GO:0017144

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Name drug metabolic process
Categary Process
Go Slim No
Go Link GO:0017144
Unique Molecular Interactions 439
Total Molecular Interactions 545
Total Single Events 6419
Pain Genes Associated 28

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for drug metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for drug metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
2 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
3 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
4 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
5 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
6 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
7 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
8 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
9 INT168459 Sult1a1 Negative_regulation of Gene_expression of Arr3 1 0.05 2.98 1.23
10 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
11 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
12 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
13 INT81583 Cyp3a23/3a1 Positive_regulation of st 1 0.04 0 1.08
14 INT81580 Cyp3a23/3a1 Positive_regulation of Nudt14 1 0.01 0 1.08
15 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
16 INT349576 Binding of Ugt2b and Sult1a1 1 0.00 0.45 1.03
17 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
18 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
19 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
20 INT130282 Cyp3a23/3a1 Positive_regulation of Gene_expression of Npy 1 0.15 0 0.94
21 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
22 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
23 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
24 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
25 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
26 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85
27 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
28 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
29 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
30 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
31 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
32 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
33 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
34 INT130283 Cyp3a23/3a1 Positive_regulation of Transcription of Npy 1 0.10 0 0.79
35 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
36 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
37 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
38 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
39 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
40 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
41 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
42 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
43 INT218933 Cyp3a23/3a1 Regulation of Alpi 1 0.00 1.07 0.73
44 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
45 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
46 INT67809 Ugt2b1 Negative_regulation of Ugt2b7 1 0.47 0 0.7
47 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
48 INT113685 Binding of Cyp3a23/3a1 and Cyp2c11 1 0.35 0 0.65
49 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
50 INT135471 Binding of CYP2B6 and UGT2B7 1 0.49 0 0.63
51 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
52 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
53 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
54 INT52816 Cyp3a23/3a1 Regulation of Localization of LH 1 0.03 0.16 0.6
55 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
56 INT43692 Cyp3a23/3a1 Negative_regulation of Gh1 1 0.04 0 0.59
57 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
58 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
59 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
60 INT43693 Cyp3a23/3a1 Positive_regulation of Localization of Prl 1 0.10 0 0.57
61 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
62 INT253998 Cyp3a23/3a1 Positive_regulation of Binding of Cxcl12 1 0.10 0.65 0.55
63 INT253990 Cyp3a23/3a1 Positive_regulation of Cxcl12 1 0.09 0.65 0.55
64 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
65 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
66 INT123896 CYP2B6 Regulation of UGT2B7 1 0.42 0 0.53
67 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
68 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
69 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
70 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
71 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
72 INT281982 Cyp3a23/3a1 Negative_regulation of Gene_expression of MDK 1 0.00 0.67 0.47
73 INT149690 M1 Negative_regulation of CYP2C8 1 0.19 0.05 0.46
74 INT218932 Cyp3a23/3a1 Regulation of Gene_expression of Alpi 1 0.00 0.53 0.46
75 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
76 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
77 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
78 INT168460 Sult1a1 Negative_regulation of Gene_expression of Ifih1 1 0.02 0.96 0.41
79 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
80 INT168463 Sult1a1 Negative_regulation of TNF 1 0.01 1 0.4
81 INT168458 Sult1a1 Negative_regulation of Tnf 1 0.09 1 0.4
82 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
83 INT168454 Sult1a1 Negative_regulation of Ifih1 1 0.02 0.89 0.39
84 INT297738 Cbr1 Positive_regulation of Ifih1 1 0.01 1.83 0.39
85 INT69468 CYP2B6 Positive_regulation of Localization of CYP3A 1 0.25 0 0.36
86 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
87 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
88 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35
89 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34
90 INT78064 Cyp3a23/3a1 Regulation of Localization of Il6 1 0.08 0.07 0.32
91 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
92 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
93 INT281970 Cyp3a23/3a1 Negative_regulation of Gene_expression of Tie1 1 0.00 0.46 0.3
94 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
95 INT59684 Binding of Gmfb and Cyp2c6 1 0.00 0 0.29
96 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
97 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
98 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
99 INT78065 Cyp3a23/3a1 Negative_regulation of Gene_expression of Il6 1 0.12 0.07 0.27
100 INT218931 Cyp3a23/3a1 Regulation of Gene_expression of Akp3 1 0.00 0.55 0.27
101 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
102 INT78061 Cyp3a23/3a1 Negative_regulation of Localization of Il6 1 0.12 0.07 0.27
103 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
104 INT114230 NR1I2 Positive_regulation of Positive_regulation of CYP2C9 1 0.13 0.61 0.27
105 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
106 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
107 INT130677 CYP2C9 Regulation of Binding of Ugt2b7 1 0.18 0 0.26
108 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
109 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
110 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
111 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
112 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
113 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
114 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
115 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
116 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
117 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
118 INT53544 Binding of CYP2B6 and HRH1 1 0.28 0 0.23
119 INT57172 Binding of RYBP and Cyp2b1 1 0.02 0 0.23
120 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
121 INT5645 Sult2a1 Positive_regulation of Positive_regulation of IGKV2-29 1 0.00 0.39 0.22
122 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
123 INT100823 Cyp2e1 Positive_regulation of Ros1 1 0.35 1.22 0.22
124 INT5646 Sult2a1 Positive_regulation of IGKV2-29 1 0.00 0.39 0.22
125 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
126 INT248171 Epo Regulation of Sult1a1 1 0.08 0.11 0.21
127 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
128 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
129 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
130 INT125550 FGFR1 Negative_regulation of Cyp2e1 1 0.02 0.06 0.18
131 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
132 INT301615 Binding of Cyp2e1 and Samsn1 1 0.02 2.42 0.18
133 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18
134 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
135 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18
136 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
137 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
138 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
139 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
140 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
141 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
142 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
143 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
144 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
145 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
146 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
147 INT125551 Binding of FGFR1 and Cyp2e1 1 0.02 0.07 0.13
148 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
149 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
150 INT125549 Binding of CYP2B6 and FGFR1 1 0.00 0.07 0.13
151 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
152 INT54131 Binding of Cbr1 and Mthfs 1 0.01 0.25 0.12
153 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
154 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
155 INT97080 CYP2E1 Regulation of HAGH 1 0.02 0 0.11
156 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
157 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
158 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
159 INT339533 VEGFA Positive_regulation of Gene_expression of CYP2C8 1 0.09 0.57 0.09
160 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
161 INT160159 Gene_expression of CYP2C9 Positive_regulation of HSP90B2P 1 0.13 0.53 0.09
162 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09
163 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
164 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
165 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
166 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
167 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
168 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
169 INT264084 CYP2C19 Regulation of CYP2C9 1 0.03 0 0.09
170 INT154914 UGT1A9 Regulation of IGHD6-6 1 0.05 0 0.09
171 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
172 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
173 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
174 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
175 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
176 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
177 INT80930 Tnf Positive_regulation of Negative_regulation of Cyp2b1 1 0.10 0.21 0.08
178 INT19725 Cyp2b1 Positive_regulation of Cyp2c22 1 0.02 0 0.07
179 INT297736 Cbr1 Positive_regulation of Ucp3 1 0.11 1.29 0.07
180 INT57965 Myo5a Negative_regulation of Cyp2e1 1 0.01 0.09 0.07
181 INT297735 Cbr1 Positive_regulation of Sod2 1 0.11 1.28 0.07
182 INT297733 Cbr1 Regulation of Gene_expression of Bcl2 1 0.05 0.94 0.07
183 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
184 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
185 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
186 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
187 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
188 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
189 INT56278 Binding of CYP2B6 and TACC2 1 0.40 0.32 0.06
190 INT285383 Cars Regulation of Regulation of Sult1a1 1 0.01 0 0.06
191 INT145624 Binding of PKLR and UGT1A9 1 0.02 0 0.06
192 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05
193 INT342221 Cyp2e1 Positive_regulation of Gene_expression of TRNAI1 1 0.03 0.22 0.05
194 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
195 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
196 INT337692 Cyp2b2 Positive_regulation of Nr1i3 1 0.00 0.31 0.05
197 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
198 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
199 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05
200 INT235313 Cyp3a23/3a1 Positive_regulation of Ins1 1 0.14 0.82 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for drug metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in drug metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
3 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
4 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
5 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
6 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
7 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
8 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
9 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
10 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
11 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
12 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
13 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
14 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39
15 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
16 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
17 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
18 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
19 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
20 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
21 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
22 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06
23 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
24 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
25 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
26 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38
27 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96
28 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
29 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
30 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
31 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
32 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
33 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
34 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
35 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
36 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
37 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
38 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
39 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
40 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
41 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53
42 INT58625 Gene_expression of Ugt2b1 19 0.77 1.95 7.05
43 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
44 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
45 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43
46 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
47 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79
48 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
49 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
50 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
51 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4
52 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
53 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2
54 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
55 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
56 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
57 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
58 INT110549 Negative_regulation of CYP2C8 15 0.59 0.54 4.78
59 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
60 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
61 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7
62 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
63 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
64 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57
65 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 9 0.45 4.91 4.56
66 INT1983 Negative_regulation of Cbr1 4 0.58 4.44 4.52
67 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
68 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
69 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
70 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
71 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
72 INT205 Negative_regulation of Cbr1 10 0.58 4.23 4.29
73 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
74 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
75 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
76 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
77 INT53395 Positive_regulation of Cyp2c6 6 0.70 0.07 3.73
78 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
79 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33
80 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
81 INT69564 Binding of Cyp3a23/3a1 11 0.34 4.67 3.2
82 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
83 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89
84 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
85 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
86 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
87 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
88 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
89 INT19685 Localization of Sult2a1 12 0.70 0.83 2.7
90 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
91 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
92 INT58624 Positive_regulation of Ugt2b1 5 0.69 0.22 2.5
93 INT3608 Regulation of Cbr1 6 0.45 2.28 2.44
94 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41
95 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39
96 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
97 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
98 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
99 INT80391 Negative_regulation of Cyp2b2 4 0.54 0.12 2.36
100 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
101 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
102 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23
103 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23
104 INT54969 Binding of Sult1a1 4 0.35 1.4 2.18
105 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
106 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
107 INT53392 Positive_regulation of Cyp2b1 8 0.68 0.68 2.13
108 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08
109 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
110 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
111 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03
112 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
113 INT107091 Regulation of Gene_expression of Cyp2e1 4 0.62 2.17 2.03
114 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
115 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02
116 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 6 0.59 3.74 2.02
117 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
118 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
119 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98
120 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
121 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97
122 INT101410 Negative_regulation of Positive_regulation of CYP2C9 5 0.42 0.23 1.96
123 INT95797 Positive_regulation of CYP2C8 8 0.50 0.55 1.94
124 INT113683 Positive_regulation of Negative_regulation of Cyp3a23/3a1 2 0.49 0.48 1.94
125 INT82649 Negative_regulation of Gene_expression of Cyp2e1 3 0.58 2.51 1.93
126 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92
127 INT63672 Negative_regulation of Ugt2b1 7 0.57 1.07 1.9
128 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
129 INT154727 Regulation of Cyp2b2 2 0.25 0 1.76
130 INT113806 Transcription of CYP2B6 7 0.67 1.75 1.73
131 INT113684 Negative_regulation of Gene_expression of Cyp3a23/3a1 5 0.36 2.04 1.71
132 INT53546 Negative_regulation of Binding of CYP2B6 5 0.43 0.24 1.67
133 INT67704 Negative_regulation of Negative_regulation of CYP2B6 3 0.41 1.69 1.66
134 INT297726 Gene_expression of Cbr1 27 0.20 7.68 1.64
135 INT12842 Binding of Cyp2b1 4 0.48 0 1.56
136 INT11418 Positive_regulation of Cbr1 5 0.14 1.82 1.5
137 INT87095 Positive_regulation of Gene_expression of CYP2C19 3 0.48 0 1.5
138 INT3607 Gene_expression of Cbr1 4 0.59 1.17 1.48
139 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
140 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
141 INT58626 Positive_regulation of Gene_expression of Ugt2b1 3 0.50 0.07 1.45
142 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
143 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
144 INT4402 Positive_regulation of Binding of CYP2B6 3 0.49 0.33 1.35
145 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
146 INT110550 Regulation of CYP2C8 3 0.45 1.59 1.34
147 INT93863 Transcription of CYP2E1 3 0.69 1.39 1.34
148 INT83822 Protein_catabolism of CYP2C9 3 0.46 1.16 1.31
149 INT71281 Positive_regulation of Gene_expression of CYP2C9 13 0.62 5.11 1.3
150 INT50031 Negative_regulation of Gene_expression of CYP2B6 5 0.57 2.37 1.29
151 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
152 INT115374 Positive_regulation of Gene_expression of Cyp2e1 6 0.67 4.36 1.27
153 INT67810 Regulation of Ugt2b1 1 0.45 0.1 1.26
154 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
155 INT123284 Positive_regulation of Positive_regulation of Cyp2e1 3 0.46 2.34 1.22
156 INT57169 Gene_expression of Cyp2b1 5 0.72 1.39 1.2
157 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
158 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
159 INT331006 Positive_regulation of Localization of CYP2C9 1 0.34 0.13 1.17
160 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
161 INT72558 Regulation of CYP2C19 6 0.54 1.97 1.14
162 INT59679 Binding of Cyp2c6 3 0.48 0.2 1.14
163 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
164 INT165310 Negative_regulation of Transcription of CYP2E1 1 0.42 1.15 1.14
165 INT3609 Regulation of Gene_expression of Cbr1 1 0.27 0.74 1.08
166 INT295326 Gene_expression of Sult1a1 2 0.65 1.29 1.06
167 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
168 INT130996 Positive_regulation of Regulation of CYP2C9 1 0.34 0 1
169 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
170 INT132623 Transcription of Cyp2e1 2 0.53 0.56 0.98
171 INT207325 Positive_regulation of Localization of Cyp3a23/3a1 1 0.42 0.61 0.98
172 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
173 INT56270 Negative_regulation of Binding of Cyp2e1 1 0.42 0.17 0.94
174 INT69779 Transcription of Ugt2b1 9 0.69 0.94 0.93
175 INT56271 Positive_regulation of Negative_regulation of Cyp2e1 1 0.46 0.17 0.93
176 INT61241 Gene_expression of Cyp2b2 1 0.56 0 0.92
177 INT99411 Positive_regulation of UGT1A9 2 0.39 0.65 0.88
178 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
179 INT157981 Binding of Cyp2b2 1 0.44 0 0.86
180 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
181 INT157982 Positive_regulation of Gene_expression of Cyp2b2 1 0.43 0 0.85
182 INT166416 Positive_regulation of Negative_regulation of CYP2B6 1 0.49 0.8 0.83
183 INT130750 Negative_regulation of Localization of CYP2B6 1 0.41 0 0.82
184 INT57168 Binding of Ugt2b1 2 0.48 0 0.81
185 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
186 INT149926 Negative_regulation of Negative_regulation of Cyp2e1 1 0.43 0.14 0.78
187 INT149927 Regulation of Negative_regulation of Cyp2e1 1 0.45 0.13 0.78
188 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
189 INT37113 Positive_regulation of Sult1a1 3 0.44 0.81 0.75
190 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
191 INT93574 Protein_catabolism of CYP2B6 3 0.96 0.16 0.75
192 INT98177 Negative_regulation of Transcription of Cyp2e1 2 0.40 0.89 0.75
193 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
194 INT94550 Negative_regulation of Gene_expression of CYP2C19 2 0.38 0 0.74
195 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
196 INT20306 Positive_regulation of Transcription of Cyp2e1 2 0.49 0.63 0.73
197 INT159556 Binding of Sult2a1 1 0.32 0.82 0.73
198 INT144390 Positive_regulation of Negative_regulation of CYP2C9 4 0.49 2.03 0.72
199 INT168367 Localization of Cyp2e1 2 0.71 0.6 0.72
200 INT145711 Regulation of Positive_regulation of CYP2C9 1 0.45 0.64 0.71
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