GO:0016601

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Name Rac protein signal transduction
Categary Process
Go Slim No
Go Link GO:0016601
Unique Molecular Interactions 36
Total Molecular Interactions 47
Total Single Events 531
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rac protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for Rac protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
2 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
3 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
4 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
5 INT94665 Nisch Negative_regulation of Maoa 1 0.07 0 0.83
6 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
7 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
8 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
9 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
10 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
11 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
12 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
13 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
14 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
15 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 0.55 0.39 0.42
16 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
17 INT84085 Binding of Gucy1a2 and Nisch 1 0.00 0.22 0.35
18 INT71518 Binding of INSRR and Nisch 1 0.00 0.22 0.35
19 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
20 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
21 INT330109 Binding of Racgap1 and Rac1 1 0.03 1.22 0.32
22 INT208084 Tlr4 Positive_regulation of Eps8l1 1 0.00 0.5 0.23
23 INT143973 Rac1 Positive_regulation of Vti1b 1 0.00 0.16 0.2
24 INT208083 Binding of Arid3b and Eps8l1 1 0.01 0.4 0.16
25 INT275157 Binding of Stat3 and Rac1 1 0.05 0.71 0.1
26 INT275158 Rac1 Positive_regulation of Stat3 1 0.07 0.72 0.1
27 INT64670 Binding of NISCH and USHBP1 1 0.01 0 0.08
28 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
29 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05
30 INT84197 Binding of MAOA and NISCH 1 0.02 0 0.05
31 INT348534 ELMO1 Positive_regulation of RAC1 1 0.02 0.7 0
32 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rac protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in Rac protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
2 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
3 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
4 INT27627 Binding of Rac1 41 0.41 22.88 13.68
5 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
6 INT64671 Gene_expression of NISCH 10 0.69 2.19 6.9
7 INT50713 Positive_regulation of Nisch 6 0.69 1.5 4.33
8 INT18785 Binding of Nisch 12 0.43 1.03 4.28
9 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
10 INT58475 Localization of Rac1 12 0.75 5.94 3.2
11 INT51099 Negative_regulation of Nisch 6 0.43 0.97 2.93
12 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
13 INT113966 Negative_regulation of Nisch 2 0.31 0.76 1.93
14 INT308845 Gene_expression of Nisch 1 0.10 3.32 1.92
15 INT130565 Localization of Nisch 1 0.71 0.17 1.86
16 INT308851 Regulation of Gene_expression of Nisch 1 0.04 2.35 1.86
17 INT66708 Negative_regulation of NISCH 2 0.38 3.1 1.43
18 INT117394 Positive_regulation of Gene_expression of NISCH 3 0.45 0.41 1.35
19 INT78949 Positive_regulation of Nisch 3 0.18 0.57 1.3
20 INT83032 Regulation of NISCH 2 0.55 1.2 1.24
21 INT67308 Positive_regulation of NISCH 3 0.62 1.21 1.22
22 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21
23 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13
24 INT150938 Regulation of Nisch 2 0.45 0.8 1.05
25 INT81211 Transcription of Rac1 4 0.54 1.05 0.89
26 INT72356 Regulation of Nisch 2 0.35 0.44 0.89
27 INT330097 Positive_regulation of Positive_regulation of Rac1 1 0.37 2.47 0.86
28 INT208060 Positive_regulation of Eps8l1 1 0.05 0.86 0.8
29 INT78948 Positive_regulation of Positive_regulation of Nisch 2 0.03 0.49 0.78
30 INT138495 Regulation of Positive_regulation of NISCH 1 0.40 0.09 0.76
31 INT59042 Gene_expression of Nisch 4 0.60 0.21 0.71
32 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7
33 INT90296 Binding of NISCH 2 0.31 0.3 0.49
34 INT208055 Gene_expression of Eps8l1 1 0.04 1.09 0.48
35 INT7081 Transcription of Nisch 2 0.69 0 0.47
36 INT81212 Negative_regulation of Transcription of Rac1 1 0.01 0 0.46
37 INT72145 Regulation of Binding of Nisch 1 0.27 0 0.45
38 INT87847 Regulation of Positive_regulation of Rac1 2 0.36 1.49 0.43
39 INT91085 Phosphorylation of NISCH 1 0.61 0.05 0.39
40 INT91086 Positive_regulation of Phosphorylation of NISCH 1 0.45 0.05 0.39
41 INT72144 Positive_regulation of Gene_expression of Nisch 1 0.47 0 0.37
42 INT124986 Positive_regulation of Localization of Rac1 3 0.50 1.22 0.33
43 INT112551 Protein_catabolism of Rac1 2 0.66 0.29 0.3
44 INT116729 Regulation of Localization of Rac1 1 0.01 0.07 0.29
45 INT208069 Regulation of Gene_expression of Eps8l1 1 0.03 0.46 0.29
46 INT99682 Phosphorylation of Rac1 1 0.54 0.72 0.28
47 INT162873 Negative_regulation of Negative_regulation of Rac1 1 0.34 0.35 0.26
48 INT330090 Regulation of Negative_regulation of Rac1 1 0.36 0.53 0.25
49 INT330093 Negative_regulation of Positive_regulation of Rac1 1 0.34 0.88 0.23
50 INT208056 Regulation of Eps8l1 1 0.02 0.07 0.18
51 INT208065 Binding of Eps8l1 1 0.02 0.4 0.16
52 INT168055 Regulation of Transcription of Rac1 1 0.36 0.34 0.16
53 INT133599 Positive_regulation of Binding of Rac1 2 0.40 0.4 0.15
54 INT330085 Regulation of Binding of Rac1 1 0.36 0.28 0.15
55 INT208054 Negative_regulation of Eps8l1 1 0.03 0.38 0.15
56 INT51098 Positive_regulation of Negative_regulation of Nisch 1 0.01 0.5 0.1
57 INT208053 Positive_regulation of Gene_expression of Eps8l1 1 0.03 0.37 0.09
58 INT302629 Positive_regulation of Rhog 1 0.33 0.07 0.07
59 INT328658 Localization of NISCH 1 0.73 0.29 0.07
60 INT302628 Gene_expression of Rhog 1 0.45 0.2 0.05
61 INT348501 Positive_regulation of ELMO1 1 0.16 1.36 0
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