GO:0016540

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Name protein autoprocessing
Categary Process
Go Slim No
Go Link GO:0016540
Unique Molecular Interactions 79
Total Molecular Interactions 107
Total Single Events 1090
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein autoprocessing. They are ordered first by their pain relevance and then by number of times they were reported for protein autoprocessing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
2 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
3 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
4 INT218062 Abat Negative_regulation of Ctse 1 0.03 0.25 0.89
5 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 0.07 0 0.8
6 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 0.43 0 0.8
7 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
8 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 0.07 0 0.8
9 INT111747 Pcsk2 Regulation of Gene_expression of Npy 1 0.29 0 0.71
10 INT149684 Negative_regulation of Parp1 Positive_regulation of Oprm1 1 0.51 0 0.65
11 INT149681 Parp1 Regulation of Transcription of Oprm1 1 0.67 0 0.63
12 INT149682 Parp1 Negative_regulation of Oprm1 1 0.47 0 0.6
13 INT149683 Parp1 Negative_regulation of Transcription of Oprm1 1 0.47 0 0.58
14 INT17610 Binding of Ctse and Trh 1 0.27 0.89 0.49
15 INT155921 PARP1 Positive_regulation of Gene_expression of IL6 1 0.49 0.44 0.48
16 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
17 INT90765 Pcsk2 Positive_regulation of Gene_expression of Pdyn 1 0.41 0 0.39
18 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
19 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
20 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
21 INT77046 Binding of Pcsk2 and Olfr714 1 0.09 0.07 0.23
22 INT341378 Positive_regulation of Ros1 Positive_regulation of Parp1 1 0.01 1.08 0.22
23 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21
24 INT81159 Binding of PARP1 and IgG-2a 1 0.00 1.02 0.21
25 INT287693 Parp1 Positive_regulation of Positive_regulation of Nfkb1 1 0.07 0.54 0.2
26 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
27 INT250550 Binding of F12 and CHDH 1 0.05 2.26 0.17
28 INT236339 Binding of PCSK1 and GOPC 1 0.05 0.14 0.17
29 INT72116 Binding of PCSK1 and POMC 1 0.32 0 0.15
30 INT72117 Binding of PCSK2 and POMC 1 0.30 0 0.15
31 INT336503 Parp1 Positive_regulation of Tubgcp2 1 0.11 0.52 0.13
32 INT336504 Parp1 Positive_regulation of Mcpt3 1 0.11 0.52 0.13
33 INT336506 Parp1 Positive_regulation of Cxcl2 1 0.16 0.52 0.13
34 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13
35 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12
36 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
37 INT96045 Capn1 Regulation of Rasgrp1 1 0.01 0.44 0.09
38 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09
39 INT310201 Binding of F12 and Chdh 1 0.04 1.06 0.08
40 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
41 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05
42 INT253193 Ros1 Regulation of Parp1 1 0.01 0.57 0.05
43 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04
44 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
45 INT261962 Binding of Parp1 and El4 1 0.19 1.33 0.03
46 INT250796 Tlr4 Positive_regulation of Parp1 1 0.14 1 0.03
47 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03
48 INT225479 Binding of Parp1 and Acsl1 1 0.00 0 0
49 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
50 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
51 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
52 INT155920 PARP1 Regulation of Gene_expression of IL6 1 0.19 0.08 0
53 INT308927 Gtf2i Positive_regulation of Gene_expression of Parp1 1 0.24 0 0
54 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0
