GO:0016881

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Name acid-amino acid ligase activity
Categary Function
Go Slim No
Go Link GO:0016881
Unique Molecular Interactions 45
Total Molecular Interactions 64
Total Single Events 159
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for acid-amino acid ligase activity. They are ordered first by their pain relevance and then by number of times they were reported for acid-amino acid ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93
2 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
3 INT59203 ecs Positive_regulation of Negative_regulation of Ube2d3 1 0.00 1.93 1.15
4 INT153039 Binding of G2e3 and LOC100360318 1 0.00 0 1.01
5 INT61698 G2e3 Regulation of Localization of Abat 1 0.05 0 0.88
6 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
7 INT59202 ecs Positive_regulation of Ube2d3 1 0.00 0.98 0.59
8 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
9 INT97043 Binding of G2e3 and Hist1h3g 1 0.01 0.5 0.36
10 INT334267 Mul1 Positive_regulation of Protein_catabolism of Tlr4 1 0.01 0.18 0.18
11 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17
12 INT226210 Akt1 Regulation of Mul1 1 0.04 0.6 0.1
13 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
14 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
15 INT342726 Binding of Laptm5 and Park2 1 0.03 0.64 0.04
16 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
17 INT342725 Pink1 Positive_regulation of Phosphorylation of Park2 1 0.29 0.62 0
18 INT219256 Binding of Ddx41 and G2e3 1 0.01 1.63 0
19 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0
20 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
21 INT317300 Binding of Park2 and Pink1 1 0.48 1.23 0
22 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0
23 INT342727 Pink1 Positive_regulation of Park2 1 0.29 0.62 0
24 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
25 INT303394 Binding of Myh3 and Mul1 1 0.04 0.38 0
26 INT219257 Binding of Cd79a and G2e3 1 0.01 0.08 0
27 INT317302 Binding of Park2 and Mul1 1 0.01 0.62 0
28 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0
29 INT333033 Binding of Itch and Laptm5 1 0.01 0 0
30 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0
31 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0
32 INT273885 Binding of Mul1 and Cul2 1 0.06 0 0
33 INT303392 Mul1 Positive_regulation of Protein_catabolism of Myh3 1 0.06 0 0
34 INT303385 Mul1 Positive_regulation of Protein_catabolism of Gopc 1 0.03 0 0
35 INT325285 COMP Positive_regulation of UBR5 1 0.00 2.9 0
36 INT317308 Binding of Park7 and Mul1 1 0.01 0.62 0
37 INT317306 Binding of Mul1 and Pink1 1 0.01 0.62 0
38 INT259051 Binding of TP53 and UBE3A 1 0.01 3.48 0
39 INT276608 Binding of UBE2S and IL33 1 0.00 0.32 0
40 INT217315 Binding of UBE2I and ERVW-1 1 0.01 1.56 0
41 INT232714 Binding of UBE2K and MMRN1 1 0.00 0.1 0
42 INT333031 Binding of Itch and Mul1 1 0.02 0 0
43 INT219254 Binding of Gopc and G2e3 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for acid-amino acid ligase activity. They are ordered first by their pain relevance and then by number of times they were reported in acid-amino acid ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60865 Gene_expression of G2e3 20 0.73 2.1 12.76
2 INT58775 Binding of G2e3 10 0.33 0.19 11.52
3 INT58774 Negative_regulation of G2e3 8 0.38 0.22 7.75
4 INT50022 Positive_regulation of G2e3 10 0.42 0.47 3.72
5 INT60864 Regulation of G2e3 4 0.21 0.64 2.54
6 INT52785 Localization of G2e3 5 0.66 0.33 2.26
7 INT100563 Regulation of Binding of G2e3 1 0.24 0 1.79
8 INT104745 Positive_regulation of Binding of G2e3 1 0.05 0.07 1.77
9 INT85955 Negative_regulation of Localization of G2e3 2 0.48 0.05 1.63
10 INT59200 Negative_regulation of Ube2d3 3 0.13 2.37 1.23
11 INT70248 Positive_regulation of Positive_regulation of G2e3 1 0.13 0.17 0.94
12 INT113121 Negative_regulation of Binding of G2e3 1 0.07 0 0.88
13 INT128143 Negative_regulation of Gene_expression of G2e3 4 0.09 0 0.82
14 INT122497 Gene_expression of UBE2S 2 0.58 0.8 0.64
15 INT149394 Positive_regulation of Mul1 4 0.12 1.89 0.53
16 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
17 INT231102 Gene_expression of Mul1 8 0.21 1.66 0.35
18 INT168693 Negative_regulation of Binding of Nedd4 1 0.31 0.29 0.21
19 INT168696 Positive_regulation of Binding of Nedd4 1 0.34 0.29 0.21
20 INT231095 Positive_regulation of Gene_expression of Mul1 1 0.13 0.82 0.19
21 INT128141 Positive_regulation of Gene_expression of G2e3 4 0.07 0 0.18
22 INT153448 Regulation of Gene_expression of G2e3 1 0.07 0 0.15
23 INT111656 Regulation of Mul1 1 0.02 0.08 0.13
24 INT273866 Binding of Mul1 4 0.11 0.69 0.09
25 INT259063 Binding of UBE3A 2 0.36 1.15 0.09
26 INT342696 Gene_expression of Park2 1 0.65 1.19 0.08
27 INT231099 Regulation of Gene_expression of Mul1 1 0.12 0.08 0.07
28 INT231090 Negative_regulation of Gene_expression of Mul1 1 0.11 0.08 0.07
29 INT247556 Binding of Ube2e3 2 0.07 1.24 0.04
30 INT317299 Binding of Park2 1 0.36 0.61 0.04
31 INT244259 Gene_expression of UBE3A 4 0.78 1.91 0
32 INT162522 Positive_regulation of Localization of G2e3 3 0.17 0.19 0
33 INT271964 Binding of HERC1 1 0.01 0.31 0
34 INT342695 Phosphorylation of Park2 1 0.79 0.62 0
35 INT217331 Binding of UBE2I 1 0.12 2.88 0
36 INT232745 Binding of UBE2K 1 0.00 0.1 0
37 INT219250 Binding of G2e3 1 0.01 0.51 0
38 INT244258 Negative_regulation of Gene_expression of UBE3A 1 0.59 0.82 0
39 INT276616 Binding of UBE2S 1 0.01 0.25 0
40 INT217339 Protein_catabolism of UBE3A 1 0.14 1.79 0
41 INT333019 Binding of Itch 1 0.13 0 0
42 INT333021 Negative_regulation of Positive_regulation of Itch 1 0.14 0 0
43 INT219246 Gene_expression of G2e3 1 0.02 1.76 0
44 INT126986 Gene_expression of UBR5 1 0.26 0 0
45 INT317277 Negative_regulation of Mul1 1 0.01 0.68 0
46 INT244260 Negative_regulation of UBE3A 1 0.59 0.86 0
47 INT333024 Positive_regulation of Itch 1 0.17 0 0
48 INT219245 Regulation of G2e3 1 0.01 0.37 0
49 INT325286 Positive_regulation of UBR5 1 0.02 2.37 0
50 INT219251 Positive_regulation of G2e3 1 0.01 0.14 0
51 INT247561 Positive_regulation of Binding of Ube2e3 1 0.09 0.64 0
52 INT217337 Gene_expression of UBE2I 1 0.26 1.32 0
53 INT217348 Positive_regulation of Gene_expression of UBE2I 1 0.23 1.32 0
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