GO:0017048

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Name Rho GTPase binding
Categary Function
Go Slim No
Go Link GO:0017048
Unique Molecular Interactions 51
Total Molecular Interactions 98
Total Single Events 452
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rho GTPase binding. They are ordered first by their pain relevance and then by number of times they were reported for Rho GTPase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
4 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
5 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
6 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
7 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
8 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
9 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
10 INT76378 Binding of Cit and Flvcr2 1 0.09 0.17 1.15
11 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
12 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
13 INT337157 Iqgap1 Regulation of Gene_expression of Ros1 1 0.07 1.91 0.72
14 INT76379 Negative_regulation of Binding of Cit and Flvcr2 1 0.11 0.08 0.58
15 INT76377 Regulation of Binding of Cit and Flvcr2 1 0.07 0.09 0.57
16 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55
17 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
18 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
19 INT113950 FLNA Regulation of Oprd1 1 0.00 0.16 0.32
20 INT337162 Binding of Kdr and Iqgap1 1 0.32 0.98 0.28
21 INT337161 Binding of Diap1 and Iqgap1 1 0.29 0.78 0.28
22 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
23 INT337158 Binding of Iqgap1 and Wasl 1 0.09 0.55 0.22
24 INT337154 Binding of Iqgap1 and Braf 1 0.13 0.64 0.18
25 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
26 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
27 INT337164 Binding of DIAPH1 and Iqgap1 1 0.53 0.37 0.14
28 INT226733 Vps4a Positive_regulation of Tsg101 1 0.00 0.25 0.1
29 INT226734 Vps4a Positive_regulation of Vps28 1 0.00 0.25 0.1
30 INT337165 Iqgap1 Positive_regulation of Gene_expression of VEGFA 1 0.03 0.27 0.09
31 INT141257 Binding of S100A8 and VCL 1 0.36 0.97 0.09
32 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07
33 INT141256 S100A8 Positive_regulation of VCL 1 0.50 0.99 0.06
34 INT141258 S100A8 Negative_regulation of VCL 1 0.43 0.99 0.06
35 INT250015 Binding of FLNA and Nos3 1 0.05 1.09 0.06
36 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
37 INT272609 Binding of Cit and Dlg4 1 0.11 0 0.03
38 INT213585 Binding of CFTR and FLNA 1 0.14 0.11 0.03
39 INT338018 Binding of AR and Flna 1 0.11 0.33 0
40 INT302909 Nav2 Positive_regulation of Arhgef16 1 0.02 0.52 0
41 INT255164 Regulation of PM20D2 Regulation of FLNA 1 0.00 0.82 0
42 INT349987 Per1 Positive_regulation of Gene_expression of Diap1 1 0.08 0 0
43 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0
44 INT255165 PM20D2 Regulation of FLNA 1 0.00 0.76 0
45 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
46 INT338021 Binding of Flna and Regulation of Transcription of AR 1 0.14 0.33 0
47 INT276587 Binding of Iqgap1 and Nphs1 1 0.08 0.33 0
48 INT255163 Binding of FLNA and PM20D2 1 0.00 0 0
49 INT236529 Binding of Om and Flna 1 0.00 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rho GTPase binding. They are ordered first by their pain relevance and then by number of times they were reported in Rho GTPase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221172 Binding of Flna 32 0.42 1.37 51.59
2 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
3 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
4 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
5 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81
6 INT39948 Binding of FLNA 45 0.42 58.05 4.27
7 INT221168 Localization of Flna 1 0.58 0.05 4.05