55 INT205387 Binding of PCSK1 and DCLK1 1 0.05 1.42 0
56 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
57 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
58 INT155916 PARP1 Positive_regulation of Gene_expression of TNF 1 0.42 0 0
59 INT155923 Negative_regulation of PARP1 Negative_regulation of Gene_expression of TNF 1 0.36 0.07 0
60 INT286444 PCSK9 Positive_regulation of Apob 1 0.02 0.49 0
61 INT326118 Binding of BMI1 and PCSK1 1 0.09 0 0
62 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
63 INT341377 Gene_expression of Ros1 Positive_regulation of Parp1 1 0.01 1.03 0
64 INT233020 SFTPA1 Negative_regulation of Parp1 1 0.00 0.58 0
65 INT205392 Binding of ANPEP and PCSK1 1 0.06 1.4 0
66 INT300199 PCSK9 Regulation of Gene_expression of LDLR 1 0.13 0.88 0
67 INT155919 Gene_expression of PARP1 Positive_regulation of Gene_expression of IL6 1 0.33 0 0
68 INT114539 Binding of Pcsk2 and Penk 1 0.07 0 0
69 INT322363 TNF Positive_regulation of Positive_regulation of Parp1 1 0.02 1.54 0
70 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
71 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
72 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
73 INT114540 Binding of Pcsk1 and Penk 1 0.06 0 0
74 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
75 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0
76 INT331117 EPO Positive_regulation of FXN 1 0.29 1.09 0
77 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
78 INT310200 Binding of Serping1 and F12 1 0.21 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein autoprocessing. They are ordered first by their pain relevance and then by number of times they were reported in protein autoprocessing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
2 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77
3 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56
4 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78
5 INT73642 Positive_regulation of Ctse 12 0.44 5.57 6.79
6 INT20676 Gene_expression of Ctse 16 0.77 10.59 4.68
7 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
8 INT51986 Negative_regulation of Pcsk2 8 0.50 1.4 4.1
9 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74
10 INT51985 Gene_expression of Pcsk2 10 0.76 1.34 3.44
11 INT115232 Negative_regulation of Ctse 2 0.36 1.29 3.37
12 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36
13 INT155091 Localization of PARP1 15 0.63 13.34 3.15
14 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06
15 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02
16 INT107677 Positive_regulation of Parp1 7 0.45 9.77 3
17 INT107674 Negative_regulation of Parp1 7 0.27 8.91 2.88
18 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
19 INT163833 Positive_regulation of Localization of PARP1 7 0.28 7.54 2.14
20 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1
21 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07
22 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89
23 INT10993 Regulation of PARP1 4 0.26 2.04 1.89
24 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8
25 INT131818 Binding of Parp1 14 0.46 8.74 1.76
26 INT58210 Gene_expression of Pcsk1 11 0.70 5.63 1.71
27 INT63586 Regulation of Parp1 5 0.43 3.28 1.68
28 INT51984 Localization of Pcsk2 3 0.66 0.37 1.62
29 INT77164 Binding of F12 8 0.47 2.66 1.48
30 INT97053 Transcription of Parp1 3 0.66 2.04 1.43
31 INT125762 Negative_regulation of Pcsk1 4 0.42 3.62 1.37
32 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27
33 INT10133 Negative_regulation of F12 16 0.49 5.21 1.26
34 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23
35 INT105122 Regulation of Ctse 4 0.27 0.57 1.23
36 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23
