GO:0016597

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Name amino acid binding
Categary Function
Go Slim No
Go Link GO:0016597
Unique Molecular Interactions 439
Total Molecular Interactions 592
Total Single Events 9442
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for amino acid binding. They are ordered first by their pain relevance and then by number of times they were reported for amino acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
2 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
3 INT142527 Binding of Slc1a2 and Slc1a3 2 0.31 0.12 2.13
4 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
5 INT352464 Gse1 Positive_regulation of Gene_expression of Slc1a3 1 0.05 1.55 1.83
6 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
7 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
8 INT40887 Penk Regulation of Th 1 0.04 0 1.53
9 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
10 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
11 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
12 INT153923 Msr1 Positive_regulation of Gene_expression of Tdo2 1 0.00 0.89 1.28
13 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
14 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
15 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
16 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
17 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
18 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
19 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
20 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
21 INT187805 Ms18 Regulation of Positive_regulation of Slc1a3 1 0.26 0.87 1.12
22 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
23 INT61687 Binding of Pah and Slc3a1 1 0.00 0.11 1.09
24 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
25 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
26 INT31547 Binding of Th and Vip 1 0.31 0 1.08
27 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
28 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
29 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
30 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
31 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
32 INT197241 Kars Regulation of Localization of Gabrg1 1 0.23 0 1.02
33 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
34 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
35 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
36 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
37 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
38 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
39 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
40 INT60827 Ddc Positive_regulation of Localization of Abat 1 0.12 0.34 0.94
41 INT60828 Ddc Positive_regulation of Abat 1 0.13 0.34 0.93
42 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
43 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
44 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
45 INT184916 Binding of da and Th 1 0.09 1.22 0.87
46 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 0.00 0.26 0.87
47 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
48 INT160413 Tat Positive_regulation of Gene_expression of Cd40lg 1 0.50 0.98 0.86
49 INT188318 MCPH1 Positive_regulation of Pah 3 0.02 3 0.85
50 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
51 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
52 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
53 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
54 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
55 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
56 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
57 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
58 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
59 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
60 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
61 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
62 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
63 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
64 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
65 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
66 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
67 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
68 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
69 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
70 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
71 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
72 INT45822 Pah Positive_regulation of Localization of Ins1 1 0.01 0.3 0.73
73 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73
74 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
75 INT46657 Mtr Regulation of Gnrh1 1 0.01 0 0.71
76 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
77 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
78 INT46656 Mtr Regulation of Prl 1 0.05 0 0.7
79 INT99937 Ddc Regulation of Transcription of Qrfp 1 0.02 0 0.69
80 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
81 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
82 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66
83 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
84 INT160414 Hivan1 Positive_regulation of Tat 1 0.15 0.84 0.66
85 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
86 INT115764 Binding of Rbm39 and Tat 1 0.00 0 0.66
87 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
88 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
89 INT50634 Ddc Regulation of Gene_expression of Glul 1 0.02 0 0.65
90 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
91 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
92 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
93 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
94 INT127057 Ddc Positive_regulation of Gene_expression of Slc1a2 1 0.01 0.06 0.63
95 INT113146 Ddc Positive_regulation of Gene_expression of Nr4a1 1 0.06 0.1 0.63
96 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
