GO:0016788

From wiki-pain
Jump to: navigation, search
Name hydrolase activity, acting on ester bonds
Categary Function
Go Slim No
Go Link GO:0016788
Unique Molecular Interactions 64
Total Molecular Interactions 103
Total Single Events 1005
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity, acting on ester bonds. They are ordered first by their pain relevance and then by number of times they were reported for hydrolase activity, acting on ester bonds. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142437 Urb1 Negative_regulation of Faah 3 0.41 2.12 1.66
2 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
3 INT310066 Negative_regulation of Pain1 Positive_regulation of Faah 1 0.03 1.32 1.23
4 INT310068 Pain1 Positive_regulation of Faah 1 0.03 1.3 1.22
5 INT285659 Binding of Faah and Mgll 1 0.15 0.99 1.11
6 INT141384 Urb1 Regulation of Faah 2 0.08 0.35 0.99
7 INT152490 Slc40a1 Negative_regulation of Faah 1 0.01 0.73 0.98
8 INT278490 Negative_regulation of Faah Positive_regulation of Trpv1 1 0.38 0.6 0.76
9 INT160985 Urb1 Negative_regulation of Negative_regulation of Faah 1 0.41 1.36 0.74
10 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
11 INT265144 Olah Positive_regulation of Prkcg 1 0.02 0 0.62
12 INT265140 Olah Regulation of Prkcg 1 0.01 0 0.62
13 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
14 INT156517 Binding of CNR1 and FAAH 3 0.38 1.53 0.53
15 INT328058 IL4 Positive_regulation of FAAH 1 0.29 4.29 0.53
16 INT156521 Binding of CNR2 and FAAH 1 0.38 0.19 0.46
17 INT156518 Binding of FAAH and NAPEPLD 1 0.38 0.19 0.46
18 INT218783 Binding of Faah and Cfp 1 0.04 0.55 0.45
19 INT79151 Binding of HLA-B and OLAH 1 0.01 0.79 0.44
20 INT79150 HLA-B Positive_regulation of OLAH 1 0.02 0.77 0.43
21 INT265137 Olah Positive_regulation of Localization of Marcks 1 0.03 0 0.42
22 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4
23 INT137380 SLC46A2 Negative_regulation of Faah 1 0.00 0 0.32
24 INT296473 Prkca Regulation of Serac1 1 0.00 0.14 0.3
25 INT4339 Binding of OLAH and Cea 1 0.00 0.79 0.29
26 INT169259 OLAH Positive_regulation of Slc35a2 1 0.19 0 0.29
27 INT328064 IL10 Positive_regulation of FAAH 1 0.05 1.48 0.26
28 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25
29 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
30 INT328059 IL4 Regulation of FAAH 1 0.25 4.57 0.21
31 INT59741 Faah Positive_regulation of Localization of Npy 1 0.01 0.16 0.21
32 INT59745 Faah Positive_regulation of Gene_expression of Npy 1 0.01 0.16 0.2
33 INT59743 Faah Positive_regulation of Transcription of Npy 1 0.01 0.16 0.2
34 INT283429 Nt5e Regulation of Gene_expression of Cxcr1 1 0.00 0.22 0.2
35 INT147229 Positive_regulation of Ccdc80 Negative_regulation of Faah 1 0.02 0.06 0.16
36 INT147230 Ccdc80 Negative_regulation of Faah 1 0.02 0.06 0.16
37 INT283428 Negative_regulation of Binding of Lcn2 and Nt5e 1 0.06 1.09 0.15
38 INT311255 Binding of Gpi1 and Nt5e 1 0.05 0.16 0.13
39 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
40 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
41 INT62775 Regulation of Binding of NT5E and OPRK1 1 0.03 0 0.1
42 INT62776 Binding of NT5E and OPRK1 1 0.02 0 0.1
43 INT152818 Faah Regulation of Trpc1 1 0.20 0.32 0.09
44 INT152817 Faah Regulation of Trpv1 1 0.29 0.32 0.09
45 INT283427 Lcn2 Positive_regulation of Nt5e 1 0.08 0.21 0.09