37 INT27155 Binding of F12 8 0.36 1.61 1.21
38 INT41628 Positive_regulation of PCSK2 2 0.31 0.58 1.21
39 INT175508 Protein_catabolism of Parp1 30 0.85 30 1.09
40 INT136005 Positive_regulation of Gene_expression of Ctse 1 0.47 0.07 1.07
41 INT123816 Positive_regulation of Gene_expression of Parp1 9 0.50 6.64 1.04
42 INT156891 Positive_regulation of Transcription of Ctse 1 0.28 0 1.03
43 INT156890 Transcription of Ctse 1 0.39 0 1.02
44 INT153125 Negative_regulation of Protein_catabolism of PARP1 8 0.32 6.57 0.98
45 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92
46 INT72944 Positive_regulation of PCSK1 3 0.49 0 0.89
47 INT165345 Localization of PCSK1 2 0.48 0.39 0.87
48 INT147616 Negative_regulation of Positive_regulation of Parp1 3 0.43 2.53 0.84
49 INT165346 Localization of PCSK2 1 0.48 0.16 0.84
50 INT106458 Negative_regulation of PCSK2 1 0.36 0.6 0.81
51 INT157610 Gene_expression of Parp1 4 0.58 2.16 0.77
52 INT91561 Regulation of Pcsk2 2 0.52 0.15 0.76
53 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74
54 INT44001 Negative_regulation of Positive_regulation of F12 5 0.59 2.53 0.73
55 INT90699 Regulation of F12 4 0.45 2.7 0.67
56 INT123814 Positive_regulation of Positive_regulation of Parp1 9 0.50 9.32 0.57
57 INT126585 Positive_regulation of Positive_regulation of PARP1 3 0.55 2.84 0.56
58 INT132388 Regulation of Regulation of Pcsk1 1 0.13 0.77 0.56
59 INT37938 Localization of Pcsk1 4 0.12 3.74 0.54
60 INT126586 Binding of PARP1 15 0.43 4.96 0.53
61 INT221932 Gene_expression of F12 4 0.66 2.61 0.5
62 INT218059 Localization of Ctse 1 0.49 0.22 0.5
63 INT109867 Negative_regulation of Negative_regulation of Parp1 2 0.42 3.37 0.49
64 INT126584 Regulation of Positive_regulation of PARP1 1 0.24 0.78 0.49
65 INT107676 Positive_regulation of Protein_catabolism of Parp1 1 0.10 0.91 0.48
66 INT233013 Positive_regulation of Positive_regulation of Parp1 1 0.23 1.78 0.47
67 INT107675 Negative_regulation of Protein_catabolism of Parp1 1 0.08 0.91 0.47
68 INT107678 Protein_catabolism of Parp1 1 0.19 0.9 0.47
69 INT90762 Regulation of Gene_expression of Pcsk1 2 0.22 0.58 0.44
70 INT90760 Positive_regulation of Pcsk2 1 0.49 0 0.44
71 INT53084 Gene_expression of PCSK2 13 0.78 3.98 0.43
72 INT157609 Regulation of Parp1 2 0.26 1.4 0.43
73 INT10994 Regulation of Gene_expression of PARP1 1 0.01 0.2 0.38
74 INT10129 Gene_expression of F12 4 0.65 3.4 0.37
75 INT186468 Positive_regulation of Protein_catabolism of Parp1 2 0.33 5.05 0.34
76 INT154804 Negative_regulation of Positive_regulation of PARP1 2 0.34 3.88 0.33
77 INT352918 Transcription of PARP1 1 0.25 0.85 0.33
78 INT287690 Negative_regulation of Positive_regulation of Parp1 1 0.20 0.65 0.33
79 INT153126 Negative_regulation of Gene_expression of PARP1 3 0.19 2.09 0.29
80 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28
81 INT169195 Negative_regulation of Localization of PARP1 1 0.27 0.99 0.26
82 INT287683 Regulation of Gene_expression of Parp1 1 0.21 0.64 0.26
83 INT77165 Regulation of Positive_regulation of F12 1 0.38 0.28 0.23
84 INT77160 Positive_regulation of Binding of F12 1 0.42 0.28 0.23
85 INT77156 Regulation of Binding of F12 1 0.13 0.25 0.23
86 INT77153 Positive_regulation of Binding of F12 1 0.14 0.26 0.22
87 INT207809 Positive_regulation of Negative_regulation of Parp1 2 0.50 1.01 0.2
88 INT284110 Positive_regulation of Transcription of PCSK2 1 0.49 3.16 0.2
89 INT175532 Localization of Parp1 9 0.74 5.73 0.17
90 INT119715 Localization of F12 3 0.67 1.24 0.17
91 INT195012 Positive_regulation of Positive_regulation of Capn1 1 0.05 0.36 0.17
92 INT195006 Positive_regulation of Capn1 1 0.07 0.36 0.17
93 INT58589 Regulation of F12 3 0.39 1.9 0.16
94 INT96541 Negative_regulation of Binding of F12 2 0.41 0.32 0.16
