GO:0017046

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Name peptide hormone binding
Categary Function
Go Slim No
Go Link GO:0017046
Unique Molecular Interactions 598
Total Molecular Interactions 836
Total Single Events 6133
Pain Genes Associated 60

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptide hormone binding. They are ordered first by their pain relevance and then by number of times they were reported for peptide hormone binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
4 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
5 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
6 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
7 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
8 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
9 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
10 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
11 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
12 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
13 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
14 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44
15 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
16 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
17 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
18 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
19 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
20 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15
21 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
22 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
23 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
24 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
25 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
26 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
27 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
28 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
29 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
30 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
31 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
32 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
33 INT113743 Mc3r Regulation of Gene_expression of Agrp 1 0.05 0.9 0.98
34 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
35 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
36 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
37 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91
38 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
39 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
40 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87
41 INT111790 Penk Regulation of Gene_expression of Npr1 1 0.22 0.56 0.86
42 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
43 INT115655 Glp1r Positive_regulation of Ins1 1 0.42 0 0.84
44 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
45 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
46 INT41156 Sst Negative_regulation of Npr1 1 0.05 0 0.84
47 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84
48 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
49 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
50 INT84102 B3GAT1 Positive_regulation of Localization of Glp1r 1 0.09 0 0.83
51 INT16438 Atp6v0d2 Regulation of Localization of Lnpep 1 0.01 0 0.81
52 INT16435 Ubqln1 Regulation of Localization of Lnpep 1 0.01 0 0.81
53 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
54 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
55 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
56 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
57 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
58 INT18402 Glp1r Regulation of Localization of Sst 1 0.19 0 0.77
59 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
60 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
61 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
62 INT353718 Binding of Rbm39 and Ghsr 1 0.01 0 0.76
63 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
64 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
65 INT57658 ASNA1 Positive_regulation of Npr1 1 0.00 0.15 0.74
66 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73
67 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 0.31 0 0.7
68 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69
69 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
70 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
71 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
72 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
73 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
74 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
75 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
76 INT6464 Sst Regulation of Negative_regulation of Npr1 1 0.01 0 0.64
77 INT6463 Oprd1 Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
78 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
