GO:0017016

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Name Ras GTPase binding
Categary Function
Go Slim No
Go Link GO:0017016
Unique Molecular Interactions 91
Total Molecular Interactions 106
Total Single Events 583
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Ras GTPase binding. They are ordered first by their pain relevance and then by number of times they were reported for Ras GTPase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
2 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
3 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
4 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
5 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
6 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
7 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
8 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
9 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
10 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
11 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
12 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
13 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
14 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
15 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39
16 INT88252 Binding of RAP1A and Krit1 1 0.36 2.25 0.33
17 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
18 INT174311 Binding of Krit1 and Rap1a 1 0.04 1.08 0.28
19 INT302438 Binding of Raf1 and Rtn4r 1 0.04 0.08 0.26
20 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
21 INT149357 Trib3 Negative_regulation of Raf1 1 0.01 0.08 0.25
22 INT149356 Prkaca Negative_regulation of Raf1 1 0.10 0.08 0.25
23 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
24 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
25 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18
26 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18
27 INT181144 Raf1 Positive_regulation of Gene_expression of El4 1 0.06 0.35 0.17
28 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
29 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
30 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
31 INT46268 MAPKAP1 Regulation of PTGS1 1 0.13 0 0.13
32 INT252779 Binding of ESR1 and RAF1 1 0.01 2.03 0.11
33 INT252778 RAF1 Positive_regulation of Positive_regulation of ROS1 1 0.04 2.05 0.11
34 INT111134 Binding of Krit1 and Rap1a 1 0.07 0.81 0.1
35 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1
36 INT314588 Binding of Ifnar1 and Positive_regulation of Raf1 1 0.13 0 0.1
37 INT269592 MAPKAP1 Positive_regulation of Phosphorylation of CFL1 1 0.03 0 0.09
38 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
39 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09
40 INT269569 MAPKAP1 Positive_regulation of PER1 1 0.01 0 0.08
41 INT250801 Binding of AP5M1 and MAPKAP1 1 0.00 1.48 0.08
42 INT269566 MAPKAP1 Positive_regulation of Localization of PER1 1 0.01 0 0.08
43 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
44 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
45 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
46 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
47 INT194701 MAP2K1 Positive_regulation of MAP2K4 1 0.21 0 0.04
48 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
49 INT194691 MAP2K1 Positive_regulation of MAP2K3 1 0.23 0 0.04
50 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
51 INT269589 MAPKAP1 Regulation of TMPO 1 0.03 0.07 0.03
52 INT269502 Lta Negative_regulation of Map2k1 1 0.17 0.48 0.03
53 INT269554 MAPKAP1 Regulation of PTGIR 1 0.00 0.07 0.03
54 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
55 INT269585 MAPKAP1 Negative_regulation of Phosphorylation of ACTN1 1 0.00 0 0
56 INT280568 MRAS Positive_regulation of RAF1 1 0.01 0.7 0
57 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0
58 INT278768 NUP98 Negative_regulation of Gene_expression of RAP1A 1 0.41 0.44 0
59 INT278771 OR51S1 Negative_regulation of Gene_expression of RAP1A 1 0.01 0.22 0
60 INT342817 Binding of HIVEP1 and MAPKAP1 1 0.01 0.92 0
61 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0
62 INT303332 ras Positive_regulation of Raf1 1 0.02 0.07 0
63 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0
64 INT278748 HOXA9 Negative_regulation of Gene_expression of RAP1A 1 0.38 0.44 0
65 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0
66 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
67 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0
68 INT269591 MAPKAP1 Positive_regulation of CA2 1 0.04 0 0
69 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0
70 INT225874 Positive_regulation of ras Positive_regulation of RAF1 1 0.00 0 0
71 INT254686 Gene_expression of Map2k1 Regulation of Gene_expression of Mdk 1 0.08 0.42 0
72 INT269565 Binding of TMPO and MAPKAP1 1 0.02 0.06 0
73 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
74 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0
75 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0
76 INT254696 Map2k2 Regulation of Map2k1 1 0.18 0.78 0
77 INT225871 RAF1 Positive_regulation of Mdk 1 0.00 0 0
78 INT269564 MAPKAP1 Regulation of Positive_regulation of RHOA 1 0.03 0 0
79 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0
80 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0
81 INT254706 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
82 INT225875 ras Positive_regulation of RAF1 1 0.00 0 0
83 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0
84 INT254702 Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0
85 INT254684 Map2k2 Positive_regulation of Map2k1 1 0.45 0.4 0
86 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
87 INT278760 EPO Positive_regulation of RAP1A 1 0.13 0.16 0
88 INT336606 Binding of Mapk8 and Map2k1 1 0.09 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Ras GTPase binding. They are ordered first by their pain relevance and then by number of times they were reported in Ras GTPase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
2 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
3 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
4 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
5 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
6 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
7 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
8 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
9 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
10 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
11 INT69196 Positive_regulation of Rap1a 2 0.29 1.18 2.06
12 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
13 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
14 INT70322 Gene_expression of MAPKAP1 10 0.65 6.06 1.7
15 INT82143 Gene_expression of Raf1 2 0.18 0.33 1.59
16 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
17 INT82140 Negative_regulation of Raf1 3 0.14 1.7 1.38
18 INT82141 Positive_regulation of Raf1 2 0.12 0.81 1.38
19 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
20 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
21 INT69195 Negative_regulation of Rap1a 1 0.10 0.34 1.33
22 INT82139 Positive_regulation of Gene_expression of Raf1 2 0.12 0.28 1.29
23 INT69210 Negative_regulation of MAPKAP1 3 0.07 0 1.23
24 INT127805 Positive_regulation of Phosphorylation of RAF1 3 0.45 1.21 1.17
25 INT108156 Positive_regulation of MAPKAP1 4 0.08 1.91 1.14
26 INT289470 Transcription of MAPKAP1 1 0.09 2.61 1.13
27 INT108157 Negative_regulation of Negative_regulation of MAPKAP1 1 0.02 0 1.11
28 INT82138 Negative_regulation of Gene_expression of Raf1 1 0.01 0.28 1.04
29 INT82142 Negative_regulation of Positive_regulation of Raf1 1 0.01 0.28 1.04
30 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
31 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
32 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
33 INT69194 Positive_regulation of Negative_regulation of Rap1a 1 0.12 0.17 0.66
34 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
35 INT171362 Gene_expression of Raf1 13 0.66 8.36 0.49
36 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
37 INT323167 Negative_regulation of Phosphorylation of RAF1 1 0.08 0 0.43
38 INT252737 Gene_expression of RAF1 12 0.58 10.97 0.42
39 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39
40 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
41 INT69414 Positive_regulation of Rap1a 1 0.67 0 0.37
42 INT181130 Positive_regulation of Gene_expression of Raf1 1 0.59 2.29 0.36
43 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
44 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
45 INT250814 Positive_regulation of Gene_expression of MAPKAP1 2 0.49 2.78 0.25
46 INT175506 Regulation of Positive_regulation of Map2k1 2 0.32 1.58 0.23
47 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
48 INT252745 Positive_regulation of Positive_regulation of RAF1 3 0.20 4.62 0.21
49 INT224563 Positive_regulation of Positive_regulation of Raf1 1 0.11 0 0.2
50 INT181125 Transcription of Raf1 2 0.59 1.14 0.18
51 INT102337 Gene_expression of RAP1A 4 0.58 1.83 0.17
52 INT180113 Gene_expression of Rap1a 2 0.27 0.13 0.15
53 INT180120 Positive_regulation of Gene_expression of Rap1a 1 0.12 0.13 0.15
54 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14
55 INT330973 Regulation of Phosphorylation of RAF1 1 0.30 1.09 0.14
56 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
57 INT175527 Localization of Map2k1 4 0.31 2.41 0.13
58 INT69413 Positive_regulation of Positive_regulation of Rap1a 1 0.67 0 0.13
59 INT284981 Protein_catabolism of RAF1 2 0.08 1.62 0.12
60 INT315042 Positive_regulation of Gene_expression of RAF1 1 0.05 0.23 0.12
61 INT46271 Regulation of MAPKAP1 3 0.29 0 0.11
62 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11
63 INT280585 Negative_regulation of Gene_expression of RAF1 1 0.13 1.88 0.11
64 INT174309 Binding of Rap1a 1 0.05 0.55 0.11
65 INT171373 Positive_regulation of Raf1 3 0.14 0.67 0.1
66 INT88251 Binding of RAP1A 1 0.03 0.57 0.09
67 INT214921 Localization of MAPKAP1 3 0.09 2.5 0.08
68 INT250810 Regulation of Gene_expression of MAPKAP1 1 0.06 1.42 0.08
69 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
70 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
71 INT252703 Localization of RAF1 2 0.32 1.3 0.07
72 INT252753 Positive_regulation of Localization of RAF1 1 0.06 1.35 0.07
73 INT224326 Binding of RAF1 3 0.13 3.11 0.05
74 INT281764 Negative_regulation of Gene_expression of Map2k1 1 0.18 1.11 0.04
75 INT181128 Localization of Raf1 1 0.69 7.07 0.04
76 INT232193 Positive_regulation of RAP1A 2 0.41 0.36 0.03
77 INT269605 Negative_regulation of Positive_regulation of MAPKAP1 1 0.06 0 0.03
78 INT70324 Phosphorylation of MAPKAP1 3 0.18 0 0
79 INT329571 Binding of MAP2K1 2 0.11 0.4 0
80 INT191648 Negative_regulation of Gene_expression of Rap1a 1 0.17 0 0
81 INT232192 Negative_regulation of Negative_regulation of RAP1A 1 0.26 0.17 0
82 INT232195 Negative_regulation of Gene_expression of RAP1A 1 0.25 0.22 0
83 INT70325 Positive_regulation of Phosphorylation of MAPKAP1 1 0.15 0 0
84 INT224535 Localization of Raf1 1 0.17 0 0
85 INT281758 Positive_regulation of Protein_catabolism of Map2k1 1 0.29 0.13 0
86 INT281756 Protein_catabolism of Map2k1 1 0.42 0.13 0
87 INT175533 Regulation of Gene_expression of Map2k1 1 0.20 1.55 0
88 INT293481 Negative_regulation of Gene_expression of Raf1 1 0.24 0.38 0
89 INT280590 Transcription of RAF1 1 0.52 0.75 0
90 INT232194 Negative_regulation of RAP1A 1 0.26 0.37 0
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