GO:0016714

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Name oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Categary Function
Go Slim No
Go Link GO:0016714
Unique Molecular Interactions 52
Total Molecular Interactions 76
Total Single Events 713
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen. They are ordered first by their pain relevance and then by number of times they were reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
2 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
3 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
4 INT184916 Binding of da and Th 1 0.09 1.22 0.87
5 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
6 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
7 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
8 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
9 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
10 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
11 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
12 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
13 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56
14 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
15 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
16 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
17 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
18 INT43587 Binding of OPRD1 and Pah 1 0.00 0.08 0.43
19 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
20 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
21 INT352821 Tph2 Regulation of Tst 1 0.31 0.46 0.36
22 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
23 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
24 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
25 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
26 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
27 INT313453 Siglec1 Regulation of Th 1 0.02 0.61 0.17
28 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
29 INT47164 Binding of Asap1 and Pah 1 0.27 0.07 0.17
30 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
31 INT313441 Th Regulation of Siglec1 1 0.02 0.22 0.13
32 INT313439 Syp Negative_regulation of Th 1 0.30 0.14 0.13
33 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
34 INT313454 Negative_regulation of Syp Negative_regulation of Th 1 0.30 0.14 0.1
35 INT313442 Th Regulation of Phosphorylation of Syp 1 0.32 0 0.08
36 INT313459 Gene_expression of Syp Negative_regulation of Th 1 0.30 0.49 0.08
37 INT313437 Th Regulation of Phosphorylation of Siglec1 1 0.04 0 0.08
38 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
39 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
40 INT313450 Th Regulation of Syp 1 0.32 0.6 0.06
41 INT242618 Binding of Slc18a3 and Th 1 0.13 0.26 0.05
42 INT313433 53T Regulation of Th 1 0.00 0 0.03
43 INT313448 Gene_expression of Syp Positive_regulation of Th 1 0.28 0 0.03
44 INT313468 Negative_regulation of Syp Regulation of Th 1 0.30 0.3 0.03
45 INT313443 Syp Positive_regulation of Binding of Th 1 0.35 0.31 0
46 INT313461 Gopc Regulation of Th 1 0.07 0 0
47 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
48 INT313457 Ppp2ca Regulation of Th 1 0.36 0 0
49 INT258614 Positive_regulation of Binding of Foxn1 and Tph2 1 0.46 0.06 0
50 INT258615 Binding of Foxn1 and Tph2 1 0.44 0.06 0
51 INT313438 Mapk1 Regulation of Th 1 0.06 0 0
52 INT313428 Binding of Syp and Th 1 0.25 0.31 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen. They are ordered first by their pain relevance and then by number of times they were reported in oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
2 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
3 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
4 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
5 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
6 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
7 INT149015 Gene_expression of Tph2 20 0.78 9.45 10.4
8 INT109265 Transcription of Th 18 0.68 4.5 8.21
9 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
10 INT66987 Regulation of Th 23 0.61 7.86 6.8
11 INT167457 Negative_regulation of Gene_expression of Tph2 5 0.57 2.27 5.9
12 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
13 INT37151 Localization of Th 13 0.57 3.11 4.82
14 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04
15 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
16 INT42485 Binding of Pah 9 0.35 3.42 3.03
17 INT248419 Negative_regulation of Tph2 11 0.59 6.32 2.59
18 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
19 INT248418 Localization of Tph2 5 0.75 2.45 1.45
20 INT126660 Positive_regulation of Gene_expression of Tph1 5 0.50 0.07 1.43
21 INT97869 Negative_regulation of Positive_regulation of Th 3 0.25 0.79 1.23
22 INT50267 Negative_regulation of Negative_regulation of Th 3 0.42 1.57 1.12
23 INT198953 Regulation of Regulation of Th 1 0.01 0.1 0.93
24 INT24242 Negative_regulation of Phosphorylation of Th 3 0.38 1.44 0.9
25 INT50266 Regulation of Negative_regulation of Th 1 0.42 0.94 0.88
26 INT248421 Regulation of Tph1 1 0.27 0.89 0.87
27 INT344348 Transcription of Tph2 1 0.71 0.98 0.87
28 INT66485 Negative_regulation of Binding of Pah 2 0.35 1.27 0.83
29 INT344349 Positive_regulation of Gene_expression of Tph2 1 0.46 0.77 0.8
30 INT344350 Positive_regulation of Tph2 1 0.69 0.82 0.78
31 INT149014 Negative_regulation of Tph1 5 0.58 1.43 0.74
32 INT149013 Positive_regulation of Tph1 3 0.47 1.1 0.65
33 INT90640 Positive_regulation of Negative_regulation of Th 2 0.40 0.58 0.39
34 INT353976 Negative_regulation of Negative_regulation of Tph2 1 0.42 0 0.35
35 INT248415 Binding of Tph2 9 0.44 3.88 0.34
36 INT349488 Positive_regulation of Localization of Th 1 0.30 0.96 0.34
37 INT332750 Regulation of Gene_expression of Tph1 1 0.11 0 0.33
38 INT277462 Regulation of Positive_regulation of Th 2 0.09 0.23 0.31
39 INT268069 Regulation of Tph2 1 0.44 0.26 0.28
40 INT353977 Regulation of Gene_expression of Tph2 1 0.26 0 0.24
41 INT313869 Gene_expression of Pah 4 0.63 3.1 0.23
42 INT335879 Negative_regulation of Gene_expression of Tph1 1 0.19 0.15 0.21
43 INT66986 Binding of Th 6 0.45 1.43 0.16
44 INT248417 Binding of Tph1 1 0.37 1.16 0.16
45 INT248416 Phosphorylation of Tph1 1 0.80 1.04 0.13
46 INT248422 Negative_regulation of Phosphorylation of Tph1 1 0.42 1.04 0.13
47 INT313420 Positive_regulation of Positive_regulation of Th 1 0.33 0.35 0.12
48 INT248420 Negative_regulation of Phosphorylation of Tph2 1 0.43 0.99 0.11
49 INT248423 Phosphorylation of Tph2 1 0.81 0.99 0.11
50 INT313868 Positive_regulation of Pah 2 0.41 0.67 0.08
51 INT313866 Positive_regulation of Positive_regulation of Pah 1 0.41 0.47 0.08
52 INT268076 Positive_regulation of Positive_regulation of Tph1 1 0.28 0.83 0.08
53 INT313408 Regulation of Phosphorylation of Th 1 0.40 0.74 0.07
54 INT313865 Positive_regulation of Gene_expression of Pah 2 0.47 0.95 0.05
55 INT138234 Transcription of Tph1 1 0.66 0 0
56 INT313870 Negative_regulation of Pah 1 0.48 2.33 0
57 INT328696 Negative_regulation of Gene_expression of Pah 1 0.16 0 0
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