46 INT146842 Tnf Regulation of Lipe 1 0.19 0.4 0.08
47 INT135108 Binding of Olah and Sec22b 1 0.05 0 0.08
48 INT283425 Lcn2 Positive_regulation of Gene_expression of Nt5e 1 0.07 0.13 0.07
49 INT283433 Nt5e Positive_regulation of Localization of IL8 1 0.01 0.21 0.07
50 INT272852 Binding of SLI2 and IAH1 1 0.05 0.25 0.05
51 INT328057 IL4 Regulation of Binding of FAAH 1 0.19 1.1 0.04
52 INT307209 Fas Positive_regulation of Fasn 1 0.05 0.13 0.03
53 INT328065 IL4 Regulation of Gene_expression of FAAH 1 0.19 0.82 0.03
54 INT328066 FAAH Regulation of IL4 1 0.16 0.97 0.03
55 INT319700 Ins1 Negative_regulation of Lipe 1 0.04 1.22 0.03
56 INT227366 Binding of CES1 and PTER 1 0.24 0 0
57 INT323572 Negative_regulation of Lipe Positive_regulation of Positive_regulation of Ly6 1 0.00 0.1 0
58 INT227365 Binding of CES2 and PTER 1 0.25 0 0
59 INT215764 Dio1 Regulation of Ces1c 1 0.00 0.05 0
60 INT215685 Slc3a1 Regulation of Ces1c 1 0.00 0.05 0
61 INT228285 Binding of Ptprc and Nt5e 1 0.06 0.25 0
62 INT307213 Srebf1 Regulation of Gene_expression of Fasn 1 0.05 0.06 0
63 INT228286 Binding of Cd14 and Nt5e 1 0.20 0.25 0
64 INT256486 Si Negative_regulation of Gene_expression of Ces1c 1 0.00 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity, acting on ester bonds. They are ordered first by their pain relevance and then by number of times they were reported in hydrolase activity, acting on ester bonds. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03
2 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78
3 INT88365 Regulation of Faah 18 0.45 6.63 12.54
4 INT107524 Gene_expression of Faah 17 0.78 7.93 11.91
5 INT73338 Gene_expression of Faah 21 0.77 6.72 10.73
6 INT108405 Gene_expression of FAAH 48 0.78 28.22 9.97
7 INT133118 Negative_regulation of FAAH 25 0.59 13.05 9.37
8 INT73342 Protein_catabolism of Faah 19 0.97 5.11 8.99
9 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07
10 INT115733 Positive_regulation of Negative_regulation of Faah 8 0.50 3.62 7.26
11 INT110515 Regulation of Negative_regulation of Faah 5 0.43 2.84 5.2
12 INT19391 Gene_expression of Nt5e 44 0.72 13.99 5.14
13 INT73341 Positive_regulation of Faah 12 0.65 4.94 4.28
14 INT44705 Gene_expression of Olah 16 0.77 10.02 4.24
15 INT73339 Localization of Faah 7 0.75 4.47 4.24
16 INT3055 Binding of OLAH 9 0.28 7.14 3.99
17 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72
18 INT18954 Negative_regulation of OLAH 9 0.09 8.31 3.67
19 INT102573 Protein_catabolism of Faah 8 0.80 2.89 3.52
20 INT104671 Binding of Faah 7 0.37 1.75 3.25
21 INT92151 Regulation of Faah 5 0.62 6.31 3.06
22 INT150870 Regulation of Gene_expression of Faah 3 0.45 2.65 2.87
23 INT107525 Positive_regulation of Faah 5 0.60 1.54 2.78
24 INT108403 Protein_catabolism of FAAH 9 0.89 2.5 2.75
25 INT89026 Positive_regulation of Nt5e 12 0.49 7.25 2.67
26 INT150869 Positive_regulation of Gene_expression of Faah 4 0.70 3.78 2.2
27 INT52072 Negative_regulation of Ces1c 6 0.31 1.37 2.13
28 INT94673 Positive_regulation of FAAH 5 0.50 7.77 2.08
29 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03
30 INT133621 Positive_regulation of Gene_expression of Faah 5 0.65 2.07 1.93
31 INT168271 Regulation of Binding of Faah 1 0.45 0.91 1.81
32 INT115737 Regulation of Protein_catabolism of Faah 3 0.44 1 1.77
33 INT310063 Binding of Faah 1 0.32 1.36 1.76
34 INT222031 Localization of Nt5e 16 0.75 3.1 1.73
35 INT104093 Positive_regulation of Olah 4 0.39 1.45 1.71
36 INT12163 Positive_regulation of OLAH 8 0.68 6.91 1.67
37 INT241733 Negative_regulation of Nt5e 4 0.40 2.84 1.58
38 INT143744 Regulation of FAAH 6 0.61 8.42 1.55
39 INT296432 Phosphorylation of Serac1 5 0.02 1.46 1.52
40 INT143743 Positive_regulation of Gene_expression of FAAH 8 0.60 6.42 1.46
41 INT141272 Binding of FAAH 7 0.48 8.27 1.46
42 INT108402 Negative_regulation of Gene_expression of FAAH 6 0.43 5.99 1.39
43 INT96420 Positive_regulation of NT5E 9 0.49 3.7 1.38
44 INT155036 Localization of NT5E 6 0.73 4.1 1.35
45 INT133619 Negative_regulation of Gene_expression of Faah 4 0.47 1.21 1.32
46 INT265165 Localization of Olah 4 0.46 1.05 1.3
47 INT339387 Gene_expression of Lipe 1 0.20 2.39 1
48 INT158944 Regulation of Localization of Faah 1 0.39 0.85 0.96
49 INT138934 Transcription of Olah 2 0.44 1.05 0.92
50 INT283402 Binding of Nt5e 10 0.30 2.53 0.85
51 INT41083 Regulation of OLAH 3 0.36 2.01 0.83
52 INT287128 Protein_catabolism of NT5E 2 0.11 0.64 0.76
53 INT294133 Regulation of Gene_expression of NT5E 4 0.12 1.36 0.71
54 INT197781 Binding of Serac1 1 0.01 0.36 0.7
55 INT44704 Regulation of Olah 2 0.24 0.53 0.69
56 INT4195 Gene_expression of Ces1c 7 0.44 2.88 0.65
57 INT133620 Regulation of Gene_expression of Faah 1 0.37 0 0.65
58 INT265173 Negative_regulation of Olah 1 0.05 0 0.62
59 INT247550 Positive_regulation of Gene_expression of Nt5e 5 0.56 3.21 0.61
60 INT146813 Positive_regulation of Ces1c 4 0.46 0.95 0.61
61 INT155035 Binding of NT5E 3 0.36 1.78 0.61
62 INT35135 Positive_regulation of Lipe 2 0.45 1.25 0.58
63 INT265162 Regulation of Gene_expression of Olah 2 0.28 1.53 0.56
64 INT265177 Positive_regulation of Gene_expression of Olah 2 0.35 0.41 0.56
65 INT111198 Gene_expression of Fasn 8 0.55 2.54 0.52
66 INT147248 Positive_regulation of Positive_regulation of Faah 1 0.50 0.46 0.52
67 INT138935 Positive_regulation of Transcription of Olah 1 0.37 0.08 0.51
68 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46
69 INT133576 Negative_regulation of Protein_catabolism of Faah 1 0.30 0.25 0.46
70 INT265170 Negative_regulation of Gene_expression of Olah 2 0.26 2.18 0.45
71 INT139690 Positive_regulation of Protein_catabolism of FAAH 1 0.50 0.52 0.44
72 INT161690 Localization of FAAH 2 0.61 0.38 0.43
73 INT43874 Negative_regulation of Binding of OLAH 1 0.03 0.97 0.43
74 INT96419 Positive_regulation of Gene_expression of NT5E 3 0.49 1.46 0.41
75 INT108404 Negative_regulation of Protein_catabolism of FAAH 1 0.33 0.25 0.41
76 INT265158 Positive_regulation of Localization of Olah 1 0.06 0 0.4
77 INT265155 Negative_regulation of Localization of Olah 1 0.05 0 0.4
78 INT17882 Regulation of Gene_expression of OLAH 1 0.34 1.16 0.39
79 INT131998 Positive_regulation of Protein_catabolism of Faah 1 0.40 0 0.36
80 INT46533 Binding of Ces1c 9 0.12 0.18 0.34
81 INT299730 Localization of OLAH 1 0.03 1.07 0.34
82 INT287129 Regulation of NT5E 3 0.12 1.02 0.32
83 INT254886 Positive_regulation of Fasn 2 0.06 0.94 0.31
84 INT310065 Positive_regulation of Localization of Faah 1 0.38 0.26 0.29
85 INT150868 Negative_regulation of Gene_expression of Faah 1 0.43 0.72 0.29
86 INT4130 Regulation of Ces1c 2 0.18 0.36 0.28
87 INT137377 Positive_regulation of Positive_regulation of Faah 1 0.34 0 0.28
88 INT339381 Positive_regulation of Gene_expression of Lipe 1 0.13 0.65 0.26
89 INT310064 Localization of Faah 1 0.56 0.21 0.26
90 INT110743 Negative_regulation of Binding of Faah 1 0.42 0.18 0.24
91 INT280226 Regulation of Protein_catabolism of FAAH 1 0.22 0.18 0.23
92 INT118482 Negative_regulation of Fasn 3 0.31 0.83 0.21
93 INT283403 Phosphorylation of Nt5e 2 0.67 0.23 0.21
94 INT294138 Positive_regulation of Localization of NT5E 1 0.14 0.41 0.21
95 INT294141 Regulation of Localization of NT5E 1 0.12 0.42 0.21
96 INT283404 Positive_regulation of Phosphorylation of Nt5e 1 0.07 0.23 0.21
97 INT247566 Transcription of Nt5e 3 0.17 1.73 0.19
98 INT136107 Negative_regulation of Negative_regulation of Faah 1 0.39 0.38 0.19
99 INT19647 Transcription of OLAH 1 0.00 0.77 0.18
100 INT161923 Positive_regulation of Binding of Faah 1 0.39 0.18 0.17
101 INT272856 Gene_expression of IAH1 1 0.10 0.51 0.16
102 INT133020 Binding of Olah 1 0.30 0.18 0.16
103 INT328073 Regulation of Binding of FAAH 1 0.42 1.01 0.16
104 INT280229 Regulation of Gene_expression of FAAH 3 0.57 2.06 0.15
105 INT95647 Negative_regulation of Negative_regulation of Faah 1 0.42 0.12 0.15
106 INT129362 Regulation of Fasn 1 0.24 0.7 0.12
107 INT261198 Phosphorylation of Lipe 1 0.07 0.92 0.1
108 INT256474 Localization of Ces1c 5 0.08 0.15 0.08
109 INT247554 Negative_regulation of Negative_regulation of Nt5e 1 0.10 1.85 0.08
110 INT272855 Positive_regulation of Gene_expression of IAH1 1 0.07 0.42 0.08
111 INT220331 Negative_regulation of IAH1 2 0.19 1.52 0.07
112 INT328069 Regulation of Transcription of FAAH 1 0.25 2.28 0.07
113 INT247552 Regulation of Nt5e 1 0.05 2.07 0.07
114 INT103704 Transcription of Faah 1 0.71 0.07 0.07
115 INT328075 Transcription of FAAH 1 0.50 2.26 0.07
116 INT339380 Regulation of Gene_expression of Lipe 1 0.11 0.26 0.06
117 INT178263 Positive_regulation of Gene_expression of Fasn 1 0.14 1.25 0.04
118 INT328071 Positive_regulation of Binding of FAAH 1 0.47 1.09 0.04
119 INT283401 Positive_regulation of Binding of Nt5e 1 0.06 0.41 0.04
120 INT172322 Negative_regulation of Gene_expression of Nt5e 1 0.41 1.03 0.04
121 INT283409 Positive_regulation of Transcription of Nt5e 1 0.07 0.06 0.03
122 INT220329 Positive_regulation of IAH1 3 0.20 4.37 0
123 INT215734 Regulation of Gene_expression of Ces1c 2 0.06 0 0
124 INT324519 Binding of IAH1 2 0.13 1.43 0
125 INT256475 Regulation of Binding of Ces1c 2 0.04 0.05 0
126 INT144917 Negative_regulation of Positive_regulation of Faah 1 0.40 0 0
127 INT283405 Positive_regulation of Localization of Nt5e 1 0.07 0 0
128 INT109291 Positive_regulation of Regulation of Faah 1 0.47 0.14 0
129 INT256484 Regulation of Phosphorylation of Ces1c 1 0.04 0.16 0
130 INT328072 Phosphorylation of FAAH 1 0.66 0.86 0
131 INT323525 Regulation of Lipe 1 0.01 0.09 0
132 INT311251 Protein_catabolism of Nt5e 1 0.53 0 0
133 INT283398 Negative_regulation of Binding of Nt5e 1 0.05 0.46 0
134 INT256477 Positive_regulation of Gene_expression of Ces1c 1 0.04 0.31 0
135 INT280225 Positive_regulation of Regulation of FAAH 1 0.38 0.64 0
136 INT256479 Phosphorylation of Ces1c 1 0.08 0.16 0
137 INT323514 Negative_regulation of Lipe 1 0.02 0.1 0
138 INT329193 Regulation of Binding of NT5E 1 0.07 0.67 0
139 INT118483 Negative_regulation of Gene_expression of Fasn 1 0.42 0.21 0
140 INT256476 Negative_regulation of Gene_expression of Ces1c 1 0.04 0.39 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox