GO:0016820

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Name hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Categary Function
Go Slim No
Go Link GO:0016820
Unique Molecular Interactions 82
Total Molecular Interactions 103
Total Single Events 938
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. They are ordered first by their pain relevance and then by number of times they were reported for hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
3 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
4 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14
5 INT214408 ATP1A4 Regulation of DNAH8 1 0.04 1.01 0.94
6 INT214409 ATP1A4 Regulation of CAPN1 1 0.01 1.01 0.93
7 INT125626 Binding of Calca and Atp8a2 1 0.00 0.4 0.76
8 INT38512 Binding of Cyp2c22 and Atp6v1c2 1 0.00 0.17 0.73
9 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
10 INT105809 ATP8A2 Positive_regulation of P2RX2 1 0.13 0.11 0.7
11 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
12 INT116369 Binding of Calca and Atp8a2 1 0.02 0.38 0.56
13 INT151558 ERLEC1 Regulation of Atp2a1 1 0.00 0.64 0.53
14 INT151557 NARG2 Regulation of Atp2a1 1 0.01 0.64 0.53
15 INT17308 Ifng Positive_regulation of Atp8a1 1 0.64 0.45 0.41
16 INT172094 Binding of Atp9a and Il27ra 1 0.01 0.98 0.4
17 INT171940 Binding of TNF and ATP2C1 1 0.08 7.32 0.39
18 INT172095 Binding of Atp9a and Trav6-3 1 0.03 0.98 0.39
19 INT179207 KCNAB2 Regulation of Gene_expression of ATP1A4 1 0.00 1.25 0.37
20 INT107189 Atp2a2 Negative_regulation of Atp2a1 1 0.27 0 0.26
21 INT305854 Polk Regulation of Gene_expression of Atp11c 1 0.05 0.73 0.26
22 INT65946 Ins1 Positive_regulation of Atp2b4 1 0.20 0.46 0.25
23 INT144800 Binding of TRPV1 and ATP8A2 1 0.22 0.14 0.23
24 INT167561 TRAP Positive_regulation of ATP8A2 1 0.17 0.56 0.23
25 INT171938 Binding of HLA-DOA and ATP2C1 1 0.01 3.88 0.2
26 INT115356 Binding of HLA-G and ATP8A1 1 0.00 0.52 0.15
27 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
28 INT347639 Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
29 INT65560 Binding of Atp9b and ANGPTL5 2 0.10 0.34 0.13
30 INT171942 Binding of HLA-DRB1 and ATP2C1 1 0.04 2.18 0.12
31 INT305855 Polk Regulation of Atp11c 1 0.02 0.73 0.11
32 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1
33 INT237813 Binding of Atp2a2 and soc 1 0.02 0 0.09
34 INT218857 INPP5E Regulation of ATP12A 1 0.01 1.95 0.09
35 INT235964 Binding of Atp9a and Aqp4 1 0.01 0.55 0.08
36 INT335444 Binding of Atp8a2 and Trpv1 1 0.01 0.4 0.08
37 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08
38 INT205537 ATP8A2 Negative_regulation of Negative_regulation of RHOXF2 1 0.01 0 0.07
39 INT237823 Binding of Atp2a2 and Stim1 1 0.06 0 0.07
40 INT328145 H2-Q13 Positive_regulation of Atp10a 1 0.54 1.23 0.07
41 INT328144 H2-Q13 Positive_regulation of Gene_expression of Atp10a 1 0.54 1.23 0.07
42 INT348690 Atp9a Positive_regulation of Gene_expression of Fgf2 1 0.00 0.21 0.05
43 INT285184 Negative_regulation of Atp2a2 Negative_regulation of Localization of Ca2 1 0.04 0.66 0.05
