GO:0016567

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Name protein ubiquitination
Categary Process
Go Slim No
Go Link GO:0016567
Unique Molecular Interactions 798
Total Molecular Interactions 1104
Total Single Events 6381
Pain Genes Associated 77

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein ubiquitination. They are ordered first by their pain relevance and then by number of times they were reported for protein ubiquitination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
5 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
6 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
7 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
8 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
9 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
10 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
11 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
12 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
13 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
14 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
15 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
16 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
17 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
18 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
19 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
20 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
21 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 0.10 1.92 1.22
22 INT59203 ecs Positive_regulation of Negative_regulation of Ube2d3 1 0.00 1.93 1.15
23 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
24 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
25 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
26 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
27 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
28 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
29 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
30 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
31 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
32 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
33 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
34 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
35 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
36 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
37 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
38 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
39 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
40 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
41 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
42 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
43 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
44 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
45 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
46 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
47 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
48 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
49 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
50 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
51 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
52 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
53 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
54 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
55 INT221938 Binding of TRPA1 and Tceb1 1 0.02 0 0.71
56 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
57 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
58 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
59 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
60 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
61 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
62 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
63 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
64 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
65 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
66 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
67 INT59202 ecs Positive_regulation of Ube2d3 1 0.00 0.98 0.59
68 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
69 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
70 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
71 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
72 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
73 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
74 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
75 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
76 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
77 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
78 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
79 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
80 INT240192 RBX1 Negative_regulation of BDNF 1 0.08 0.13 0.52
81 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
82 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
83 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
84 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
85 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
86 INT215543 Negative_regulation of Trim33 Negative_regulation of Gopc 1 0.15 0.35 0.48
87 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
88 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
89 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
90 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
91 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
92 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
93 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
94 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
95 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
96 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
97 INT240193 RBX1 Positive_regulation of Gene_expression of BDNF 1 0.10 0 0.43
98 INT20221 Binding of Grcc10 and Fbxo6 1 0.00 0 0.42
99 INT121378 Fancl Positive_regulation of MIF 1 0.01 0.92 0.42
100 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
101 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
102 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42
103 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
104 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
105 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
106 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
107 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
108 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
109 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
110 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
111 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
112 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
113 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
114 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
115 INT151698 Binding of RNF130 and Vwf 1 0.04 0.29 0.37
116 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
117 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
118 INT151694 Binding of FBL and RNF130 1 0.40 0.23 0.36
119 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
120 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
121 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
122 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
123 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
124 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
125 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
126 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
127 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
128 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
129 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
130 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
