GO:0017154

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Name semaphorin receptor activity
Categary Function
Go Slim No
Go Link GO:0017154
Unique Molecular Interactions 106
Total Molecular Interactions 183
Total Single Events 610
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for semaphorin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for semaphorin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
2 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
3 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
4 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
5 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
6 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1
7 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
8 INT67908 Binding of Cck and Plxna3 1 0.04 0.54 0.84
9 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
10 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56
11 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
12 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
13 INT221630 Binding of Fes and Plxna1 1 0.01 1.02 0.5
14 INT97950 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of ST3GAL3 1 0.02 0.72 0.5
15 INT36340 Binding of NRP2 and Penk 1 0.04 0.07 0.39
16 INT221637 Binding of Plxna1 and Fer 1 0.01 0.59 0.36
17 INT304339 Negative_regulation of CD79A Positive_regulation of NRP2 1 0.06 0.86 0.33
18 INT304338 CD79A Positive_regulation of NRP2 1 0.08 0.84 0.32
19 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29
20 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
21 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
22 INT347531 Binding of Nrp2 and Sema3b 1 0.04 0.99 0.28
23 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
24 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
25 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
26 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
27 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
28 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
29 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
30 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
31 INT221656 Plxna1 Negative_regulation of Fer 1 0.02 0.59 0.15
32 INT221632 Plxna1 Negative_regulation of Fes 1 0.02 0.58 0.15
33 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
34 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14
35 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13
36 INT146997 Binding of PLXNA3 and RLS 1 0.36 0.47 0.1
37 INT224026 P2RY6 Positive_regulation of NRP2 1 0.10 0.98 0.1
38 INT221655 Plxna1 Negative_regulation of Phosphorylation of Fes 1 0.02 0.17 0.08
39 INT221657 Sema3a Positive_regulation of Binding of Plxna1 1 0.01 0.39 0.05
40 INT221663 Fes Positive_regulation of Binding of Plxna1 1 0.02 0.4 0.05
41 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
42 INT173053 Binding of VEGFA and NRP2 3 0.12 1.36 0.04
43 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
44 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04
45 INT311925 Binding of NRP2 and SEMA3A 1 0.26 0.06 0.04
46 INT265764 NRP1 Positive_regulation of FLT1 1 0.45 0 0.04
47 INT315915 VEGFA Regulation of NRP1 1 0.22 0.32 0.04
48 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
49 INT311926 Binding of NRP1 and SEMA3A 1 0.26 0.48 0.04
50 INT265749 Binding of FLT1 and NRP1 1 0.43 0 0.04
51 INT315912 VEGFA Regulation of NRP2 1 0.04 0.32 0.04
52 INT221624 Binding of Fyn and Plxna1 1 0.01 0.29 0.03
53 INT302051 AAVS1 Positive_regulation of Gene_expression of Nrp2 1 0.02 0.33 0.03
54 INT221651 Binding of Fyn and Plxna2 1 0.01 0.29 0.03
55 INT311927 AASDH Positive_regulation of NRP2 1 0.02 0.1 0.03
56 INT347533 Tmem131 Negative_regulation of Gene_expression of Nrp2 1 0.04 0 0
57 INT265744 VEGFA Regulation of Localization of NRP1 1 0.25 0 0
58 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
59 INT353189 Plxna3 Negative_regulation of Cyp4a8 1 0.01 0.35 0
60 INT276285 Binding of SEPHS1 and PLXNA3 1 0.00 0.41 0
61 INT265767 Positive_regulation of Binding of VEGFA and NRP1 1 0.46 0 0
62 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
63 INT311948 Binding of NRP1 and Plxna3 1 0.05 0.26 0
64 INT311947 Binding of SEMA3A and Plxna3 1 0.07 0.26 0
65 INT265752 NRP1 Negative_regulation of Gene_expression of FLT1 1 0.33 0 0
66 INT221633 Binding of Akt1 and Plxna1 1 0.00 0 0
67 INT265765 Binding of NRP1 and GOPC 1 0.13 0 0
68 INT351678 Nrp1 Regulation of Binding of Ecm1 1 0.00 1.55 0
69 INT265737 Binding of AR and NRP1 1 0.10 0 0
70 INT265751 NRP1 Negative_regulation of Localization of FLT1 1 0.33 0 0
71 INT265756 Positive_regulation of Binding of AR and NRP1 1 0.10 0 0
72 INT196185 Binding of SEMA3A and Nrp1 1 0.01 0.05 0
73 INT265757 Regulation of Binding of VEGFA and NRP1 1 0.41 0 0
74 INT221638 Binding of Nrp1 and Sema3a 1 0.05 0.38 0
75 INT265738 NRP1 Positive_regulation of KLKB1 1 0.03 0 0
76 INT265741 Negative_regulation of Binding of FLT1 and NRP1 1 0.38 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for semaphorin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in semaphorin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92
2 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3
3 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73
4 INT82347 Regulation of PLXNA3 5 0.60 4.59 2.45
5 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4
6 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
7 INT64609 Negative_regulation of PLXNA3 5 0.57 3.64 1.94
8 INT196158 Binding of NRP2 16 0.06 7.03 1.73
9 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
10 INT16622 Positive_regulation of PLXNA3 6 0.67 5.2 1.69
11 INT174107 Binding of Plxna3 4 0.21 2.95 1.62
12 INT146511 Gene_expression of Nrp2 25 0.78 8.67 1.55
13 INT221531 Gene_expression of Plxna1 7 0.75 4.51 1.31
14 INT132551 Negative_regulation of Plxna2 3 0.36 0.86 1.11
15 INT158651 Gene_expression of Plxna2 9 0.66 1.98 0.98
16 INT104079 Gene_expression of Plxna3 4 0.65 0.86 0.94
17 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
18 INT196182 Localization of NRP2 9 0.46 3.61 0.8
19 INT62760 Localization of PLXNA3 3 0.78 2.06 0.8
20 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
21 INT168189 Positive_regulation of PLXNA2 1 0.20 0.49 0.75
22 INT221548 Phosphorylation of Plxna1 1 0.02 1.71 0.74
23 INT139205 Binding of NRP1 27 0.45 4.34 0.71
24 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
25 INT265800 Localization of NRP1 14 0.75 3.66 0.69
26 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
27 INT342318 Localization of PLXNA2 1 0.25 0.75 0.67
28 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
29 INT104078 Localization of Plxna3 1 0.78 0.36 0.64
30 INT11847 Regulation of Plxna3 3 0.44 0.45 0.52
31 INT97962 Negative_regulation of NRP2 2 0.08 0.91 0.5
32 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46
33 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
34 INT112379 Positive_regulation of Gene_expression of NRP2 3 0.50 0.18 0.46
35 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
36 INT158652 Positive_regulation of Gene_expression of Plxna2 3 0.59 0.17 0.41
37 INT46873 Positive_regulation of Plxna3 1 0.49 0 0.38
38 INT283911 Positive_regulation of Negative_regulation of Plxna2 1 0.33 0 0.33
39 INT104082 Negative_regulation of Plxna3 1 0.41 0.19 0.32
40 INT104084 Negative_regulation of Localization of Plxna3 1 0.57 0.19 0.32
41 INT104080 Regulation of Localization of Plxna3 1 0.60 0.17 0.32
42 INT104083 Negative_regulation of Gene_expression of Plxna3 1 0.42 0.19 0.32
43 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
44 INT158730 Gene_expression of Plxna3 4 0.65 1.82 0.29
45 INT158728 Regulation of Gene_expression of Plxna3 1 0.44 0.28 0.29
46 INT158731 Positive_regulation of Gene_expression of Plxna3 1 0.49 0.28 0.29
47 INT264305 Negative_regulation of Gene_expression of NRP1 3 0.40 1.4 0.25
48 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25
49 INT248347 Negative_regulation of PLXNA2 1 0.38 0.24 0.22
50 INT302039 Negative_regulation of Nrp2 6 0.51 1.65 0.19
51 INT227947 Regulation of Plxna3 1 0.07 0.2 0.19
52 INT347525 Positive_regulation of Nrp2 1 0.50 0.81 0.18
53 INT311446 Negative_regulation of Gene_expression of PLXNA2 1 0.12 1.1 0.18
54 INT265792 Regulation of Localization of NRP1 1 0.22 0.21 0.13
55 INT265797 Regulation of Protein_catabolism of NRP1 1 0.51 0.21 0.13
56 INT203612 Positive_regulation of NRP2 2 0.33 0.49 0.12
57 INT143446 Positive_regulation of Gene_expression of NRP1 1 0.45 1.02 0.12
58 INT302043 Negative_regulation of Gene_expression of Nrp2 5 0.59 1.53 0.1
59 INT325509 Localization of Plxna1 1 0.73 0.16 0.09
60 INT353299 Positive_regulation of Gene_expression of Plxna1 1 0.67 0.28 0.08
61 INT347526 Regulation of Gene_expression of Nrp2 1 0.62 0.65 0.07
62 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07
63 INT221570 Binding of Plxna1 1 0.01 0.59 0.05
64 INT354593 Regulation of Gene_expression of PLXNA2 1 0.04 0.34 0.05
65 INT302038 Positive_regulation of Gene_expression of Nrp2 3 0.50 1.12 0.03
66 INT283914 Localization of Plxna2 1 0.50 0.68 0.03
67 INT283915 Positive_regulation of Plxna2 1 0.31 0.68 0.03
68 INT243224 Regulation of Plxna2 2 0.13 1.58 0
69 INT235629 Phosphorylation of NRP1 2 0.76 0.81 0
70 INT151311 Transcription of Plxna2 2 0.58 0.36 0
71 INT302040 Transcription of Nrp2 2 0.53 0.05 0
72 INT353172 Negative_regulation of Plxna3 1 0.01 0.14 0
73 INT347529 Negative_regulation of Transcription of Nrp2 1 0.43 0 0
74 INT196157 Regulation of NRP2 1 0.00 0.16 0
75 INT113675 Regulation of Gene_expression of NRP1 1 0.00 1.62 0
76 INT196170 Regulation of Gene_expression of NRP2 1 0.00 0.16 0
77 INT315923 Negative_regulation of Positive_regulation of NRP1 1 0.40 0.19 0
78 INT311924 Transcription of Plxna3 1 0.10 0 0
79 INT158649 Regulation of Negative_regulation of Plxna2 1 0.23 0 0
80 INT158650 Negative_regulation of Gene_expression of Plxna2 1 0.36 0.13 0
81 INT243220 Binding of Plxna2 1 0.06 0.87 0
82 INT158655 Negative_regulation of Negative_regulation of Plxna2 1 0.36 0 0
83 INT302041 Negative_regulation of Gene_expression of Nrp1 1 0.07 0.14 0
84 INT302037 Regulation of Nrp2 1 0.18 0.26 0
85 INT158654 Regulation of Gene_expression of Plxna2 1 0.38 0 0
86 INT265785 Positive_regulation of Localization of NRP1 1 0.41 0 0
87 INT311944 Negative_regulation of Gene_expression of NRP2 1 0.39 0.17 0
88 INT265793 Regulation of NRP1 1 0.22 0 0
89 INT296201 Binding of Plxna3 1 0.36 0.08 0
90 INT265798 Positive_regulation of Binding of NRP1 1 0.41 0 0
91 INT188898 Negative_regulation of Localization of PLXNA3 1 0.09 0.47 0
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