GO:0016942

From wiki-pain
Jump to: navigation, search
Name insulin-like growth factor binding protein complex
Categary Component
Go Slim No
Go Link GO:0016942
Unique Molecular Interactions 136
Total Molecular Interactions 219
Total Single Events 1906
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor binding protein complex. They are ordered first by their pain relevance and then by number of times they were reported for insulin-like growth factor binding protein complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
2 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
3 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
4 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
5 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
6 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
7 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
8 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
9 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
10 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
11 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
12 INT133002 Mmp9 Regulation of Negative_regulation of Igfbp3 1 0.26 0.39 0.42
13 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
14 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
15 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
16 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
17 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
18 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
19 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
20 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
21 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
22 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
23 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
24 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
25 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
26 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
27 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
28 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
29 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
30 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
31 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
32 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
33 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
34 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
35 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
36 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
37 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
38 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
39 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
40 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
41 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
42 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
43 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
44 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11
45 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11
46 INT258147 IGFBP3 Negative_regulation of Hcrt 1 0.28 1.87 0.11
47 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
48 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
49 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1
50 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1
51 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
52 INT137368 Retn Positive_regulation of Gene_expression of IGF1 1 0.00 0.17 0.1
53 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1
54 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
55 INT78446 Binding of GH1 and IGFBP3 1 0.11 0.48 0.1
56 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09
57 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
58 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09
59 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09
60 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
61 INT124732 Gh Regulation of Positive_regulation of IGFBP3 1 0.00 0.24 0.08
62 INT192293 Binding of IGF1 and IL1B 1 0.15 0.08 0.08
63 INT49372 Gh Positive_regulation of Gene_expression of IGFBP3 1 0.00 0.51 0.08
64 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08
65 INT354113 Binding of IGFBP3 and MIR524 1 0.01 0.69 0.07
66 INT354125 Binding of IGFBP3 and MIR15B 1 0.00 0.7 0.07
67 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
68 INT265883 IGF1 Positive_regulation of Transcription of FOXO1 1 0.17 1.14 0.07
69 INT70762 IGF1 Regulation of Gh 1 0.00 0.17 0.07
70 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
71 INT354111 Binding of IGFBP3 and MIR125A 1 0.11 0.7 0.07
