GO:0016702

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Name oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Categary Function
Go Slim No
Go Link GO:0016702
Unique Molecular Interactions 349
Total Molecular Interactions 417
Total Single Events 9019
Pain Genes Associated 28

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
3 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
4 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
5 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
6 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
7 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
8 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
9 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
10 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
11 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15
12 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
13 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
14 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
15 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
16 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
17 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
18 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86
19 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
20 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
21 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
22 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
23 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
24 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
25 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
26 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
27 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69
28 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63
29 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
30 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
31 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61
32 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
33 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
34 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
35 INT45781 Regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.16 0.61
36 INT35154 PLOD1 Regulation of PRL 2 0.17 0 0.6
37 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58
38 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58
39 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58
40 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
41 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
42 INT75490 LEPRE1 Positive_regulation of Gene_expression of COL7A1 1 0.03 0.52 0.57
43 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
44 INT220051 Fcgr4 Positive_regulation of Gene_expression of Ido1 1 0.01 1.24 0.55
45 INT23485 HBE1 Positive_regulation of Localization of PLOD1 1 0.04 0 0.54
46 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
47 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
48 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54
49 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
50 INT23482 HBE1 Positive_regulation of PLOD1 1 0.04 0 0.53
51 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
52 INT70244 POMC Positive_regulation of Localization of PLOD1 1 0.21 0 0.53
53 INT23484 Positive_regulation of HBE1 Positive_regulation of PLOD1 1 0.04 0 0.53
54 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52
55 INT116541 Binding of Ptgs2 and ZNF398 1 0.00 0.68 0.52
56 INT105849 Il1b Positive_regulation of Positive_regulation of Ptgs1 1 0.07 0.38 0.51
57 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
58 INT39248 NPL Regulation of PLOD1 1 0.14 0.16 0.49
59 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
60 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
61 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
62 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
63 INT131809 Nfkb1 Positive_regulation of Gene_expression of Ptgs1 1 0.12 0.73 0.48
64 INT129551 Sag Negative_regulation of Gene_expression of Ptgs1 1 0.08 0.88 0.48
65 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
66 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
67 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
68 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
69 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
70 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46
71 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 0.12 0.41 0.46
72 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45
73 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
74 INT23481 POMC Regulation of Localization of PLOD1 1 0.20 0 0.42
75 INT53470 Acsm3 Regulation of Ptgs1 1 0.15 0 0.42
76 INT53469 Negative_regulation of Acsm3 Regulation of Ptgs1 1 0.24 0 0.42
77 INT76154 Binding of NCOR2 and Negative_regulation of Localization of PLOD1 1 0.02 0 0.42
78 INT53471 Binding of Ptgs1 and Acsm3 1 0.17 0 0.41
79 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
80 INT139683 Binding of Cldn11 and 2410016O06Rik 1 0.02 1.06 0.4
81 INT139684 Binding of Cd4 and 2410016O06Rik 1 0.02 1.05 0.4
82 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
83 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39
84 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
85 INT220050 Ctla4 Positive_regulation of Ido1 1 0.31 1.45 0.38
86 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
87 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
88 INT74244 Ptgs1 Regulation of Positive_regulation of Penk 1 0.09 0.19 0.37
89 INT93694 Binding of Hspa8 and Ptgs1 1 0.30 0.79 0.36
90 INT167045 TRPA1 Regulation of PTGS1 1 0.19 0.1 0.35
91 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
92 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
93 INT89501 Il6 Positive_regulation of Ptgs2 1 0.01 1.07 0.35
94 INT25354 Chi3l1 Negative_regulation of Ptgs1 1 0.00 0.39 0.34
95 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
96 INT43388 OPRM1 Positive_regulation of Localization of PLOD1 1 0.27 0 0.34
97 INT5388 PTGS1 Negative_regulation of APRT 1 0.21 0.4 0.34
98 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
99 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
100 INT310900 Binding of DEFB1 and Kdm5d 1 0.10 1.98 0.33
101 INT68557 ZNF697 Negative_regulation of PTGS1 1 0.02 0.59 0.33
102 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
103 INT128677 Positive_regulation of Binding of TET1 and Tet2 1 0.26 0.8 0.33
104 INT35690 Dpp6 Regulation of Jmjd1c 1 0.17 0 0.33
105 INT128678 Binding of TET1 and Tet2 1 0.19 0.8 0.33
106 INT52700 Prkcg Positive_regulation of Ptgs2 1 0.12 0.3 0.32
107 INT31042 Ghrh Positive_regulation of Localization of PLOD1 1 0.08 0 0.32
108 INT31039 Gnrh1 Negative_regulation of Localization of PLOD1 1 0.05 0 0.32
109 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
110 INT31043 Ghrh Positive_regulation of PLOD1 1 0.03 0 0.31
111 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
112 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
113 INT213062 PTGS1 Regulation of Gene_expression of MMP9 1 0.04 0.25 0.3
114 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
115 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
116 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
117 INT65539 PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.18 0.3
118 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
119 INT74942 HGF Positive_regulation of PTGS1 1 0.11 0.25 0.29
120 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
121 INT65540 Gene_expression of PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.05 0.17 0.29
122 INT35079 CRH Negative_regulation of Localization of PLOD1 1 0.06 0 0.29
123 INT89911 PLOD1 Positive_regulation of Localization of PRL 1 0.12 0 0.29
124 INT89912 PLOD1 Positive_regulation of Localization of GH1 1 0.04 0 0.29
125 INT89897 PLOD1 Positive_regulation of Localization of POMC 1 0.13 0 0.29
126 INT81479 Binding of Ptgs1 and ZNF398 1 0.00 0.17 0.28
127 INT122000 Negative_regulation of PTGS1 Positive_regulation of Gene_expression of TNF 1 0.23 0.11 0.28
128 INT67768 NPL Positive_regulation of PLOD1 1 0.30 0 0.28
129 INT102335 DFP Negative_regulation of Ptgs1 1 0.04 0.31 0.28
130 INT243214 Myst2 Negative_regulation of Gene_expression of Ptgs2 1 0.01 1.4 0.28
131 INT67769 Regulation of NPL Positive_regulation of PLOD1 1 0.17 0 0.28
132 INT158266 Olr1745 Negative_regulation of Ptgs1 1 0.01 0.52 0.27
133 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
134 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
135 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
136 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26
137 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
138 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
139 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
140 INT64860 PTGS1 Negative_regulation of PTGS2 1 0.07 0 0.26
141 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26
142 INT53951 Negative_regulation of Trib3 Negative_regulation of Gene_expression of Ptgs1 1 0.01 0.43 0.26
143 INT335126 Ptgs2 Positive_regulation of Gene_expression of PPARA 1 0.24 0.72 0.25
144 INT66257 Negative_regulation of Ptgs1 Positive_regulation of Gene_expression of Tnf 1 0.03 0.44 0.25
145 INT76224 Ptgs1 Regulation of Gene_expression of PECAM1 1 0.00 0.25 0.25
146 INT38711 CYSLTR1 Positive_regulation of Gene_expression of PTGS1 1 0.08 0.14 0.25
147 INT102625 IL6 Regulation of Gene_expression of PTGS2 1 0.11 0.29 0.24
148 INT126551 Agt Positive_regulation of Gene_expression of Ptgs1 1 0.25 0.92 0.24
149 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
150 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
151 INT166663 Mpzl2 Negative_regulation of Positive_regulation of Ptgs2 1 0.29 0.3 0.24
152 INT102617 PTAFR Regulation of Gene_expression of PTGS2 1 0.12 0.29 0.24
153 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
154 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23
155 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23
156 INT284433 Kdm5d Regulation of KITLG 1 0.00 0.57 0.23
157 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
158 INT284432 KITLG Regulation of Kdm5d 1 0.00 0.57 0.23
159 INT145014 Positive_regulation of GAST Positive_regulation of PTGS2 1 0.31 0.51 0.22
160 INT149882 Binding of Ptgs1 and Ptges 1 0.01 0.15 0.22
161 INT133164 Ptgs2 Regulation of Tnf 1 0.14 0.98 0.22
162 INT145012 GAST Positive_regulation of PTGS2 1 0.42 0.51 0.22
163 INT295430 BRD2 Positive_regulation of PLOD1 1 0.02 0.33 0.22
164 INT112134 Gast Positive_regulation of Gene_expression of Ptgs2 1 0.28 0.19 0.21
165 INT35151 PLOD1 Regulation of PGR 1 0.09 0 0.21
166 INT35149 PLOD1 Regulation of GHRH 1 0.02 0 0.21
167 INT69318 ST3GAL4 Positive_regulation of Gene_expression of PTGS2 1 0.35 0.09 0.21
168 INT112136 Egf Positive_regulation of Gene_expression of Ptgs2 1 0.21 0.19 0.21
169 INT35150 PLOD1 Regulation of LHB 1 0.09 0 0.21
170 INT283747 Tbs1 Positive_regulation of Ptgs2 1 0.00 0 0.2
171 INT231639 Binding of PTGER2 and PTGS2 1 0.00 0.44 0.19
172 INT117517 PROC Positive_regulation of PTGS2 1 0.01 0.61 0.19
173 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
174 INT220053 Il10 Positive_regulation of Ido1 1 0.14 0.74 0.19
175 INT25053 Crh Regulation of PLOD1 1 0.11 0 0.19
176 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
177 INT32360 DBI Positive_regulation of Localization of PLOD1 1 0.05 0 0.19
178 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19
179 INT192902 HGF Regulation of Kdm5d 1 0.00 0.36 0.19
180 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
181 INT73332 IL1B Positive_regulation of Transcription of PTGS2 1 0.44 0.54 0.18
182 INT127503 Mpz Positive_regulation of Ptgs1 1 0.14 0.9 0.18
183 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18
184 INT255431 Airn Negative_regulation of Gene_expression of Ptgs1 1 0.00 0.66 0.17
185 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17
186 INT93693 Positive_regulation of Binding of Hspa8 and Ptgs1 1 0.31 0.38 0.17
187 INT119130 Binding of Nos2 and Ptgs2 1 0.33 0.07 0.17
188 INT12521 Binding of PLOD1 and POMC 1 0.26 1.96 0.17
189 INT25050 Crh Negative_regulation of PLOD1 1 0.11 0 0.17
190 INT354819 Binding of Cpox and Ptgs2 1 0.02 0.45 0.16
191 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16
192 INT334182 Tdo2 Positive_regulation of Gene_expression of Ngf 1 0.07 0.08 0.16
193 INT328484 Ptgs1 Positive_regulation of Ros1 1 0.00 0.58 0.16
194 INT69317 PTGS2 Positive_regulation of Gene_expression of PTGS1 1 0.42 0.09 0.16
195 INT141753 Nfkb1 Regulation of Ptgs2 1 0.16 1.18 0.16
196 INT146745 UGCG Positive_regulation of Gene_expression of PTGS2 1 0.23 0.1 0.16
197 INT63453 Positive_regulation of PTGS1 Positive_regulation of Gene_expression of PLEKHM1 1 0.05 0.09 0.16
198 INT141754 Nfkb1 Regulation of Positive_regulation of Ptgs2 1 0.16 1.21 0.16
199 INT327556 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.85 0.15
200 INT176621 PTGS2 Regulation of Gene_expression of PTGER2 1 0.00 0.09 0.15

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
3 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
4 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
5 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
6 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
7 INT920 Localization of PLOD1 223 0.81 42.25 78.7
8 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
9 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
10 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
11 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
12 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
13 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
14 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
15 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
16 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03
17 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
18 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72
19 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51
20 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
21 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
22 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
23 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61
24 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
25 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
26 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87
27 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
28 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
29 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
30 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
31 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95
32 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
33 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98
34 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54
35 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
36 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
37 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
38 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
39 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
40 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
41 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
42 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
43 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39
44 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05
45 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
46 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
47 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
48 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
49 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9
50 INT9889 Gene_expression of Alox5 34 0.63 20.83 8.85
51 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
52 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71
53 INT20234 Regulation of Gene_expression of Ptgs1 11 0.44 6.55 7.72
54 INT170295 Positive_regulation of Ido1 40 0.67 28.89 7.61
55 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52
56 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23
57 INT248206 Gene_expression of Tdo2 15 0.78 9.17 7.16
58 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
59 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
60 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29
61 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
62 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12
63 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1
64 INT170315 Positive_regulation of Gene_expression of Ido1 50 0.67 25.39 6.06
65 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02
66 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87
67 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86
68 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71
69 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4
70 INT39256 Localization of PTGS1 17 0.74 6.62 5.1
71 INT170311 Negative_regulation of Ido1 16 0.48 14.47 4.81
72 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72
73 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52
74 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
75 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
76 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04
77 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81
78 INT53200 Binding of Ptgs2 11 0.48 5.08 3.54
79 INT142084 Positive_regulation of Kdm5d 22 0.29 5.88 3.17
80 INT52694 Negative_regulation of Positive_regulation of Ptgs2 9 0.43 4.72 3.11
81 INT77615 Positive_regulation of Negative_regulation of Ptgs1 6 0.50 1.55 3.11
82 INT25031 Negative_regulation of Gene_expression of PLOD1 14 0.54 3.86 2.89
83 INT90402 Positive_regulation of Gene_expression of Ptgs1 13 0.31 4.83 2.88
84 INT76342 Positive_regulation of Gene_expression of Alox5 9 0.56 5.29 2.87
85 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
86 INT27607 Localization of Ptgs1 7 0.59 3.22 2.6
87 INT127176 Transcription of Ptgs2 8 0.58 4.68 2.58
88 INT34969 Negative_regulation of Binding of Ptgs1 4 0.37 1.55 2.55
89 INT17846 Binding of Ptgs2 8 0.32 4.66 2.48
90 INT70197 Negative_regulation of Positive_regulation of Ptgs1 6 0.24 2.61 2.44
91 INT53476 Positive_regulation of Localization of Ptgs1 6 0.49 2.88 2.35
92 INT170323 Regulation of Gene_expression of Ido1 11 0.60 8.74 2.33
93 INT12033 Binding of PLOD1 15 0.48 8.04 2.3
94 INT9887 Negative_regulation of Gene_expression of Ptgs1 7 0.42 2.94 2.3
95 INT78958 Regulation of Negative_regulation of Ptgs2 6 0.42 2.61 2.3
96 INT88241 Positive_regulation of Positive_regulation of Ptgs1 3 0.45 1.71 2.25
97 INT36534 Negative_regulation of Positive_regulation of PLOD1 5 0.56 1.39 2.14
98 INT54823 Phosphorylation of PTGS1 4 0.51 1.61 2.14
99 INT75493 Gene_expression of LEPRE1 1 0.32 1.62 2.12
100 INT32557 Negative_regulation of Negative_regulation of PTGS1 8 0.43 3.44 2.1
101 INT104006 Binding of Kdm5d 26 0.26 8.09 2.07
102 INT90688 Negative_regulation of Tdo2 12 0.59 5.82 2.02
103 INT7974 Regulation of Gene_expression of PLOD1 6 0.42 0.41 1.99
104 INT7973 Positive_regulation of Regulation of PLOD1 5 0.42 0.42 1.99
105 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
106 INT101985 Positive_regulation of Positive_regulation of Ptgs1 4 0.15 4.13 1.98
107 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96
108 INT77805 Regulation of Gene_expression of Ptgs2 6 0.51 2.7 1.92
109 INT52691 Positive_regulation of Transcription of Ptgs2 5 0.44 3 1.9
110 INT133826 Negative_regulation of Kdm5d 15 0.16 7.88 1.83
111 INT53812 Regulation of Gene_expression of Ptgs1 5 0.38 0.89 1.78
112 INT64915 Regulation of Negative_regulation of PTGS1 4 0.20 1.81 1.76
113 INT34552 Regulation of Gene_expression of Alox5 3 0.50 5.06 1.75
114 INT39229 Regulation of Alox5 6 0.57 3.2 1.72
115 INT78956 Regulation of Transcription of Ptgs1 3 0.35 1.42 1.7
116 INT27608 Localization of Alox5 7 0.61 2.66 1.69
117 INT59077 Transcription of PTGS1 11 0.43 2.37 1.65
118 INT128670 Binding of TET1 10 0.42 3.96 1.63
119 INT60857 Negative_regulation of Regulation of Ptgs1 1 0.07 2.22 1.61
120 INT25033 Negative_regulation of Negative_regulation of PLOD1 4 0.55 0.36 1.6
121 INT9885 Negative_regulation of Gene_expression of Alox5 3 0.14 2.28 1.59
122 INT149622 Positive_regulation of Transcription of Ptgs2 3 0.28 2.48 1.46
123 INT20130 Positive_regulation of Hpd 6 0.35 4.48 1.44
124 INT37886 Positive_regulation of Positive_regulation of PLOD1 1 0.69 0 1.43
125 INT190768 Regulation of Positive_regulation of Ptgs2 1 0.04 1.2 1.41
126 INT86823 Regulation of Transcription of PTGS2 3 0.19 1.48 1.4
127 INT89209 Negative_regulation of Binding of Ptgs1 6 0.06 2.7 1.39
128 INT73260 Regulation of Positive_regulation of PTGS1 3 0.26 2.65 1.37
129 INT27212 Regulation of Hpd 5 0.02 2.33 1.35
130 INT135658 Phosphorylation of Ptgs2 2 0.23 1.39 1.34
131 INT1651 Positive_regulation of Negative_regulation of PLOD1 4 0.46 0.49 1.33
132 INT186268 Positive_regulation of Tdo2 13 0.50 8 1.32
133 INT42318 Negative_regulation of Hpd 2 0.31 0.57 1.24
134 INT56219 Gene_expression of KDM5D 16 0.53 5.59 1.23
135 INT101026 Positive_regulation of Negative_regulation of Ptgs2 2 0.35 1.01 1.23
136 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21
137 INT59078 Positive_regulation of Transcription of PTGS2 5 0.69 2.36 1.17
138 INT130198 Negative_regulation of Binding of PTGS1 3 0.34 2.6 1.16
139 INT220046 Positive_regulation of Negative_regulation of Ido1 1 0.41 2.98 1.12
140 INT62981 Protein_catabolism of PTGS2 5 0.78 1.09 1.11
141 INT64862 Negative_regulation of Negative_regulation of PTGS2 3 0.36 0.76 1.09
142 INT70505 Positive_regulation of Positive_regulation of Ptgs2 4 0.49 2.22 1.08
143 INT78353 Positive_regulation of Positive_regulation of PTGS1 4 0.27 0.95 1.06
144 INT83647 Negative_regulation of Negative_regulation of Ptgs2 1 0.28 1.97 1.05
145 INT64177 Negative_regulation of Transcription of PTGS2 4 0.41 1.99 1.03
146 INT34553 Binding of Alox5 3 0.10 0.65 1.03
147 INT165009 Regulation of Negative_regulation of Alox5 1 0.05 1 1.01
148 INT63284 Transcription of Ptgs1 5 0.66 1.34 0.97
149 INT44446 Regulation of Regulation of PLOD1 3 0.38 1.85 0.97
150 INT62980 Protein_catabolism of Ptgs1 3 0.59 0.93 0.97
151 INT75492 Negative_regulation of LEPRE1 2 0.40 0.84 0.96
152 INT68265 Positive_regulation of Negative_regulation of Ptgs2 3 0.46 0.08 0.92
153 INT100142 Negative_regulation of Localization of PTGS1 2 0.35 1.71 0.91
154 INT69553 Negative_regulation of Regulation of PTGS1 1 0.16 0.78 0.91
155 INT291677 Transcription of Alox5 1 0.58 3.91 0.91
156 INT42319 Gene_expression of Hpd 5 0.44 11.25 0.9
157 INT93406 Positive_regulation of Regulation of Ptgs1 2 0.14 0 0.9
158 INT80142 Positive_regulation of Localization of PTGS1 4 0.21 1.52 0.87
159 INT149624 Regulation of Transcription of Ptgs2 1 0.16 0.84 0.84
160 INT220043 Positive_regulation of Positive_regulation of Ido1 2 0.41 1.94 0.83
161 INT115770 Negative_regulation of Positive_regulation of Ptgs2 4 0.43 0.94 0.79
162 INT64929 Positive_regulation of LEPRE1 3 0.41 0.75 0.78
163 INT120057 Regulation of Localization of PTGS2 1 0.28 0.14 0.78
164 INT56220 Positive_regulation of KDM5D 4 0.41 1.68 0.74
165 INT71950 Positive_regulation of Binding of PTGS2 2 0.31 0.31 0.74
166 INT78957 Regulation of Transcription of Ptgs2 1 0.17 0.49 0.72
167 INT82544 Regulation of Positive_regulation of PTGS2 4 0.39 1.41 0.71
168 INT127175 Negative_regulation of Transcription of Ptgs2 3 0.47 2.11 0.7
169 INT93854 Positive_regulation of Transcription of Ptgs1 3 0.19 0.54 0.66
170 INT39865 Regulation of Positive_regulation of PLOD1 2 0.27 0.71 0.66
171 INT92341 Localization of Ptgs2 5 0.75 2.04 0.64
172 INT23612 Regulation of Negative_regulation of Ptgs1 3 0.19 0.69 0.64
173 INT56222 Positive_regulation of Gene_expression of KDM5D 4 0.41 1.29 0.57
174 INT108319 Regulation of Positive_regulation of Ptgs1 1 0.16 0.08 0.57
175 INT115772 Positive_regulation of Localization of Ptgs2 1 0.46 0.5 0.55
176 INT124836 Positive_regulation of Binding of Ptgs1 1 0.10 0.25 0.55
177 INT64928 Regulation of LEPRE1 2 0.24 1.26 0.54
178 INT42321 Regulation of Gene_expression of Hpd 1 0.20 0.1 0.54
179 INT115771 Positive_regulation of Positive_regulation of Ptgs2 1 0.46 0.5 0.54
180 INT272772 Gene_expression of Fto 2 0.76 3.76 0.52
181 INT69369 Binding of Tdo2 4 0.33 0.07 0.51
182 INT187721 Transcription of PLOD1 4 0.49 4.69 0.51
183 INT87959 Phosphorylation of Ptgs1 3 0.63 0.37 0.51
184 INT187714 Regulation of Negative_regulation of PLOD1 1 0.09 0 0.51
185 INT170299 Negative_regulation of Gene_expression of Ido1 12 0.57 2.59 0.5
186 INT142835 Regulation of Localization of Ptgs2 2 0.25 0.26 0.5
187 INT91220 Positive_regulation of Binding of Ptgs1 1 0.02 0.76 0.47
188 INT220048 Protein_catabolism of Ido1 1 0.81 1.03 0.47
189 INT39228 Regulation of Regulation of Ptgs1 2 0.39 0.38 0.45
190 INT39227 Regulation of Regulation of Alox5 2 0.36 0.38 0.45
191 INT39931 Negative_regulation of TET1 1 0.37 0 0.44
192 INT94036 Negative_regulation of Transcription of Ptgs2 1 0.30 0.52 0.43
193 INT191930 Negative_regulation of Negative_regulation of Ptgs1 1 0.07 0.94 0.42
194 INT270034 Negative_regulation of Positive_regulation of Ido1 1 0.19 2.23 0.42
195 INT268066 Regulation of Tdo2 5 0.32 3.13 0.41
196 INT270027 Regulation of Positive_regulation of Ido1 1 0.23 1.17 0.39
197 INT170318 Regulation of Ido1 6 0.38 2.63 0.38
198 INT34551 Regulation of Binding of Alox5 1 0.08 0.19 0.38
199 INT231345 Positive_regulation of Localization of Ptgs1 1 0.16 0.82 0.36
200 INT160513 Localization of Kdm5d 7 0.60 1.59 0.35
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