GO:0016572

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Name histone phosphorylation
Categary Process
Go Slim No
Go Link GO:0016572
Unique Molecular Interactions 58
Total Molecular Interactions 99
Total Single Events 456
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for histone phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
2 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
3 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
4 INT73654 Binding of Jun and Pim3 1 0.02 0.99 0.58
5 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
6 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
7 INT255933 Tauph Positive_regulation of Rps6ka5 1 0.00 0.1 0.32
8 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32
9 INT255945 MAPK14 Positive_regulation of Rps6ka5 1 0.06 0.1 0.32
10 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29
11 INT73652 Jun Positive_regulation of Pim3 1 0.02 0.48 0.29
12 INT73651 Fos Positive_regulation of Pim3 1 0.04 0.48 0.29
13 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
14 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29
15 INT73655 Binding of Pim3 and Fos 1 0.03 0.49 0.28
16 INT286701 Rps6ka5 Positive_regulation of Phosphorylation of Creb1 1 0.20 0.18 0.28
17 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28
18 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
19 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
20 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
21 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
22 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
23 INT316489 Stat3 Positive_regulation of Transcription of Ccnb1 1 0.02 1.27 0.04
24 INT333852 Binding of Ccna1 and Cdk2 1 0.20 0.48 0.04
25 INT237206 LGALS4 Regulation of Gene_expression of Ccnb1 1 0.05 0 0.03
26 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
27 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
28 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
29 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
30 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
31 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0
32 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
33 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
34 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
35 INT205984 Mapk8 Positive_regulation of Map3k12 1 0.15 0.24 0
36 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
37 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
38 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
39 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
40 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0
41 INT205987 Ptn Positive_regulation of Map3k12 1 0.03 0.24 0
42 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
43 INT295043 Akt1 Positive_regulation of Cdk2 1 0.10 0.93 0
44 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
45 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
46 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
47 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
48 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
49 INT333850 Binding of Ccne1 and Cdk2 1 0.26 0 0
50 INT268315 Cdk1 Positive_regulation of Mcm5 1 0.33 0.25 0
51 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
52 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
53 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0
54 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
55 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in histone phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161352 Gene_expression of Map3k12 3 0.24 0.59 6.16
2 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
3 INT85359 Negative_regulation of Map3k12 6 0.51 0.07 1.89
4 INT281639 Binding of Map3k12 2 0.02 3.05 1.68
5 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
6 INT109507 Regulation of Map3k12 2 0.54 0 1.43
7 INT354377 Negative_regulation of Negative_regulation of Map3k12 1 0.10 0 1.27
8 INT70138 Positive_regulation of Ccnb1 7 0.41 4.31 1.26
9 INT354379 Negative_regulation of Gene_expression of Map3k12 1 0.12 0 1.24
10 INT354378 Regulation of Gene_expression of Map3k12 1 0.12 0 1.23
11 INT108740 Localization of Map3k12 2 0.68 0.09 1.15
12 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
13 INT286689 Phosphorylation of Rps6ka5 2 0.53 0.51 0.84
14 INT255849 Positive_regulation of Rps6ka5 2 0.36 0.45 0.81
15 INT26289 Positive_regulation of Map3k12 2 0.11 0 0.79
16 INT114880 Negative_regulation of Cdk2 7 0.35 3.89 0.77
17 INT98784 Gene_expression of Ccnb1 11 0.59 4.53 0.75
18 INT28118 Binding of Atm 13 0.38 12.24 0.68
19 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
20 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6
21 INT114872 Negative_regulation of Gene_expression of Cdk2 2 0.35 1.21 0.6
22 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
23 INT337103 Positive_regulation of Phosphorylation of Rps6ka5 1 0.33 0.34 0.59
24 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
25 INT127451 Positive_regulation of Cdk1 1 0.20 0.27 0.4
26 INT67793 Binding of Pim3 1 0.03 0 0.4
27 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39
28 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
29 INT237161 Regulation of Ccnb1 5 0.17 2.71 0.32
30 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
31 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
32 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
33 INT98783 Negative_regulation of Gene_expression of Ccnb1 1 0.26 0.69 0.21
34 INT113354 Regulation of Pim3 1 0.02 0 0.19
35 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
36 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15
37 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15
38 INT201462 Binding of CDK2 12 0.39 5.2 0.12
39 INT56346 Gene_expression of Pim3 1 0.01 0.11 0.11
40 INT56345 Negative_regulation of Gene_expression of Pim3 1 0.00 0.11 0.11
41 INT284684 Negative_regulation of Binding of Map3k12 1 0.01 0.36 0.1
42 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
43 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
44 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
45 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
46 INT302272 Localization of CDK2 2 0.30 1.09 0.09
47 INT226414 Negative_regulation of Ccnb1 2 0.02 2.16 0.08
48 INT326819 Negative_regulation of Cdk1 1 0.16 0.39 0.08
49 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
50 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04
51 INT316438 Transcription of Ccnb1 1 0.02 1.24 0.04
52 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
53 INT282568 Positive_regulation of Cdk2 6 0.34 2.95 0.03
54 INT207803 Regulation of Atm 3 0.41 1.15 0.03
55 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03
56 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
57 INT332373 Binding of Ccnb1 1 0.34 0 0.03
58 INT207807 Localization of Atm 4 0.74 0.21 0
59 INT169427 Transcription of CDK2 2 0.09 0.42 0
60 INT249788 Positive_regulation of Gene_expression of Ccnb1 2 0.44 0.51 0
61 INT242456 Binding of Cdk2 2 0.16 1.29 0
62 INT236691 Regulation of Cdk1 2 0.20 0.46 0
63 INT295036 Positive_regulation of Positive_regulation of Cdk2 2 0.34 0.93 0
64 INT236705 Phosphorylation of Cdk2 2 0.31 1.39 0
65 INT252642 Transcription of Atm 1 0.53 0.18 0
66 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
67 INT295035 Negative_regulation of Positive_regulation of Cdk2 1 0.22 0.87 0
68 INT169913 Positive_regulation of Gene_expression of Cdk2 1 0.21 0.08 0
69 INT277859 Protein_catabolism of Cdk2 1 0.43 0.23 0
70 INT333793 Transcription of Cdk2 1 0.46 0 0
71 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
72 INT333816 Regulation of Positive_regulation of Cdk2 1 0.30 0 0
73 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
74 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
75 INT108739 Negative_regulation of Localization of Map3k12 1 0.42 0.09 0
76 INT268284 Gene_expression of Cdk1 1 0.26 0.25 0
77 INT256925 Protein_catabolism of Ccnb1 1 0.24 0.74 0
78 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
79 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
80 INT333817 Localization of Cdk2 1 0.50 0.22 0
81 INT256906 Regulation of Gene_expression of Ccnb1 1 0.17 0.39 0
82 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
83 INT331145 Phosphorylation of Ccnb1 1 0.17 0.58 0
84 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
85 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
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