GO:0016849

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Name phosphorus-oxygen lyase activity
Categary Function
Go Slim No
Go Link GO:0016849
Unique Molecular Interactions 38
Total Molecular Interactions 40
Total Single Events 374
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphorus-oxygen lyase activity. They are ordered first by their pain relevance and then by number of times they were reported for phosphorus-oxygen lyase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
2 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
3 INT305034 Adcy8 Regulation of Localization of Adcy1 1 0.35 1.51 0.77
4 INT305033 Adcy1 Regulation of Localization of Adcy8 1 0.35 1.51 0.77
5 INT190788 Adcy8 Positive_regulation of Adcy1 1 0.23 0.77 0.77
6 INT130356 Adcy10 Negative_regulation of Positive_regulation of Crp 1 0.13 0.23 0.71
7 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69
8 INT130357 Adcy10 Regulation of Fgg 1 0.03 0.2 0.66
9 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
10 INT281081 Prkaca Positive_regulation of Gene_expression of Adcy1 1 0.12 0 0.63
11 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
12 INT281078 Prkacb Positive_regulation of Gene_expression of Adcy1 1 0.03 0 0.63
13 INT281076 Adcy1 Positive_regulation of Mdk 1 0.07 0 0.62
14 INT333309 Binding of Htr1b and Adcy1 1 0.01 0 0.53
15 INT140140 Adcy1 Regulation of Regulation of Atf6b 1 0.14 0.34 0.41
16 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37
17 INT151545 Adcy1 Positive_regulation of Regulation of Fmr1 1 0.48 0.37 0.37
18 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37
19 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
20 INT327383 Il13 Positive_regulation of Gene_expression of Cd38 1 0.19 0 0.25
21 INT196823 Adcy5 Positive_regulation of Prkaca 1 0.13 0 0.22
22 INT318357 Binding of Pmp2 and Adcy3 1 0.06 0.26 0.2
23 INT318356 Positive_regulation of Binding of Slc10a7 and Adcy3 1 0.17 0.26 0.2
24 INT318358 Positive_regulation of Binding of Pmp2 and Adcy3 1 0.08 0.26 0.2
25 INT318359 Binding of Slc10a7 and Adcy3 1 0.12 0.26 0.2
26 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
27 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
28 INT154355 Binding of Nppc and Npr1 1 0.19 0.43 0.18
29 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
30 INT249198 CD38 Positive_regulation of CA2 1 0.16 0.16 0.08
31 INT257226 Phosphorylation of Prkacb Positive_regulation of Npr1 1 0.00 0 0.08
32 INT249158 CD38 Regulation of CA2 1 0.13 0.07 0.04
33 INT289764 Pgf Regulation of Adcy3 1 0.12 0 0.03
34 INT289761 Adcy1 Regulation of Adcy3 1 0.09 0 0.03
35 INT240722 Cd38 Positive_regulation of Localization of Ca2 1 0.04 0.79 0
36 INT264864 Cd38 Positive_regulation of Localization of INS 1 0.06 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphorus-oxygen lyase activity. They are ordered first by their pain relevance and then by number of times they were reported in phosphorus-oxygen lyase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
2 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6
3 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
4 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42
5 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
6 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27
7 INT106721 Regulation of Adcy1 6 0.45 2.32 4.17
8 INT128138 Positive_regulation of Positive_regulation of Adcy1 5 0.45 2.67 3.25
9 INT99104 Gene_expression of Npr1 5 0.78 3.31 2.8
10 INT137616 Gene_expression of Cd38 19 0.67 9.37 2.54
11 INT190783 Binding of Adcy1 3 0.35 1.35 2.03
12 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95
13 INT289739 Positive_regulation of Adcy3 3 0.28 0.64 1.63
14 INT305029 Localization of Adcy1 2 0.70 5.94 1.63
15 INT168860 Positive_regulation of Cd38 5 0.70 4.07 1.57
