GO:0016616

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Name oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Categary Function
Go Slim No
Go Link GO:0016616
Unique Molecular Interactions 58
Total Molecular Interactions 68
Total Single Events 397
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
2 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77
3 INT127585 Binding of CNR2 and Ctbp1 1 0.00 0.6 0.76
4 INT127584 Binding of CNR1 and Ctbp1 1 0.00 0.6 0.75
5 INT288323 Glyr1 Regulation of Sds 1 0.05 0.2 0.72
6 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7
7 INT288326 Sds Positive_regulation of Glyr1 1 0.10 0.12 0.68
8 INT288324 Sds Positive_regulation of Gene_expression of Glyr1 1 0.10 0.12 0.68
9 INT802 Aap Regulation of Grhpr 1 0.01 0 0.6
10 INT92802 Binding of PPIG and GRHPR 1 0.03 0.11 0.47
11 INT309370 Positive_regulation of Glyr1 Positive_regulation of Positive_regulation of Gphn 1 0.01 0 0.47
12 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
13 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
14 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
15 INT308889 Binding of Idh1 and Adp 1 0.02 0 0.36
16 INT176009 Binding of GRHPR and ZNF677 1 0.00 0.57 0.36
17 INT308890 Binding of Idh1 and P2ry13 1 0.06 0 0.35
18 INT288325 Binding of Glyr1 and Sds 1 0.07 0 0.3
19 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25
20 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24
21 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23
22 INT186957 Nsdhl Positive_regulation of Tmed4 1 0.04 0.71 0.23
23 INT261373 Nsdhl Positive_regulation of Gene_expression of Gfap 1 0.10 2.05 0.19
24 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
25 INT186954 Binding of Des and Nsdhl 1 0.06 0.32 0.16
26 INT335125 Me1 Positive_regulation of Localization of Fads2 1 0.07 0.09 0.16
27 INT261384 Nsdhl Negative_regulation of Gene_expression of Mbp 1 0.01 1.43 0.14
28 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13
29 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12
30 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11
31 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
32 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1
33 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
34 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09
35 INT47719 Gpr143 Regulation of Grhpr 1 0.00 0.08 0.08
36 INT261376 Nsdhl Positive_regulation of Gene_expression of Nrgn 1 0.06 0.86 0.08
37 INT261386 Nsdhl Positive_regulation of Map2 1 0.08 0.59 0.07
38 INT261395 Nsdhl Positive_regulation of Syn1 1 0.00 0.59 0.07
39 INT261392 Binding of Nsdhl and Syn1 1 0.00 0.65 0.07
40 INT261385 LH Regulation of Localization of Nsdhl 1 0.02 0.65 0.05
41 INT261382 Nsdhl Regulation of Il6 1 0.03 0.66 0.04
42 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
43 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04
44 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03
45 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03
46 INT283360 Binding of Ctbp2 and Srr 1 0.10 0 0.03
47 INT186960 Positive_regulation of Nsdhl Positive_regulation of Tmed4 1 0.03 0.05 0.03
