GO:0016539

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Name intein-mediated protein splicing
Categary Process
Go Slim No
Go Link GO:0016539
Unique Molecular Interactions 46
Total Molecular Interactions 63
Total Single Events 293
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for intein-mediated protein splicing. They are ordered first by their pain relevance and then by number of times they were reported for intein-mediated protein splicing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
2 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
3 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
4 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
5 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
6 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
7 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
8 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
9 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
10 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
11 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
12 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
13 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
14 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
15 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
16 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
17 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
18 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
19 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
20 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
21 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
22 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
23 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
24 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
25 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
26 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
27 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
28 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
29 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
30 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
31 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
32 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
33 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
34 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
35 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
36 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
37 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
38 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
39 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
40 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
41 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
42 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
43 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
44 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
45 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
46 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for intein-mediated protein splicing. They are ordered first by their pain relevance and then by number of times they were reported in intein-mediated protein splicing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
2 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
3 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
4 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
5 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
6 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
7 INT113042 Localization of IHH 1 0.70 0.77 0.61
8 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
9 INT206484 Localization of Shh 2 0.75 1.14 0.46
10 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
11 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
12 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
13 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
14 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
15 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
16 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
17 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
18 INT278241 Regulation of IHH 2 0.31 1.16 0.14
19 INT253190 Localization of Shh 2 0.77 1.06 0.13
20 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
21 INT270442 Transcription of Shh 1 0.53 0.25 0.09
22 INT213515 Binding of Shh 8 0.37 1.92 0.08
23 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08
24 INT270453 Regulation of Shh 1 0.27 0.83 0.08
25 INT205973 Binding of SHH 3 0.35 1.03 0.07
26 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
27 INT256862 Regulation of Shh 1 0.25 0 0.07
28 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
29 INT251811 Positive_regulation of IHH 1 0.29 0.09 0.05
30 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
31 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
32 INT165149 Positive_regulation of Ihh 1 0.42 0.09 0.04
33 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
34 INT253181 Transcription of Shh 1 0.68 0.54 0.03
35 INT294470 Transcription of IHH 1 0.16 0.28 0.03
36 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
37 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
38 INT290929 Binding of Shh 1 0.31 0.1 0
39 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
40 INT301356 Binding of Ihh 1 0.08 0.06 0
41 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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