97 INT152766 TAT Positive_regulation of Positive_regulation of MYLK 1 0.44 0.67 0.61
98 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
99 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
100 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
101 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
102 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
103 INT152765 TAT Regulation of Positive_regulation of MYLK 1 0.40 0.66 0.6
104 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
105 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
106 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
107 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
108 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
109 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56
110 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
111 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
112 INT220051 Fcgr4 Positive_regulation of Gene_expression of Ido1 1 0.01 1.24 0.55
113 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
114 INT56733 Ddc Positive_regulation of Localization of GLUL 1 0.00 0 0.54
115 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
116 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
117 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
118 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
119 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
120 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
121 INT93740 Ddc Positive_regulation of Tnf 1 0.00 1.45 0.5
122 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
123 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
124 INT90252 Binding of PPBP and TAT 1 0.39 5.55 0.48
125 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48
126 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
127 INT346913 Binding of Kars and Positive_regulation of Gene_expression of Ros1 1 0.03 1.25 0.46
128 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45
129 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 0.05 1.24 0.45
130 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
131 INT291384 Cntf Positive_regulation of Slc1a3 1 0.26 0.34 0.45
132 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
133 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
134 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 0.00 0.68 0.43
135 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
136 INT43587 Binding of OPRD1 and Pah 1 0.00 0.08 0.43
137 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
138 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
139 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
140 INT97789 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Nos2 1 0.12 0.23 0.4
141 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
142 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
143 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
144 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
145 INT326472 AGXT Negative_regulation of PGAP1 1 0.00 0.05 0.39
146 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
147 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
148 INT64639 Slc1a1 Positive_regulation of Ddc 1 0.30 0.3 0.38
149 INT220050 Ctla4 Positive_regulation of Ido1 1 0.31 1.45 0.38
150 INT50635 Ddc Regulation of Gene_expression of Penk 1 0.03 0 0.38
151 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38
152 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38
153 INT281155 Binding of ITIH4 and Ddc 1 0.09 1.27 0.37
154 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
155 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36
156 INT352821 Tph2 Regulation of Tst 1 0.31 0.46 0.36
157 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
158 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
159 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
160 INT261597 Binding of PAH and COPD 1 0.00 1.08 0.34
161 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
162 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
163 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
164 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
165 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
166 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
167 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
168 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33
169 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
170 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
171 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
172 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
173 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
174 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
175 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
176 INT1757 DDC Regulation of Localization of GH1 1 0.01 0 0.31
177 INT96102 Binding of TAT and Selp 1 0.04 0.7 0.3
178 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
179 INT55404 Binding of ENG and Th 1 0.02 0 0.3
180 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
181 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
182 INT96082 Binding of SELP and TAT 1 0.40 0.69 0.3
183 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
184 INT96099 Binding of TAT and F2 1 0.01 0.68 0.29
185 INT49904 Gtf3a Regulation of Dpys 1 0.02 0.06 0.28
186 INT261609 Binding of PAH and Hypt 1 0.00 1.26 0.28
187 INT78484 Binding of DBH and TH 1 0.09 0 0.28
188 INT352461 Calca Regulation of Gene_expression of Slc1a3 1 0.03 0 0.27
189 INT352451 Gse1 Regulation of Slc1a3 1 0.01 0 0.27
190 INT352455 Gse1 Regulation of Gene_expression of Slc1a3 1 0.04 0 0.27
191 INT352449 Dusp1 Regulation of Gene_expression of Slc1a3 1 0.05 0 0.27
192 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
193 INT105003 Binding of PDYN and SHMT2 1 0.04 0.49 0.26
194 INT216040 Binding of Comt and Prodh 1 0.30 1.71 0.26
195 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
196 INT107955 Gtf3a Positive_regulation of Hdc 1 0.07 0.3 0.26
197 INT107954 Il1f5 Positive_regulation of Hdc 1 0.09 0.3 0.26
