression of Gnrhr 1 0.10 0 0.65
35 INT779 Nts Positive_regulation of Gene_expression of Gnrhr 1 0.28 0 0.65
36 INT40450 Cck Regulation of Gnrhr 1 0.23 0 0.65
37 INT773 Prss12 Positive_regulation of Gnrhr 1 0.04 0 0.64
38 INT54155 Positive_regulation of Glra2 Positive_regulation of Localization of Gnrhr 1 0.02 0 0.63
39 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
40 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
41 INT82065 Negative_regulation of Gnrhr Negative_regulation of Localization of LH 1 0.45 0 0.61
42 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
43 INT26997 SST Positive_regulation of Negative_regulation of Gnrhr 1 0.00 0.08 0.59
44 INT30462 Gnrhr Positive_regulation of Localization of Gh1 2 0.21 0.08 0.58
45 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57
46 INT45736 Prl Positive_regulation of Gene_expression of Gnrhr 1 0.00 0.1 0.56
47 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55
48 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55
49 INT55206 Prl Negative_regulation of Gnrhr 1 0.37 0 0.54
50 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 0.00 0.54 0.54
51 INT149886 Npw Negative_regulation of Localization of Gnrhr 1 0.36 0 0.54
52 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 0.00 0.54 0.54
53 INT149885 Npw Negative_regulation of Gnrhr 1 0.36 0 0.54
54 INT55203 Prl Negative_regulation of Localization of Gnrhr 1 0.37 0 0.51
55 INT49150 GAL Regulation of Localization of Gnrhr 1 0.00 0.09 0.51
56 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
57 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
58 INT1311 Lct Positive_regulation of Localization of Gnrhr 1 0.03 0 0.45
59 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
60 INT325391 Binding of Ghrl and Ghsr 2 0.17 0.14 0.43
61 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43
62 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
63 INT83749 Gnrhr Positive_regulation of Gene_expression of Fos 2 0.21 0.14 0.39
64 INT34865 Ghrh Positive_regulation of Gene_expression of Gnrhr 1 0.07 0 0.37
65 INT74466 Mzb1 Positive_regulation of Localization of Gnrhr 1 0.28 0 0.37
66 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36
67 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35
68 INT42042 Binding of Gnrhr and MCG 1 0.01 0.26 0.35
69 INT12710 Gnrhr Regulation of Prl 1 0.00 0.63 0.35
70 INT54930 Gnrhr Regulation of Gene_expression of Ghrh 1 0.10 0.16 0.34
71 INT27099 Vip Positive_regulation of Localization of Gnrhr 1 0.01 0.36 0.33
72 INT8975 Gal Positive_regulation of Localization of Gnrhr 1 0.00 0.06 0.33
73 INT74469 GNRH1 Positive_regulation of Localization of Gnrhr 1 0.04 0 0.31
74 INT83750 Gh1 Regulation of Gene_expression of Ghsr 1 0.36 0 0.29
75 INT295549 Ghrl Positive_regulation of Gene_expression of Ghsr 1 0.29 0 0.29
76 INT30266 Binding of Penk and Gnrhr 1 0.10 0.32 0.29
77 INT60448 NPY Positive_regulation of Gnrhr 1 0.01 0 0.29
78 INT60449 GAL Positive_regulation of Gnrhr 1 0.00 0 0.29
79 INT59757 Man2a2 Positive_regulation of Localization of Gnrhr 1 0.07 0 0.29
80 INT30264 Binding of Pomc and Gnrhr 1 0.22 0.32 0.29
81 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
82 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
83 INT38352 LH Regulation of Localization of Gnrhr 1 0.21 0 0.27
84 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