131 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
132 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
133 INT190806 Ubd Regulation of Abp1 1 0.20 0.82 0.32
134 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
135 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
136 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
137 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
138 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
139 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
140 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
141 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
142 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
143 INT145284 Msr1 Negative_regulation of FEM1B 1 0.01 0 0.29
144 INT31507 FEM1B Positive_regulation of Localization of POMC 1 0.51 0 0.29
145 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
146 INT31508 FEM1B Positive_regulation of Gene_expression of CRH 1 0.54 0 0.28
147 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
148 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
149 INT31505 CRH Positive_regulation of Gene_expression of FEM1B 1 0.54 0 0.28
150 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
151 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
152 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
153 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
154 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
155 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
156 INT221939 Tceb1 Negative_regulation of Positive_regulation of TRPA1 1 0.02 0 0.26
157 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
158 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
159 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
160 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
161 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
162 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
163 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
164 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
165 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
166 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
167 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
168 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
169 INT329530 Malt1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.48 0.22
170 INT224431 TNF Positive_regulation of Gene_expression of FBXO2 1 0.47 0.35 0.22
171 INT223570 Binding of Mri1 and Uhrf2 1 0.02 0.56 0.22
172 INT224452 Il1 Positive_regulation of Gene_expression of FBXO2 1 0.37 0.35 0.22
173 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
174 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
175 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
176 INT116469 VEGFA Positive_regulation of Amfr 1 0.01 1.39 0.21
177 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
178 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
179 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
180 INT116466 Vegfa Positive_regulation of Amfr 1 0.07 1.41 0.21
181 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
182 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
183 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
184 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
185 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
186 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
187 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
188 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
189 INT334267 Mul1 Positive_regulation of Protein_catabolism of Tlr4 1 0.01 0.18 0.18
190 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
191 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18
192 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
193 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
194 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
195 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
196 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
197 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
198 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17
199 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
200 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein ubiquitination. They are ordered first by their pain relevance and then by number of times they were reported in protein ubiquitination. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
6 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
7 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
8 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
9 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
10 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
11 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
12 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
13 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
14 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
15 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
16 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
17 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36
18 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
19 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
20 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
21 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
22 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
23 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
24 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
25 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
26 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
27 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
28 INT48270 Negative_regulation of RNF130 44 0.57 21.31 6.14
29 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
30 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
31 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
32 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
33 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
34 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
35 INT134657 Localization of Akt1 37 0.68 11.58 4.62
36 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
37 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
38 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
39 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
40 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
41 INT75136 Binding of Akt1 27 0.27 8.81 4.15
42 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
43 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
44 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
45 INT136692 Localization of Akt1 12 0.78 2.14 3.65
46 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
47 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
48 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
49 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
50 INT54749 Binding of BTRC 7 0.09 0.88 2.9
51 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
52 INT80880 Gene_expression of ARRB2 4 0.65 3.51 2.71
53 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
54 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
55 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
56 INT214355 Binding of Akt1 13 0.36 3.72 2.59
57 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
58 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
59 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
60 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
61 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21
62 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
63 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
64 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
65 INT275860 Negative_regulation of Localization of TNFAIP1 1 0.03 4.41 1.91
