GO:0017156

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Name calcium ion-dependent exocytosis
Categary Process
Go Slim No
Go Link GO:0017156
Unique Molecular Interactions 102
Total Molecular Interactions 141
Total Single Events 835
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium ion-dependent exocytosis. They are ordered first by their pain relevance and then by number of times they were reported for calcium ion-dependent exocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
2 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
3 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
4 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
5 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
6 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
7 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
8 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
9 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
10 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
11 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
12 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
13 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7
14 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
15 INT255287 Binding of Stx1a and Vti1b 1 0.35 0 0.58
16 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
17 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
18 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
19 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
20 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
21 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
22 INT255285 Binding of Snap25 and Stx1a 1 0.07 0 0.33
23 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
24 INT255292 Regulation of Binding of Napb and Vamp2 1 0.07 0 0.3
25 INT255286 Binding of Napb and Vamp2 1 0.09 0 0.29
26 INT255291 Binding of Napb and Stx1a 1 0.21 0 0.29
27 INT255284 Binding of Vamp2 and Vti1b 1 0.16 0 0.29
28 INT48161 RIMS3 Negative_regulation of Gene_expression of LTC4S 1 0.16 0.07 0.28
29 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
30 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
31 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
32 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
33 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
34 INT354519 Cacna1c Regulation of Mri1 1 0.00 1.15 0.21
35 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
36 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
37 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
38 INT214952 Vamp2 Regulation of Rims1 1 0.17 0 0.12
39 INT214955 Binding of Syt1 and Vamp2 1 0.22 0 0.1
40 INT214957 Vamp2 Regulation of Neu3 1 0.00 0 0.1
41 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
42 INT249413 Binding of Vamp2 and Napa 1 0.15 0.05 0.09
43 INT263761 Grin1 Regulation of Localization of Vamp2 1 0.27 0.17 0.07
44 INT263777 Grin2a Regulation of Localization of Vamp2 1 0.26 0.17 0.07
45 INT263734 Dlg4 Regulation of Localization of Vamp2 1 0.15 0.17 0.07
46 INT303055 Akt1 Negative_regulation of Syt1 1 0.21 0 0.07
47 INT263739 Grin2b Regulation of Localization of Vamp2 1 0.24 0.17 0.07
48 INT111933 Cacna1c Positive_regulation of PENK 1 0.01 0 0.07
49 INT254463 Binding of Camk2a and Cacna1c 1 0.00 0.17 0.06
50 INT263735 Localization of Neto1 Regulation of Localization of Vamp2 1 0.35 0.18 0.05
51 INT303086 Binding of Mafk and Syt1 1 0.23 0.18 0.05
52 INT303057 Binding of Syn1 and Syt1 1 0.07 0.19 0.05
53 INT303059 Binding of Syt1 and Sdcbp 1 0.04 0.19 0.05
54 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
55 INT249421 Binding of Stx1a and Vamp2 1 0.10 0 0.04
56 INT249414 Binding of Stx1a and Dcaf12l2 1 0.00 0 0.04
57 INT249404 Binding of Snap25 and Vamp2 1 0.16 0 0.04
58 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
59 INT303054 Rorb Positive_regulation of Gene_expression of Syt1 1 0.01 0 0.03
60 INT249417 Binding of Stx1a and Napa 1 0.13 0 0
61 INT249426 Mbp Positive_regulation of Stx1a 1 0.10 0.11 0
62 INT325589 Nppa Regulation of Cacna1c 1 0.05 0 0
63 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
64 INT79649 RIMS3 Regulation of Positive_regulation of ITGAL 1 0.00 0 0
65 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
66 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0
67 INT79652 RIMS3 Regulation of GSR 1 0.03 0 0
68 INT249408 Mbp Positive_regulation of Localization of Stx1a 1 0.11 0.33 0
69 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0
70 INT249405 Binding of Mbp and Stx1a 1 0.11 0 0
71 INT79645 RIMS3 Positive_regulation of Phosphorylation of GSR 1 0.04 0 0
72 INT249420 Stx1a Positive_regulation of Binding of Snap25 1 0.13 0 0
73 INT249410 Vamp2 Regulation of Binding of Stx1a 1 0.06 0 0
74 INT79648 RIMS3 Positive_regulation of Phosphorylation of CTNNBL1 1 0.01 0 0
75 INT217770 MIR181A1 Regulation of PPP3CB 1 0.00 0.7 0
76 INT249407 Mbp Positive_regulation of Localization of Vamp2 1 0.13 0.11 0
77 INT249422 Binding of Mbp and Vamp2 1 0.12 0 0
78 INT79647 RIMS3 Positive_regulation of Binding of GSR 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium ion-dependent exocytosis. They are ordered first by their pain relevance and then by number of times they were reported in calcium ion-dependent exocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
4 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
5 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
6 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
7 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
8 INT141751 Localization of Syt1 21 0.78 11.19 5.98
9 INT141750 Positive_regulation of Localization of Syt1 10 0.67 5.53 5.28
10 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
