GO:0016831

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Name carboxy-lyase activity
Categary Function
Go Slim No
Go Link GO:0016831
Unique Molecular Interactions 57
Total Molecular Interactions 64
Total Single Events 873
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for carboxy-lyase activity. They are ordered first by their pain relevance and then by number of times they were reported for carboxy-lyase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT283050 Binding of Gad2 and Trpm8 1 0.23 2.02 1.93
2 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 0.58 0.81 1.23
3 INT270053 HOXD12 Positive_regulation of Gene_expression of GAD1 1 0.03 0.68 1.12
4 INT270052 GAD1 Positive_regulation of Gene_expression of SFTPA1 1 0.03 0.68 1.11
5 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 0.00 0.26 0.87
6 INT110236 Hk1 Regulation of CSAD 1 0.01 1.57 0.84
7 INT317705 Gad2 Regulation of Gene_expression of Gabrg1 1 0.28 0.53 0.8
8 INT151252 CSAD Positive_regulation of Positive_regulation of Ltp 1 0.06 0.81 0.67
9 INT151251 CSAD Regulation of Positive_regulation of Ltp 1 0.04 0.82 0.65
10 INT98386 GAD1 Positive_regulation of Gene_expression of Abat 1 0.30 1.67 0.62
11 INT338447 GAD1 Negative_regulation of Slc32a1 1 0.04 0.59 0.47
12 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
13 INT250975 Binding of FMOD and CSAD 1 0.01 0.86 0.41
14 INT50514 CSAD Regulation of Cebpz 1 0.02 0.48 0.38
15 INT156898 Binding of cerebral blood flow and CSAD 1 0.00 0.45 0.33
16 INT156897 Binding of CSAD and Cebpz 1 0.13 0.45 0.33
17 INT344748 NFKB2 Regulation of Gene_expression of GAD1 1 0.07 0.87 0.33
18 INT42253 Bbx Regulation of Gad1 1 0.15 0 0.3
19 INT98385 Abat Negative_regulation of GAD1 1 0.24 1.28 0.3
20 INT229332 BAS Negative_regulation of Pck1 1 0.01 0.2 0.28
21 INT107955 Gtf3a Positive_regulation of Hdc 1 0.07 0.3 0.26
22 INT107954 Il1f5 Positive_regulation of Hdc 1 0.09 0.3 0.26
23 INT353979 Ddc Positive_regulation of Pet1 1 0.49 0 0.26
24 INT272618 Positive_regulation of Binding of GAD1 and CEBPZ 1 0.14 0.91 0.25
25 INT272619 Binding of GAD1 and CEBPZ 1 0.10 0.91 0.25
26 INT138088 Ddc Regulation of Transcription of Nr4a1 1 0.02 0.16 0.24
27 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
28 INT344746 GAD1 Regulation of Gene_expression of ABAT 1 0.19 0.75 0.23
29 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22
30 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21
31 INT47607 Psl1 Positive_regulation of Odc1 1 0.51 0.14 0.19
32 INT62341 Sst Negative_regulation of Hdc 1 0.03 0 0.18
33 INT62342 Gast Positive_regulation of Hdc 1 0.10 0 0.18
34 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14
35 INT271553 Binding of Gad2 and Gfap 1 0.24 0 0.13
36 INT240121 Hdc Regulation of Trem1 1 0.06 0.66 0.13
37 INT47609 Positive_regulation of Psl1 Positive_regulation of Odc1 1 0.45 0 0.1
38 INT47610 Regulation of Psl1 Positive_regulation of Odc1 1 0.26 0.06 0.1
39 INT114367 Binding of GAD2 and SEPHS1 1 0.11 0.55 0.1
40 INT218733 Trh Positive_regulation of Gene_expression of Hdc 1 0.27 0 0.09
41 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
