GO:0017055

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Name negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
Categary Process
Go Slim No
Go Link GO:0017055
Unique Molecular Interactions 68
Total Molecular Interactions 123
Total Single Events 706
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of RNA polymerase II transcriptional preinitiation complex assembly. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of RNA polymerase II transcriptional preinitiation complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
2 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
3 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
4 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
5 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
6 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
7 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
8 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
9 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
10 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
11 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
12 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
13 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
14 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
15 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
16 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
17 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
18 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
19 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
20 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
21 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
22 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
23 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
24 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
25 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25
26 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25
27 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
28 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
29 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24
30 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
31 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
32 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23
33 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
34 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
35 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
36 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
37 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
38 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
39 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
40 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
41 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
42 INT324815 Binding of Hmgb1 and Caprin1 1 0.01 0.65 0.19
43 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
44 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
45 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
46 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
47 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
48 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
49 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
50 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
51 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13
52 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
53 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12
54 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12
55 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12
56 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
57 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
58 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09
59 INT4580 Positive_regulation of Thra Positive_regulation of Babr 1 0.00 0 0.07
60 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
61 INT324859 Hmgb1 Positive_regulation of ecs 1 0.03 0.74 0.03
62 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
63 INT264396 NR1H4 Positive_regulation of THRA 1 0.01 0.09 0.03
64 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0
65 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0
66 INT300664 Binding of Gla and Thra 1 0.08 0 0
67 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
68 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of RNA polymerase II transcriptional preinitiation complex assembly. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of RNA polymerase II transcriptional preinitiation complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
2 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
3 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
4 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
5 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
6 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73
7 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
8 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
9 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
10 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
11 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
12 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01
13 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
14 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
15 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
16 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
17 INT2681 Binding of Thra 11 0.32 5.98 1.27
18 INT2682 Regulation of Thra 4 0.55 0.49 1.21
19 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
20 INT19277 Gene_expression of Thra 4 0.58 0.68 1.1
21 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
22 INT253957 Gene_expression of THRA 14 0.58 7.07 0.97
23 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
24 INT219980 Positive_regulation of THRA 4 0.49 1.17 0.96
25 INT219983 Binding of THRA 1 0.08 1.08 0.82
26 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
27 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
28 INT343799 Negative_regulation of Transcription of HMGB1 1 0.32 0.37 0.5
29 INT215070 Regulation of Localization of Hmgb1 4 0.26 2.23 0.49
30 INT219981 Negative_regulation of THRA 3 0.09 0.46 0.49
31 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49
32 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45
33 INT219982 Transcription of THRA 1 0.15 0.72 0.45
34 INT352592 Positive_regulation of Negative_regulation of Hmgb1 1 0.44 1.31 0.42
35 INT258283 Positive_regulation of Positive_regulation of Hmgb1 3 0.44 3.1 0.3
36 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3
37 INT304404 Localization of THRA 1 0.12 0.68 0.22
38 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21
39 INT266367 Positive_regulation of Binding of HMGB1 1 0.26 0.31 0.21
40 INT266364 Protein_catabolism of HMGB1 1 0.34 0.29 0.19
41 INT304406 Positive_regulation of Localization of THRA 1 0.07 0.25 0.17
42 INT266353 Negative_regulation of Binding of HMGB1 1 0.22 0.22 0.17
43 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15
44 INT344828 Protein_catabolism of Hmgb1 1 0.48 0.67 0.14
45 INT344810 Positive_regulation of Protein_catabolism of Hmgb1 1 0.27 0.67 0.14
46 INT318343 Regulation of Binding of Hmgb1 1 0.11 0.41 0.1
47 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09
48 INT299469 Regulation of HMGB1 2 0.18 2.27 0.03
49 INT266358 Regulation of Binding of HMGB1 1 0.14 0 0.03
50 INT299470 Regulation of Gene_expression of HMGB1 1 0.18 1.58 0
51 INT210870 Gene_expression of Thra 1 0.35 0.23 0
52 INT304412 Regulation of Localization of THRA 1 0.06 0 0
53 INT293537 Negative_regulation of Gene_expression of Thra 1 0.24 0.11 0
54 INT46503 Positive_regulation of Negative_regulation of Thra 1 0.07 0 0
55 INT293535 Regulation of Gene_expression of Thra 1 0.26 0.28 0
56 INT304407 Regulation of Gene_expression of THRA 1 0.06 0.07 0
57 INT258279 Positive_regulation of Binding of Hmgb1 1 0.45 0.26 0
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