16 INT26488 Regulation of Npr1 4 0.39 0.88 1.56
17 INT168861 Positive_regulation of Gene_expression of Cd38 2 0.50 2.01 1.47
18 INT168859 Regulation of Cd38 1 0.27 0.11 1.33
19 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27
20 INT117933 Positive_regulation of Gene_expression of Cd38 3 0.38 1.62 1.23
21 INT89756 Positive_regulation of Positive_regulation of Npr1 2 0.47 0.9 1.19
22 INT168864 Positive_regulation of Positive_regulation of Cd38 1 0.47 0.05 1.18
23 INT81136 Binding of Npr1 6 0.48 1.45 1.15
24 INT196743 Binding of Adcy5 1 0.25 0 1.04
25 INT193069 Positive_regulation of Gene_expression of CD38 4 0.15 4.06 1.01
26 INT190776 Negative_regulation of Gene_expression of Adcy1 3 0.43 0.96 0.93
27 INT196762 Negative_regulation of Adcy5 5 0.39 1.49 0.8
28 INT61427 Gene_expression of Adcy3 6 0.55 0.53 0.77
29 INT196734 Positive_regulation of Adcy5 1 0.35 0 0.75
30 INT130425 Negative_regulation of Negative_regulation of Adcy1 2 0.43 0.57 0.65
31 INT89855 Localization of Npr1 1 0.20 0.32 0.57
32 INT190778 Positive_regulation of Gene_expression of Adcy1 2 0.50 1.49 0.55
33 INT333289 Positive_regulation of Binding of Adcy1 1 0.28 0 0.52
34 INT235847 Transcription of Adcy1 2 0.25 0.42 0.5
35 INT235845 Positive_regulation of Transcription of Adcy1 1 0.13 0.43 0.44
36 INT117932 Positive_regulation of Cd38 2 0.35 1.17 0.43
37 INT134731 Localization of Cd38 4 0.70 0.87 0.41
38 INT22236 Negative_regulation of CD38 2 0.41 0.1 0.36
39 INT336709 Negative_regulation of Localization of Adcy1 1 0.35 0.88 0.34
40 INT164337 Localization of Adcy5 1 0.38 0 0.33
41 INT164338 Regulation of Adcy5 1 0.14 0 0.33
42 INT264860 Binding of Cd38 1 0.39 2.36 0.31
43 INT214579 Positive_regulation of CD38 4 0.24 1.22 0.3
44 INT242985 Regulation of Gene_expression of Npr1 1 0.03 0.85 0.29
45 INT117931 Positive_regulation of Positive_regulation of Cd38 1 0.35 0.3 0.26
46 INT289743 Regulation of Positive_regulation of Adcy3 1 0.25 0 0.25
47 INT289745 Positive_regulation of Positive_regulation of Adcy3 1 0.28 0 0.25
48 INT325293 Negative_regulation of Gene_expression of CD38 1 0.14 0.55 0.22
49 INT130423 Regulation of Positive_regulation of Adcy1 1 0.05 0.1 0.21
50 INT89848 Positive_regulation of Localization of Npr1 1 0.13 0.15 0.18
51 INT130457 Binding of CD38 2 0.16 0.75 0.17
52 INT154771 Positive_regulation of Localization of Cd38 1 0.08 0.87 0.16
53 INT285210 Regulation of Adcy3 1 0.28 0.07 0.14
54 INT264858 Negative_regulation of Binding of Cd38 1 0.34 0.79 0.14
55 INT264863 Negative_regulation of Cd38 1 0.34 0.79 0.14
56 INT264857 Negative_regulation of Gene_expression of Cd38 1 0.34 1.57 0.12
57 INT196776 Negative_regulation of Negative_regulation of Adcy5 1 0.22 0 0.11
58 INT289728 Positive_regulation of Gene_expression of Adcy3 1 0.28 0 0.1
59 INT285212 Negative_regulation of Gene_expression of Adcy3 1 0.30 0.17 0.1
60 INT133351 Regulation of Cd38 1 0.15 1.6 0.09
61 INT257197 Phosphorylation of Npr1 1 0.03 0 0.08
62 INT125747 Positive_regulation of Gene_expression of Npr1 1 0.70 0.62 0.07
63 INT106237 Protein_catabolism of CD38 1 0.62 0.06 0.06
64 INT289737 Transcription of Adcy3 1 0.38 0 0.05
65 INT289730 Negative_regulation of Transcription of Adcy1 1 0.15 0 0.05
66 INT289732 Negative_regulation of Transcription of Adcy3 1 0.24 0 0.05
67 INT196788 Positive_regulation of Binding of Adcy5 1 0.22 0 0.05
68 INT214575 Localization of CD38 3 0.34 2.31 0.04
69 INT214568 Positive_regulation of Localization of CD38 1 0.21 1.09 0
70 INT279689 Regulation of Gene_expression of Adcy10 1 0.02 0.16 0
71 INT289726 Negative_regulation of Adcy3 1 0.24 0 0
72 INT264862 Regulation of Gene_expression of Cd38 1 0.36 0.84 0
73 INT279686 Gene_expression of Adcy10 1 0.03 0.37 0
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