95 INT250795 Negative_regulation of Gene_expression of Parp1 4 0.41 5.01 0.15
96 INT199856 Negative_regulation of Protein_catabolism of Parp1 2 0.41 1.46 0.15
97 INT325373 Negative_regulation of Binding of PARP1 1 0.31 0.98 0.15
98 INT164161 Regulation of PCSK1 3 0.30 2.09 0.14
99 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14
100 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14
101 INT119714 Protein_catabolism of F12 1 0.84 0.14 0.14
102 INT10128 Negative_regulation of Gene_expression of F12 2 0.01 0.33 0.12
103 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12
104 INT91559 Regulation of Gene_expression of Pcsk2 1 0.23 0.15 0.12
105 INT322280 Binding of PCSK9 1 0.33 0.94 0.12
106 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11
107 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11
108 INT284101 Transcription of PCSK2 1 0.67 1.57 0.1
109 INT310198 Positive_regulation of Positive_regulation of F12 1 0.38 1.63 0.09
110 INT123574 Localization of F12 1 0.15 0.25 0.09
111 INT96040 Regulation of Capn1 1 0.06 0.44 0.09
112 INT199646 Transcription of Fxn 2 0.67 4.78 0.08
113 INT253175 Regulation of Positive_regulation of Parp1 2 0.52 0.97 0.08
114 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08
115 INT175513 Positive_regulation of Localization of Parp1 2 0.23 2.23 0.07
116 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07
117 INT214097 Protein_catabolism of Pcsk2 1 0.12 0 0.07
118 INT315598 Localization of FXN 1 0.43 1.04 0.07
119 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05
120 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05
121 INT253176 Regulation of Gene_expression of Parp1 2 0.23 0.61 0.05
122 INT257999 Phosphorylation of PARP1 1 0.12 0.28 0.05
123 INT155929 Positive_regulation of Negative_regulation of PARP1 2 0.49 1.02 0.04
124 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04
125 INT236481 Negative_regulation of Negative_regulation of PARP1 1 0.15 0.95 0.04
126 INT199648 Regulation of Fxn 1 0.29 2.14 0.04
127 INT199651 Binding of Fxn 3 0.30 1.45 0.03
128 INT246130 Regulation of Transcription of Capn1 1 0.44 0.97 0.03
129 INT291518 Positive_regulation of Negative_regulation of Fxn 1 0.47 1.1 0.03
130 INT246125 Transcription of Capn1 1 0.69 0.97 0.03
131 INT232490 Binding of PCSK1 5 0.27 0.07 0
132 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0
133 INT315635 Positive_regulation of FXN 2 0.41 5.76 0
134 INT155927 Positive_regulation of Binding of PARP1 2 0.49 0.32 0
135 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0
136 INT229769 Regulation of Transcription of Pcsk1 1 0.09 0.85 0
137 INT291511 Positive_regulation of Transcription of Fxn 1 0.47 0.09 0
138 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0
139 INT331131 Regulation of Gene_expression of FXN 1 0.37 1.49 0
140 INT291516 Negative_regulation of Transcription of Fxn 1 0.54 0.77 0
141 INT175530 Regulation of Protein_catabolism of Parp1 1 0.09 1.36 0
142 INT326466 Regulation of Gene_expression of F12 1 0.03 0.6 0
143 INT315637 Transcription of FXN 1 0.40 1.44 0
144 INT315555 Binding of FXN 1 0.28 1.29 0
145 INT326119 Positive_regulation of Binding of PCSK1 1 0.37 0 0
146 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0
147 INT207802 Regulation of Localization of Parp1 1 0.45 0.35 0
148 INT300232 Gene_expression of PCSK9 1 0.57 0.8 0
149 INT286443 Positive_regulation of PCSK9 1 0.16 0.48 0
150 INT291507 Regulation of Negative_regulation of Fxn 1 0.37 0.87 0
151 INT250579 Transcription of F12 1 0.62 0.77 0
152 INT291512 Regulation of Gene_expression of Fxn 1 0.37 0.06 0
153 INT57641 Positive_regulation of Gene_expression of PCSK2 1 0.40 0.34 0
154 INT331130 Negative_regulation of FXN 1 0.48 4.93 0
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