GO:0017147

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Name Wnt-protein binding
Categary Function
Go Slim No
Go Link GO:0017147
Unique Molecular Interactions 56
Total Molecular Interactions 90
Total Single Events 285
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Wnt-protein binding. They are ordered first by their pain relevance and then by number of times they were reported for Wnt-protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5
2 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
3 INT5544 Ptpro Regulation of Syt17 1 0.05 0 0.6
4 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
5 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
6 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
7 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
8 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
9 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
10 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
11 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
12 INT149222 Binding of Fzd5 and Suds3 1 0.02 0.44 0.07
13 INT233502 Fzd5 Positive_regulation of Gene_expression of Il12a 1 0.04 0.33 0.07
14 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
15 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
16 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
17 INT167565 Binding of ERG and LRP5 1 0.02 0.94 0.03
18 INT115609 Binding of ERBB2 and SFRP5 3 0.15 1.83 0
19 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
20 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0
21 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0
22 INT289099 KCNA1 Positive_regulation of Gene_expression of FZD5 1 0.00 0.84 0
23 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
24 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
25 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
26 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0
27 INT347124 Binding of FZD1 and Lrp1 1 0.11 0.24 0
28 INT297848 Binding of Fzd4 and Ndp 1 0.04 1.19 0
29 INT233520 Tlr4 Positive_regulation of Fzd1 1 0.03 0.09 0
30 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
31 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
32 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
33 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0
34 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
35 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
36 INT242165 Wnt2 Positive_regulation of Gene_expression of Fzd1 1 0.15 0.26 0
37 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0
38 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0
39 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
40 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
41 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
42 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
43 INT242166 Fzd1 Positive_regulation of Positive_regulation of Wnt2 1 0.13 0.24 0
44 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
45 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0
46 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Wnt-protein binding. They are ordered first by their pain relevance and then by number of times they were reported in Wnt-protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
2 INT271464 Transcription of Ptpro 1 0.02 0.95 1.4
3 INT65121 Negative_regulation of Ptpro 1 0.02 0.97 1.36
4 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
5 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
6 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
7 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
8 INT270447 Binding of Smo 2 0.07 2.61 0.78
9 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
10 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
11 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
12 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
13 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
14 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54
15 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51
16 INT130801 Localization of SFRP4 4 0.28 2.41 0.49
17 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
18 INT186593 Gene_expression of SFRP5 1 0.16 3.94 0.46
19 INT201856 Regulation of SFRP4 1 0.00 1.4 0.46
20 INT201843 Negative_regulation of SFRP4 1 0.01 0.63 0.31
21 INT356400 Transcription of Smo 1 0.02 0.05 0.3
22 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
23 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
24 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
25 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
26 INT271459 Positive_regulation of Ptpro 1 0.01 1.09 0.27
27 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
28 INT334543 Negative_regulation of Positive_regulation of LRP5 1 0.23 1.81 0.25
29 INT173655 Binding of LRP5 10 0.39 3.06 0.22
30 INT242141 Gene_expression of Fzd1 1 0.21 2.5 0.21
31 INT186598 Binding of SFRP5 1 0.07 0.92 0.21
32 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
33 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
34 INT233462 Regulation of Fzd1 1 0.45 0.33 0.08
35 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06
36 INT345344 Regulation of SMO 1 0.23 1.07 0.06
37 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
38 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
39 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
40 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
41 INT262772 Binding of SMO 1 0.27 0.59 0.05
42 INT287946 Positive_regulation of Gene_expression of FZD5 2 0.20 1.69 0.04
43 INT262777 Localization of SMO 1 0.59 0.6 0.04
44 INT242172 Protein_catabolism of LRP5 1 0.64 0.06 0.04
45 INT191746 Gene_expression of Ptpro 1 0.28 0.85 0.04
46 INT287941 Gene_expression of FZD5 2 0.23 2.94 0.03
47 INT347119 Localization of FZD1 1 0.68 0.16 0.03
48 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03
49 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
50 INT297757 Transcription of Lrp5 2 0.68 0.82 0
51 INT297820 Regulation of Transcription of Lrp5 2 0.44 0.83 0
52 INT307613 Phosphorylation of LRP5 1 0.08 0.1 0
53 INT186600 Regulation of SFRP5 1 0.06 1.58 0
54 INT289120 Regulation of Gene_expression of FZD5 1 0.13 0.33 0
55 INT173644 Negative_regulation of Gene_expression of LRP5 1 0.15 0.59 0
56 INT297821 Regulation of Fzd4 1 0.03 0.57 0
57 INT252242 Gene_expression of Smo 1 0.01 0.23 0
58 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
59 INT315189 Binding of SFRP1 1 0.15 2.96 0
60 INT242143 Regulation of Gene_expression of Fzd1 1 0.14 0.25 0
61 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
62 INT186590 Transcription of SFRP5 1 0.14 1.17 0
63 INT342375 Positive_regulation of Binding of Lrp5 1 0.46 0.85 0
64 INT297791 Transcription of Fzd4 1 0.06 0.58 0
65 INT302465 Localization of LRP5 1 0.61 0 0
66 INT233478 Negative_regulation of Fzd1 1 0.31 0.09 0
67 INT304048 Negative_regulation of Gene_expression of SFRP4 1 0.34 0.97 0
68 INT289131 Negative_regulation of Gene_expression of FZD5 1 0.13 0.69 0
69 INT205956 Localization of Smo 1 0.06 0.71 0
70 INT201624 Regulation of FZD1 1 0.01 0 0
71 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
72 INT191744 Binding of Ptpro 1 0.15 0.79 0
73 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
74 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
75 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
76 INT242126 Positive_regulation of Fzd1 1 0.16 0.25 0
77 INT307611 Positive_regulation of Phosphorylation of LRP5 1 0.05 0.1 0
78 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
79 INT335873 Transcription of Lrp6 1 0.64 0.25 0
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