79 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
80 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
81 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
82 INT35159 FSHR Regulation of PRL 2 0.34 0 0.6
83 INT60537 Gnrh1 Positive_regulation of Localization of FSHR 1 0.00 0.19 0.6
84 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
85 INT98815 Binding of Crhr2 and Ucn 3 0.32 0.5 0.56
86 INT251161 Binding of Trpv1 and Rxfp2 1 0.06 0.18 0.55
87 INT108021 Binding of Pomc and Mc4r 1 0.00 0.97 0.55
88 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54
89 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
90 INT255463 Binding of Avp and Avpr1a 1 0.06 0.67 0.54
91 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
92 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
93 INT214164 Binding of Mc4r and Pomc 1 0.39 1.31 0.53
94 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
95 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
96 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
97 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52
98 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52
99 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
100 INT89187 Agrp Negative_regulation of Mc3r 1 0.33 0 0.51
101 INT43075 Slc6a14 Regulation of Positive_regulation of Npr1 1 0.01 0 0.51
102 INT43076 Slc6a14 Regulation of Npr1 1 0.01 0 0.51
103 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51
104 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
105 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
106 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
107 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
108 INT355687 Art2b Positive_regulation of Gene_expression of Mc3r 1 0.02 1.01 0.48
109 INT8317 Fshr Regulation of Localization of LH 1 0.29 0 0.48
110 INT39178 NPL Regulation of FSHR 1 0.03 0 0.46
111 INT55265 Ptgdr Negative_regulation of Npr1 1 0.01 0 0.46
112 INT52679 Positive_regulation of Npr1 Positive_regulation of Positive_regulation of VSX1 1 0.00 0 0.45
113 INT151890 Binding of PRLR and Adarb1 1 0.00 0 0.45
114 INT327386 TNF Regulation of Gene_expression of Oxtr 1 0.20 0.98 0.45
115 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
116 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
117 INT325391 Binding of Ghrl and Ghsr 2 0.17 0.14 0.43
118 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
119 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
120 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43
121 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
122 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
123 INT25027 CRH Negative_regulation of Negative_regulation of FSHR 1 0.25 0 0.42
124 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
125 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
126 INT59742 Glp1r Positive_regulation of Gene_expression of Npy 1 0.27 0.32 0.41
127 INT59740 Glp1r Positive_regulation of Localization of Npy 1 0.25 0.33 0.41
128 INT59739 Glp1r Positive_regulation of Transcription of Npy 1 0.25 0.32 0.41
129 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4
130 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
131 INT57649 Oprd1 Positive_regulation of Npr1 1 0.01 0.1 0.39
132 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
133 INT95999 Binding of Npr1 and Cnr1 1 0.05 0 0.39
134 INT169507 Oxt Regulation of Gene_expression of Oxtr 2 0.20 0.84 0.38
135 INT55427 Grpr Positive_regulation of Localization of Glp1r 1 0.02 0 0.38
136 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
137 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37
138 INT214140 Agrp Positive_regulation of Mc3r 1 0.34 0.23 0.37
139 INT214158 Binding of Agrp and Mc3r 1 0.35 0.18 0.37
140 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37
141 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37
142 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36
143 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
144 INT42560 OXTR Positive_regulation of Gene_expression of PGF 1 0.50 0.36 0.36
145 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
146 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
147 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35
148 INT327381 Il13 Regulation of Gene_expression of Oxtr 1 0.37 0.88 0.35
149 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
150 INT12522 Binding of FSHR and POMC 1 0.33 3.89 0.34
151 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
152 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
153 INT55426 Sct Positive_regulation of Localization of Glp1r 1 0.49 0 0.33
154 INT214157 Positive_regulation of Mc3r Regulation of Npy 1 0.14 0.49 0.33
155 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
156 INT201484 Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb 1 0.34 0.96 0.32
157 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
