GO:0016580

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Name Sin3 complex
Categary Component
Go Slim No
Go Link GO:0016580
Unique Molecular Interactions 56
Total Molecular Interactions 64
Total Single Events 291
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Sin3 complex. They are ordered first by their pain relevance and then by number of times they were reported for Sin3 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
2 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
3 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
4 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
5 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
6 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
7 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
8 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
9 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21
10 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
11 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
12 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
13 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
14 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
15 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
16 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
17 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
18 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
19 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
20 INT149223 Binding of PHC3 and Suds3 1 0.03 0.44 0.07
21 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
22 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
23 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
24 INT268675 Binding of NCOR2 and SIN3A 1 0.27 2.54 0.07
25 INT149222 Binding of Fzd5 and Suds3 1 0.02 0.44 0.07
26 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
27 INT218953 Esyt1 Negative_regulation of Ncor1 1 0.00 0.1 0.05
28 INT319111 Binding of Yy1 and Sap30 1 0.01 0 0.04
29 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
30 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
31 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
32 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
33 INT299455 Binding of Mxd1 and Suds3 1 0.01 0.47 0
34 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
35 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
36 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
37 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
38 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
39 INT301469 Negative_regulation of Binding of Sin3a and Smyd2 1 0.28 0.31 0
40 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
41 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0
42 INT299462 Binding of Mxd1 and Sin3a 1 0.08 0.62 0
43 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
44 INT301475 Binding of Sin3a and Smyd2 1 0.32 0.31 0
45 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
46 INT299463 Binding of Sin3a and SIDT1 1 0.39 0.31 0
47 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
48 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
49 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
50 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0
51 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
52 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Sin3 complex. They are ordered first by their pain relevance and then by number of times they were reported in Sin3 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
2 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
3 INT137532 Negative_regulation of HEY2 1 0.31 1.69 3.18
4 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
5 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
6 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
7 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
8 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
9 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
10 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
11 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
12 INT144540 Negative_regulation of Gene_expression of Sin3a 1 0.57 0.85 0.75
13 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
14 INT144544 Gene_expression of Sin3a 1 0.75 0.84 0.74
15 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
16 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
17 INT148385 Positive_regulation of HEY2 1 0.38 1.09 0.62
18 INT189347 Phosphorylation of CSNK2A1 4 0.11 1.62 0.57
19 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
20 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
21 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
22 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
23 INT63268 Negative_regulation of Ncor1 5 0.32 0.51 0.34
24 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
25 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
26 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
27 INT257786 Localization of NCOR1 1 0.68 0.36 0.24
28 INT63271 Regulation of Ncor1 2 0.26 0.8 0.18
29 INT280465 Negative_regulation of Sin3a 2 0.41 1.07 0.17
30 INT63270 Gene_expression of Ncor1 7 0.56 0.65 0.15
31 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
32 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
33 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
34 INT180607 Positive_regulation of Suds3 1 0.05 0 0.08
35 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
36 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
37 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
38 INT171527 Gene_expression of NCOR1 3 0.51 0.49 0.06
39 INT354439 Positive_regulation of NCOR1 1 0.35 0.15 0.06
40 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
41 INT299425 Binding of Sin3a 2 0.36 0.92 0.04
42 INT180606 Gene_expression of Suds3 1 0.05 0.21 0.04
43 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
44 INT319065 Localization of Sap30 1 0.12 0 0.04
45 INT210871 Transcription of Ncor1 3 0.50 0 0.03
46 INT319062 Positive_regulation of Binding of Sap30 1 0.08 0.05 0.03
47 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
48 INT218945 Localization of Ncor1 1 0.32 0.15 0.03
49 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
50 INT277248 Localization of HEY2 1 0.73 0.5 0.03
51 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
52 INT319067 Binding of Sap30 1 0.06 0.05 0.03
53 INT342653 Regulation of Transcription of Ncor1 1 0.31 0 0.03
54 INT277595 Localization of Hdac1 4 0.73 0.81 0
55 INT63269 Positive_regulation of Ncor1 2 0.66 0.05 0
56 INT261751 Regulation of Hdac1 2 0.41 0 0
57 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
58 INT342659 Positive_regulation of Gene_expression of Ncor1 1 0.35 0 0
59 INT337478 Binding of HDAC2 1 0.14 0.07 0
60 INT319154 Transcription of Hdac1 1 0.66 0 0
61 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
62 INT210872 Regulation of Gene_expression of Ncor1 1 0.06 0 0
63 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
64 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
65 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
66 INT189359 Negative_regulation of Phosphorylation of CSNK2A1 1 0.06 0 0
67 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
68 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
69 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
70 INT341052 Gene_expression of HEY2 1 0.04 0.12 0
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