GO:0016790

From wiki-pain
Jump to: navigation, search
Name thiolester hydrolase activity
Categary Function
Go Slim No
Go Link GO:0016790
Unique Molecular Interactions 92
Total Molecular Interactions 127
Total Single Events 2203
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thiolester hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported for thiolester hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
2 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
3 INT17299 Prss12 Regulation of Localization of Acot1 3 0.05 0 2.07
4 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
5 INT30743 Cck Regulation of Localization of Acot1 1 0.02 0 1.64
6 INT18592 Sst Regulation of Localization of Acot1 2 0.22 0 1.61
7 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
8 INT62018 CSF2 Regulation of ACOT1 1 0.12 0.47 1.21
9 INT18596 Fdft1 Regulation of Localization of Acot1 1 0.06 0 1.14
10 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 0.11 0 1.11
11 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
12 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
13 INT18595 Fdft1 Positive_regulation of Localization of Acot1 1 0.08 0 0.96
14 INT18597 Sst Positive_regulation of Localization of Acot1 1 0.29 0 0.96
15 INT154259 Nts Positive_regulation of Acot1 1 0.04 0 0.91
16 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87
17 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85
18 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84
19 INT128739 Penk Negative_regulation of Acot1 1 0.19 0 0.77
20 INT164713 Binding of Avp and Positive_regulation of Localization of Acot1 1 0.32 0.43 0.69
21 INT164715 Avp Positive_regulation of Localization of Acot1 1 0.28 0.43 0.69
22 INT172698 Ugt1a6 Negative_regulation of Localization of Acot1 1 0.01 0 0.68
23 INT56669 Nts Regulation of Localization of Acot1 2 0.12 0 0.65
24 INT164721 Binding of NT5C and Acot1 1 0.04 0.45 0.65
25 INT164714 Binding of Avp and Acot1 1 0.26 0.45 0.64
26 INT190525 Acot1 Positive_regulation of Localization of S100a8 1 0.00 0.86 0.63
27 INT190526 Acot1 Positive_regulation of Il1 1 0.01 0.87 0.63
28 INT28032 TNIP3 Negative_regulation of Acot1 1 0.00 0 0.47
29 INT109780 WAS Regulation of Localization of Acot1 1 0.01 0.26 0.46
30 INT53649 Acot1 Positive_regulation of Calca 1 0.25 0 0.44
31 INT87009 Acot1 Negative_regulation of Hc3 1 0.19 0.34 0.43
32 INT5531 Binding of Acot1 and Chrna2 1 0.12 0 0.42
33 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42
34 INT171186 Binding of PPFIA4 and ACOT1 1 0.00 0.37 0.42
35 INT171183 Binding of BHLHE23 and ACOT1 1 0.01 0.36 0.42
36 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
37 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
38 INT49123 Negative_regulation of Nka1 Positive_regulation of Acot1 1 0.06 0 0.38
39 INT49122 Nka1 Positive_regulation of Acot1 1 0.07 0 0.38
40 INT340850 Binding of IGHE and Baat 1 0.07 0.27 0.37
41 INT87769 Binding of Acot1 and Treh 1 0.00 0 0.35
42 INT343366 Acsf2 Negative_regulation of Acot1 1 0.05 0 0.31
43 INT58898 Adcyap1 Regulation of Localization of Acot1 1 0.17 0 0.28
44 INT58899 Vip Regulation of Localization of Acot1 1 0.17 0 0.28
45 INT272174 Acot1 Regulation of Ca2 1 0.01 0 0.26
46 INT40964 Binding of Eef1a1 and Positive_regulation of Localization of Acot1 1 0.08 0 0.26
47 INT160225 Acot1 Negative_regulation of Ache 1 0.28 2.18 0.25
48 INT97868 Binding of Chrna2 and Regulation of Acot1 1 0.09 0 0.23
49 INT124383 ACOT1 Positive_regulation of MME 1 0.01 0.17 0.22
50 INT167486 Positive_regulation of Binding of CD63 and ACOT1 1 0.01 0 0.21
51 INT167485 Binding of CD63 and ACOT1 1 0.00 0 0.21
52 INT80927 Acot1 Positive_regulation of Car2 1 0.31 0 0.2
53 INT180441 Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19
54 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
55 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
56 INT60417 Chrm1 Regulation of Localization of Acot1 1 0.13 0 0.19
57 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
58 INT159720 Slc5a7 Regulation of Gene_expression of Acot1 1 0.12 0 0.19
59 INT180440 Positive_regulation of Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19
60 INT159722 Slc5a7 Positive_regulation of Gene_expression of Acot1 1 0.12 0 0.19
61 INT159721 Hc3 Negative_regulation of Gene_expression of Acot1 1 0.04 0 0.19
62 INT60348 Trh Positive_regulation of Positive_regulation of Acot1 1 0.29 0.44 0.17
63 INT10197 Dclk2 Positive_regulation of Localization of Acot1 1 0.03 0.26 0.15
64 INT10198 Dclk2 Regulation of Localization of Acot1 1 0.02 0.26 0.15
65 INT141224 Ache Regulation of Acot1 1 0.09 0.29 0.14
66 INT75791 Positive_regulation of Htr3a Regulation of Acot1 1 0.23 0.12 0.14
67 INT110107 Acot1 Positive_regulation of Localization of Prkce 1 0.11 0 0.12
68 INT104327 Fen1 Negative_regulation of Baat 1 0.31 0.75 0.12
69 INT104325 Regulation of Fen1 Negative_regulation of Baat 1 0.19 0.75 0.12
70 INT141223 Bche Regulation of Gene_expression of Acot1 1 0.09 0 0.1
71 INT141225 Bche Regulation of Acot1 1 0.09 0 0.1
72 INT5529 Acot1 Positive_regulation of Chrna2 1 0.17 0 0.09
73 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08
74 INT227303 Zbp1 Regulation of Transcription of Baat 1 0.09 1.43 0.08
75 INT205589 Binding of PPT2 and COQ2 1 0.04 1.02 0.07
76 INT5530 Positive_regulation of Binding of Acot1 and Chrna2 1 0.15 0 0.07
77 INT291174 Rpa1 Positive_regulation of Baat 1 0.03 0.63 0.04
78 INT266452 Binding of Acot1 and GOPC 1 0.02 1.23 0.04
79 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04
80 INT266039 Binding of Acot1 and Amh-rs5 1 0.00 0.13 0.04
81 INT251701 Bche Regulation of Gene_expression of Acot1 1 0.03 0.25 0.03
82 INT49894 Acot1 Positive_regulation of Rrsv 1 0.10 0 0
83 INT266453 SNRNP70 Regulation of Acot1 1 0.00 0.53 0
84 INT268013 Binding of Nos3 and Acot1 1 0.02 1.48 0
85 INT104328 Fen1 Positive_regulation of Baat 1 0.33 0.63 0
86 INT205588 Binding of SNRNP70 and PPT2 1 0.03 0.26 0
87 INT104326 Regulation of Fen1 Positive_regulation of Baat 1 0.19 0.63 0
88 INT181835 Binding of Baat and Ppara 1 0.09 0.31 0
89 INT291173 Ins1 Regulation of Baat 1 0.12 0.83 0
90 INT192087 Atr Regulation of Localization of Acot1 1 0.04 0 0
91 INT49893 Acot1 Positive_regulation of Nrf1 1 0.00 0 0
92 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thiolester hydrolase activity. They are ordered first by their pain relevance and then by number of times they were reported in thiolester hydrolase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1352 Localization of Acot1 728 0.80 73.01 296.01
2 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35
3 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17
4 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13
5 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56
6 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44
7 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68
8 INT605 Regulation of Acot1 61 0.62 10.7 26.34
9 INT45437 Localization of Acot1 84 0.79 17.37 22.18
10 INT20721 Localization of ACOT1 47 0.80 11.37 10.95
11 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46
12 INT3983 Positive_regulation of Acot1 30 0.68 5.83 8.34
13 INT12757 Negative_regulation of Positive_regulation of Acot1 16 0.42 2.27 8.25
14 INT127 Positive_regulation of ACOT1 16 0.32 5.12 6.57
15 INT45101 Positive_regulation of Gene_expression of Acot1 13 0.40 2.2 6.55
16 INT13854 Positive_regulation of Positive_regulation of Acot1 13 0.50 1.78 6.03
17 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43
18 INT27803 Regulation of ACOT1 16 0.38 5.94 4.64
19 INT45433 Positive_regulation of Localization of Acot1 18 0.45 1.9 4.32
20 INT3722 Negative_regulation of Acot1 19 0.42 4.88 4.21
21 INT94132 Binding of ACOT1 7 0.13 2.62 4.04
22 INT5526 Binding of Acot1 13 0.30 0.67 4
23 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52
24 INT115227 Regulation of Localization of Acot1 12 0.60 0.15 3.51
25 INT41490 Regulation of Acot1 14 0.45 1.59 3.34
26 INT27973 Gene_expression of ACOT1 31 0.65 15.7 3.15
27 INT20722 Regulation of Localization of ACOT1 5 0.27 1.43 2.86
28 INT20060 Protein_catabolism of Acot1 6 0.56 0.22 2.45
29 INT70420 Positive_regulation of Localization of ACOT1 11 0.30 1.26 2.25
30 INT20720 Negative_regulation of Localization of ACOT1 6 0.35 2.66 2.25
31 INT22719 Negative_regulation of Negative_regulation of Acot1 5 0.43 0.77 2.2
32 INT42172 Negative_regulation of Gene_expression of Acot1 7 0.38 1.64 1.96
33 INT117024 Negative_regulation of Localization of Acot1 6 0.41 1.56 1.7
34 INT159718 Negative_regulation of Gene_expression of Acot1 4 0.16 1.4 1.56
35 INT56309 Positive_regulation of Baat 9 0.39 8.47 1.51
36 INT60220 Positive_regulation of Gene_expression of Acot1 6 0.38 0.52 1.49
37 INT62021 Negative_regulation of Positive_regulation of ACOT1 1 0.18 0.51 1.24
38 INT133112 Regulation of Baat 2 0.61 11.99 1.2
39 INT132987 Positive_regulation of Positive_regulation of Acot1 5 0.39 1.43 1.12
40 INT56310 Gene_expression of Baat 15 0.44 15.5 1.11
41 INT20061 Negative_regulation of Protein_catabolism of Acot1 2 0.36 0 1.08
42 INT22720 Regulation of Negative_regulation of Acot1 3 0.24 0.34 1.04
43 INT123577 Negative_regulation of Positive_regulation of Baat 2 0.58 1.78 1.02
44 INT87765 Binding of Acot1 4 0.07 2.59 0.95
45 INT45082 Protein_catabolism of Acot1 4 0.20 1.15 0.92
46 INT17296 Regulation of Positive_regulation of Acot1 2 0.24 0.29 0.65
47 INT44696 Gene_expression of Baat 5 0.64 3.1 0.59
48 INT107422 Positive_regulation of Regulation of Acot1 1 0.37 0 0.59
49 INT90984 Transcription of PPT2 1 0.08 0.07 0.58
50 INT356226 Positive_regulation of Transcription of Acot1 1 0.06 0.28 0.54
51 INT356223 Transcription of Acot1 1 0.07 0.28 0.54
52 INT22721 Regulation of Protein_catabolism of Acot1 2 0.23 0.17 0.53
53 INT340845 Regulation of Baat 1 0.08 0 0.47
54 INT166858 Positive_regulation of Protein_catabolism of Acot1 1 0.10 0 0.43
55 INT104324 Negative_regulation of Baat 4 0.38 9.79 0.42
56 INT166857 Negative_regulation of Protein_catabolism of Acot1 1 0.12 0 0.42
57 INT32052 Positive_regulation of Negative_regulation of Acot1 2 0.24 0.73 0.41
58 INT104323 Regulation of Positive_regulation of Baat 2 0.39 1.61 0.38
59 INT44695 Binding of Baat 1 0.26 0.67 0.32
60 INT45081 Negative_regulation of Negative_regulation of Acot1 1 0.03 0 0.28
61 INT46357 Regulation of Gene_expression of Acot1 4 0.45 1.1 0.26
62 INT45435 Positive_regulation of Negative_regulation of Acot1 2 0.39 0 0.26
63 INT45434 Negative_regulation of Positive_regulation of Acot1 2 0.41 0 0.25
64 INT44697 Positive_regulation of Gene_expression of Baat 1 0.42 0.6 0.24
65 INT133113 Positive_regulation of Positive_regulation of Baat 1 0.46 0.57 0.22
66 INT181826 Transcription of Baat 4 0.35 4.43 0.2
67 INT181819 Binding of Baat 2 0.24 0.96 0.19
68 INT287253 Regulation of Negative_regulation of ACOT1 1 0.06 0.22 0.15
69 INT227280 Regulation of Gene_expression of Baat 4 0.26 3.82 0.14
70 INT73811 Regulation of Regulation of Acot1 1 0.05 0.07 0.14
71 INT63907 Regulation of Positive_regulation of Acot1 1 0.20 0.14 0.12
72 INT287252 Positive_regulation of Gene_expression of ACOT1 1 0.05 0.18 0.12
73 INT246312 Regulation of Gene_expression of Acot1 2 0.07 0.15 0.1
74 INT242256 Negative_regulation of Regulation of ACOT1 1 0.26 0.53 0.1
75 INT220704 Protein_catabolism of ACOT1 1 0.02 1.19 0.08
76 INT227277 Regulation of Transcription of Baat 1 0.19 1.02 0.05
77 INT227263 Negative_regulation of Gene_expression of Baat 2 0.24 2.78 0.03
78 INT181830 Positive_regulation of Transcription of Baat 1 0.18 0.31 0
79 INT205595 Gene_expression of PPT2 1 0.05 0 0
80 INT180416 Phosphorylation of Acot1 1 0.09 0.19 0
81 INT307985 Positive_regulation of Negative_regulation of ACOT1 1 0.01 0.26 0
82 INT49891 Positive_regulation of Regulation of Acot1 1 0.11 0 0
83 INT348051 Transcription of ACOT1 1 0.44 0.58 0
84 INT227264 Localization of Baat 1 0.32 0.46 0
85 INT205597 Positive_regulation of PPT2 1 0.05 0.43 0
86 INT348050 Negative_regulation of Gene_expression of ACOT1 1 0.27 1.05 0
87 INT180421 Positive_regulation of Phosphorylation of Acot1 1 0.07 0.14 0
88 INT205599 Binding of PPT2 1 0.04 0.74 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox