GO:0016787

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Name hydrolase activity
Categary Function
Go Slim No
Go Link GO:0016787
Unique Molecular Interactions 3388
Total Molecular Interactions 4446
Total Single Events 40161
Pain Genes Associated 614

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported for hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
3 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
4 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
5 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
6 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
7 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67
8 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
9 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
10 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
11 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
12 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
13 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
14 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
15 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
16 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73
17 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
18 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
19 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
20 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
21 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
22 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45
23 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
24 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
25 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
26 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
27 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
28 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26
29 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25
30 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
31 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
32 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
33 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
34 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
35 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
36 INT17299 Prss12 Regulation of Localization of Acot1 3 0.05 0 2.07
37 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
38 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
39 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97
40 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
41 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
42 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
43 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
44 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92
45 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92
46 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
47 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
48 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
49 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
50 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
51 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
52 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
53 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
54 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
55 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
56 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
57 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 0.01 1.74 1.67
58 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
59 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
60 INT30743 Cck Regulation of Localization of Acot1 1 0.02 0 1.64
61 INT67966 Cck Positive_regulation of Adarb1 2 0.03 0 1.63
62 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
63 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
64 INT18592 Sst Regulation of Localization of Acot1 2 0.22 0 1.61
65 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
66 INT94033 Binding of Adarb1 and SLAMF6 1 0.01 0 1.61
67 INT109739 Binding of ITPA and Pcyt1b 1 0.16 0.72 1.6
68 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
69 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
70 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
71 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
72 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58
73 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
74 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
75 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
76 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
77 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
78 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
79 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
80 INT317538 Binding of Neu3 and Mors1 1 0.00 0 1.51
81 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
82 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
83 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
84 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
85 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 0.10 0.1 1.44
86 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
87 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
88 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
89 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43
90 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
91 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
92 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
93 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
94 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
95 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
96 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
97 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 0.06 0.49 1.39
98 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
99 INT73377 Npy Regulation of Adarb1 2 0.03 0.15 1.38
100 INT133933 Binding of DNM2 and TP53INP2 1 0.00 0 1.38
101 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
102 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
103 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
104 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
105 INT115272 Neu1 Positive_regulation of Coq10a 1 0.43 0.41 1.35
106 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
107 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 0.03 0.1 1.32
108 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3
109 INT112097 Sstr1 Positive_regulation of Adarb1 1 0.02 0.15 1.29
110 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
111 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
112 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
113 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
114 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
115 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
116 INT100816 PPP1R14C Regulation of Ppp1cc 1 0.08 0 1.27
117 INT195541 Lct Positive_regulation of Gene_expression of Grm2 1 0.02 0.4 1.27
118 INT219686 Binding of CEL and COPD 1 0.12 11.35 1.26
119 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
120 INT128776 Cntn1 Positive_regulation of Gene_expression of Pde6b 1 0.02 0.55 1.26
121 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25
122 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
123 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
124 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
125 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
126 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
127 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
128 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
129 INT310066 Negative_regulation of Pain1 Positive_regulation of Faah 1 0.03 1.32 1.23
130 INT310069 Negative_regulation of Pain1 Positive_regulation of Mgll 1 0.02 1.32 1.23
