GO:0017015

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Name regulation of transforming growth factor beta receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0017015
Unique Molecular Interactions 366
Total Molecular Interactions 476
Total Single Events 2944
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of transforming growth factor beta receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of transforming growth factor beta receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
2 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
3 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
4 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
5 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
6 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
7 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
8 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
9 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
10 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
11 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
12 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
13 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
14 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
15 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
16 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
17 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
18 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
19 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
20 INT6975 Zeb1 Positive_regulation of St8sia1 1 0.03 0.17 0.91
21 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
22 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
23 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
24 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
25 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
26 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
27 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
28 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
29 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
30 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
31 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
32 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
33 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
34 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
35 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
36 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
37 INT32719 ENG Regulation of LH 2 0.00 0 0.64
38 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
39 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
40 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
41 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
42 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
43 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
44 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
45 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
46 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
47 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
48 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
49 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
50 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
51 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
52 INT89145 TGFB1 Positive_regulation of Tcstv1 1 0.00 0.49 0.49
53 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
54 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
55 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
56 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
57 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
58 INT215543 Negative_regulation of Trim33 Negative_regulation of Gopc 1 0.15 0.35 0.48
59 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
60 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
61 INT102213 Binding of ENG and HP 1 0.01 0 0.47
62 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
63 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
64 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
65 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
66 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
67 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
68 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
69 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
70 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
71 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
72 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39
73 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39
74 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
75 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
76 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38
77 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38
78 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
79 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
80 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
81 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
82 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
83 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33
84 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
85 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33
86 INT239079 D0H4S114 Positive_regulation of Gene_expression of Cpa1 1 0.11 0.3 0.32
87 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
88 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
89 INT55404 Binding of ENG and Th 1 0.02 0 0.3
90 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
91 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
92 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
93 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
94 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
95 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
96 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
97 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
98 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
99 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
100 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
101 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
102 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
103 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
104 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
105 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
106 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25
107 INT225098 ZNF630 Regulation of Localization of TGFB1 1 0.01 0.44 0.24
108 INT225105 ZNF630 Regulation of TGFB1 1 0.01 0.44 0.24
109 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
110 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
111 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
112 INT112596 Tgfb1 Negative_regulation of Negative_regulation of Mptp1 1 0.26 0.72 0.22
113 INT112595 Tgfb1 Negative_regulation of Gene_expression of Mptp1 1 0.27 0.72 0.22
114 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
115 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
116 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21
117 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
118 INT92692 Tgfb1 Positive_regulation of Gene_expression of Fn1 1 0.27 0.91 0.2
119 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
120 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
121 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19
122 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
123 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
124 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
125 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19
126 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19
127 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
128 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19
129 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
130 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18
131 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18