158 INT31044 Gnrh1 Negative_regulation of Localization of FSHR 1 0.04 0 0.32
159 INT31040 Ghrh Positive_regulation of Localization of FSHR 1 0.05 0 0.31
160 INT55429 Binding of Gip and Glp1r 1 0.39 0 0.31
161 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
162 INT62616 Regulation of Binding of PRLR and ST14 1 0.00 0 0.31
163 INT31041 Ghrh Positive_regulation of FSHR 1 0.05 0 0.31
164 INT62615 Binding of PRLR and ST14 1 0.00 0 0.31
165 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
166 INT75042 Binding of MC2R and MC4R 1 0.00 0.18 0.3
167 INT116680 Binding of ADRBK1 and Oxtr 1 0.18 0.14 0.3
168 INT75041 Binding of MC2R and MC3R 1 0.01 0.18 0.3
169 INT246690 exf Regulation of Localization of Ide 1 0.00 0.17 0.3
170 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
171 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
172 INT55425 Gip Positive_regulation of Localization of Glp1r 1 0.44 0 0.3
173 INT340177 Binding of Oxt and Avpr1a 6 0.15 2.24 0.29
174 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
175 INT35080 CRH Negative_regulation of Localization of FSHR 1 0.03 0 0.29
176 INT83750 Gh1 Regulation of Gene_expression of Ghsr 1 0.36 0 0.29
177 INT295549 Ghrl Positive_regulation of Gene_expression of Ghsr 1 0.29 0 0.29
178 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29
179 INT118545 Binding of Agtr2 and Msr1 1 0.00 0.09 0.29
180 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
181 INT45544 Ncapg2 Regulation of Localization of Lnpep 1 0.00 0 0.28
182 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
183 INT98816 Crhr2 Positive_regulation of Negative_regulation of Ucn 1 0.33 0.09 0.28
184 INT240807 Arc Regulation of Gene_expression of Lepr 1 0.05 0.72 0.28
185 INT45541 Agt Positive_regulation of Lnpep 1 0.03 0 0.27
186 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27
187 INT233781 Binding of PTH1R and SCT 1 0.18 0 0.27
188 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
189 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27
190 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 0.00 0 0.27
191 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
192 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26
193 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
194 INT149358 Binding of Oprm1 and Positive_regulation of Positive_regulation of Npr1 1 0.00 0.09 0.26
195 INT83220 Gucy1a2 Positive_regulation of Positive_regulation of Glp1r 1 0.02 0 0.26
196 INT16895 Regulation of GHSR Regulation of GH1 1 0.23 0 0.26
197 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 0.01 0 0.26
198 INT54263 Ghsr Regulation of Localization of Gh1 1 0.23 0 0.26
199 INT115413 Binding of Penk and Oxtr 1 0.00 0 0.25
200 INT327387 TNF Positive_regulation of Oxtr 1 0.15 0.28 0.25

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptide hormone binding. They are ordered first by their pain relevance and then by number of times they were reported in peptide hormone binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
2 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
3 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
4 INT16431 Localization of Lnpep 62 0.70 6.28 23.94
5 INT1644 Regulation of FSHR 77 0.55 15.62 21.49
6 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
7 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
8 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
9 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
10 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
11 INT912 Localization of FSHR 91 0.79 23.61 15.58
12 INT129 Localization of OXTR 51 0.80 11.08 15.36
13 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33
14 INT64447 Transcription of Mc4r 14 0.61 6.08 15.29
15 INT8989 Binding of Npr1 25 0.36 5.52 14.58
16 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
17 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04
18 INT64445 Gene_expression of Mc4r 17 0.78 5.06 12.91
19 INT89181 Gene_expression of Mc3r 33 0.77 22.48 11.85
20 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
21 INT56494 Localization of Ide 73 0.68 22.9 11.26
22 INT85017 Positive_regulation of Mc4r 13 0.67 7.56 10.86
23 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69
24 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65
25 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
26 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
27 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
28 INT12367 Binding of PRLR 17 0.03 2.05 9.69
29 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
30 INT78038 Gene_expression of Oxtr 43 0.78 18.72 9.38
31 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87
32 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
33 INT64449 Negative_regulation of Gene_expression of Mc4r 7 0.58 2 7.86
34 INT10627 Positive_regulation of Lnpep 24 0.69 3.36 7.85