44 INT143993 Prdx2 Positive_regulation of Atp13a4 1 0.00 0 0.05
45 INT348694 Atp9a Negative_regulation of Serpine1 1 0.00 0.24 0.03
46 INT331324 Binding of HLA-G and Atp8a1 1 0.03 0.16 0.03
47 INT348691 Atp9a Positive_regulation of Plau 1 0.00 0.31 0.03
48 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
49 INT298054 Binding of Atp9a and Bpifa2 1 0.00 0.33 0
50 INT196954 Binding of Atp8a1 and E2f1 1 0.40 0.49 0
51 INT249200 ATP2A2 Negative_regulation of CA2 1 0.01 0 0
52 INT256825 Binding of Atp2b4 and Chordc1 1 0.02 0.27 0
53 INT317313 Atp13a2 Negative_regulation of Snca 1 0.13 0.59 0
54 INT297005 Binding of ATP12A and ATP6V0A1 1 0.04 0.3 0
55 INT348693 Atp9a Positive_regulation of Fgf2 1 0.00 0.07 0
56 INT320767 Atp11c Negative_regulation of Dsg1a 1 0.05 1.71 0
57 INT320771 Atp11c Regulation of Localization of Dsg1a 1 0.03 1.46 0
58 INT342432 Binding of Rhoa and Positive_regulation of Atp9a 1 0.20 0 0
59 INT298051 Binding of Atp9a and Vip 1 0.00 0 0
60 INT280138 Binding of NOVA2 and Atp9a 1 0.00 1.32 0
61 INT258923 Binding of CD8A and Atp8a1 1 0.23 0.07 0
62 INT240723 Atp2b2 Positive_regulation of Localization of Ca2 1 0.11 0.43 0
63 INT65561 Binding of VWF and Atp9b 1 0.22 0.34 0
64 INT81743 Tgfb1 Negative_regulation of Gene_expression of Atp9a 1 0.00 0.21 0
65 INT328142 Binding of Atp10a and Snrpn 1 0.30 0.3 0
66 INT109766 Binding of B4GALNT1 and ATP8A2 1 0.00 0.18 0
67 INT348692 Atp9a Positive_regulation of Gene_expression of Mmp9 1 0.00 0.07 0
68 INT317320 Binding of Snca and Atp13a2 1 0.08 0.58 0
69 INT273287 Binding of Atp2a2 and Pln 1 0.08 0.26 0
70 INT348695 Atp9a Positive_regulation of Mmp9 1 0.00 0.07 0
71 INT273290 Binding of Atp2a2 and Tlx2 1 0.05 0.26 0
72 INT278219 CIITA Positive_regulation of Gene_expression of Atp9a 1 0.00 0.1 0
73 INT240724 Atp2b2 Positive_regulation of Ca2 1 0.11 0.54 0
74 INT300891 Binding of Atp9a and Tgm2 1 0.00 0.39 0
75 INT278215 Ciita Positive_regulation of Gene_expression of Atp9a 1 0.11 0.1 0
76 INT336781 Negative_regulation of ERAP2 Negative_regulation of Atp8a1 1 0.48 0.31 0
77 INT320769 Atp11c Regulation of Dsg1a 1 0.05 5.87 0
78 INT300892 Binding of Atp8a1 and Tgm2 1 0.01 0.68 0
79 INT300890 Binding of Atp9a and Cd79a 1 0.00 0 0
80 INT273291 Atp2a2 Regulation of Car2 1 0.10 0.31 0
81 INT189107 Binding of Atp8a1 and Tap1 1 0.39 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. They are ordered first by their pain relevance and then by number of times they were reported in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01
2 INT116367 Binding of Atp8a2 33 0.28 6.42 13.3
3 INT125624 Gene_expression of Atp8a2 12 0.15 3.91 4.85
4 INT26229 Positive_regulation of ATP8A2 6 0.67 2.1 4.48
5 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26
6 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94
7 INT328127 Gene_expression of Atp10a 1 0.75 6.42 3.67
8 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52
9 INT102741 Gene_expression of Atp9b 20 0.75 8.01 3.34
10 INT81280 Binding of Atp9a 20 0.47 11.14 3.24
11 INT108728 Regulation of ATP1A2 4 0.45 3.65 3.04
12 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04
13 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65
14 INT162682 Phosphorylation of Atp9a 1 0.80 0 2.57
15 INT114011 Negative_regulation of ATP1A2 5 0.45 6.12 2.41
16 INT27114 Gene_expression of Atp11c 20 0.42 22.22 2.37
17 INT88183 Localization of Atp2a2 6 0.63 2.1 2.22
18 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96
19 INT101432 Positive_regulation of Gene_expression of Atp9a 13 0.10 7.86 1.95
20 INT51000 Positive_regulation of Atp9a 12 0.49 5.63 1.93
21 INT41359 Negative_regulation of Atp2b4 10 0.46 3.32 1.76
22 INT56590 Positive_regulation of Atp2b4 7 0.28 2.64 1.76
23 INT103959 Gene_expression of ATP1A2 3 0.67 2.47 1.68
24 INT116368 Localization of Atp8a2 4 0.07 1.43 1.66
25 INT23606 Regulation of Atp2b4 10 0.25 3.33 1.63
26 INT101431 Negative_regulation of Gene_expression of Atp9a 12 0.06 4.64 1.57
27 INT82866 Localization of Atp9a 13 0.78 6.95 1.56
28 INT24414 Negative_regulation of ATP8A2 5 0.43 1.63 1.46
29 INT114013 Binding of ATP1A2 3 0.47 3.51 1.46
30 INT118581 Positive_regulation of ATP1A2 3 0.21 1.81 1.4
31 INT103960 Gene_expression of ATP1A4 4 0.73 3.05 1.34
32 INT259459 Positive_regulation of Atp8a2 3 0.01 1.64 1.34
33 INT179217 Positive_regulation of ATP1A4 2 0.11 0.91 1.34
34 INT141082 Transcription of Atp9a 6 0.15 3.56 1.26
35 INT92331 Gene_expression of ATP8A2 6 0.75 2.99 1.21
36 INT24416 Localization of ATP8A2 4 0.73 2.21 1.2
37 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14
38 INT101433 Regulation of Gene_expression of Atp9a 7 0.10 5.77 1.13
39 INT191145 Positive_regulation of Gene_expression of Atp8a1 14 0.67 5.24 1.02
40 INT219993 Regulation of Gene_expression of Atp9b 1 0.44 2.3 0.96
41 INT214417 Regulation of ATP1A4 1 0.38 1.01 0.93
42 INT106495 Positive_regulation of Localization of Atp2a2 1 0.37 0.19 0.91
43 INT20352 Binding of ATP8A2 3 0.35 1.01 0.89
44 INT21246 Negative_regulation of ATP1A4 3 0.10 3.3 0.79
45 INT17302 Positive_regulation of Atp8a1 7 0.49 2.56 0.78
46 INT73429 Negative_regulation of Atp2a2 20 0.20 9.05 0.74
47 INT121618 Negative_regulation of Atp6v1c2 1 0.43 0.66 0.7
48 INT125625 Positive_regulation of Binding of Atp8a2 1 0.00 0.36 0.69
49 INT102738 Binding of Atp9b 4 0.36 1.65 0.68
50 INT20213 Binding of Atp11c 6 0.08 2.11 0.66
51 INT262633 Negative_regulation of Gene_expression of Atp8a1 7 0.57 2.52 0.65
52 INT81075 Negative_regulation of Atp9b 7 0.57 1.39 0.64
53 INT147063 Negative_regulation of Atp11c 3 0.06 2.28 0.61
54 INT152763 Binding of ATP2C1 2 0.32 4.11 0.61
55 INT68143 Localization of Atp13a4 1 0.00 0 0.61
56 INT292065 Negative_regulation of Binding of Atp8a2 1 0.01 0.57 0.58
57 INT107187 Gene_expression of Atp2a1 1 0.43 0 0.52
58 INT53282 Negative_regulation of Atp2b2 4 0.15 2.6 0.45
59 INT166435 Negative_regulation of Atp2a2 8 0.43 0.4 0.44
60 INT78592 Positive_regulation of Atp9b 4 0.49 1.54 0.44
61 INT61149 Regulation of Atp11c 1 0.11 1.67 0.43
62 INT219991 Negative_regulation of Gene_expression of Atp9b 2 0.41 0.9 0.41
63 INT107188 Regulation of Gene_expression of Atp2a2 1 0.54 0 0.39
64 INT171953 Regulation of ATP2C1 1 0.07 2.21 0.38
65 INT9344 Regulation of Atp9a 6 0.28 1.74 0.37
66 INT179223 Regulation of Gene_expression of ATP1A4 1 0.02 1.23 0.37
67 INT152764 Gene_expression of ATP2C1 1 0.58 0.72 0.33
68 INT164827 Negative_regulation of Atp2a1 1 0.43 0.15 0.32
69 INT86128 Negative_regulation of ATP2C1 1 0.09 1.65 0.31
70 INT81174 Regulation of Atp9b 1 0.30 0 0.28
71 INT179215 Positive_regulation of Gene_expression of ATP1A4 1 0.06 0.24 0.28
72 INT239955 Gene_expression of Atp2a1 7 0.29 0.78 0.26
73 INT130293 Negative_regulation of Gene_expression of ATP8A2 1 0.42 0.8 0.26
74 INT52267 Localization of Atp2b4 1 0.21 0.89 0.25
75 INT166432 Positive_regulation of Atp2a2 5 0.44 0.45 0.24
76 INT187459 Positive_regulation of Positive_regulation of Atp9a 1 0.07 0.71 0.24
77 INT179220 Negative_regulation of Gene_expression of ATP1A4 1 0.04 1.11 0.24
78 INT186624 Localization of Atp8a1 5 0.73 1.06 0.22
79 INT67962 Protein_catabolism of ATP8A2 1 0.64 0.7 0.22
80 INT171955 Localization of ATP2C1 1 0.12 4.02 0.22
81 INT219986 Positive_regulation of Gene_expression of Atp9b 1 0.49 0.54 0.22
82 INT65834 Negative_regulation of ATP2A2 4 0.07 2.39 0.21
83 INT300326 Transcription of Atp9b 7 0.12 0.39 0.2
84 INT102742 Positive_regulation of Binding of Atp9b 1 0.49 0.38 0.2
85 INT354927 Positive_regulation of Gene_expression of ATP8A2 1 0.02 1.39 0.19
86 INT6838 Binding of Atp2b4 4 0.08 0.8 0.18
87 INT27160 Positive_regulation of Atp13a4 1 0.00 0.74 0.18
88 INT135566 Positive_regulation of Positive_regulation of Atp2b4 1 0.01 0.45 0.18
89 INT328124 Negative_regulation of Gene_expression of Atp10a 1 0.41 0 0.17
90 INT71436 Negative_regulation of Gene_expression of Atp11c 1 0.23 1.87 0.17
91 INT71437 Positive_regulation of Gene_expression of Atp11c 2 0.27 5.63 0.16
92 INT271019 Negative_regulation of Atp2a1 1 0.19 1.75 0.16
93 INT164832 Positive_regulation of Atp2a1 1 0.30 0.07 0.16
94 INT164828 Negative_regulation of Negative_regulation of Atp2a1 1 0.31 0.07 0.16
95 INT24413 Negative_regulation of Localization of ATP8A2 1 0.42 0.08 0.16
96 INT276766 Negative_regulation of ATP8A1 1 0.01 1.76 0.16
97 INT166433 Gene_expression of Atp2a2 7 0.68 2.82 0.15
98 INT328137 Positive_regulation of Gene_expression of Atp10a 1 0.49 0.49 0.15
99 INT297202 Regulation of Atp2a2 2 0.16 1.71 0.14
100 INT259458 Positive_regulation of Gene_expression of Atp8a2 1 0.01 0.51 0.14
101 INT114012 Negative_regulation of Binding of ATP1A2 1 0.45 1.01 0.14
102 INT6837 Positive_regulation of Binding of Atp2b4 1 0.00 0 0.14
103 INT328125 Localization of Atp10a 1 0.73 0.09 0.13
104 INT334565 Localization of Atp9b 1 0.01 0 0.13
105 INT27117 Transcription of Atp11c 2 0.06 1.09 0.12
106 INT129426 Transcription of ATP8A2 1 0.23 0.24 0.12
107 INT189093 Binding of Atp8a1 10 0.47 2.6 0.11
108 INT37060 Transcription of Atp8a1 4 0.67 2.39 0.11
109 INT259460 Negative_regulation of Atp8a2 1 0.01 0.51 0.11
110 INT178185 Regulation of Atp8a1 2 0.44 1.7 0.1
111 INT240716 Negative_regulation of Gene_expression of Atp2b2 1 0.09 0.78 0.1
112 INT115357 Positive_regulation of ATP8A1 1 0.01 0.55 0.1
113 INT342408 Positive_regulation of Binding of Atp9a 1 0.49 0 0.1
114 INT322449 Regulation of Atp2a1 1 0.13 1.22 0.1
115 INT114084 Binding of ATP8A1 1 0.01 0.42 0.1
116 INT218859 Negative_regulation of ATP12A 2 0.11 2.86 0.09
117 INT240713 Gene_expression of Atp2b2 1 0.14 1.16 0.09
118 INT240717 Negative_regulation of Localization of Atp2a2 1 0.13 1.3 0.08
119 INT240714 Negative_regulation of Localization of Atp2b2 1 0.09 1.3 0.08
120 INT237804 Binding of Atp2a2 1 0.06 0 0.07
121 INT305839 Regulation of Gene_expression of Atp11c 1 0.03 0.44 0.06
122 INT336604 Regulation of Gene_expression of Atp2a2 1 0.05 0.81 0.05
123 INT322455 Negative_regulation of Gene_expression of Atp2a1 1 0.12 0.54 0.04
124 INT339976 Positive_regulation of Transcription of Atp8a1 1 0.49 0.6 0.04
125 INT240715 Localization of Atp2b2 1 0.16 1.07 0.04
126 INT201163 Regulation of Atp2a2 4 0.08 2.97 0.03
127 INT201169 Negative_regulation of Regulation of Atp2a2 1 0.08 0.61 0.03
128 INT201161 Positive_regulation of Regulation of Atp2a2 1 0.06 0.56 0.03
129 INT271023 Negative_regulation of Negative_regulation of Atp2a1 1 0.19 0.06 0.03
130 INT191143 Regulation of Gene_expression of Atp8a1 3 0.60 0.94 0
131 INT240720 Transcription of Atp2a2 2 0.20 1.26 0
132 INT322446 Negative_regulation of Transcription of Atp2a1 1 0.12 0.21 0
133 INT320005 Negative_regulation of Atp13a4 1 0.42 0.15 0
134 INT253593 Binding of Atp13a4 1 0.03 0.42 0
135 INT300332 Regulation of Transcription of Atp9b 1 0.06 0 0
136 INT320756 Localization of Atp11c 1 0.07 0.78 0
137 INT317272 Protein_catabolism of Atp13a2 1 0.35 0.47 0
138 INT296913 Positive_regulation of Transcription of Atp2a2 1 0.02 1.33 0
139 INT183492 Positive_regulation of Atp11c 1 0.06 0 0
140 INT255202 Gene_expression of ATP2A2 1 0.65 0.41 0
141 INT166436 Negative_regulation of Localization of Atp2a2 1 0.37 0 0
142 INT322460 Positive_regulation of Atp2a1 1 0.10 0.42 0
143 INT300331 Positive_regulation of Transcription of Atp9b 1 0.11 0.09 0
144 INT83729 Gene_expression of ATP8A1 1 0.01 0 0
145 INT53281 Regulation of Atp2a1 1 0.11 0 0
146 INT328128 Protein_catabolism of Atp10a 1 0.86 0 0
147 INT268645 Positive_regulation of ATP2B3 1 0.01 0.15 0
148 INT322457 Transcription of Atp2a1 1 0.16 0.21 0
149 INT336758 Protein_catabolism of Atp8a1 1 0.64 0 0
150 INT317273 Gene_expression of Atp13a2 1 0.23 0.87 0
151 INT328130 Regulation of Gene_expression of Atp10a 1 0.44 0.23 0
152 INT166434 Localization of Atp2a2 1 0.66 0 0
153 INT317283 Binding of Atp13a2 1 0.13 0.58 0
154 INT273281 Regulation of Negative_regulation of Atp2a2 1 0.11 0.23 0
155 INT296912 Positive_regulation of Atp2a2 1 0.02 0.66 0
156 INT339975 Positive_regulation of Negative_regulation of Atp8a1 1 0.49 1.28 0
157 INT196110 Negative_regulation of Gene_expression of Atp2a2 1 0.09 0.05 0
158 INT240721 Negative_regulation of Negative_regulation of Atp2a2 1 0.13 1.07 0
159 INT296924 Positive_regulation of Positive_regulation of Atp2a2 1 0.02 0.67 0
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