42 INT301641 Irs2 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
43 INT262190 Foxo1 Positive_regulation of Pck1 1 0.04 0.15 0.06
44 INT79985 Gdnf Negative_regulation of Negative_regulation of GAD1 1 0.04 0.46 0.04
45 INT79986 Gdnf Negative_regulation of Gene_expression of GAD1 1 0.03 0.46 0.04
46 INT240875 Gene_expression of Sod1 Negative_regulation of Gene_expression of Pck1 1 0.33 0.27 0.03
47 INT240876 Gene_expression of Sod1 Negative_regulation of Pck1 1 0.33 0.27 0.03
48 INT47608 Negative_regulation of Psl1 Positive_regulation of Odc1 1 0.47 0.08 0
49 INT318544 Paics Regulation of Ecm1 1 0.00 1.43 0
50 INT233323 GAD1 Regulation of HMGCR 1 0.09 0.2 0
51 INT129864 Ddc Positive_regulation of Gene_expression of Fosb 1 0.02 0.13 0
52 INT299447 Lhb Positive_regulation of Gene_expression of Odc1 1 0.24 0.3 0
53 INT328906 Binding of LMNA and CSAD 1 0.11 0 0
54 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0
55 INT240942 Ins1 Regulation of Transcription of Pck1 1 0.08 0.73 0
56 INT323492 Ins1 Regulation of Gene_expression of Pck1 1 0.08 0.16 0
57 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 0.03 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for carboxy-lyase activity. They are ordered first by their pain relevance and then by number of times they were reported in carboxy-lyase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11
2 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4
3 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53
4 INT220 Negative_regulation of Ddc 16 0.59 2.94 8.66
5 INT46112 Regulation of GAD1 15 0.52 11.09 8.37
6 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07
7 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47
8 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54
9 INT157121 Gene_expression of GAD2 15 0.67 7.21 5.91
10 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59
11 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51
12 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8
13 INT106971 Positive_regulation of Gene_expression of GAD1 19 0.58 10.89 4.59
14 INT119785 Localization of GAD1 7 0.63 5.99 4.34
15 INT141125 Regulation of Gene_expression of GAD1 5 0.52 8.81 3.63
16 INT42251 Regulation of Gad1 10 0.44 5.25 3.45
17 INT35009 Binding of CSAD 12 0.41 10.74 3.21
18 INT149795 Gene_expression of Ddc 8 0.73 1.5 3.06
19 INT165514 Regulation of Gad2 7 0.45 3.15 2.76
20 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54
21 INT52871 Regulation of Hdc 6 0.60 3.26 2.51
22 INT90566 Positive_regulation of Gene_expression of Gad1 5 0.48 1.46 2.42
23 INT30061 Negative_regulation of Hdc 8 0.59 2.14 2.27
24 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09
25 INT49210 Transcription of GAD1 8 0.60 3.48 2.06
26 INT66082 Regulation of CSAD 5 0.27 4.72 1.99
27 INT207830 Localization of GAD2 10 0.65 0.49 1.97
28 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96
29 INT79983 Negative_regulation of Gene_expression of GAD1 7 0.41 4.02 1.9
30 INT63716 Transcription of Hdc 10 0.69 7.57 1.82
31 INT46733 Positive_regulation of Odc1 16 0.70 2.1 1.71
32 INT96642 Transcription of Gad2 4 0.59 0.88 1.59
33 INT87316 Negative_regulation of Gad2 6 0.58 1.61 1.56
34 INT36148 Binding of GAD1 10 0.41 7.91 1.47
35 INT46736 Negative_regulation of Odc1 10 0.51 7.6 1.39
36 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36
37 INT96641 Transcription of Gad1 3 0.60 0.84 1.36
38 INT4480 Positive_regulation of Ddc 3 0.39 0.53 1.3
39 INT227150 Localization of Gad1 4 0.49 0.15 1.22
40 INT96643 Positive_regulation of Gene_expression of Gad2 3 0.49 0.15 1.18
41 INT165513 Negative_regulation of Regulation of Gad1 1 0.41 1.59 1.11
42 INT161968 Positive_regulation of Gene_expression of GAD2 2 0.40 0.91 1.04
43 INT63719 Positive_regulation of Transcription of Hdc 3 0.52 3.91 1.01
44 INT93244 Localization of CSAD 2 0.60 1.59 1
45 INT148863 Positive_regulation of Localization of GAD1 1 0.38 1.41 1
46 INT18925 Gene_expression of Paics 3 0.52 1.25 0.93
47 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89
48 INT110298 Regulation of Positive_regulation of GAD1 2 0.38 0.99 0.89
49 INT180240 Binding of Gad1 7 0.47 2.99 0.86
50 INT162818 Transcription of CSAD 1 0.60 1.15 0.78
51 INT95699 Binding of Gad2 5 0.40 1.14 0.73
52 INT270701 Localization of Gad2 2 0.74 0.12 0.73
53 INT344771 Transcription of GAD2 1 0.27 0.09 0.7
54 INT49211 Positive_regulation of Positive_regulation of GAD1 2 0.50 1.79 0.68
55 INT96639 Positive_regulation of Transcription of Gad2 1 0.45 0.09 0.66
56 INT96638 Regulation of Transcription of Gad2 1 0.26 0.09 0.66
57 INT271481 Regulation of Regulation of Gad2 1 0.21 0.59 0.65
58 INT207835 Positive_regulation of Localization of GAD2 1 0.01 0.1 0.65
59 INT161252 Positive_regulation of GAD2 2 0.49 0.08 0.63
60 INT150209 Regulation of Transcription of GAD1 1 0.04 0.42 0.62
61 INT180244 Positive_regulation of Gad2 4 0.49 1.07 0.61
62 INT96618 Positive_regulation of Positive_regulation of CSAD 1 0.39 1.15 0.59
63 INT180239 Negative_regulation of Gene_expression of Gad2 2 0.42 1.59 0.55
64 INT123645 Negative_regulation of Transcription of Gad1 2 0.42 0.76 0.52
65 INT229276 Negative_regulation of Pck1 4 0.54 4.56 0.51
66 INT158745 Regulation of Paics 1 0.24 0.58 0.48
67 INT58679 Gene_expression of Odc1 13 0.78 9.55 0.45
68 INT207836 Negative_regulation of GAD2 2 0.37 0.19 0.45
69 INT354256 Negative_regulation of Gene_expression of CSAD 1 0.08 0.75 0.45
70 INT270700 Negative_regulation of Negative_regulation of Gad2 1 0.50 0 0.41
71 INT46737 Negative_regulation of Positive_regulation of Odc1 7 0.58 0.87 0.38
72 INT240924 Transcription of Pck1 7 0.66 3.6 0.37
73 INT292607 Negative_regulation of Transcription of GAD1 1 0.02 0.72 0.36
74 INT229284 Positive_regulation of Pck1 6 0.43 1.24 0.35
75 INT84392 Localization of Hdc 2 0.70 0.98 0.34
76 INT108298 Regulation of BCKDHA 3 0.22 1.17 0.33
77 INT271543 Negative_regulation of Localization of Gad2 1 0.49 0.06 0.31
78 INT46111 Regulation of Regulation of GAD1 1 0.12 0.18 0.31
79 INT318274 Regulation of Gene_expression of GAD2 1 0.39 0 0.3
80 INT98316 Regulation of Gene_expression of Gad2 1 0.26 0.1 0.3
81 INT46729 Regulation of Positive_regulation of Odc1 2 0.45 0.06 0.27
82 INT199354 Gene_expression of Pck1 13 0.72 5.57 0.26
83 INT257802 Positive_regulation of Transcription of Gad1 1 0.44 0 0.23
84 INT258091 Localization of Ddc 1 0.08 0.12 0.22
85 INT149796 Regulation of Gene_expression of Ddc 2 0.42 0.09 0.21
86 INT236560 Negative_regulation of Gene_expression of Pck1 4 0.54 1.67 0.2
87 INT136187 Positive_regulation of Positive_regulation of Hdc 1 0.61 0.81 0.2
88 INT63721 Regulation of Transcription of Hdc 3 0.45 1.72 0.19
89 INT46731 Regulation of Odc1 2 0.46 0.99 0.19
90 INT114368 Binding of GAD2 1 0.30 1.13 0.19
91 INT184904 Regulation of Ddc 1 0.24 0.06 0.19
92 INT108300 Positive_regulation of BCKDHA 3 0.39 1.74 0.18
93 INT180242 Positive_regulation of Binding of Gad1 1 0.49 0.86 0.17
94 INT46730 Binding of Odc1 1 0.32 0 0.17
95 INT108299 Negative_regulation of BCKDHA 1 0.36 0.59 0.16
96 INT266600 Negative_regulation of Gene_expression of Odc1 1 0.51 1.06 0.15
97 INT62337 Negative_regulation of Positive_regulation of Hdc 1 0.07 0 0.14
98 INT318275 Negative_regulation of Gene_expression of GAD2 1 0.37 0.5 0.1
99 INT63717 Negative_regulation of Transcription of Hdc 1 0.43 0.89 0.1
100 INT271549 Negative_regulation of Binding of Gad2 1 0.36 0 0.09
101 INT58680 Transcription of Odc1 1 0.53 0 0.09
102 INT112167 Regulation of Localization of Hdc 1 0.27 0.27 0.09
103 INT240937 Negative_regulation of Transcription of Pck1 3 0.39 0.32 0.08
104 INT207837 Negative_regulation of Localization of GAD2 1 0.01 0 0.08
105 INT63720 Protein_catabolism of Hdc 1 0.57 0.8 0.08
106 INT301567 Positive_regulation of Transcription of Pck1 1 0.14 0.64 0.08
107 INT47604 Positive_regulation of Positive_regulation of Odc1 1 0.50 0.07 0.08
108 INT218726 Binding of Hdc 1 0.19 0.26 0.08
109 INT63718 Positive_regulation of Protein_catabolism of Hdc 1 0.41 0.83 0.08
110 INT58681 Positive_regulation of Gene_expression of Odc1 2 0.70 1.13 0.07
111 INT218728 Negative_regulation of Gene_expression of Hdc 1 0.22 0.4 0.07
112 INT180243 Phosphorylation of Gad2 1 0.52 0.48 0.06
113 INT304627 Regulation of Negative_regulation of GAD1 1 0.39 0.9 0.06
114 INT353974 Negative_regulation of Gene_expression of Ddc 1 0.35 0.21 0.05
115 INT218727 Negative_regulation of Binding of Hdc 1 0.22 0.14 0.05
116 INT344772 Negative_regulation of Positive_regulation of GAD1 1 0.31 0.17 0.04
117 INT79984 Positive_regulation of Negative_regulation of GAD1 1 0.04 0.42 0.04
118 INT236569 Positive_regulation of Gene_expression of Pck1 4 0.64 1.88 0.03
119 INT180241 Positive_regulation of Binding of Gad2 1 0.39 0.29 0.03
120 INT199330 Regulation of Pck1 3 0.57 3.12 0
121 INT199341 Localization of Pck1 2 0.65 1.29 0
122 INT218730 Positive_regulation of Gene_expression of Hdc 1 0.26 0.32 0
123 INT240835 Regulation of Gene_expression of Pck1 1 0.47 0.59 0
124 INT240854 Positive_regulation of Regulation of Pck1 1 0.36 0.59 0
125 INT328909 Regulation of Gene_expression of CSAD 1 0.16 0 0
126 INT240926 Regulation of Transcription of Pck1 1 0.42 1.34 0
127 INT132990 Positive_regulation of Binding of BCKDHA 1 0.18 0.17 0
128 INT180232 Protein_catabolism of Gad1 1 0.87 0.52 0
129 INT132991 Binding of BCKDHA 1 0.16 0.17 0
130 INT240936 Regulation of Negative_regulation of Pck1 1 0.36 0.47 0
131 INT240925 Binding of Pck1 1 0.34 0.78 0
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