85 INT38353 Gnrh1 Regulation of Localization of Gnrhr 1 0.20 0 0.27
86 INT60914 Iapp Regulation of Gnrhr 1 0.17 0 0.27
87 INT157080 Ghrl Positive_regulation of Localization of Gnrhr 2 0.23 0.7 0.26
88 INT16895 Regulation of GHSR Regulation of GH1 1 0.23 0 0.26
89 INT54263 Ghsr Regulation of Localization of Gh1 1 0.23 0 0.26
90 INT77736 Pnoc Positive_regulation of Localization of Gnrhr 1 0.24 0 0.23
91 INT40448 Cck Regulation of Localization of Gnrhr 1 0.23 0 0.23
92 INT143909 SST Regulation of Gnrhr 1 0.00 0 0.22
93 INT19905 Trh Regulation of Gnrhr 1 0.00 0.25 0.22
94 INT35211 Ghsr Positive_regulation of Localization of Gh1 5 0.31 0 0.21
95 INT352961 Ghrl Positive_regulation of Localization of GHSR 1 0.18 1.19 0.21
96 INT316203 Ghsr Positive_regulation of Transcription of Agrp 1 0.02 1.5 0.19
97 INT3615 Gnrhr Regulation of Localization of Gh1 1 0.26 0 0.19
98 INT3619 Trh Positive_regulation of Localization of Gnrhr 2 0.48 0.2 0.18
99 INT325421 PHF20 Positive_regulation of Localization of Gnrhr 1 0.00 0.39 0.17
100 INT30419 Gnrhr Regulation of Sst 1 0.02 0.27 0.15
101 INT25149 Gnrhr Regulation of Localization of Ins1 1 0.21 0.1 0.15
102 INT16892 GHSR Positive_regulation of Localization of GH1 1 0.36 0 0.15
103 INT83748 Ghsr Positive_regulation of Gene_expression of Fos 1 0.27 0 0.15
104 INT30421 Gnrhr Regulation of Crh 1 0.11 0.27 0.15
105 INT49683 Negative_regulation of Sst Positive_regulation of Localization of Gnrhr 1 0.01 0 0.15
106 INT31848 SST Regulation of Localization of Gnrhr 1 0.01 0 0.14
107 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
108 INT17523 Ghsr Positive_regulation of Localization of Gh 2 0.02 0.24 0.13
109 INT34760 Gh1 Positive_regulation of Localization of Gnrhr 1 0.09 0 0.13
110 INT122221 Gnrhr Regulation of Gene_expression of LH 1 0.03 0 0.12
111 INT339254 GNRHR Regulation of GNRH1 1 0.24 0.23 0.12
112 INT117857 Mln Positive_regulation of Localization of Gnrhr 1 0.14 0 0.12
113 INT64590 Gnrhr Positive_regulation of Positive_regulation of Ins1 1 0.14 0.33 0.12
114 INT122230 Gnrhr Regulation of Gene_expression of Pomc 1 0.00 0 0.12
115 INT122229 Gnrhr Regulation of Gene_expression of Gnrh1 1 0.05 0 0.12
116 INT295528 Ghsr Positive_regulation of Gene_expression of Fos 1 0.61 0 0.11
117 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
118 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
119 INT295544 Gene_expression of Ghsr Positive_regulation of Gene_expression of Fos 1 0.44 0 0.09
120 INT157079 Ghrl Positive_regulation of Gnrhr 1 0.23 0 0.09
121 INT144865 Positive_regulation of Gnrhr Positive_regulation of Localization of Gh1 1 0.27 0 0.09
122 INT325418 Ghrl Positive_regulation of Ghsr 1 0.16 0 0.08
123 INT34930 Gh1 Regulation of Localization of Gnrhr 1 0.04 0 0.08
124 INT323490 Ghsr Regulation of Ins1 1 0.26 0.54 0.07
125 INT84505 Ghsr Positive_regulation of Localization of Gnrhr 1 0.20 0 0.07
126 INT17524 Negative_regulation of Ghsr Regulation of Gh 1 0.01 0 0.06
127 INT17526 Ghsr Regulation of Gh 1 0.01 0 0.06
128 INT66590 Gnrhr Regulation of Ldlr 1 0.02 0.4 0.06
129 INT295537 Ghsr Positive_regulation of Localization of Gh 1 0.24 0 0.06
130 INT299457 Foxl2 Positive_regulation of Gnrhr 1 0.42 0.56 0.05
131 INT323498 Ghsr Positive_regulation of Ins1 1 0.24 0.23 0.05
132 INT295532 Ghsr Positive_regulation of Localization of Ghrh 1 0.40 0 0.03
133 INT323497 Negative_regulation of Ghsr Positive_regulation of Ins1 1 0.24 0 0.03
134 INT299461 Foxl2 Regulation of Gnrhr 1 0.24 0.12 0
135 INT299454 Gene_expression of Foxl2 Positive_regulation of Positive_regulation of Gnrhr 1 0.42 0 0
136 INT100609 Gnrhr Regulation of Cyp2c22 1 0.02 0.19 0
137 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0
138 INT76601 Ghsr Positive_regulation of Localization of Prl 1 0.69 0 0
139 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0
140 INT76602 Ghsr Regulation of Prl 1 0.27 0 0
141 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0
142 INT70770 Fga Regulation of TAPT1 1 0.00 0.65 0
143 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0
144 INT261357 Negative_regulation of Gh1 Regulation of Gnrhr 1 0.00 1.26 0
145 INT17540 Ghsr Regulation of GHRH 1 0.22 0 0
146 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0
147 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0
148 INT188292 Ghrl Regulation of Gnrhr 1 0.01 0.19 0
149 INT299437 Regulation of Foxl2 Regulation of Gnrhr 1 0.21 0.05 0
150 INT299441 Foxl2 Regulation of Gene_expression of Gnrhr 1 0.24 0 0
151 INT76603 Ghsr Positive_regulation of Gh1 1 0.19 0 0
152 INT17525 Ghsr Regulation of Lhb 1 0.01 0 0
153 INT323496 Binding of Rip and Ghsr 1 0.08 0.34 0
154 INT331405 Binding of Gh and Ghsr 1 0.08 0.13 0
155 INT76600 Ghsr Positive_regulation of Prl 1 0.22 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for growth hormone-releasing hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in growth hormone-releasing hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT767 Localization of Gnrhr 565 0.80 106.68 214.57
2 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56
3 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64
4 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23
5 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66
6 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54
7 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93
8 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41
9 INT18660 Binding of Gnrhr 45 0.41 10.6 16.85
10 INT327 Negative_regulation of Positive_regulation of Gnrhr 17 0.53 4.22 10.21
11 INT14368 Regulation of Gene_expression of Gnrhr 13 0.61 3.23 8.45
12 INT18661 Localization of Ghsr 32 0.78 3.19 5.2
13 INT18345 Positive_regulation of Positive_regulation of Gnrhr 16 0.42 4.99 4.91
14 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6
15 INT33071 Negative_regulation of Gene_expression of Gnrhr 13 0.53 5.99 4.41
16 INT16588 Positive_regulation of Gene_expression of Gnrhr 14 0.62 4.76 3.35
17 INT15062 Transcription of Gnrhr 9 0.65 1.88 3.2
18 INT1360 Negative_regulation of Regulation of Gnrhr 5 0.43 0.77 2.86
19 INT19009 Positive_regulation of Ghsr 17 0.64 5.71 2.78
20 INT15607 Localization of GNRHR 14 0.62 7.56 2.3
21 INT21037 Regulation of Regulation of Gnrhr 2 0.45 0.21 2.3
22 INT35210 Gene_expression of Ghsr 39 0.75 6 2.24
23 INT323480 Negative_regulation of Ghsr 4 0.36 0.9 2.06
24 INT43165 Regulation of Positive_regulation of Gnrhr 3 0.27 0.1 1.86
25 INT51952 Negative_regulation of Binding of Gnrhr 4 0.46 0.29 1.81
26 INT19007 Binding of Ghsr 5 0.46 0.46 1.6
27 INT35209 Positive_regulation of Negative_regulation of Gnrhr 5 0.48 1.38 1.53
28 INT15605 Regulation of Localization of GNRHR 4 0.40 0 1.36
29 INT57852 Regulation of Ghsr 15 0.59 1.02 1.1
30 INT149090 Positive_regulation of Ghsr 10 0.70 2.33 1.06
31 INT167716 Negative_regulation of Gene_expression of Gnrhr 2 0.35 6.64 0.93
32 INT16898 Localization of GHSR 8 0.74 1.76 0.91
33 INT75050 Binding of GHSR 3 0.47 0.64 0.89
34 INT353715 Negative_regulation of Gene_expression of Ghsr 1 0.35 0 0.89
35 INT32963 Negative_regulation of Localization of GNRHR 3 0.29 2.48 0.84
36 INT36811 Regulation of Binding of Gnrhr 1 0.35 0 0.78
37 INT167717 Gene_expression of Gnrhr 5 0.55 2.49 0.69
38 INT295519 Localization of Ghsr 7 0.72 0.75 0.68
39 INT61506 Localization of Ghrhr 1 0.51 0 0.61
40 INT139927 Localization of Gnrhr 4 0.74 0.1 0.59
41 INT21377 Regulation of GNRHR 3 0.58 0.14 0.59
42 INT51953 Positive_regulation of Binding of Gnrhr 2 0.36 0.73 0.59
43 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53
44 INT19005 Positive_regulation of Positive_regulation of Ghsr 1 0.49 0 0.53
45 INT224959 Positive_regulation of Gene_expression of Ghsr 5 0.45 1.09 0.5
46 INT32962 Positive_regulation of Localization of GNRHR 3 0.41 0.59 0.49
47 INT16897 Gene_expression of GHSR 6 0.77 0.46 0.41
48 INT177438 Negative_regulation of GNRHR 3 0.18 3.39 0.4
49 INT58364 Positive_regulation of GHSR 2 0.56 0.35 0.39
50 INT295911 Positive_regulation of Transcription of Gnrhr 1 0.02 0.98 0.39
51 INT13064 Positive_regulation of GNRHR 2 0.36 0.93 0.35
52 INT21376 Regulation of Regulation of GNRHR 1 0.26 0 0.34
53 INT188281 Transcription of Ghsr 1 0.66 0.8 0.34
54 INT98692 Negative_regulation of Regulation of Ghsr 2 0.21 0.15 0.24
55 INT151710 Negative_regulation of Transcription of Gnrhr 1 0.42 0.09 0.23
56 INT16900 Negative_regulation of GHSR 1 0.42 0 0.22
57 INT151709 Transcription of Gnrhr 1 0.71 0.09 0.22
58 INT83747 Regulation of Gene_expression of Ghsr 2 0.26 0.27 0.21
59 INT139926 Regulation of Localization of Gnrhr 1 0.18 0 0.21
60 INT113159 Negative_regulation of Gnrhr 1 0.33 0 0.19
61 INT57851 Regulation of Regulation of Ghsr 1 0.04 0 0.19
62 INT95417 Regulation of Gnrhr 3 0.48 0 0.16
63 INT65898 Negative_regulation of Ghsr 3 0.26 2.01 0.16
64 INT10523 Negative_regulation of Negative_regulation of Gnrhr 2 0.36 0.86 0.16
65 INT323470 Binding of Ghsr 4 0.40 1.94 0.13
66 INT55048 Transcription of GNRHR 2 0.69 0.63 0.13
67 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
68 INT325417 Regulation of Positive_regulation of Ghsr 1 0.41 0.1 0.09
69 INT95418 Regulation of Regulation of Gnrhr 1 0.35 0 0.08
70 INT169094 Positive_regulation of Localization of Gnrhr 1 0.38 0 0.07
71 INT323461 Negative_regulation of Localization of Ghsr 1 0.35 0.76 0.04
72 INT76597 Positive_regulation of Gene_expression of Ghsr 7 0.63 2.51 0.03
73 INT188284 Negative_regulation of Gene_expression of Ghsr 2 0.41 0.17 0.03
74 INT323460 Transcription of Ghsr 1 0.59 0.84 0.03
75 INT262891 Positive_regulation of Ghrhr 1 0.15 0.33 0
76 INT161017 Regulation of Transcription of Gnrhr 1 0.41 0 0
77 INT331401 Regulation of Ghsr 1 0.38 0 0
78 INT55046 Binding of GNRHR 1 0.37 0.53 0
79 INT323481 Transcription of GHSR 1 0.67 0 0
80 INT161015 Negative_regulation of Transcription of Gnrhr 1 0.39 0 0
81 INT76598 Positive_regulation of Localization of Ghsr 1 0.45 0 0
82 INT299412 Positive_regulation of Gnrhr 1 0.38 0 0
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