72 INT51273 IGF1 Positive_regulation of IGFBP2 1 0.37 0.13 0.06
73 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06
74 INT51276 IGF1 Negative_regulation of GH1 1 0.10 0.13 0.06
75 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
76 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
77 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05
78 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05
79 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
80 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
81 INT312226 INPP5K Positive_regulation of IGFBP5 1 0.12 0.07 0.05
82 INT218616 Binding of IGFBP3 and INS 1 0.07 0.68 0.05
83 INT275758 Binding of xn and Igfbp3 1 0.03 5.39 0.04
84 INT258148 Gene_expression of IGFBP3 Negative_regulation of Hcrt 1 0.28 0.86 0.04
85 INT202233 IGFBP1 Regulation of IGF1 1 0.22 0.19 0.04
86 INT275754 Regulation of Binding of xn and Igfbp3 1 0.02 0.79 0.04
87 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03
88 INT265891 IGF1 Regulation of AKT1 1 0.05 1.24 0.03
89 INT265884 IGF1 Regulation of CREB1 1 0.13 1.31 0.03
90 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
91 INT265879 IGF1 Regulation of FOXO1 1 0.11 1.37 0.03
92 INT258144 IGFBP3 Regulation of Gene_expression of Hcrt 1 0.30 2.23 0.03
93 INT265880 IGF1 Regulation of PIK3CG 1 0.10 1.23 0.03
94 INT208410 IGF1 Positive_regulation of TXK 1 0.08 0.9 0.03
95 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
96 INT174532 PTH Positive_regulation of Transcription of IGF1 1 0.06 0.51 0
97 INT275760 Binding of Igfbp3 and xn 1 0.00 1.32 0
98 INT234622 IGFBP3 Positive_regulation of TNFSF10 1 0.56 1.08 0
99 INT258150 IGFBP3 Regulation of Gene_expression of Gopc 1 0.05 1.22 0
100 INT258146 Binding of IGFBP3 and Hcrt 1 0.23 2.04 0
101 INT206854 ESR1 Regulation of IGF1 1 0.01 0.33 0
102 INT278495 IGFBP2 Positive_regulation of Gene_expression of IGF1 1 0.20 0 0
103 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0
104 INT128489 IGF1 Negative_regulation of Positive_regulation of INS 1 0.26 0.38 0
105 INT275733 Igfbp3 Regulation of Ins1 1 0.03 0.16 0
106 INT278498 IGFBP3 Regulation of GH1 1 0.06 0 0
107 INT234621 CDX2 Negative_regulation of IGFBP3 1 0.38 0.8 0
108 INT75319 IGF1 Positive_regulation of Gh 1 0.00 0.26 0
109 INT258086 Binding of CSF2 and IGFBP3 1 0.05 1.18 0
110 INT258145 IGFBP3 Regulation of Hcrt 1 0.16 0.56 0
111 INT87748 IGF1 Positive_regulation of INS 1 0.41 0.17 0
112 INT215209 Binding of Igf1 and Igfbp3 1 0.11 0 0
113 INT264297 Binding of IGF1 and NOL3 1 0.36 0.44 0
114 INT218615 Negative_regulation of INS Negative_regulation of Gene_expression of IGF1 1 0.33 0.89 0
115 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0
116 INT258152 IGFBP3 Regulation of Transcription of Hcrt 1 0.40 0.42 0
117 INT137934 IGF1 Regulation of Tgfb1 1 0.00 0 0
118 INT215205 Binding of Igf2 and Igfbp3 1 0.04 0 0
119 INT258087 Negative_regulation of ANTXR2 Negative_regulation of Gene_expression of IGFBP3 1 0.04 0.29 0
120 INT141959 Binding of IGFBP3 and Igf2 1 0.01 0.09 0
121 INT234623 Binding of CDX2 and IGFBP3 1 0.32 1.71 0
122 INT202247 Binding of IGF1 and Igfbp1 1 0.16 0.21 0
123 INT258151 IGFBP3 Negative_regulation of Binding of Hcrt 1 0.28 0.49 0
124 INT16355 GH1 Positive_regulation of IGF1 1 0.24 0.25 0
125 INT213264 INS Positive_regulation of Localization of IGF1 1 0.16 1.77 0
126 INT132069 Binding of Igf1 and Igfbp3 1 0.38 0.08 0
127 INT246469 Binding of IGF1 and Gh 1 0.03 0.2 0
128 INT180858 TGFB1 Regulation of Transcription of IGFBP3 1 0.24 0.77 0
129 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0
130 INT137929 IGF1 Regulation of TGFB3 1 0.00 0 0
131 INT258149 IGFBP3 Negative_regulation of Gene_expression of Hcrt 1 0.38 1.1 0
132 INT349955 ARMC9 Regulation of IGF1 1 0.01 0 0
133 INT75318 Gh Regulation of Gene_expression of IGF1 1 0.00 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor binding protein complex. They are ordered first by their pain relevance and then by number of times they were reported in insulin-like growth factor binding protein complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
2 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
3 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
4 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
5 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
6 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
7 INT34777 Localization of IGF1 82 0.80 42.68 8.62
8 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19
9 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78
10 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
11 INT16130 Binding of IGF1 67 0.48 27.43 2.95