8 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97
9 INT276520 Gene_expression of Iqgap1 2 0.76 8.67 3.1
10 INT221171 Positive_regulation of Localization of Flna 1 0.39 0.05 2.9
11 INT76375 Binding of Cit 6 0.12 0.39 2.77
12 INT99550 Regulation of FLNA 51 0.54 27.88 2.58
13 INT46646 Localization of FLNA 19 0.73 18.83 2.53
14 INT259224 Negative_regulation of Flna 1 0.23 0.15 2.51
15 INT221177 Negative_regulation of Gene_expression of Flna 2 0.33 0 2.22
16 INT221179 Regulation of Flna 1 0.24 0.13 2.04
17 INT111944 Phosphorylation of VCL 3 0.73 5.23 1.72
18 INT221166 Positive_regulation of Flna 2 0.39 0.09 1.7
19 INT76376 Negative_regulation of Binding of Cit 1 0.15 0.22 1.64
20 INT106534 Gene_expression of Dock9 3 0.65 1.62 1.63
21 INT259219 Negative_regulation of Negative_regulation of Flna 1 0.23 0 1.47
22 INT337151 Positive_regulation of Gene_expression of Iqgap1 1 0.68 3.69 1.16
23 INT337150 Negative_regulation of Iqgap1 1 0.42 2.47 0.92
24 INT142423 Negative_regulation of Positive_regulation of FLNA 2 0.05 0.99 0.89
25 INT111941 Regulation of Phosphorylation of VCL 1 0.27 0.66 0.8
26 INT111942 Positive_regulation of Phosphorylation of VCL 1 0.30 0.67 0.8
27 INT106533 Positive_regulation of Gene_expression of Dock9 1 0.49 0.33 0.65
28 INT279647 Regulation of Cit 1 0.27 0 0.64
29 INT276535 Binding of Iqgap1 2 0.47 2.16 0.59
30 INT272569 Gene_expression of Cit 2 0.40 0 0.5
31 INT279645 Binding of Cit 1 0.29 0.46 0.45
32 INT30080 Binding of Arhgef16 1 0.11 0.54 0.45
33 INT34037 Regulation of Arhgef16 1 0.15 0.6 0.45
34 INT127085 Regulation of Gene_expression of Dock9 1 0.17 0.95 0.41
35 INT113949 Positive_regulation of Gene_expression of FLNA 2 0.44 0.34 0.39
36 INT221178 Positive_regulation of Gene_expression of Flna 1 0.39 0 0.38
37 INT214618 Transcription of FLNA 4 0.51 8.06 0.37
38 INT337149 Positive_regulation of Iqgap1 1 0.46 0.84 0.34
39 INT337145 Localization of Diap1 1 0.37 0.7 0.22
40 INT134059 Negative_regulation of Negative_regulation of FLNA 1 0.02 0.38 0.18
41 INT226628 Negative_regulation of Vps4a 1 0.00 0.58 0.16
42 INT226664 Gene_expression of Vps4a 1 0.00 0.64 0.15
43 INT337163 Localization of DIAPH1 1 0.68 0.41 0.14
44 INT337147 Localization of Iqgap1 1 0.74 0.45 0.12
45 INT304610 Positive_regulation of Localization of FLNA 1 0.09 0.98 0.12
46 INT337144 Positive_regulation of Localization of Diap1 1 0.24 0.36 0.11
47 INT279642 Negative_regulation of Cit 1 0.25 0 0.1
48 INT226630 Positive_regulation of Vps4a 1 0.01 0.78 0.1
49 INT276543 Regulation of Iqgap1 2 0.27 0.49 0.08
50 INT226633 Regulation of Vps4a 1 0.00 0.26 0.08
51 INT305385 Negative_regulation of Localization of FLNA 1 0.16 0.79 0.08
52 INT279640 Regulation of Gene_expression of Cit 1 0.27 0 0.07
53 INT141261 Negative_regulation of VCL 1 0.45 0.95 0.07
54 INT263798 Gene_expression of VCL 1 0.18 1.14 0.05
55 INT178278 Regulation of Positive_regulation of FLNA 1 0.04 0.4 0.05
56 INT236523 Binding of Flna 3 0.30 0.45 0.03
57 INT276544 Gene_expression of Flna 3 0.63 1.97 0
58 INT276523 Negative_regulation of Gene_expression of Flna 2 0.48 0.8 0
59 INT246980 Binding of DIAPH1 1 0.04 0.11 0
60 INT297037 Regulation of DIAPH1 1 0.27 0.1 0
61 INT349986 Positive_regulation of Diap1 1 0.08 0 0
62 INT255171 Negative_regulation of Binding of FLNA 1 0.14 0.39 0
63 INT214620 Regulation of Localization of FLNA 1 0.02 0.46 0
64 INT104239 Negative_regulation of Cit 1 0.06 0 0
65 INT349985 Gene_expression of Diap1 1 0.11 0 0
66 INT283878 Localization of VCL 1 0.19 1.12 0
67 INT269630 Positive_regulation of DIAPH1 1 0.01 0 0
68 INT214621 Regulation of Gene_expression of FLNA 1 0.02 1.09 0
69 INT337958 Localization of Flna 1 0.61 0.43 0
70 INT307737 Binding of VCL 1 0.13 0.36 0
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