35 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81
36 INT168915 Gene_expression of Oxtr 49 0.75 20.53 7.22
37 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
38 INT47944 Positive_regulation of Localization of Glp1r 23 0.70 0.16 6.79
39 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
40 INT47942 Positive_regulation of Glp1r 38 0.70 15.94 6.47
41 INT6459 Regulation of Negative_regulation of Npr1 10 0.53 0.16 6.44
42 INT64444 Negative_regulation of Mc4r 9 0.58 5.12 6.44
43 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
44 INT7021 Positive_regulation of Negative_regulation of Npr1 8 0.22 1.02 6.36
45 INT72110 Gene_expression of Glp1r 48 0.78 22.46 6.17
46 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
47 INT6195 Transcription of Npr1 9 0.69 3 5.94
48 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
49 INT69974 Positive_regulation of Oxtr 30 0.70 2.44 5.73
50 INT7018 Positive_regulation of Gene_expression of Npr1 10 0.59 5.09 5.66
51 INT9895 Binding of GHR 18 0.36 4.8 5.65
52 INT10624 Regulation of Lnpep 13 0.61 3.27 5.6
53 INT13706 Localization of Npr1 10 0.59 0.83 5.42
54 INT18661 Localization of Ghsr 32 0.78 3.19 5.2
55 INT27805 Regulation of Avpr1a 5 0.60 3.11 5.19
56 INT113636 Positive_regulation of Hcrtr1 10 0.70 8.29 5.18
57 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07
58 INT16432 Positive_regulation of Localization of Lnpep 12 0.32 1.15 5.05
59 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04
60 INT130 Negative_regulation of OXTR 19 0.43 4.63 4.96
61 INT923 Positive_regulation of Localization of FSHR 14 0.43 2.48 4.96
62 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92
63 INT21650 Regulation of OXTR 29 0.61 5.99 4.91
64 INT105608 Positive_regulation of Mc3r 9 0.68 8.53 4.83
65 INT64446 Negative_regulation of Transcription of Mc4r 4 0.43 1.01 4.8
66 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78
67 INT13313 Regulation of PRLR 7 0.07 1.65 4.77
68 INT64441 Regulation of Transcription of Mc4r 3 0.27 2.93 4.62
69 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6
70 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
71 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
72 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47
73 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
74 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
75 INT37379 Regulation of Localization of Glp1r 10 0.62 0.16 4.32
76 INT64448 Gene_expression of Mc3r 7 0.74 3.27 4.3
77 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
78 INT78033 Positive_regulation of Gene_expression of Oxtr 10 0.70 2.5 4.15
79 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
80 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
81 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
82 INT9822 Binding of Agtr2 9 0.36 3 3.93
83 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
84 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82
85 INT113634 Gene_expression of Hcrtr1 5 0.77 34.43 3.76
86 INT17975 Positive_regulation of Localization of OXTR 11 0.69 1.72 3.72
87 INT39786 Transcription of Lnpep 3 0.69 0.52 3.61
88 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
89 INT18825 Gene_expression of PRLR 8 0.40 2 3.47
90 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46
91 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45
92 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
93 INT32340 Negative_regulation of Lnpep 14 0.49 2.63 3.26
94 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
95 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
96 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12
97 INT17673 Negative_regulation of Localization of Lnpep 8 0.09 2.63 3.12
98 INT210838 Positive_regulation of Mc4r 17 0.53 6.79 3.06
99 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03
100 INT118107 Positive_regulation of Avpr1b 4 0.66 6.89 2.99
101 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
102 INT18399 Regulation of Glp1r 11 0.53 3.78 2.97
103 INT19206 Regulation of Gene_expression of OXTR 5 0.62 0.58 2.96
104 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
105 INT128 Negative_regulation of Localization of OXTR 7 0.59 2.92 2.86
106 INT54449 Positive_regulation of Transcription of Npr1 3 0.45 1.73 2.81
107 INT3812 Negative_regulation of Avpr1a 8 0.59 1.42 2.8
108 INT99104 Gene_expression of Npr1 5 0.78 3.31 2.8
109 INT19009 Positive_regulation of Ghsr 17 0.64 5.71 2.78
110 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78
111 INT12903 Gene_expression of Lnpep 14 0.71 1.3 2.78
112 INT130028 Positive_regulation of Gene_expression of Mc4r 2 0.45 0.41 2.7
113 INT25646 Negative_regulation of PRLR 5 0.08 0.08 2.62
114 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
115 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
116 INT191974 Regulation of Ide 16 0.38 9.54 2.52
117 INT26205 Positive_regulation of Positive_regulation of NPR1 3 0.24 1.57 2.52