132 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
133 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
134 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
135 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
136 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
137 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
138 INT160083 TGFB1 Positive_regulation of Gene_expression of L1CAM 1 0.16 1.53 0.16
139 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
140 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14
141 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
142 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
143 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
144 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13
145 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
146 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
147 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
148 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
149 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
150 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
151 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
152 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
153 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11
154 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
155 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
156 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
157 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
158 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
159 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
160 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
161 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09
162 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
163 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09
164 INT338433 Il17f Positive_regulation of Gene_expression of IL8 1 0.01 1.62 0.09
165 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09
166 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
167 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08
168 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08
169 INT134832 TGFB1 Regulation of YAP1 1 0.16 0.68 0.08
170 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
171 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
172 INT304330 TGFB1 Positive_regulation of ECM1 1 0.00 0.31 0.08
173 INT251232 Slc17a6 Positive_regulation of Tgfb1 1 0.03 0 0.08
174 INT134835 TGFB1 Regulation of Gene_expression of YAP1 1 0.49 0.69 0.08
175 INT134834 TGFB1 Positive_regulation of YAP1 1 0.55 0.81 0.08
176 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
177 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
178 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07
179 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
180 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
181 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
182 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
183 INT94851 TGFB1 Regulation of Gene_expression of COL7A1 1 0.03 0.06 0.06
184 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05
185 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
186 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
187 INT233850 Zeb1 Positive_regulation of Itk 1 0.04 0.58 0.04
188 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
189 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
190 INT233848 Zeb1 Positive_regulation of Snai1 1 0.07 0.58 0.04
191 INT233853 Zeb1 Positive_regulation of Snai2 1 0.09 0.58 0.04
192 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
193 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
194 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
195 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04
196 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
197 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
198 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
199 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
200 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of transforming growth factor beta receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of transforming growth factor beta receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
2 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
3 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
4 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
5 INT10799 Localization of ENG 63 0.78 18.67 27.28
6 INT239070 Gene_expression of D0H4S114 1 0.77 17.16 23.78
7 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
8 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
9 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
10 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
11 INT7674 Regulation of ENG 42 0.30 11.41 14.44
12 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
13 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
14 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
15 INT23375 Binding of ENG 17 0.47 6.02 6.46
16 INT254269 Gene_expression of Il17f 12 0.48 13.29 6.02
17 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
18 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
19 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
20 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
21 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
22 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
23 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
24 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
25 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
26 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
27 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
28 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
29 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
30 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
31 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
32 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
33 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
34 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
35 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
36 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
37 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
38 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
39 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
40 INT239077 Regulation of Gene_expression of D0H4S114 1 0.39 1.7 2.34
41 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
42 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
43 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
44 INT12086 Regulation of Localization of TGFB1 4 0.43 1.65 2.09
45 INT239071 Positive_regulation of D0H4S114 1 0.44 1.74 2.09
46 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
47 INT350632 Positive_regulation of Il17f 2 0.29 6.22 1.96
48 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
49 INT239069 Positive_regulation of Gene_expression of D0H4S114 1 0.69 1.39 1.9
50 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84
51 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
52 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
53 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
54 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
55 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63
56 INT239078 Localization of D0H4S114 1 0.61 1.48 1.63
57 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55
58 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
59 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51
60 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
61 INT228040 Negative_regulation of Transcription of Tgfb1 1 0.04 0.49 1.42
62 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4
63 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
64 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3
65 INT300541 Negative_regulation of Gene_expression of Il17f 3 0.26 2.6 1.27
66 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
67 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
68 INT254179 Localization of Il17f 3 0.49 3.29 1.25
69 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
70 INT338411 Positive_regulation of Gene_expression of Il17f 5 0.29 4.58 1.21
71 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
72 INT239074 Negative_regulation of Gene_expression of D0H4S114 1 0.42 0.95 1.12
73 INT239073 Negative_regulation of D0H4S114 1 0.37 0.94 1.11
74 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
75 INT300538 Negative_regulation of Il17f 2 0.26 1.98 1.07
76 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
77 INT239072 Protein_catabolism of D0H4S114 1 0.57 0.81 0.98
78 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
79 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
80 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
81 INT215518 Negative_regulation of Trim33 2 0.57 0.43 0.88
82 INT285477 Positive_regulation of Zeb1 2 0.17 0.86 0.86
83 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
84 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
85 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
86 INT102848 Negative_regulation of Localization of Tgfb1 3 0.10 1.81 0.83
87 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
88 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
89 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76
90 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
91 INT90790 Regulation of Localization of Tgfb1 2 0.29 0.46 0.75
92 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
93 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72
94 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
95 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
96 INT337046 Positive_regulation of Binding of Tgfb1 1 0.30 1.1 0.69
97 INT215519 Protein_catabolism of Trim33 1 0.86 0.39 0.69
98 INT121302 Positive_regulation of Localization of Tgfb1 5 0.07 1.91 0.67
99 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66
100 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
101 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
102 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
103 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
104 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
105 INT239076 Binding of D0H4S114 1 0.31 0.69 0.63
106 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6
107 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59
108 INT138140 Protein_catabolism of Tgfb1 2 0.09 0.87 0.59
109 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
110 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
111 INT69683 Positive_regulation of Transcription of Tgfb1 1 0.67 0 0.53
112 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
113 INT300542 Binding of Il17f 2 0.05 1.68 0.5
114 INT120074 Regulation of Gene_expression of Smad7 1 0.58 2.05 0.5
115 INT6808 Localization of Zeb1 2 0.18 0 0.45
116 INT353934 Positive_regulation of Negative_regulation of Il17f 1 0.31 0.9 0.44
117 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
118 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43
119 INT133315 Gene_expression of ZEB1 4 0.59 2.93 0.42
120 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
121 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
122 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
123 INT69680 Positive_regulation of Positive_regulation of Tgfb1 3 0.67 1.04 0.35
124 INT285492 Transcription of Zeb1 1 0.17 0.61 0.33
125 INT285469 Positive_regulation of Transcription of Zeb1 1 0.12 0.61 0.33
126 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
127 INT134840 Gene_expression of SMAD7 1 0.74 2.74 0.31
128 INT92100 Binding of Smad4 5 0.31 2.23 0.3
129 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
130 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
131 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
132 INT184716 Binding of Smad7 2 0.34 0.91 0.29
133 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
134 INT272890 Regulation of Negative_regulation of Smad7 1 0.19 1.33 0.29
135 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
136 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
137 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24
138 INT228793 Negative_regulation of Gene_expression of Smad7 5 0.25 2.33 0.23
139 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
140 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22
141 INT265311 Localization of Smad2 5 0.50 1.57 0.21
142 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
143 INT218762 Localization of ZEB1 2 0.65 0.09 0.2
144 INT218763 Regulation of ZEB1 1 0.39 0.32 0.2
145 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
146 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
147 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
148 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
149 INT85330 Positive_regulation of Regulation of Tgfb1 1 0.41 0.67 0.17
150 INT122201 Binding of Tgfb1 1 0.16 0.17 0.17
151 INT338405 Regulation of Il17f 1 0.04 0.58 0.16
152 INT228790 Positive_regulation of Smad7 4 0.41 0.58 0.15
153 INT133100 Negative_regulation of Localization of Tgfb1 2 0.28 1.48 0.15
154 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
155 INT297455 Positive_regulation of Gdf2 1 0.01 0.75 0.15
156 INT135490 Localization of Smad2 1 0.51 0.08 0.14
157 INT90940 Binding of Eng 5 0.35 1.92 0.13
158 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
159 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
160 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
161 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
162 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
163 INT218760 Negative_regulation of ZEB1 4 0.38 1.38 0.09
164 INT14738 Negative_regulation of Regulation of TGFB1 2 0.41 0.81 0.09
165 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
166 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
167 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
168 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
169 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08
170 INT353267 Negative_regulation of Positive_regulation of Smad7 1 0.25 0.32 0.08
171 INT254790 Localization of Smad4 2 0.37 0.54 0.06
172 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
173 INT139093 Regulation of Negative_regulation of Tgfb1 1 0.27 0.44 0.06
174 INT265338 Regulation of Eng 2 0.42 0.94 0.05
175 INT251230 Positive_regulation of Negative_regulation of Tgfb1 1 0.09 0 0.05
176 INT347149 Localization of Smad7 1 0.67 0 0.05
177 INT230042 Binding of ZEB1 1 0.03 0.99 0.05
178 INT136115 Positive_regulation of Regulation of TGFB1 1 0.11 0.16 0.05
179 INT230041 Negative_regulation of Gene_expression of ZEB1 1 0.03 1.03 0.05
180 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
181 INT262799 Localization of Smad3 6 0.56 2.09 0.04
182 INT337908 Binding of Smad2 3 0.24 1.06 0.04
183 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
184 INT233847 Gene_expression of Zeb1 1 0.32 0.63 0.04
185 INT334291 Positive_regulation of Gene_expression of SMAD4 1 0.18 0 0.04
186 INT233840 Positive_regulation of Gene_expression of Zeb1 1 0.25 0.63 0.04
187 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
188 INT185020 Positive_regulation of Negative_regulation of TGFB1 1 0.43 0.44 0.04
189 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03
190 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
191 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
192 INT180881 Regulation of Positive_regulation of TGFB1 2 0.32 1.32 0.03
193 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
194 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
195 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
196 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03
197 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
198 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
199 INT353280 Phosphorylation of Smad7 1 0.48 0.06 0.03
200 INT245858 Positive_regulation of Gene_expression of Eng 1 0.12 0 0.03
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