131 INT310068 Pain1 Positive_regulation of Faah 1 0.03 1.3 1.22
132 INT310067 Pain1 Positive_regulation of Mgll 1 0.02 1.29 1.21
133 INT62018 CSF2 Regulation of ACOT1 1 0.12 0.47 1.21
134 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
135 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
136 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19
137 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19
138 INT109380 Binding of Adarb1 and Fos 1 0.02 0.38 1.19
139 INT351715 Pax3 Negative_regulation of Adarb1 1 0.00 0 1.19
140 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
141 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
142 INT73075 Adarb1 Regulation of Fos 1 0.01 0.07 1.18
143 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
144 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
145 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
146 INT182159 Binding of HGF and DCPS 1 0.01 2.5 1.17
147 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
148 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
149 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
150 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
151 INT164722 Avp Regulation of NT5C 1 0.06 0.88 1.15
152 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
153 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
154 INT18596 Fdft1 Regulation of Localization of Acot1 1 0.06 0 1.14
155 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14
156 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
157 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
158 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
159 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
160 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
161 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
162 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
163 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
164 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
165 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
166 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
167 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
168 INT68161 Mthfs Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.12
169 INT68155 Pla2g1b Positive_regulation of Positive_regulation of Mthfs 1 0.03 0.64 1.12
170 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
171 INT285659 Binding of Faah and Mgll 1 0.15 0.99 1.11
172 INT207437 Binding of PLA2G7 and ERAL1 1 0.14 3.64 1.11
173 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11
174 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
175 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 0.11 0 1.11
176 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
177 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
178 INT21331 Binding of Adarb1 and Gm5195 1 0.00 0.26 1.08
179 INT33338 Adarb1 Positive_regulation of Localization of Gh1 1 0.04 0 1.08
180 INT37153 Binding of Mpz and Ptpn2 1 0.12 0.68 1.08
181 INT33336 Adarb1 Positive_regulation of Negative_regulation of Gh1 1 0.03 0 1.08
182 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 0.01 0 1.08
183 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
184 INT33337 Adarb1 Positive_regulation of Gh1 1 0.03 0 1.08
185 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
186 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
187 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 0.32 0.42 1.07
188 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 0.01 0.73 1.07
189 INT81581 Plec Positive_regulation of Nudt14 1 0.01 0 1.07
190 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
191 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
192 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
193 INT18828 DNM2 Positive_regulation of Localization of LTB4R 1 0.01 0.07 1.06
194 INT57509 Trh Negative_regulation of Adarb1 1 0.02 0.22 1.05
195 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05
196 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
197 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
198 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
199 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
200 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported in hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1352 Localization of Acot1 728 0.80 73.01 296.01
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92
4 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57
5 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35
6 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17
7 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4
8 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
9 INT4637 Binding of Adarb1 132 0.41 14.48 67.76
10 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
11 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13
12 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
13 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
14 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
15 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15
16 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
17 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03
18 INT5214 Localization of Cpe 49 0.73 13.3 44.36
19 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
20 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
21 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56
22 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78
23 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44
24 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23
25 INT2699 Binding of Cpe 40 0.48 7.07 33.64
26 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
27 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28
28 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01
29 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
30 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
31 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4
32 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
33 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89
34 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68
35 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59
36 INT605 Regulation of Acot1 61 0.62 10.7 26.34
37 INT276 Regulation of Ache 83 0.62 16.75 25.99
38 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
39 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39
40 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
41 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58
42 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89
43 INT45437 Localization of Acot1 84 0.79 17.37 22.18
44 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83
45 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
46 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36
47 INT4894 Transcription of Ppt1 34 0.67 5.93 21.06
48 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
49 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4
50 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
51 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
52 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88
53 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
54 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18
55 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
56 INT16110 Positive_regulation of ZC3H12D 30 0.46 6.27 18.72
57 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51
58 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
59 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
60 INT1060 Negative_regulation of Pla2g1b 50 0.57 22.91 18.12
61 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
62 INT21072 Localization of Adarb1 26 0.69 2.76 17.95
63 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
64 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81
65 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
66 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
67 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
68 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
69 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01
70 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87
71 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87
72 INT258328 Gene_expression of Aicda 76 0.71 58.29 16.86
73 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74
74 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
75 INT1000 Localization of Ggh 31 0.75 2.74 16.41
76 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4
77 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
78 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
79 INT19071 Localization of Ache 66 0.81 5.1 16.27
80 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
81 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86
82 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
83 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
84 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73
85 INT83682 Positive_regulation of Abcb1a 22 0.68 3.3 15.6
86 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1
87 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
88 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92
89 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
90 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
91 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52
92 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85
93 INT94051 Positive_regulation of Arg1 41 0.60 36.22 13.72
94 INT116367 Binding of Atp8a2 33 0.28 6.42 13.3
95 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
96 INT18616 Positive_regulation of Positive_regulation of Adarb1 18 0.33 2.04 13.18
97 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93
98 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87
99 INT84307 Binding of Cftr 31 0.47 26.19 12.8
100 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5
101 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
102 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
103 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12
104 INT107524 Gene_expression of Faah 17 0.78 7.93 11.91
105 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67
106 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57
107 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
108 INT48009 Gene_expression of Pde6b 38 0.68 15.03 11.41
109 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41
110 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
111 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
112 INT95585 Negative_regulation of Pde12 18 0.43 8.32 11.23
113 INT96259 Positive_regulation of Plcg1 11 0.49 3.01 11.15
114 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06
115 INT91357 Regulation of Dnm2 5 0.61 0 11.06
116 INT17826 Positive_regulation of Pla2g1b 39 0.70 11.35 10.97
117 INT20721 Localization of ACOT1 47 0.80 11.37 10.95
118 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8
119 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
120 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
121 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
122 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58
123 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
124 INT113765 Phosphorylation of Adarb1 10 0.05 4.91 10.51
125 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
126 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46
127 INT6574 Negative_regulation of Pla2g1b 35 0.59 11.4 10.44
128 INT54473 Binding of ABCB1 30 0.48 8.65 10.38
129 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3
130 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
131 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
132 INT1252 Binding of Ache 46 0.48 9.94 10.25
133 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
134 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
135 INT112969 Negative_regulation of Mcpt1 30 0.45 20.17 10.11
136 INT119777 Negative_regulation of Naalad2 9 0.40 5.93 10.11
137 INT27937 Gene_expression of Klkb1 35 0.55 1.86 10.08
138 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
139 INT64054 Positive_regulation of Tmprss11d 19 0.67 9.33 9.99
140 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
141 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
142 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94
143 INT113603 Negative_regulation of Gene_expression of Mcpt1 26 0.41 22.82 9.91
144 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
145 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73
146 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
147 INT15722 Positive_regulation of PPAP2A 25 0.43 4.83 9.65
148 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65
149 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55
150 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47
151 INT13610 Regulation of Acyp2-ps1 10 0.62 3.29 9.4
152 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
153 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31
154 INT106595 Negative_regulation of Dnm2 10 0.58 0.15 9.29
155 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
156 INT45209 Positive_regulation of PLA2G2A 37 0.69 33.21 9.02
157 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95
158 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
159 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83
160 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83
161 INT13432 Positive_regulation of Klkb1 23 0.57 5.36 8.65
162 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62
163 INT112967 Regulation of Mcpt1 15 0.54 13.03 8.58
164 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
165 INT105777 Gene_expression of Pde4a 30 0.76 12.67 8.52
166 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49
167 INT24651 Positive_regulation of Transcription of Ppt1 12 0.47 2.88 8.42
168 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
169 INT3983 Positive_regulation of Acot1 30 0.68 5.83 8.34
170 INT195203 Binding of Tenc1 14 0.32 13.97 8.28
171 INT12757 Negative_regulation of Positive_regulation of Acot1 16 0.42 2.27 8.25
172 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2
173 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
174 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
175 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13
176 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07
177 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
178 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03
179 INT116996 Regulation of Pgp 9 0.51 7.51 8.01
180 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
181 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
182 INT25958 Regulation of Ace 26 0.59 11.88 7.87
183 INT110004 Gene_expression of Plcg1 7 0.41 2.61 7.87
184 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83
185 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67
186 INT14207 Gene_expression of DNM2 20 0.67 5.76 7.64
187 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58
188 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
189 INT11441 Negative_regulation of Anpep 18 0.59 3.73 7.51
190 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48
191 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44
192 INT26707 Binding of PPAP2A 21 0.35 6.01 7.43
193 INT79456 Gene_expression of PDE4A 35 0.77 19.42 7.42
194 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4
195 INT524 Positive_regulation of Cpa1 12 0.39 4.74 7.38
196 INT2802 Negative_regulation of Asrgl1 14 0.59 2.69 7.37
197 INT152347 Binding of GCH1 8 0.37 6.13 7.36
198 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32
199 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
200 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28
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