198 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
199 INT353979 Ddc Positive_regulation of Pet1 1 0.49 0 0.26
200 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25

Single Events

The table below shows the top 100 pain related interactions that have been reported for amino acid binding. They are ordered first by their pain relevance and then by number of times they were reported in amino acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
3 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
4 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
5 INT7327 Regulation of Th 164 0.62 29.67 110.14
6 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
7 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
8 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
9 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31
10 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
11 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
12 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
13 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97
14 INT350 Localization of Th 79 0.80 10.26 41.17
15 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
16 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
17 INT7326 Transcription of Th 83 0.72 13.5 35.33
18 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
19 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
20 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
21 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
22 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
23 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
24 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
25 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
26 INT135673 Positive_regulation of Slc1a3 23 0.57 5.45 21.45
27 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
28 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
29 INT6230 Localization of Ddc 40 0.79 13.11 20.88
30 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
31 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
32 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
33 INT128013 Negative_regulation of Gene_expression of Slc1a3 20 0.59 10.65 16.13
34 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
35 INT13716 Positive_regulation of TH 33 0.68 19.11 16
36 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98
37 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
38 INT98109 Regulation of Slc1a3 15 0.52 6.87 14.43
39 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
40 INT135674 Positive_regulation of Gene_expression of Slc1a3 11 0.62 5.21 13.61
41 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32
42 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
43 INT182574 Localization of Slc1a3 10 0.73 5.47 11.44
44 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
45 INT141 Binding of Th 21 0.48 3.53 11.04
46 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
47 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
48 INT149015 Gene_expression of Tph2 20 0.78 9.45 10.4
49 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19
50 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
51 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
52 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
53 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63
54 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84
55 INT220 Negative_regulation of Ddc 16 0.59 2.94 8.66
56 INT86792 Gene_expression of Kars 17 0.77 4.24 8.58
57 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
58 INT109265 Transcription of Th 18 0.68 4.5 8.21
59 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
60 INT18025 Binding of Pah 32 0.45 30.72 7.93
61 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
62 INT170295 Positive_regulation of Ido1 40 0.67 28.89 7.61
63 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6
64 INT159946 Gene_expression of Mat1a 23 0.77 15.33 7.49
65 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43
66 INT4284 Regulation of Ddc 17 0.43 8.17 7.31
67 INT155680 Gene_expression of Slc1a3 22 0.66 6.76 7.23
68 INT248206 Gene_expression of Tdo2 15 0.78 9.17 7.16
69 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
70 INT127014 Negative_regulation of Negative_regulation of Slc1a3 6 0.54 2.11 6.98
71 INT49464 Positive_regulation of Dpys 7 0.47 0.5 6.96
72 INT39418 Negative_regulation of Tdo2 12 0.57 0.8 6.93
73 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
74 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86
75 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
76 INT66987 Regulation of Th 23 0.61 7.86 6.8
77 INT3506 Localization of TH 12 0.81 0.78 6.66
78 INT46518 Localization of Mtr 12 0.65 1.31 6.55
79 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29
80 INT69499 Binding of Nos1 15 0.36 2.56 6.23
81 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
82 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
83 INT170315 Positive_regulation of Gene_expression of Ido1 50 0.67 25.39 6.06
84 INT136153 Binding of Slc1a3 7 0.40 2.71 6.01
85 INT167457 Negative_regulation of Gene_expression of Tph2 5 0.57 2.27 5.9
86 INT135675 Positive_regulation of Negative_regulation of Slc1a3 4 0.45 0.38 5.87
87 INT84673 Localization of Nos1 19 0.80 5.01 5.62
88 INT8866 Positive_regulation of TAT 30 0.67 18.06 5.57
89 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51
90 INT135672 Negative_regulation of Positive_regulation of Slc1a3 4 0.38 0.33 5.49
91 INT10006 Regulation of Mtr 9 0.23 3.56 5.42
92 INT30317 Regulation of TH 14 0.43 7.27 5.38
93 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35
94 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
95 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
96 INT73608 Localization of Nos2 21 0.75 9.58 5.05
97 INT99536 Regulation of Gene_expression of Slc1a3 6 0.60 1.76 5.04
98 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
99 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
100 INT155681 Negative_regulation of Gene_expression of Slc1a3 5 0.36 2.26 4.86
101 INT11298 Gene_expression of Ido1 6 0.58 6.71 4.85
102 INT37151 Localization of Th 13 0.57 3.11 4.82
103 INT170311 Negative_regulation of Ido1 16 0.48 14.47 4.81
104 INT197229 Positive_regulation of Kars 5 0.54 1.89 4.81
105 INT143557 Positive_regulation of Ido1 6 0.40 5.34 4.8
106 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
107 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36
108 INT28030 Binding of Otc 5 0.37 2.72 4.3
109 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
110 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
111 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04
112 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88
113 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
114 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67
115 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66
116 INT14319 Localization of SHMT2 3 0.03 1.91 3.61
117 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
118 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36
119 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
120 INT24751 Gene_expression of Mtr 8 0.36 1.34 3.34
121 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
122 INT126223 Binding of Nos2 17 0.37 6 3.22
123 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
124 INT187803 Negative_regulation of Localization of Slc1a3 1 0.23 1.24 3.2
125 INT197220 Positive_regulation of Gene_expression of Kars 3 0.39 0.29 3.15
126 INT9110 Binding of PAH 32 0.41 42.1 3.1
127 INT149795 Gene_expression of Ddc 8 0.73 1.5 3.06
128 INT42485 Binding of Pah 9 0.35 3.42 3.03
129 INT3869 Gene_expression of SHMT2 7 0.37 3.6 3.03
130 INT137301 Negative_regulation of Gene_expression of TPH1 5 0.12 1.49 2.98
131 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
132 INT155685 Regulation of Gene_expression of Slc1a3 2 0.50 0.77 2.85
133 INT108433 Negative_regulation of Mat1a 16 0.57 14.15 2.82
134 INT47812 Negative_regulation of Localization of Ddc 5 0.51 1.99 2.8
135 INT29651 Regulation of Pah 11 0.37 9.95 2.79
136 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
137 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6
138 INT16406 Positive_regulation of Negative_regulation of Ddc 6 0.67 0.53 2.6
139 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
140 INT248419 Negative_regulation of Tph2 11 0.59 6.32 2.59
141 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
142 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
143 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
144 INT197225 Regulation of Positive_regulation of Kars 1 0.35 0 2.56
145 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53
146 INT52871 Regulation of Hdc 6 0.60 3.26 2.51
147 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
148 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
149 INT200217 Localization of PAH 10 0.36 15.51 2.46
150 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44
151 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
152 INT49896 Regulation of Dpys 5 0.58 0.16 2.41
153 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
154 INT170323 Regulation of Gene_expression of Ido1 11 0.60 8.74 2.33
155 INT167858 Regulation of Gene_expression of Mat1a 3 0.61 2.97 2.33
156 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33
157 INT30061 Negative_regulation of Hdc 8 0.59 2.14 2.27
158 INT195110 Positive_regulation of Gene_expression of Slc1a3 5 0.44 2.88 2.27
159 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
160 INT45396 Positive_regulation of Tdo2 6 0.61 0.92 2.1
161 INT61011 Regulation of TPH1 4 0.22 1.17 2.09
162 INT90688 Negative_regulation of Tdo2 12 0.59 5.82 2.02
163 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02
164 INT157095 Binding of Ddc 5 0.27 4.6 2
165 INT243846 Localization of DDC 3 0.63 0.66 1.99
166 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96
167 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
168 INT127053 Transcription of Slc1a3 4 0.43 0.8 1.9
169 INT143561 Positive_regulation of Positive_regulation of Ido1 1 0.36 1.84 1.89
170 INT167853 Positive_regulation of Gene_expression of Mat1a 5 0.35 3.8 1.88
171 INT90687 Gene_expression of Tdo2 1 0.64 0.88 1.86
172 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
173 INT63716 Transcription of Hdc 10 0.69 7.57 1.82
174 INT3505 Binding of TH 5 0.39 2.6 1.8
175 INT61685 Positive_regulation of Gene_expression of Pah 6 0.43 4.05 1.79
176 INT168068 Positive_regulation of Mat1a 3 0.46 8.82 1.77
177 INT150248 Positive_regulation of Gene_expression of Ido1 2 0.43 2.68 1.77
178 INT25582 Regulation of Mtr 2 0.03 0.4 1.76
179 INT151270 Positive_regulation of Positive_regulation of Slc1a3 1 0.57 0 1.69
180 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
181 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
182 INT198066 Negative_regulation of Slc1a3 2 0.41 1.25 1.68
183 INT145545 Transcription of TH 3 0.67 1.48 1.64
184 INT138294 Regulation of Negative_regulation of Slc1a3 1 0.29 0.17 1.62
185 INT53451 Regulation of TAT 6 0.44 3.07 1.61
186 INT155829 Negative_regulation of Protein_catabolism of Slc1a3 1 0.34 0.1 1.6
187 INT155828 Protein_catabolism of Slc1a3 1 0.80 0.1 1.6
188 INT22966 Negative_regulation of Positive_regulation of Pah 2 0.50 2.03 1.56
189 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
190 INT44493 Regulation of SHMT2 3 0.29 0.45 1.55
191 INT159947 Negative_regulation of Gene_expression of Mat1a 2 0.42 4.01 1.46
192 INT248418 Localization of Tph2 5 0.75 2.45 1.45
193 INT126660 Positive_regulation of Gene_expression of Tph1 5 0.50 0.07 1.43
194 INT82676 Negative_regulation of Gene_expression of Ddc 4 0.55 0.55 1.43
195 INT47446 Regulation of Localization of Mtr 1 0.05 0.07 1.42
196 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
197 INT19619 Positive_regulation of SHMT2 6 0.08 1.05 1.35
198 INT333291 Positive_regulation of Gene_expression of DDC 1 0.49 0.13 1.35
199 INT186268 Positive_regulation of Tdo2 13 0.50 8 1.32
200 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32
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