48 INT283341 Binding of Ctbp1 and Fig4 1 0.06 0 0
49 INT234357 GRHPR Regulation of MRT5 1 0.00 0.05 0
50 INT318378 Binding of Uevld and Vmn1r7 1 0.02 0.92 0
51 INT281814 Negative_regulation of Akt1 Positive_regulation of Phgdh 1 0.00 1.7 0
52 INT283354 Binding of Ctbp2 and Fig4 1 0.04 0 0
53 INT318102 Binding of RPL5 and Ldha 1 0.08 0.66 0
54 INT228557 Gopc Negative_regulation of Grhpr 1 0.00 0.5 0
55 INT283347 Binding of Srr and Ctbp1 1 0.13 0 0
56 INT318099 Binding of Ldha and Ppia 1 0.36 0.66 0
57 INT209643 AR Positive_regulation of PYCR1 1 0.31 1.17 0
58 INT228563 Grhpr Regulation of Negative_regulation of Coq10a 1 0.00 0.71 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT800 Negative_regulation of Grhpr 21 0.42 10.3 7.17
2 INT11177 Localization of Ldha 17 0.81 5.74 6.13
3 INT3645 Positive_regulation of Grhpr 17 0.42 3.64 6.06
4 INT112873 Gene_expression of Glyr1 28 0.76 2.88 5.94
5 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58
6 INT100161 Positive_regulation of Phgdh 6 0.49 0.77 3.81
7 INT112872 Negative_regulation of Glyr1 9 0.42 2.4 3.59
8 INT28923 Negative_regulation of Ldha 8 0.58 4.94 3.11
9 INT3644 Regulation of Grhpr 7 0.28 0.92 3
10 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71
11 INT7978 Positive_regulation of Nsdhl 9 0.43 5.6 2.63
12 INT17963 Gene_expression of Ldha 11 0.75 6.53 2.48
13 INT117799 Positive_regulation of Glyr1 4 0.46 0.42 1.98
14 INT45723 Gene_expression of Grhpr 5 0.52 1.04 1.96
15 INT122346 Gene_expression of Hsd3b1 1 0.75 0 1.78
16 INT108273 Gene_expression of Phgdh 7 0.65 2.29 1.48
17 INT122345 Positive_regulation of Gene_expression of Hsd3b1 1 0.49 0 1.34
18 INT58861 Positive_regulation of Localization of Ldha 2 0.25 0.1 1.26
19 INT100162 Regulation of Positive_regulation of Phgdh 1 0.08 0 1.18
20 INT46058 Regulation of Gene_expression of Grhpr 1 0.02 0.17 1.18
21 INT15594 Positive_regulation of Ldha 3 0.26 0.96 1.14
22 INT59179 Positive_regulation of GRHPR 5 0.14 2.57 1.09
23 INT13263 Binding of Ctbp1 2 0.41 0.57 1.06
24 INT122347 Transcription of Hsd3b1 1 0.52 0 0.99
25 INT108274 Positive_regulation of Gene_expression of Phgdh 1 0.15 0.38 0.93
26 INT288317 Positive_regulation of Gene_expression of Glyr1 2 0.13 0.36 0.9
27 INT309353 Positive_regulation of Positive_regulation of Glyr1 1 0.03 0 0.9
28 INT251224 Negative_regulation of Gene_expression of Glyr1 3 0.12 0.17 0.75
29 INT186941 Localization of Nsdhl 2 0.46 2.7 0.74
30 INT97865 Binding of GRHPR 1 0.05 0.23 0.72
31 INT45726 Positive_regulation of Gene_expression of Grhpr 1 0.04 0 0.69
32 INT165333 Regulation of Ldha 1 0.17 0.62 0.64
33 INT107119 Positive_regulation of Idh1 1 0.36 0.42 0.63
34 INT801 Positive_regulation of Negative_regulation of Grhpr 1 0.01 0 0.58
35 INT175294 Binding of Phgdh 2 0.06 1.37 0.57
36 INT118549 Negative_regulation of Phosphorylation of Glyr1 1 0.32 0.35 0.54
37 INT118550 Phosphorylation of Glyr1 1 0.61 0.35 0.53
38 INT125791 Regulation of Localization of Ldha 1 0.22 0.09 0.52
39 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51
40 INT309344 Regulation of Glyr1 2 0.13 0.36 0.51
41 INT108275 Positive_regulation of Positive_regulation of Phgdh 1 0.15 0 0.5
42 INT309340 Negative_regulation of Negative_regulation of Glyr1 1 0.03 0.47 0.49
43 INT38433 Gene_expression of GRHPR 3 0.06 0.42 0.48
44 INT150511 Negative_regulation of Me1 1 0.59 0.47 0.48
45 INT309336 Localization of Glyr1 1 0.05 0.09 0.48
46 INT122348 Regulation of Hsd3b1 1 0.60 0 0.46
47 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43
48 INT261353 Negative_regulation of Gene_expression of Nsdhl 1 0.17 0.71 0.43
49 INT7979 Binding of Nsdhl 6 0.30 3.71 0.4
50 INT175295 Negative_regulation of Gene_expression of Phgdh 1 0.08 1.04 0.39
51 INT308876 Binding of Idh1 2 0.23 0.77 0.35
52 INT186939 Positive_regulation of Positive_regulation of Nsdhl 2 0.31 0.86 0.34
53 INT309356 Binding of Glyr1 1 0.02 0.36 0.34
54 INT59178 Negative_regulation of Positive_regulation of GRHPR 1 0.10 0.24 0.34
55 INT150512 Regulation of Me1 1 0.45 0.26 0.26
56 INT150510 Positive_regulation of Gene_expression of Me1 1 0.50 0.2 0.21
57 INT150513 Gene_expression of Me1 1 0.78 0.2 0.21
58 INT13262 Regulation of Ctbp1 1 0.01 0.25 0.18
59 INT144307 Transcription of PYCR1 1 0.67 0.1 0.18
60 INT209657 Gene_expression of PYCR1 1 0.62 3.91 0.18
61 INT184344 Transcription of Phgdh 1 0.67 0.75 0.17
62 INT147951 Gene_expression of Idh1 1 0.11 0.34 0.16
63 INT206915 Regulation of Gene_expression of Nsdhl 2 0.22 1 0.13
64 INT90231 Regulation of Idh1 1 0.02 0.1 0.13
65 INT90230 Transcription of Idh1 1 0.03 0.1 0.13
66 INT288311 Transcription of Glyr1 1 0.14 0 0.11
67 INT282122 Positive_regulation of Gene_expression of Ldha 3 0.11 1.58 0.1
68 INT309349 Regulation of Binding of Glyr1 1 0.02 0.28 0.1
69 INT276413 Gene_expression of Ctbp2 10 0.46 0.81 0.09
70 INT206912 Positive_regulation of Gene_expression of Nsdhl 2 0.25 1.59 0.09
71 INT153697 Regulation of GRHPR 1 0.03 0.71 0.09
72 INT190409 Localization of Me1 1 0.73 0.08 0.08
73 INT288315 Regulation of Gene_expression of Glyr1 1 0.12 0 0.06
74 INT16799 Positive_regulation of Phosphorylation of Ctbp1 1 0.10 0 0.05
75 INT59573 Positive_regulation of Gene_expression of GRHPR 1 0.02 0.17 0.05
76 INT16801 Phosphorylation of Ctbp1 1 0.16 0 0.05
77 INT283336 Positive_regulation of Ctbp2 1 0.23 0 0.04
78 INT209672 Regulation of PYCR1 1 0.22 0.89 0.04
79 INT219709 Localization of Phgdh 1 0.73 0.05 0.04
80 INT209671 Negative_regulation of Gene_expression of PYCR1 1 0.34 1.1 0.03
81 INT329871 Negative_regulation of Gene_expression of Grhpr 1 0.29 0.07 0.03
82 INT283318 Localization of Ctbp1 1 0.54 0 0.03
83 INT276409 Localization of Ctbp2 2 0.54 0.73 0
84 INT227125 Transcription of Ctbp2 2 0.36 0.23 0
85 INT206914 Regulation of Localization of Nsdhl 1 0.22 0.46 0
86 INT283339 Binding of Ctbp2 1 0.22 0 0
87 INT283324 Gene_expression of Ctbp1 1 0.18 0 0
88 INT116899 Negative_regulation of Localization of Ldha 1 0.59 0 0
89 INT282121 Negative_regulation of Gene_expression of Ldha 1 0.09 0.52 0
90 INT186936 Transcription of Nsdhl 1 0.42 0.11 0
91 INT44405 Binding of Grhpr 1 0.01 0 0
92 INT283340 Positive_regulation of Gene_expression of Ctbp2 1 0.23 0 0
93 INT115692 Negative_regulation of Binding of Nsdhl 1 0.36 0 0
94 INT209665 Negative_regulation of PYCR1 1 0.34 1.06 0
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