118 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5
119 INT168913 Negative_regulation of Avpr1a 7 0.43 5.88 2.47
120 INT168914 Gene_expression of Avpr1a 10 0.75 5.51 2.45
121 INT16433 Regulation of Localization of Lnpep 6 0.11 0.32 2.45
122 INT6638 Binding of Oxtr 14 0.34 1.52 2.43
123 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
124 INT30857 Binding of OXTR 10 0.48 2.27 2.42
125 INT22019 Regulation of GHR 9 0.62 2.56 2.39
126 INT210833 Regulation of Mc4r 4 0.30 1.57 2.38
127 INT34266 Negative_regulation of Binding of PRLR 3 0.01 0 2.35
128 INT115654 Localization of Glp1r 11 0.75 3.79 2.34
129 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32
130 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
131 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
132 INT10626 Regulation of Positive_regulation of Lnpep 2 0.11 0.1 2.31
133 INT72109 Negative_regulation of Localization of Glp1r 8 0.59 0.8 2.3
134 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
135 INT35210 Gene_expression of Ghsr 39 0.75 6 2.24
136 INT133681 Positive_regulation of Gene_expression of Mc3r 5 0.67 5.38 2.19
137 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
138 INT214122 Negative_regulation of Mc3r 5 0.43 3.59 2.14
139 INT6460 Regulation of Gene_expression of Npr1 4 0.52 2.19 2.13
140 INT39134 Positive_regulation of Ace2 3 0.14 0.57 2.13
141 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
142 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
143 INT323480 Negative_regulation of Ghsr 4 0.36 0.9 2.06
144 INT47509 Gene_expression of Avpr1a 2 0.65 2.04 2.06
145 INT5681 Localization of Avpr1a 5 0.60 1.92 2.02
146 INT59737 Negative_regulation of Glp1r 15 0.43 6.94 2.01
147 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
148 INT169505 Positive_regulation of Oxtr 8 0.57 4.23 2
149 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
150 INT149761 Negative_regulation of MAS1 5 0.29 1.91 1.95
151 INT39133 Binding of Ace2 3 0.30 0.8 1.89
152 INT68857 Positive_regulation of Rxfp2 5 0.34 1.51 1.86
153 INT178130 Binding of EDNRB 12 0.36 6.18 1.84
154 INT14413 Regulation of Positive_regulation of Npr1 7 0.62 0.71 1.78
155 INT139535 Gene_expression of Avpr1b 4 0.73 14.2 1.78
156 INT11098 Regulation of NPR1 5 0.37 1.39 1.74
157 INT101875 Binding of MC4R 6 0.47 0.19 1.73
158 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
159 INT113897 Positive_regulation of Transcription of Mc4r 1 0.45 0 1.7
160 INT77415 Localization of GLP1R 23 0.63 11.1 1.69
161 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
162 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66
163 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
164 INT95321 Localization of Hcrtr1 4 0.79 14.81 1.66
165 INT89008 Gene_expression of Lepr 2 0.65 5.39 1.66
166 INT43045 Negative_regulation of Regulation of Npr1 3 0.12 0.17 1.65
167 INT12062 Positive_regulation of Gene_expression of OXTR 9 0.69 1.04 1.63
168 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62
169 INT149762 Regulation of MAS1 8 0.31 5.34 1.61
170 INT255462 Binding of Avpr1a 8 0.47 2.41 1.61
171 INT19007 Binding of Ghsr 5 0.46 0.46 1.6
172 INT152385 Gene_expression of Rxfp2 2 0.30 0.86 1.59
173 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
174 INT178264 Positive_regulation of Gene_expression of Mc4r 10 0.43 3.52 1.57
175 INT26488 Regulation of Npr1 4 0.39 0.88 1.56
176 INT242212 Gene_expression of GLP1R 29 0.65 11.36 1.52
177 INT7033 Binding of FSHR 19 0.37 6.66 1.52
178 INT139514 Localization of EDNRB 7 0.73 4.63 1.52
179 INT31921 Negative_regulation of Localization of Npr1 2 0.17 0 1.51
180 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
181 INT93350 Binding of Lepr 17 0.05 27.21 1.5
182 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
183 INT118106 Binding of Avpr1b 3 0.35 3.83 1.48
184 INT6194 Regulation of Transcription of Npr1 2 0.05 0.08 1.46
185 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
186 INT1641 Positive_regulation of Negative_regulation of FSHR 3 0.41 1.7 1.43
187 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42
188 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
189 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4
190 INT67465 Positive_regulation of Regulation of Npr1 1 0.05 0.14 1.4
191 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39
192 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
193 INT327376 Positive_regulation of Gene_expression of Oxtr 10 0.57 2.91 1.36
194 INT78034 Localization of Oxtr 7 0.81 1.09 1.36
195 INT148883 Gene_expression of HCRTR1 8 0.36 24.82 1.35
196 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
197 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
198 INT214111 Localization of Mc3r 2 0.72 1.81 1.34
199 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
200 INT264798 Binding of GLP1R 9 0.40 2.95 1.27
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