GO:0016573

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Name histone acetylation
Categary Process
Go Slim No
Go Link GO:0016573
Unique Molecular Interactions 109
Total Molecular Interactions 154
Total Single Events 686
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone acetylation. They are ordered first by their pain relevance and then by number of times they were reported for histone acetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
2 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
3 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
4 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
5 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
6 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
7 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
8 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
9 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
10 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
11 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
12 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48
13 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
14 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
15 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
16 INT319729 Binding of Rela and Crebbp 1 0.02 0.88 0.37
17 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
18 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32
19 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25
20 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
21 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
22 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22
23 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
24 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
25 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
26 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
27 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
28 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
29 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
30 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
31 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
32 INT119265 Binding of CREBBP and PPM1E 1 0.01 0.46 0.17
33 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
34 INT194811 Binding of Crebbp and Nfatc1 1 0.00 0.07 0.16
35 INT194826 Binding of CREB1 and Crebbp 1 0.02 0.07 0.16
36 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
37 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
38 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12
39 INT195662 Binding of PROC and KAT8 1 0.10 2.25 0.12
40 INT319726 Crebbp Positive_regulation of Binding of Rela 1 0.02 0.37 0.12
41 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
42 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12
43 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12
44 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
45 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
46 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
47 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11
48 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
49 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
50 INT350011 Binding of BMI1 and IL6 1 0.01 0.58 0.1
51 INT297589 Binding of HAT1 and Il10 1 0.00 1.14 0.08
52 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
53 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
54 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
55 INT297559 Binding of IL6 and HAT1 1 0.00 1.13 0.08
56 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
57 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
58 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
59 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
60 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
61 INT332944 Binding of HAT1 and Polr2a 1 0.00 0.27 0.03
62 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
63 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0
64 INT243106 Binding of Crebbp and Src 1 0.05 0.52 0
65 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0
66 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
67 INT177267 Binding of CXADR and NCOA3 1 0.17 0 0
68 INT225645 Binding of TAF1 and Acp5 1 0.01 0 0
69 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0
70 INT267257 BCL11B Regulation of Transcription of BMI1 1 0.28 0.74 0
71 INT172604 Binding of EP300 and TP53 1 0.00 0 0
72 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
73 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
74 INT235165 Atxn3 Regulation of Transcription of Crebbp 1 0.02 0.3 0
75 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
76 INT326118 Binding of BMI1 and PCSK1 1 0.09 0 0
77 INT172605 Positive_regulation of Binding of EP300 and TP53 1 0.00 0 0
78 INT332963 Atp6v1e1 Negative_regulation of Binding of Crebbp 1 0.08 0 0
79 INT267259 BCL11B Regulation of BMI1 1 0.65 1.48 0
80 INT243111 Binding of Crebbp and Ep300 1 0.16 0.17 0
81 INT225543 Binding of D0Nrs1 and Ep300 1 0.01 0 0
82 INT225563 Binding of Tpr and Ep300 1 0.00 0 0
83 INT225622 Binding of STL and Ep300 1 0.01 0 0
84 INT225587 Binding of Kat2b and Cytip 1 0.12 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone acetylation. They are ordered first by their pain relevance and then by number of times they were reported in histone acetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23
2 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
3 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
4 INT165228 Binding of BMI1 13 0.47 25.36 7.97
5 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
6 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
7 INT2213 Regulation of EP300 10 0.54 4.72 4.5
8 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11
9 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
10 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
11 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
12 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
13 INT171514 Binding of EP300 13 0.32 4.32 2.01
14 INT171251 Regulation of BMI1 8 0.20 10.46 2.01
15 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
16 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
17 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
18 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
19 INT172622 Localization of EP300 8 0.65 2.56 1.72
20 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
21 INT192563 Gene_expression of HAT1 8 0.38 4.47 1.71
22 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
23 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
24 INT319724 Binding of Crebbp 1 0.16 4.19 1.34
25 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
26 INT263523 Regulation of Binding of BMI1 1 0.34 3.01 1.3
27 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
28 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
29 INT207183 Binding of Bmi1 1 0.01 16.24 1.14
30 INT167650 Binding of Ep300 1 0.09 0.14 1
31 INT192564 Binding of HAT1 5 0.15 2.77 0.96
32 INT117880 Negative_regulation of Crebbp 3 0.38 0.69 0.94
33 INT114922 Phosphorylation of Crebbp 2 0.21 0.92 0.94
34 INT217683 Localization of BMI1 7 0.68 6.28 0.87
35 INT217685 Negative_regulation of BMI1 7 0.18 6.01 0.82
36 INT317792 Negative_regulation of Binding of HAT1 2 0.07 1.82 0.81
37 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
38 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75
39 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
40 INT161471 Gene_expression of Bmi1 9 0.76 11.47 0.72
41 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
42 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
43 INT280463 Binding of Mecp2 3 0.37 4 0.63
44 INT114955 Positive_regulation of Gene_expression of CREBBP 2 0.23 0.24 0.61
45 INT172617 Positive_regulation of HAT1 7 0.33 5.47 0.54
46 INT182835 Phosphorylation of Crebbp 2 0.26 0.78 0.54
47 INT117879 Regulation of Crebbp 1 0.24 0 0.54
48 INT182836 Positive_regulation of Crebbp 2 0.21 0.76 0.53
49 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
50 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
51 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
52 INT203478 Gene_expression of Crebbp 3 0.46 2.15 0.44
53 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
54 INT207182 Positive_regulation of Bmi1 1 0.02 6.81 0.41
55 INT319725 Positive_regulation of Binding of Crebbp 1 0.17 1.12 0.4
56 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
57 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
58 INT187587 Binding of Ep300 11 0.35 2.37 0.34
59 INT152670 Negative_regulation of HAT1 4 0.07 1.04 0.32
60 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
61 INT172625 Regulation of HAT1 9 0.35 9.21 0.28
62 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
63 INT195678 Binding of KAT8 1 0.16 1.47 0.26
64 INT161464 Regulation of Gene_expression of Bmi1 1 0.44 3.01 0.26
65 INT319719 Negative_regulation of Binding of Crebbp 1 0.14 0.51 0.26
66 INT220604 Binding of Kat5 2 0.11 0.7 0.25
67 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
68 INT195676 Negative_regulation of KAT8 2 0.19 2.63 0.23
69 INT221770 Positive_regulation of Phosphorylation of Crebbp 1 0.14 0.21 0.23
70 INT239796 Binding of TAF1 1 0.01 0.33 0.23
71 INT174663 Positive_regulation of KAT8 4 0.11 3.45 0.22
72 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
73 INT212787 Negative_regulation of Binding of EP300 1 0.13 0.53 0.2
74 INT256666 Regulation of Gene_expression of EP300 1 0.14 0.07 0.2
75 INT213914 Positive_regulation of NCOA3 1 0.44 1.34 0.2
76 INT256661 Regulation of Positive_regulation of EP300 1 0.23 0.07 0.2
77 INT161469 Regulation of Bmi1 1 0.61 2.41 0.19
78 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
79 INT174662 Regulation of KAT8 2 0.10 1.09 0.18
80 INT323897 Positive_regulation of Gene_expression of BMI1 2 0.22 3.8 0.17
81 INT213912 Positive_regulation of Gene_expression of NCOA3 1 0.44 1.06 0.15
82 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15
83 INT152666 Negative_regulation of CREBBP 2 0.06 0.52 0.14
84 INT161470 Regulation of Negative_regulation of Bmi1 1 0.27 1.49 0.13
85 INT161473 Negative_regulation of Bmi1 1 0.42 1.49 0.13
86 INT319722 Positive_regulation of Crebbp 1 0.17 0.62 0.12
87 INT319723 Protein_catabolism of Crebbp 1 0.30 0.56 0.12
88 INT319721 Gene_expression of Crebbp 2 0.23 0.76 0.11
89 INT213913 Gene_expression of NCOA3 3 0.50 1.11 0.1
90 INT213911 Positive_regulation of Positive_regulation of NCOA3 1 0.32 0.67 0.1
91 INT171528 Binding of CREBBP 3 0.07 0.47 0.08
92 INT333913 Negative_regulation of Gene_expression of HAT1 1 0.03 0.15 0.08
93 INT264425 Negative_regulation of Negative_regulation of HAT1 1 0.05 0.14 0.07
94 INT161472 Positive_regulation of Gene_expression of Bmi1 1 0.68 1.43 0.06
95 INT304935 Transcription of Bmi1 1 0.08 0.65 0.05
96 INT284952 Phosphorylation of HAT1 1 0.05 0 0.05
97 INT292252 Phosphorylation of EP300 1 0.20 0.55 0.05
98 INT319060 Localization of Crebbp 2 0.73 0 0.04
99 INT172624 Binding of NCOA3 4 0.22 1.05 0.03
100 INT203460 Negative_regulation of Gene_expression of Crebbp 2 0.25 0.73 0.03
101 INT243077 Regulation of Crebbp 1 0.27 0.13 0.03
102 INT203462 Negative_regulation of Crebbp 1 0.02 0.62 0.03
103 INT243085 Positive_regulation of Gene_expression of Crebbp 1 0.30 0.14 0.03
104 INT187585 Binding of Crebbp 6 0.36 0.11 0
105 INT235154 Transcription of Ep300 2 0.24 1.38 0
106 INT267272 Transcription of BMI1 2 0.48 1.35 0
107 INT172620 Localization of CREBBP 2 0.09 0.06 0
108 INT337420 Negative_regulation of Localization of Crebbp 1 0.41 0 0
109 INT340511 Localization of Crebbp 1 0.26 0 0
110 INT222914 Negative_regulation of Gene_expression of EP300 1 0.02 0.05 0
111 INT351707 Localization of HAT1 1 0.06 0.67 0
112 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
113 INT292838 Gene_expression of TAF1 1 0.04 0.48 0
114 INT337421 Negative_regulation of Binding of Crebbp 1 0.41 0 0
115 INT276802 Negative_regulation of Gene_expression of CREBBP 1 0.03 0 0
116 INT195675 Gene_expression of KAT8 1 0.30 1.38 0
117 INT340512 Positive_regulation of Gene_expression of Crebbp 1 0.17 0 0
118 INT235158 Transcription of Crebbp 1 0.05 0.29 0
119 INT320939 Transcription of Mecp2 1 0.69 0.2 0
120 INT328132 Regulation of Mecp2 1 0.40 1 0
121 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
122 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
123 INT341511 Regulation of Regulation of HAT1 1 0.15 1.63 0
124 INT332952 Positive_regulation of Binding of Crebbp 1 0.35 0 0
125 INT217687 Negative_regulation of Positive_regulation of BMI1 1 0.01 0.69 0
126 INT264447 Positive_regulation of Gene_expression of HAT1 1 0.06 0.17 0
127 INT267271 Regulation of Gene_expression of BMI1 1 0.25 0.7 0
128 INT174666 Localization of KAT8 1 0.11 0.05 0
129 INT217690 Negative_regulation of Negative_regulation of BMI1 1 0.01 0.76 0
130 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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