GO:0016709

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Name oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
Categary Function
Go Slim No
Go Link GO:0016709
Unique Molecular Interactions 26
Total Molecular Interactions 42
Total Single Events 470
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
2 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
3 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
4 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
5 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
6 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
7 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
8 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
9 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
10 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
11 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
12 INT125550 FGFR1 Negative_regulation of Cyp2e1 1 0.02 0.06 0.18
13 INT125551 Binding of FGFR1 and Cyp2e1 1 0.02 0.07 0.13
14 INT97080 CYP2E1 Regulation of HAGH 1 0.02 0 0.11
15 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
16 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
17 INT125643 Cyp2e1 Positive_regulation of Transcription of Cyp2c11 1 0.51 0 0
18 INT125656 Cyp2e1 Positive_regulation of Transcription of Cyp2b2 1 0.07 0 0
19 INT125646 Cyp2b2 Positive_regulation of Transcription of Cyp2e1 1 0.07 0 0
20 INT125652 Cyp2c6 Positive_regulation of Transcription of Cyp2e1 1 0.49 0 0
21 INT125650 Cyp2e1 Positive_regulation of Transcription of Cyp2c6 1 0.49 0 0
22 INT125661 Cyp2c11 Positive_regulation of Transcription of Cyp2e1 1 0.51 0 0
23 INT168313 Binding of NAT2 and CYP2E1 1 0.21 0.08 0
24 INT125654 Cyp2e1 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.43 0 0
25 INT20321 Binding of CYP2E1 and CYP21A2 1 0.00 0 0
26 INT20323 Binding of CYP2E1 and CYP26A1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
2 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
3 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
4 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
5 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
6 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
7 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
8 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
9 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
10 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
11 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
12 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
13 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
14 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08
15 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03
16 INT107091 Regulation of Gene_expression of Cyp2e1 4 0.62 2.17 2.03
17 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98
18 INT82649 Negative_regulation of Gene_expression of Cyp2e1 3 0.58 2.51 1.93
19 INT93863 Transcription of CYP2E1 3 0.69 1.39 1.34
20 INT165310 Negative_regulation of Transcription of CYP2E1 1 0.42 1.15 1.14
21 INT149926 Negative_regulation of Negative_regulation of Cyp2e1 1 0.43 0.14 0.78
22 INT149927 Regulation of Negative_regulation of Cyp2e1 1 0.45 0.13 0.78
23 INT98177 Negative_regulation of Transcription of Cyp2e1 2 0.40 0.89 0.75
24 INT20306 Positive_regulation of Transcription of Cyp2e1 2 0.49 0.63 0.73
25 INT168367 Localization of Cyp2e1 2 0.71 0.6 0.72
26 INT79097 Positive_regulation of Binding of Cyp2e1 1 0.50 0.53 0.69
27 INT149928 Positive_regulation of Negative_regulation of Cyp2e1 2 0.50 0.35 0.68
28 INT154347 Regulation of Gene_expression of CYP2E1 2 0.27 0.22 0.53
29 INT144666 Positive_regulation of Binding of CYP2E1 1 0.50 0.25 0.3
30 INT71517 Localization of CYP2E1 3 0.75 0 0.28
31 INT344069 Negative_regulation of Binding of CYP2E1 1 0.15 0.05 0.17
32 INT137620 Protein_catabolism of Cyp2e1 1 0.16 0 0.11
33 INT168366 Positive_regulation of Localization of Cyp2e1 1 0.48 0.05 0.09
34 INT231566 Negative_regulation of Gene_expression of CYP2E1 1 0.25 0 0.05
35 INT191845 Regulation of Negative_regulation of CYP2E1 1 0.45 0.26 0.03
36 INT71516 Protein_catabolism of CYP2E1 1 1.00 0 0
37 INT222893 Phosphorylation of CYP2E1 1 0.58 1.52 0
38 INT191846 Regulation of Regulation of CYP2E1 1 0.27 0 0
39 INT83245 Regulation of Positive_regulation of CYP2E1 1 0.44 1.19 0
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