12 INT51279 Regulation of IGFBP3 17 0.49 15.89 2.45
13 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
14 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9
15 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73
16 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
17 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41
18 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21
19 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
20 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
21 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
22 INT215202 Localization of Igfbp3 3 0.62 2.5 0.91
23 INT132068 Gene_expression of Igfbp3 10 0.64 3.73 0.83
24 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
25 INT117849 Negative_regulation of Gene_expression of IGFBP3 8 0.39 8.75 0.75
26 INT277652 Negative_regulation of Localization of Igfbp3 1 0.11 0.74 0.72
27 INT49370 Localization of IGFBP3 21 0.81 9.85 0.71
28 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
29 INT277647 Negative_regulation of Igfbp3 1 0.15 0.94 0.62
30 INT335991 Positive_regulation of Localization of Igfbp3 1 0.42 1.57 0.61
31 INT67341 Transcription of IGFBP3 27 0.72 30.46 0.57
32 INT277649 Localization of Igfbp3 1 0.20 0.69 0.55
33 INT63364 Positive_regulation of Igfbp3 9 0.64 1.92 0.53
34 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
35 INT132996 Positive_regulation of Gene_expression of Igfbp3 4 0.49 3.2 0.5
36 INT61067 Positive_regulation of Igfbp3 3 0.41 1.21 0.5
37 INT124719 Regulation of Regulation of IGFBP3 3 0.36 2.02 0.38
38 INT294079 Protein_catabolism of IGFBP3 3 0.27 1.89 0.38
39 INT132995 Negative_regulation of Igfbp3 1 0.44 0.36 0.38
40 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
41 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
42 INT277650 Negative_regulation of Transcription of Igfbp3 1 0.11 0.24 0.3
43 INT277654 Transcription of Igfbp3 1 0.18 0.24 0.3
44 INT145860 Negative_regulation of Gene_expression of Igfbp3 2 0.35 1.52 0.27
45 INT124720 Regulation of Gene_expression of IGFBP3 2 0.39 3.1 0.26
46 INT132992 Negative_regulation of Gene_expression of Igfbp3 1 0.37 0.84 0.26
47 INT268478 Negative_regulation of Positive_regulation of Igfbp5 1 0.26 0.64 0.26
48 INT268477 Positive_regulation of Igfbp5 1 0.31 0.63 0.25
49 INT258095 Binding of Igfbp3 4 0.29 2.86 0.23
50 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
51 INT132067 Binding of Igfbp3 7 0.33 2.51 0.19
52 INT215200 Regulation of Igfbp3 3 0.35 0.71 0.18
53 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
54 INT312242 Binding of IGFBP5 2 0.08 0.69 0.18
55 INT165152 Gene_expression of Igfbp5 1 0.70 0.13 0.18
56 INT275741 Positive_regulation of Gene_expression of Igfbp3 2 0.25 1.3 0.17
57 INT294084 Regulation of Negative_regulation of IGFBP3 1 0.08 0.81 0.14
58 INT285629 Regulation of Binding of Igfbp3 1 0.35 0.56 0.13
59 INT268476 Protein_catabolism of Igfbp5 1 0.40 0.25 0.13
60 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
61 INT48615 Positive_regulation of Binding of IGF1 5 0.50 0.54 0.11
62 INT75111 Negative_regulation of Positive_regulation of IGFBP3 2 0.40 3.44 0.09
63 INT165155 Regulation of Igfbp5 1 0.55 0.07 0.09
64 INT312250 Protein_catabolism of IGFBP5 1 0.22 0.24 0.08
65 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07
66 INT124721 Regulation of Localization of IGFBP3 1 0.10 0.23 0.07
67 INT234630 Negative_regulation of Transcription of IGFBP3 1 0.43 2.1 0.06
68 INT132066 Regulation of Igfbp3 1 0.56 0.09 0.06
69 INT67340 Localization of IGFBP5 1 0.55 0.17 0.06
70 INT202238 Regulation of Transcription of IGF1 1 0.38 0 0.06
71 INT234629 Regulation of Transcription of IGFBP3 3 0.40 3.29 0.05
72 INT275737 Positive_regulation of Binding of Igfbp3 1 0.18 0 0.05
73 INT231433 Positive_regulation of Binding of IGFBP3 2 0.34 0.6 0.04
74 INT312249 Gene_expression of IGFBP5 1 0.18 0.07 0.04
75 INT278502 Positive_regulation of Positive_regulation of IGFBP3 1 0.26 0.4 0.03
76 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0
77 INT202239 Negative_regulation of Negative_regulation of IGF1 2 0.39 0.53 0
78 INT180890 Positive_regulation of Transcription of IGFBP3 2 0.47 2.18 0
79 INT307056 Positive_regulation of Localization of IGFBP3 1 0.39 0.99 0
80 INT67335 Transcription of IGFBP5 1 0.37 0 0
81 INT274266 Regulation of Positive_regulation of IGF1 1 0.35 0.17 0
82 INT264308 Negative_regulation of Regulation of IGF1 1 0.39 0.23 0
83 INT275743 Negative_regulation of Binding of Igfbp3 1 0.16 0.2 0
84 INT307062 Negative_regulation of Localization of IGFBP3 1 0.24 0.05 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox