GO:0016538

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Name cyclin-dependent protein kinase regulator activity
Categary Function
Go Slim No
Go Link GO:0016538
Unique Molecular Interactions 66
Total Molecular Interactions 87
Total Single Events 731
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for cyclin-dependent protein kinase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124108 Binding of RYBP and Ccne1 1 0.09 0.34 1.26
2 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63
3 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
4 INT309148 Dlat Positive_regulation of Cks2 1 0.00 0.54 0.36
5 INT242162 Binding of Ccnd1 and Wnt2 1 0.10 0.23 0.34
6 INT304277 CCNE1 Positive_regulation of IL1RN 1 0.00 1.93 0.31
7 INT304278 CCNE1 Positive_regulation of IL8 1 0.02 1.93 0.31
8 INT304280 CCNE1 Positive_regulation of IL6 1 0.00 1.93 0.31
9 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16
10 INT327325 Binding of Hnrnpd and Ccnd1 1 0.03 0.38 0.16
11 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
12 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
13 INT196433 Cdk4 Negative_regulation of Ccnd1 1 0.10 1.17 0.13
14 INT184522 Positive_regulation of Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.95 0.11
15 INT184521 Ptger2 Regulation of Localization of Ccnd1 1 0.01 0.94 0.11
16 INT184520 Ptger2 Regulation of Ccnd1 1 0.00 0.94 0.11
17 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
18 INT185279 Binding of CCND1 and CDK4 4 0.13 2.05 0.08
19 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
20 INT340567 Jun Positive_regulation of Gene_expression of Ccnd1 1 0.05 0.27 0.07
21 INT215693 Trib3 Regulation of Gene_expression of Ccnd1 1 0.00 0.09 0.07
22 INT333840 Binding of Cables1 and Mir17 1 0.03 0.52 0.05
23 INT316485 Stat3 Positive_regulation of Transcription of Ccnd1 1 0.23 1.27 0.04
24 INT207702 CCND1 Regulation of MSMB 1 0.22 0.69 0.04
25 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03
26 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
27 INT223067 IFI27 Negative_regulation of CCND1 1 0.05 0.65 0.03
28 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
29 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0
30 INT144030 STAT3 Regulation of CCND1 2 0.09 1.05 0
31 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
32 INT170858 Binding of IFI27 and Ccne2 1 0.01 0.17 0
33 INT272518 Positive_regulation of Binding of Ccnd1 and Celf1 1 0.01 0 0
34 INT269948 Sox17 Positive_regulation of Gene_expression of Ccnd1 1 0.61 0.19 0
35 INT269920 Positive_regulation of Binding of Ccnd1 and Qsox1 1 0.10 0 0
36 INT224291 Negative_regulation of ESR1 Positive_regulation of CCND1 1 0.16 0.07 0
37 INT333843 Ccne1 Regulation of Regulation of Mir103-2 1 0.06 0 0
38 INT250658 FOS Positive_regulation of CCND1 1 0.03 0.6 0
39 INT145338 Binding of PYGO1 and Positive_regulation of Transcription of CCND1 1 0.07 0 0
40 INT196434 Binding of Ccne2 and Cdc25a 1 0.01 0.48 0
41 INT269925 Binding of Ccnd1 and Qsox1 1 0.07 0 0
42 INT338197 CCND1 Negative_regulation of AR 1 0.24 0 0
43 INT269949 Sox17 Positive_regulation of Ccnd1 1 0.61 0.96 0
44 INT181121 SLC4A1 Regulation of Cks1b 1 0.00 0.42 0
45 INT302154 STAT3 Regulation of Transcription of CCND1 1 0.04 0.99 0
46 INT315486 Slfn1 Negative_regulation of Ccnd1 1 0.07 0.28 0
47 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0
48 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
49 INT314678 Binding of CCNE1 and CCNE2 1 0.03 1.41 0
50 INT285878 Negative_regulation of Binding of CCND1 and CDK4 1 0.00 0.44 0
51 INT269945 Sox17 Positive_regulation of Localization of Ccnd1 1 0.39 0 0
52 INT186051 IFI27 Regulation of Gene_expression of CCND1 1 0.30 0.66 0
53 INT269922 Sox17 Regulation of Ccnd1 1 0.47 0 0
54 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
55 INT333850 Binding of Ccne1 and Cdk2 1 0.26 0 0
56 INT201756 CDKN1B Positive_regulation of Localization of Ccnd1 1 0.04 0 0
57 INT269931 Binding of Ccnd1 and Sox17 1 0.33 0.19 0
58 INT229007 MIA3 Positive_regulation of Gene_expression of Ccnd1 1 0.01 0.55 0
59 INT224290 ESR1 Positive_regulation of CCND1 1 0.17 0.07 0
60 INT314684 Binding of CCND1 and ESR1 1 0.22 0.42 0
61 INT145334 Binding of BCL9 and Positive_regulation of Transcription of CCND1 1 0.41 0 0
62 INT287071 Tlr4 Positive_regulation of Ccnd1 1 0.02 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in cyclin-dependent protein kinase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
2 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93
3 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65
4 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24
5 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66
6 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26
7 INT93398 Negative_regulation of Gene_expression of Ccnd1 5 0.44 2.61 2.12
8 INT104402 Positive_regulation of CCND1 15 0.70 11.77 2.08
9 INT112867 Positive_regulation of Gene_expression of Ccnd1 15 0.56 13.22 1.77
10 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31
11 INT136972 Negative_regulation of Cks2 2 0.04 0.49 1.19
12 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15
13 INT144427 Transcription of Ccnd1 10 0.41 7.89 1.07
14 INT59198 Regulation of Ccnd1 11 0.47 6.54 0.9
15 INT163280 Negative_regulation of Phosphorylation of CCND1 6 0.19 3.92 0.87
16 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86
17 INT146013 Negative_regulation of Gene_expression of Ccne1 4 0.21 1.19 0.85
18 INT146014 Gene_expression of Ccne1 5 0.54 1.31 0.84
19 INT146012 Negative_regulation of Ccne2 1 0.20 0.13 0.84
20 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81
21 INT144432 Positive_regulation of Transcription of Ccnd1 4 0.36 2.36 0.63
22 INT58987 Positive_regulation of Ccne1 1 0.49 0 0.59
23 INT58988 Positive_regulation of Gene_expression of Ccne1 1 0.67 0 0.59
24 INT128498 Regulation of CCND1 17 0.39 12.51 0.58
25 INT58989 Gene_expression of Ccne1 2 0.75 0.79 0.58
26 INT146802 Positive_regulation of Ccnd1 4 0.38 1.37 0.53
27 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51
28 INT258835 Localization of Ccnd1 3 0.53 2.7 0.5
29 INT146522 Negative_regulation of Positive_regulation of CCND1 3 0.30 2.04 0.48
30 INT196424 Binding of Ccnd1 5 0.29 3.34 0.47
31 INT93400 Negative_regulation of Ccnd1 4 0.33 0.77 0.47
32 INT158643 Negative_regulation of Negative_regulation of CCND1 2 0.31 2.43 0.45
33 INT236642 Positive_regulation of Gene_expression of Cks2 1 0.05 0.69 0.39
34 INT236638 Gene_expression of Cks2 1 0.07 0.56 0.32
35 INT304298 Positive_regulation of CCNE1 2 0.46 2.95 0.31
36 INT186057 Binding of CCND1 8 0.31 5.92 0.26
37 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24
38 INT264095 Negative_regulation of Gene_expression of Ccne2 1 0.02 0.34 0.22
39 INT236641 Regulation of Cks2 1 0.02 0.98 0.22
40 INT170847 Gene_expression of Ccne2 6 0.58 2.98 0.21
41 INT146801 Regulation of Ccnd1 5 0.34 2.4 0.19
42 INT236640 Positive_regulation of Cks2 1 0.05 0.56 0.19
43 INT42569 Binding of Ccne1 1 0.21 0.38 0.19
44 INT236639 Localization of Cks2 1 0.06 0.55 0.15
45 INT145248 Negative_regulation of Negative_regulation of Ccnd1 1 0.23 0.47 0.13
46 INT196428 Negative_regulation of Binding of Ccnd1 1 0.14 1.17 0.13
47 INT196427 Negative_regulation of Transcription of Ccnd1 1 0.14 1.17 0.12
48 INT169908 Localization of Ccnd1 7 0.57 2.68 0.11
49 INT184473 Regulation of Gene_expression of Ccnd1 5 0.40 2.73 0.1
50 INT302244 Negative_regulation of CCNE1 1 0.01 1.03 0.1
51 INT215750 Transcription of Ccnd1 2 0.14 2.23 0.09
52 INT145375 Transcription of CCND1 7 0.52 3.86 0.07
53 INT173183 Regulation of CCNE1 1 0.05 0.4 0.06
54 INT215731 Positive_regulation of Transcription of Ccnd1 1 0.13 0.1 0.06
55 INT176590 Positive_regulation of Transcription of CCND1 1 0.17 0.27 0.05
56 INT333809 Localization of Cables1 1 0.38 0.52 0.05
57 INT290786 Phosphorylation of Ccne2 1 0.05 0.08 0.04
58 INT290804 Positive_regulation of Phosphorylation of Ccne2 1 0.03 0.08 0.04
59 INT221830 Negative_regulation of Transcription of CCND1 3 0.18 2.15 0.03
60 INT249773 Localization of Cks1b 1 0.59 0.55 0.03
61 INT249797 Protein_catabolism of Cks1b 1 0.55 0.55 0.03
62 INT249779 Positive_regulation of Protein_catabolism of Cks1b 1 0.39 0.56 0.03
63 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03
64 INT258832 Regulation of Transcription of Ccnd1 1 0.16 1.57 0.03
65 INT236643 Binding of Cks2 1 0.03 0.34 0.03
66 INT302266 Negative_regulation of Phosphorylation of CCNE1 1 0.02 0.29 0.03
67 INT314725 Gene_expression of CCNE1 3 0.52 2.45 0
68 INT181110 Gene_expression of Cks1b 2 0.56 0.43 0
69 INT269897 Positive_regulation of Ccne1 2 0.35 0 0
70 INT282087 Regulation of Ccne1 2 0.19 1.44 0
71 INT215727 Regulation of Gene_expression of Ccnd1 2 0.12 0.49 0
72 INT225215 Negative_regulation of Positive_regulation of Ccnd1 2 0.13 1.33 0
73 INT236700 Phosphorylation of Ccnd1 2 0.18 1.89 0
74 INT225220 Positive_regulation of Positive_regulation of Ccnd1 1 0.14 1.2 0
75 INT333800 Localization of Ccne1 1 0.53 0.22 0
76 INT305634 Localization of CCND1 1 0.07 2.69 0
77 INT276362 Protein_catabolism of CCND1 1 0.10 0.66 0
78 INT277667 Positive_regulation of Gene_expression of Ccne2 1 0.01 0.52 0
79 INT333815 Regulation of Gene_expression of Ccne1 1 0.43 0 0
80 INT256915 Regulation of Ccne2 1 0.34 0.98 0
81 INT297265 Positive_regulation of Positive_regulation of CCND1 1 0.07 0.94 0
82 INT330350 Positive_regulation of Negative_regulation of CCND1 1 0.08 1.3 0
83 INT256905 Positive_regulation of Ccne2 1 0.52 1.08 0
84 INT235459 Positive_regulation of Protein_catabolism of Ccnd1 1 0.13 0.49 0
85 INT276346 Regulation of Protein_catabolism of CCND1 1 0.04 0.66 0
86 INT269909 Positive_regulation of Localization of Ccnd1 1 0.38 0 0
87 INT228997 Phosphorylation of Ccnd1 1 0.10 0.52 0
88 INT282081 Positive_regulation of Gene_expression of Ccne1 1 0.04 0.29 0
89 INT204068 Negative_regulation of Gene_expression of Ccne1 1 0.03 0.47 0
90 INT333824 Transcription of Ccne1 1 0.48 0 0
91 INT314716 Positive_regulation of Gene_expression of CCNE1 1 0.16 1.48 0
92 INT322520 Binding of Ccne1 1 0.35 0 0
93 INT302232 Negative_regulation of Binding of CCND1 1 0.11 0.84 0
94 INT196432 Binding of Ccne2 1 0.03 0.48 0
95 INT302253 Phosphorylation of CCNE1 1 0.03 0.29 0
96 INT235458 Protein_catabolism of Ccnd1 1 0.19 0.24 0
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