GO:0016628

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Name oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Categary Function
Go Slim No
Go Link GO:0016628
Unique Molecular Interactions 27
Total Molecular Interactions 31
Total Single Events 91
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
2 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
3 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
4 INT96765 LBR Positive_regulation of Gene_expression of TP53INP2 1 0.11 0.5 0.62
5 INT176371 LBR Positive_regulation of IL12A 1 0.04 1.22 0.55
6 INT176367 LBR Positive_regulation of IFNA1 1 0.02 1.22 0.55
7 INT49358 Binding of DHCR24 and Pdyn 1 0.00 0 0.53
8 INT48102 Positive_regulation of LBR Positive_regulation of Positive_regulation of OR7A5 1 0.21 0 0.48
9 INT176366 LBR Regulation of IFNA1 1 0.04 0.91 0.46
10 INT176361 Positive_regulation of LBR Positive_regulation of Gene_expression of IL18 1 0.10 0.84 0.39
11 INT176363 IFNA1 Regulation of Positive_regulation of LBR 1 0.04 0.69 0.34
12 INT307017 LBR Positive_regulation of Gene_expression of TNF 1 0.02 0.58 0.32
13 INT307014 LBR Positive_regulation of Gene_expression of IL6 1 0.01 0.58 0.32
14 INT21321 Pomc Positive_regulation of LBR 1 0.04 0 0.31
15 INT135463 Binding of DHCR24 and Fos 1 0.35 0.17 0.19
16 INT135462 Binding of DHCR24 and Cfp 1 0.00 0.17 0.18
17 INT182326 LBR Positive_regulation of Gene_expression of Birc5 1 0.00 0.46 0.17
18 INT39207 LBR Positive_regulation of Gene_expression of IL2 1 0.23 0 0.11
19 INT307007 MT1JP Positive_regulation of Localization of LBR 1 0.01 0 0.05
20 INT213383 Srd5a3 Negative_regulation of Gene_expression of AR 1 0.01 0.7 0.04
21 INT323707 LBR Positive_regulation of MIR146A 1 0.02 0.1 0.03
22 INT314965 Binding of Lbr and Blvrb 1 0.00 0.13 0
23 INT314971 Binding of ITGAX and Lbr 1 0.05 0.07 0
24 INT314966 Binding of Lbr and H2 1 0.01 0.07 0
25 INT314970 Binding of Cd40 and Lbr 1 0.03 0.07 0
26 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
27 INT314964 Binding of Cd86 and Lbr 1 0.03 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48106 Positive_regulation of LBR 11 0.49 5.14 2.86
2 INT11139 Gene_expression of LBR 20 0.75 5.13 2.78
3 INT44773 Negative_regulation of LBR 6 0.57 2.32 2.03
4 INT8911 Regulation of DHCR24 1 0.05 1.91 1.71
5 INT59029 Positive_regulation of DHCR24 2 0.22 0.51 1.18
6 INT28643 Positive_regulation of Gene_expression of LBR 3 0.11 2.43 1.16
7 INT31805 Localization of LBR 3 0.73 1.23 1.13
8 INT71378 Transcription of LBR 2 0.07 1.34 1.03
9 INT44772 Negative_regulation of Negative_regulation of LBR 2 0.42 0.38 0.92
10 INT4762 Negative_regulation of DHCR24 5 0.45 0.68 0.8
11 INT46148 Binding of LBR 5 0.31 1.58 0.64
12 INT307027 Positive_regulation of Localization of LBR 1 0.05 0.82 0.61
13 INT176375 Positive_regulation of Positive_regulation of LBR 1 0.10 1.12 0.53
14 INT21831 Positive_regulation of Lbr 2 0.37 0 0.39
15 INT3044 Regulation of LBR 2 0.44 0.1 0.35
16 INT14181 Binding of DHCR24 1 0.04 0 0.34
17 INT107163 Negative_regulation of Lbr 1 0.15 0 0.29
18 INT21829 Regulation of Lbr 1 0.04 0 0.24
19 INT135460 Gene_expression of DHCR24 2 0.58 0.57 0.2
20 INT135459 Positive_regulation of Negative_regulation of DHCR24 1 0.38 0.18 0.19
21 INT135461 Protein_catabolism of DHCR24 1 0.44 0.27 0.17
22 INT64474 Regulation of Positive_regulation of LBR 1 0.22 0.08 0.13
23 INT55486 Negative_regulation of Positive_regulation of LBR 1 0.41 1.07 0.08
24 INT303974 Phosphorylation of LBR 2 0.79 0.24 0.06
25 INT303973 Negative_regulation of Phosphorylation of LBR 1 0.41 0.14 0.06
26 INT21830 Localization of Lbr 1 0.14 0 0.04
27 INT330661 Regulation of Phosphorylation of LBR 1 0.03 0.1 0
28 INT94006 Negative_regulation of Srd5a3 1 0.06 1.17 0
29 INT193182 Localization of DHCR24 1 0.10 0.22 0
30 INT298394 Positive_regulation of Binding of LBR 1 0.05 0.31 0
31 INT314951 Binding of Lbr 1 0.04 0.13 0
32 INT314945 Gene_expression of Lbr 1 0.08 0.63 0
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