GO:0016712

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Name oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Categary Function
Go Slim No
Go Link GO:0016712
Unique Molecular Interactions 232
Total Molecular Interactions 291
Total Single Events 3429
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
2 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
3 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
4 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
5 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
6 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
7 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
8 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
9 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
10 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
11 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
12 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
13 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
14 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
15 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
16 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
17 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
18 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
19 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
20 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
21 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
22 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
23 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
24 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
25 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
26 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
27 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
28 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
29 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
30 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
31 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
32 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
33 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
34 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
35 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
36 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
37 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
38 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
39 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
40 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
41 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
42 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
43 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
44 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
45 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
46 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
47 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
48 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
49 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
50 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
51 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
52 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
53 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27
54 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
55 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
56 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
57 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
58 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
59 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
60 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
61 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
62 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
63 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
64 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
65 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
66 INT100823 Cyp2e1 Positive_regulation of Ros1 1 0.35 1.22 0.22
67 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
68 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
69 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2
70 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
71 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
72 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
73 INT125550 FGFR1 Negative_regulation of Cyp2e1 1 0.02 0.06 0.18
74 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
75 INT301615 Binding of Cyp2e1 and Samsn1 1 0.02 2.42 0.18
76 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
77 INT121380 Casr Positive_regulation of Positive_regulation of Cyp3a11 1 0.15 0.25 0.18
78 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
79 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
80 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
81 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
82 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
83 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
84 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
85 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
86 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
87 INT125551 Binding of FGFR1 and Cyp2e1 1 0.02 0.07 0.13
88 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
89 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
90 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
91 INT97080 CYP2E1 Regulation of HAGH 1 0.02 0 0.11
92 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
93 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
94 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
95 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
96 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09
97 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
98 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
99 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
100 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
101 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
102 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
103 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
104 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
105 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
106 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
107 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
108 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
109 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
110 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
111 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
112 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07
113 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
114 INT57965 Myo5a Negative_regulation of Cyp2e1 1 0.01 0.09 0.07
115 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07
116 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
117 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
118 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
119 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
120 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
121 INT342221 Cyp2e1 Positive_regulation of Gene_expression of TRNAI1 1 0.03 0.22 0.05
122 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
123 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
124 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
125 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
126 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
127 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
128 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
129 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
130 INT262171 Binding of Cyp3a11 and Rare1 1 0.02 0.15 0.03
131 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
132 INT262217 Casr Regulation of Cyp3a11 1 0.05 0.13 0.03
133 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
134 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
135 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
136 INT125643 Cyp2e1 Positive_regulation of Transcription of Cyp2c11 1 0.51 0 0
137 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
138 INT125656 Cyp2e1 Positive_regulation of Transcription of Cyp2b2 1 0.07 0 0
139 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
140 INT275667 Binding of CYP1B1 and GLC3C 1 0.27 0.99 0
141 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
142 INT301640 Positive_regulation of Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.03 0.25 0
143 INT262204 Nr1i2 Positive_regulation of Cyp3a11 1 0.33 0.08 0
144 INT125646 Cyp2b2 Positive_regulation of Transcription of Cyp2e1 1 0.07 0 0
145 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
146 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
147 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
148 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
149 INT220411 Ptger2 Positive_regulation of Cyp19a1 1 0.09 0.83 0
150 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
151 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
152 INT262213 Plec Positive_regulation of Cyp3a11 1 0.02 0 0
153 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
154 INT125652 Cyp2c6 Positive_regulation of Transcription of Cyp2e1 1 0.49 0 0
155 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
156 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
157 INT299459 Foxl2 Positive_regulation of Cyp19a1 1 0.34 0.07 0
158 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
159 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
160 INT125650 Cyp2e1 Positive_regulation of Transcription of Cyp2c6 1 0.49 0 0
161 INT125661 Cyp2c11 Positive_regulation of Transcription of Cyp2e1 1 0.51 0 0
162 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
163 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
164 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
165 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
166 INT199711 2610029G23Rik Regulation of Cyp2e1 1 0.03 0.45 0
167 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
168 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
169 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
170 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
171 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
172 INT168313 Binding of NAT2 and CYP2E1 1 0.21 0.08 0
173 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
174 INT261981 EP400 Negative_regulation of CYP1B1 1 0.01 0.22 0
175 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0
176 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
177 INT125654 Cyp2e1 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.43 0 0
178 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
179 INT262192 Nr1i2 Regulation of Positive_regulation of Cyp3a11 1 0.32 0 0
180 INT20321 Binding of CYP2E1 and CYP21A2 1 0.00 0 0
181 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0
182 INT20323 Binding of CYP2E1 and CYP26A1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
2 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
3 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
4 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
5 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
6 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
7 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
8 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
9 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
10 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
11 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
12 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
13 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
14 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
15 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
16 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
17 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
18 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
19 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
20 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
21 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
22 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
23 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
24 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76
25 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
26 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
27 INT76025 Positive_regulation of Cyp3a11 20 0.69 5.88 6.91
28 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
29 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
30 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
31 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
32 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
33 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
34 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
35 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
36 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
37 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
38 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
39 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
40 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
41 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
42 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
43 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
44 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
45 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
46 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
47 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
48 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
49 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
50 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16
51 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
52 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
53 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
54 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
55 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
56 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
57 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
58 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
59 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
60 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
61 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
62 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
63 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
64 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
65 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
66 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
67 INT120234 Positive_regulation of Gene_expression of Cyp3a11 4 0.46 2.21 2.13
68 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
69 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08
70 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
71 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
72 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03
73 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
74 INT107091 Regulation of Gene_expression of Cyp2e1 4 0.62 2.17 2.03
75 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
76 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 6 0.59 3.74 2.02
77 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
78 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
79 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98
80 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
81 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
82 INT82649 Negative_regulation of Gene_expression of Cyp2e1 3 0.58 2.51 1.93
83 INT96723 Regulation of Cyp3a11 5 0.44 2 1.83
84 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
85 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
86 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
87 INT93863 Transcription of CYP2E1 3 0.69 1.39 1.34
88 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
89 INT115374 Positive_regulation of Gene_expression of Cyp2e1 6 0.67 4.36 1.27
90 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
91 INT123284 Positive_regulation of Positive_regulation of Cyp2e1 3 0.46 2.34 1.22
92 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
93 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
94 INT165310 Negative_regulation of Transcription of CYP2E1 1 0.42 1.15 1.14
95 INT134957 Positive_regulation of Transcription of Cyp3a11 1 0.42 0.43 1.11
96 INT134956 Transcription of Cyp3a11 1 0.48 0.43 1.1
97 INT96873 Gene_expression of CYP1B1 28 0.78 11.81 1.09
98 INT168395 Transcription of Cyp19a1 2 0.51 2.5 1.06
99 INT168397 Gene_expression of Cyp19a1 2 0.06 1.77 1.06
100 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
101 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
102 INT132623 Transcription of Cyp2e1 2 0.53 0.56 0.98
103 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
104 INT168398 Localization of Cyp19a1 1 0.08 0.89 0.97
105 INT56270 Negative_regulation of Binding of Cyp2e1 1 0.42 0.17 0.94
106 INT56271 Positive_regulation of Negative_regulation of Cyp2e1 1 0.46 0.17 0.93
107 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
108 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
109 INT96879 Positive_regulation of CYP1B1 14 0.70 5.73 0.78
110 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
111 INT149926 Negative_regulation of Negative_regulation of Cyp2e1 1 0.43 0.14 0.78
112 INT149927 Regulation of Negative_regulation of Cyp2e1 1 0.45 0.13 0.78
113 INT96725 Regulation of Gene_expression of Cyp3a11 2 0.30 0.3 0.77
114 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
115 INT142923 Binding of Cyp3a11 1 0.36 0.38 0.76
116 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
117 INT98177 Negative_regulation of Transcription of Cyp2e1 2 0.40 0.89 0.75
118 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
119 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
120 INT20306 Positive_regulation of Transcription of Cyp2e1 2 0.49 0.63 0.73
121 INT168367 Localization of Cyp2e1 2 0.71 0.6 0.72
122 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
123 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
124 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
125 INT79097 Positive_regulation of Binding of Cyp2e1 1 0.50 0.53 0.69
126 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
127 INT149928 Positive_regulation of Negative_regulation of Cyp2e1 2 0.50 0.35 0.68
128 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
129 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
130 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
131 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
132 INT154347 Regulation of Gene_expression of CYP2E1 2 0.27 0.22 0.53
133 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
134 INT163991 Positive_regulation of Regulation of Cyp2e1 1 0.70 0.28 0.52
135 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
136 INT163994 Positive_regulation of Binding of Cyp2e1 2 0.50 0.45 0.5
137 INT137556 Negative_regulation of Cyp19a1 3 0.35 1.53 0.48
138 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
139 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
140 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
141 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
142 INT262087 Gene_expression of Cyp2d9 1 0.01 1.64 0.44
143 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
144 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
145 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
146 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
147 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
148 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
149 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
150 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
151 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
152 INT144666 Positive_regulation of Binding of CYP2E1 1 0.50 0.25 0.3
153 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
154 INT120230 Negative_regulation of Gene_expression of Cyp3a11 1 0.30 0.17 0.29
155 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
156 INT71517 Localization of CYP2E1 3 0.75 0 0.28
157 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
158 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
159 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
160 INT282487 Regulation of Negative_regulation of Cyp19a1 1 0.22 0.6 0.27
161 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
162 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
163 INT96888 Negative_regulation of Gene_expression of CYP1B1 5 0.43 1.13 0.23
164 INT96885 Localization of CYP1B1 4 0.80 2.11 0.23
165 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
166 INT96883 Positive_regulation of Gene_expression of CYP1B1 3 0.70 1.24 0.22
167 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
168 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
169 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
170 INT96887 Regulation of Gene_expression of CYP1B1 2 0.45 0.9 0.2
171 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
172 INT262132 Negative_regulation of Positive_regulation of Cyp3a11 1 0.28 0.4 0.2
173 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
174 INT344069 Negative_regulation of Binding of CYP2E1 1 0.15 0.05 0.17
175 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
176 INT107731 Negative_regulation of Cyp2d9 2 0.02 0.49 0.16
177 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
178 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
179 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
180 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
181 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
182 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
183 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
184 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
185 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
186 INT137620 Protein_catabolism of Cyp2e1 1 0.16 0 0.11
187 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
188 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
189 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
190 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
191 INT168366 Positive_regulation of Localization of Cyp2e1 1 0.48 0.05 0.09
192 INT152879 Regulation of Negative_regulation of Cyp2e1 1 0.45 0.8 0.08
193 INT220399 Positive_regulation of Cyp19a1 4 0.43 2.2 0.07
194 INT274054 Localization of CYP1A1 1 0.12 0 0.07
195 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
196 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
197 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06
198 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
199 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
200 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05
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