66 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85
67 INT80885 Positive_regulation of Gene_expression of ARRB2 3 0.49 1.36 1.82
68 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
69 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
70 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
71 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69
72 INT224975 Gene_expression of Ube3a 5 0.76 7.18 1.69
73 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
74 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
75 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
76 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
77 INT81222 Binding of RNF130 9 0.47 5.38 1.54
78 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
79 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
80 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
81 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47
82 INT158184 Localization of ARRB2 2 0.52 1.3 1.47
83 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
84 INT243339 Localization of TNFAIP1 4 0.41 3.7 1.39
85 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
86 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
87 INT158183 Positive_regulation of Negative_regulation of ARRB2 1 0.35 1.13 1.33
88 INT224447 Gene_expression of FBXO2 7 0.75 7.33 1.31
89 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
90 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
91 INT59200 Negative_regulation of Ube2d3 3 0.13 2.37 1.23
92 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22
93 INT23525 Regulation of FEM1B 5 0.44 1.26 1.22
94 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
95 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
96 INT116537 Binding of ARRB2 1 0.34 0.3 1.19
97 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
98 INT159835 Negative_regulation of Trim2 1 0.09 1.81 1.14
99 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
100 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
101 INT128412 Positive_regulation of Cand1 5 0.67 3.58 1.1
102 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
103 INT41009 Gene_expression of Ubd 2 0.52 1.67 1.07
104 INT16024 Regulation of Cand1 5 0.60 2.74 1.04
105 INT223563 Gene_expression of Uhrf2 4 0.48 1.15 1.04
106 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
107 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
108 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
109 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
110 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
111 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
112 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
113 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
114 INT351587 Positive_regulation of Gene_expression of Uhrf2 1 0.29 0.81 0.92
115 INT215518 Negative_regulation of Trim33 2 0.57 0.43 0.88
116 INT278709 Gene_expression of CBL 4 0.14 3.91 0.85
117 INT68665 Binding of Vhl 9 0.48 10.3 0.82
118 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
119 INT221926 Regulation of Tceb1 1 0.02 0.72 0.79
120 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
121 INT181326 Binding of TNFAIP1 2 0.29 0.81 0.74
122 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
123 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
124 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71
125 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
126 INT215519 Protein_catabolism of Trim33 1 0.86 0.39 0.69
127 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
128 INT11551 Localization of VHL 12 0.65 22.76 0.68
129 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67
130 INT173087 Gene_expression of VHLL 5 0.62 8.44 0.67
131 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
132 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63
133 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
134 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
135 INT100370 Negative_regulation of Gene_expression of Vhl 1 0.06 0.9 0.62
136 INT99673 Localization of Cand1 1 0.73 0.15 0.62
137 INT31512 Gene_expression of FEM1B 3 0.65 0.43 0.6
138 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
139 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
140 INT320096 Negative_regulation of SAE1 10 0.12 3.85 0.59
141 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
142 INT288354 Gene_expression of Mgrn1 1 0.60 0 0.58
143 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
144 INT221928 Gene_expression of Tceb1 1 0.04 0 0.57
145 INT79870 Regulation of RNF130 3 0.44 1.12 0.56
146 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
147 INT74016 Binding of VHL 20 0.48 15.49 0.54
148 INT190799 Positive_regulation of Ubd 1 0.41 1.15 0.54
149 INT149394 Positive_regulation of Mul1 4 0.12 1.89 0.53
150 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
151 INT181325 Positive_regulation of TNFAIP1 4 0.36 4.64 0.52
152 INT288355 Localization of Mgrn1 1 0.67 0 0.52
153 INT240206 Negative_regulation of RBX1 1 0.08 0.15 0.51
154 INT319248 Positive_regulation of Positive_regulation of Cbl 1 0.08 0.94 0.51
155 INT71157 Positive_regulation of RNF130 7 0.67 2.77 0.5
156 INT315427 Positive_regulation of Uhrf2 2 0.38 0.33 0.5
157 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
158 INT226164 Gene_expression of Trim63 5 0.68 4.77 0.49
159 INT89258 Localization of STUB1 3 0.14 0.67 0.49
160 INT319278 Positive_regulation of Cbl 1 0.08 0.92 0.49
161 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
162 INT351920 Regulation of Gene_expression of VHLL 1 0.36 0.99 0.46
163 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
164 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
165 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
166 INT238793 Gene_expression of Cbl 6 0.03 3.01 0.43
167 INT323739 Regulation of IRAK1 3 0.23 1.73 0.43
168 INT270000 Localization of IRAK1 3 0.73 0.82 0.43
169 INT44600 Gene_expression of MALT1 6 0.75 6.14 0.42
170 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
171 INT343940 Binding of Uhrf2 2 0.30 0.06 0.42
172 INT343891 Positive_regulation of Gene_expression of IRAK1 1 0.23 0.3 0.42
173 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
174 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
175 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
176 INT167084 Binding of Cbl 3 0.10 1.34 0.39
177 INT182790 Positive_regulation of SAE1 3 0.49 3.18 0.39
178 INT203081 Gene_expression of Trim63 2 0.56 1.53 0.39
179 INT156120 Localization of Arrb1 1 0.00 0 0.38
180 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
181 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
182 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
183 INT231102 Gene_expression of Mul1 8 0.21 1.66 0.35
184 INT217464 Binding of Traf6 5 0.29 1.28 0.35
185 INT84798 Gene_expression of Vhl 2 0.48 2.28 0.35
186 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
187 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
188 INT221930 Binding of Tceb1 1 0.02 0 0.33
189 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
190 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
191 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
192 INT190797 Positive_regulation of Positive_regulation of Ubd 1 0.41 0.83 0.32
193 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
194 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
195 INT226170 Positive_regulation of Gene_expression of Trim63 5 0.44 3.96 0.31
196 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
197 INT168837 Gene_expression of TRPC4AP 1 0.43 1.31 0.31
198 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
199 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
200 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29
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