GO:0017049

From wiki-pain
Jump to: navigation, search
Name GTP-Rho binding
Categary Function
Go Slim No
Go Link GO:0017049
Unique Molecular Interactions 45
Total Molecular Interactions 61
Total Single Events 424
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for GTP-Rho binding. They are ordered first by their pain relevance and then by number of times they were reported for GTP-Rho binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42
2 INT193031 CHRM2 Positive_regulation of ROCK1 1 0.00 0.12 0.24
3 INT45934 PKN1 Regulation of NOTCH2NL 1 0.01 0 0.2
4 INT45933 PKN1 Regulation of PKN3 1 0.05 0 0.2
5 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
6 INT193080 ROCK1 Positive_regulation of Ppp1r14a 1 0.00 0.13 0.18
7 INT251349 Ifnar1 Positive_regulation of Rock1 1 0.01 1.27 0.16
8 INT120553 Y-27632 Negative_regulation of Rock1 1 0.01 0.15 0.15
9 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
10 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
11 INT243309 TNFAIP1 Positive_regulation of Localization of TNF 1 0.07 0.71 0.08
12 INT243313 TNFAIP1 Positive_regulation of TNF 1 0.31 0.71 0.08
13 INT159854 Gene_expression of IL2 Regulation of Gene_expression of CDC42EP5 1 0.01 0.16 0.07
14 INT354715 Binding of PKN1 and Pick1 1 0.01 0.19 0.04
15 INT263427 Pdgfb Positive_regulation of Phosphorylation of Rock1 1 0.00 0 0.04
16 INT354682 Binding of ASIC1 and PKN1 1 0.01 0.19 0.04
17 INT269584 Binding of CFL1 and ROCK1 1 0.03 0.05 0.03
18 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03
19 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
20 INT241460 Rock1 Positive_regulation of Phosphorylation of MLC1 1 0.38 0.63 0.03
21 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03
22 INT241456 Tgtp1 Positive_regulation of Rock1 1 0.01 0 0
23 INT241448 Binding of Rock1 and Tgtp1 1 0.01 0 0
24 INT222868 Binding of Chuk and Pkn1 1 0.00 0 0
25 INT258209 ROCK1 Regulation of ARR3 1 0.00 0.2 0
26 INT254866 Positive_regulation of C3 Negative_regulation of Rock1 1 0.02 0 0
27 INT258202 ROCK1 Positive_regulation of MYL2 1 0.14 0.2 0
28 INT254861 C3 Negative_regulation of Rock1 1 0.02 0 0
29 INT183861 Binding of CAV1 and CDC42EP5 1 0.03 3.21 0
30 INT321969 Negative_regulation of Rock1 Negative_regulation of VEGFA 1 0.03 0.65 0
31 INT180124 Rhob Positive_regulation of Rock1 1 0.14 0 0
32 INT286422 Binding of Cdc42ep5 and Dock4 1 0.01 0.84 0
33 INT353439 Negative_regulation of Rock1 Negative_regulation of Hc3 1 0.08 0.2 0
34 INT353436 Rock1 Positive_regulation of Myo1f 1 0.02 0.23 0
35 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0
36 INT302633 Rac1 Regulation of Cdc42ep2 1 0.01 0 0
37 INT327872 Binding of Postn and Pkn1 1 0.03 0.21 0
38 INT353434 Binding of Rock1 and Rnd3 1 0.22 0.26 0
39 INT353435 Binding of Pdpk1 and Rock1 1 0.09 0.27 0
40 INT254856 Tgfb1 Negative_regulation of Rock1 1 0.01 0 0
41 INT180125 Rhoa Positive_regulation of Rock1 1 0.14 0 0
42 INT261730 ROCK1 Positive_regulation of Positive_regulation of F2R 1 0.37 0 0
43 INT345184 Lpar1 Positive_regulation of Rock1 1 0.00 0.62 0
44 INT235021 PKP1 Regulation of CDC42EP5 1 0.00 0.06 0
45 INT353438 Rnd3 Negative_regulation of Rock1 1 0.26 2.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for GTP-Rho binding. They are ordered first by their pain relevance and then by number of times they were reported in GTP-Rho binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36
2 INT123563 Negative_regulation of Rock1 7 0.55 16.56 5.78
3 INT120550 Negative_regulation of Rock1 27 0.42 18.38 5.66
4 INT48850 Gene_expression of PKN1 16 0.52 1.93 1.92
5 INT275860 Negative_regulation of Localization of TNFAIP1 1 0.03 4.41 1.91
6 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85
7 INT243339 Localization of TNFAIP1 4 0.41 3.7 1.39
8 INT168720 Regulation of Negative_regulation of Rock1 1 0.43 1.31 1.23
9 INT180095 Gene_expression of Rock1 22 0.55 4.9 1.14
10 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13
11 INT146198 Positive_regulation of Rock1 16 0.49 5.86 1.1
12 INT263403 Positive_regulation of Rock1 3 0.38 4.68 1.09
13 INT111858 Regulation of Rock1 1 0.41 0.75 1.09
14 INT146199 Negative_regulation of Negative_regulation of Rock1 1 0.22 0.7 0.8
15 INT48851 Positive_regulation of Gene_expression of PKN1 2 0.27 0.67 0.78
16 INT181326 Binding of TNFAIP1 2 0.29 0.81 0.74
17 INT116946 Positive_regulation of CDC42EP5 3 0.05 1.89 0.66
18 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63
19 INT114405 Regulation of Pkn1 1 0.44 1.58 0.61
20 INT181325 Positive_regulation of TNFAIP1 4 0.36 4.64 0.52
21 INT172310 Positive_regulation of PKN1 6 0.12 2 0.51
22 INT146189 Positive_regulation of Positive_regulation of Rock1 2 0.26 1.27 0.47
23 INT263390 Phosphorylation of Rock1 1 0.17 0 0.41
24 INT263413 Positive_regulation of Phosphorylation of Rock1 1 0.11 0 0.37
25 INT180106 Regulation of Rock1 5 0.31 2.37 0.36
26 INT263400 Positive_regulation of Positive_regulation of Rock1 1 0.11 0.4 0.34
27 INT180105 Localization of Rock1 2 0.53 0.66 0.31
28 INT66060 Regulation of Gene_expression of PKN1 1 0.23 0 0.3
29 INT185436 Gene_expression of ROCK1 5 0.52 6.85 0.29
30 INT287251 Negative_regulation of PKN1 6 0.01 1.86 0.25
31 INT258250 Positive_regulation of ROCK1 7 0.51 2.07 0.22
32 INT180115 Phosphorylation of Rock1 5 0.58 1.21 0.22
33 INT185443 Regulation of ROCK1 4 0.18 3.32 0.21
34 INT20828 Positive_regulation of Negative_regulation of TNFAIP1 1 0.36 0.1 0.19
35 INT233130 Regulation of PKN1 2 0.02 0.69 0.18
36 INT180092 Positive_regulation of Gene_expression of Rock1 6 0.36 0.95 0.16
37 INT159860 Regulation of CDC42EP5 4 0.05 0.9 0.16
38 INT241419 Binding of Rock1 4 0.25 1.93 0.16
39 INT287249 Localization of PKN1 3 0.03 0.78 0.14
40 INT181323 Regulation of TNFAIP1 4 0.35 0.92 0.11
41 INT301204 Gene_expression of Cdc42ep2 3 0.44 1.39 0.08
42 INT321962 Negative_regulation of Positive_regulation of Rock1 1 0.33 1.17 0.07
43 INT159861 Gene_expression of CDC42EP5 1 0.05 0.16 0.07
44 INT341887 Positive_regulation of Positive_regulation of ROCK1 1 0.01 0.12 0.05
45 INT344635 Negative_regulation of Binding of Rock1 1 0.04 0.24 0.04
46 INT343555 Regulation of Gene_expression of ROCK1 1 0.15 1.02 0.04
47 INT192237 Phosphorylation of ROCK1 2 0.19 0.39 0.03
48 INT173588 Negative_regulation of CDC42EP5 2 0.01 1.08 0.03
49 INT343556 Positive_regulation of Gene_expression of ROCK1 1 0.23 1.05 0.03
50 INT180102 Regulation of Protein_catabolism of Rock1 1 0.32 0.27 0.03
51 INT180111 Protein_catabolism of Rock1 1 0.63 0.27 0.03
52 INT222851 Binding of Pkn1 4 0.03 0.1 0
53 INT233129 Binding of PKN1 3 0.03 0 0
54 INT180110 Regulation of Positive_regulation of Rock1 2 0.32 0.24 0
55 INT181322 Positive_regulation of Gene_expression of TNFAIP1 2 0.39 3.28 0
56 INT327869 Positive_regulation of Pkn1 1 0.04 0.32 0
57 INT269651 Positive_regulation of Phosphorylation of ROCK1 1 0.11 0.29 0
58 INT258237 Negative_regulation of Negative_regulation of ROCK1 1 0.32 0.16 0
59 INT298917 Binding of CDC42EP5 1 0.01 0.3 0
60 INT180093 Negative_regulation of Gene_expression of Rock1 1 0.30 0.07 0
61 INT353419 Positive_regulation of Negative_regulation of Rock1 1 0.20 0.2 0
62 INT269598 Regulation of Positive_regulation of PKN1 1 0.07 0 0
63 INT181324 Regulation of Gene_expression of TNFAIP1 1 0.35 0 0
64 INT180112 Positive_regulation of Phosphorylation of Rock1 1 0.36 0 0
65 INT254794 Negative_regulation of Cdc42ep2 1 0.01 0.7 0
66 INT287594 Negative_regulation of Pkn1 1 0.01 0.12 0
67 INT327859 Gene_expression of Pkn1 1 0.07 0 0
68 INT301233 Negative_regulation of Gene_expression of Cdc42ep2 1 0.24 1.36 0
69 INT321961 Gene_expression of Rock1 1 0.51 0.79 0
70 INT321964 Binding of Rock1 1 0.28 0.96 0
71 INT353416 Regulation of Gene_expression of Rock1 1 0.18 0 0
72 INT353432 Positive_regulation of Regulation of Rock1 1 0.19 0.24 0
73 INT269645 Negative_regulation of Positive_regulation of ROCK1 1 0.10 0 0
74 INT287254 Positive_regulation of Negative_regulation of PKN1 1 0.01 0.41 0
75 INT286390 Gene_expression of Cdc42ep5 1 0.02 0.82 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox