GO:0017017

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Name MAP kinase tyrosine/serine/threonine phosphatase activity
Categary Function
Go Slim No
Go Link GO:0017017
Unique Molecular Interactions 49
Total Molecular Interactions 58
Total Single Events 290
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MAP kinase tyrosine/serine/threonine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported for MAP kinase tyrosine/serine/threonine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
2 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
3 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
4 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
5 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69
6 INT274871 Positive_regulation of Cbr2 Positive_regulation of Positive_regulation of Dusp6 1 0.02 0.72 0.67
7 INT352463 Gse1 Regulation of Gene_expression of Dusp1 1 0.07 0 0.59
8 INT144932 DUSP5 Negative_regulation of TRPV1 1 0.00 0 0.48
9 INT191691 Igh-Dex Positive_regulation of Dusp1 1 0.02 1.8 0.46
10 INT352445 Gse1 Positive_regulation of Gene_expression of Dusp1 1 0.06 0.41 0.34
11 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32
12 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
13 INT352458 Dusp1 Regulation of Gene_expression of Tnc 1 0.07 0 0.28
14 INT352443 Gse1 Regulation of Dusp1 1 0.03 0 0.27
15 INT352449 Dusp1 Regulation of Gene_expression of Slc1a3 1 0.05 0 0.27
16 INT352466 Calca Regulation of Gene_expression of Dusp1 1 0.04 0 0.27
17 INT106761 Tlr4 Positive_regulation of Dusp1 1 0.01 0.16 0.21
18 INT334314 Tlr4 Positive_regulation of Gene_expression of Dusp1 1 0.01 0.37 0.19
19 INT274832 Dusp6 Positive_regulation of Localization of Tlr4 1 0.00 0 0.19
20 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
21 INT267017 Bdnf Positive_regulation of Dusp6 1 0.13 0.1 0.07
22 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05
23 INT341533 DUSP4 Regulation of MAPK8 1 0.03 0.28 0.05
24 INT274833 Negative_regulation of Dusp6 Positive_regulation of Mapk1 1 0.01 0 0.04
25 INT274830 Tlr4 Positive_regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
26 INT274829 Tlr4 Regulation of Gene_expression of Dusp6 1 0.00 0.06 0.03
27 INT221467 Binding of Creb1 and Dusp1 1 0.10 0 0
28 INT274831 Dusp6 Positive_regulation of Tlr4 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MAP kinase tyrosine/serine/threonine phosphatase activity. They are ordered first by their pain relevance and then by number of times they were reported in MAP kinase tyrosine/serine/threonine phosphatase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106757 Gene_expression of Dusp1 9 0.66 10.45 7.26
2 INT106756 Positive_regulation of Gene_expression of Dusp1 7 0.59 7.65 5.24
3 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21
4 INT106760 Positive_regulation of Dusp1 16 0.59 8.5 3.35
5 INT111099 Positive_regulation of Dusp1 11 0.68 7.62 3.18
6 INT111098 Regulation of Dusp1 5 0.27 3.03 2.45
7 INT317880 Regulation of Gene_expression of Dusp1 2 0.42 2.98 1.94
8 INT274884 Positive_regulation of Dusp6 1 0.07 2.08 1.52
9 INT207092 Localization of Dusp1 6 0.70 4.7 1.51
10 INT274892 Gene_expression of Dusp6 1 0.08 1.81 1.4
11 INT274888 Negative_regulation of Dusp6 1 0.06 1.82 0.93
12 INT42766 Localization of Dusp1 1 0.10 0 0.84
13 INT226221 Binding of Dusp1 1 0.04 0.92 0.68
14 INT274881 Regulation of Dusp6 1 0.04 0.9 0.63
15 INT274885 Negative_regulation of Gene_expression of Dusp6 1 0.04 0.89 0.6
16 INT191677 Positive_regulation of Gene_expression of Dusp1 2 0.20 4.93 0.55
17 INT274880 Negative_regulation of Positive_regulation of Dusp6 1 0.04 0.89 0.52
18 INT144943 Positive_regulation of DUSP5 1 0.00 0 0.47
19 INT218920 Phosphorylation of Dusp1 5 0.44 1.13 0.41
20 INT106758 Negative_regulation of Positive_regulation of Dusp1 1 0.18 0.3 0.37
21 INT111097 Negative_regulation of Dusp1 3 0.58 1.41 0.32
22 INT178400 Negative_regulation of Gene_expression of Dusp1 4 0.40 3.61 0.31
23 INT106759 Negative_regulation of Gene_expression of Dusp1 2 0.36 0.59 0.3
24 INT352436 Positive_regulation of Positive_regulation of Dusp1 1 0.17 0.32 0.28
25 INT274883 Positive_regulation of Gene_expression of Dusp6 1 0.07 0.39 0.27
26 INT274876 Positive_regulation of Positive_regulation of Dusp6 1 0.04 0.49 0.25
27 INT218923 Regulation of Dusp1 1 0.07 1.85 0.21
28 INT310567 Negative_regulation of Dusp1 1 0.10 0.07 0.17
29 INT334313 Positive_regulation of Phosphorylation of Dusp1 1 0.38 0.33 0.16
30 INT221451 Negative_regulation of Positive_regulation of Dusp1 2 0.35 1.17 0.14
31 INT341569 Regulation of DUSP5 1 0.09 0.28 0.05
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