11 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
12 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
13 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1
14 INT22578 Gene_expression of Syt1 43 0.77 11.02 3.66
15 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
16 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
17 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
18 INT151268 Phosphorylation of Syt1 4 0.61 1.65 2.95
19 INT141752 Negative_regulation of Localization of Syt1 5 0.42 4.96 2.68
20 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
21 INT346375 Protein_catabolism of Vamp2 1 0.33 1.56 2.46
22 INT249378 Negative_regulation of Vamp2 3 0.20 0.27 2.4
23 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22
24 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
25 INT112368 Positive_regulation of Cacna1c 8 0.46 2.94 1.97
26 INT151272 Positive_regulation of Phosphorylation of Syt1 2 0.45 0.32 1.93
27 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
28 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
29 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
30 INT171816 Gene_expression of Stx1a 5 0.20 1.67 1.65
31 INT123076 Gene_expression of Cacna1c 7 0.37 1.91 1.56
32 INT15048 Regulation of Cacna1c 4 0.29 3.26 1.47
33 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
34 INT65452 Negative_regulation of Cacna1c 8 0.09 0.8 1.44
35 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
36 INT106273 Positive_regulation of Positive_regulation of Syt1 2 0.29 1.22 1.42
37 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
38 INT171147 Binding of Syt1 7 0.35 6.11 1.36
39 INT77752 Binding of Cacna1c 3 0.22 0.22 1.31
40 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
41 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
42 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
43 INT66452 Positive_regulation of Cacna1c 6 0.19 2.56 1.08
44 INT249383 Binding of Vamp2 5 0.23 0.33 1.03
45 INT78935 Localization of Cacna1c 3 0.48 1.25 0.97
46 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
47 INT234081 Gene_expression of Vamp2 9 0.51 0.71 0.94
48 INT249377 Localization of Vamp2 4 0.51 0.4 0.93
49 INT201222 Positive_regulation of STX1A 1 0.45 0.51 0.93
50 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
51 INT171818 Localization of Stx1a 1 0.08 0.22 0.85
52 INT123075 Positive_regulation of Gene_expression of Cacna1c 1 0.05 0.73 0.73
53 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71
54 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69
55 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
56 INT22577 Positive_regulation of Gene_expression of Syt1 6 0.50 1.49 0.65
57 INT346370 Regulation of Localization of Vamp2 1 0.15 0.08 0.53
58 INT346393 Regulation of Protein_catabolism of Vamp2 1 0.09 0.08 0.53
59 INT336690 Negative_regulation of Gene_expression of Vamp2 2 0.16 0.28 0.46
60 INT249396 Binding of Stx1a 9 0.15 0.23 0.42
61 INT234083 Gene_expression of Stx1a 10 0.64 1.41 0.41
62 INT146045 Regulation of Gene_expression of Syt1 4 0.21 0.84 0.4
63 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
64 INT106271 Negative_regulation of Positive_regulation of Syt1 1 0.25 0.34 0.3
65 INT160928 Negative_regulation of Syt1 4 0.57 1.9 0.25
66 INT290851 Regulation of Stx1a 1 0.09 0.26 0.24
67 INT101742 Regulation of Cacna1c 3 0.22 1.35 0.23
68 INT64080 Positive_regulation of Stx1a 3 0.08 0 0.2
69 INT221896 Protein_catabolism of Syt1 2 0.22 0.36 0.2
70 INT224030 Localization of Cacna1c 1 0.01 2.01 0.18
71 INT101741 Binding of Cacna1c 3 0.28 1.49 0.17
72 INT216261 Regulation of Gene_expression of Cacna1c 3 0.25 1.12 0.15
73 INT64081 Regulation of Stx1a 3 0.25 0.07 0.14
74 INT199810 Positive_regulation of Gene_expression of Cacna1c 2 0.43 0.81 0.13
75 INT346395 Positive_regulation of Protein_catabolism of Vamp2 1 0.16 0.13 0.13
76 INT250736 Protein_catabolism of Cacna1c 1 0.14 0.06 0.12
77 INT217824 Positive_regulation of PPP3CB 2 0.19 1.02 0.11
78 INT172390 Negative_regulation of Gene_expression of Cacna1c 2 0.17 2.33 0.11
79 INT290852 Binding of Stx1a 1 0.13 0 0.11
80 INT334306 Positive_regulation of Stx1a 1 0.10 0.65 0.11
81 INT320951 Negative_regulation of Gene_expression of Stx1a 1 0.40 0.56 0.11
82 INT287082 Gene_expression of Vamp3 1 0.18 0.99 0.11
83 INT351388 Positive_regulation of Binding of Syt1 1 0.11 0.33 0.1
84 INT303069 Transcription of Syt1 1 0.41 0 0.09
85 INT249379 Positive_regulation of Vamp2 3 0.33 0 0.08
86 INT234092 Regulation of Vamp2 2 0.20 0.17 0.05
87 INT170506 Positive_regulation of Positive_regulation of Cacna1c 1 0.04 0.09 0.05
88 INT351387 Regulation of Syt1 1 0.11 0.32 0.05
89 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
90 INT172389 Regulation of Binding of Cacna1c 1 0.07 0.19 0.05
91 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
92 INT320948 Negative_regulation of Stx1a 1 0.41 0.41 0.04
93 INT170512 Regulation of Gene_expression of Cacna1c 1 0.04 0.1 0.03
94 INT336691 Regulation of Gene_expression of Vamp2 1 0.19 0.43 0.03
95 INT243247 Localization of Stx1a 3 0.42 0.53 0
96 INT171149 Negative_regulation of Gene_expression of Syt1 2 0.45 0.22 0
97 INT249387 Positive_regulation of Regulation of Stx1a 1 0.20 0.07 0
98 INT287083 Binding of Vamp3 1 0.14 1.58 0
99 INT325563 Negative_regulation of Positive_regulation of Cacna1c 1 0.05 0 0
100 INT217815 Gene_expression of PPP3CB 1 0.01 1.07 0
101 INT249380 Positive_regulation of Phosphorylation of Stx1a 1 0.19 0.07 0
102 INT287084 Regulation of Vamp3 1 0.12 0.71 0
103 INT252138 Binding of STX1A 1 0.35 0 0
104 INT249397 Negative_regulation of Binding of Vamp2 1 0.28 0 0
105 INT249400 Negative_regulation of Binding of Stx1a 1 0.17 0.08 0
106 INT325551 Positive_regulation of Negative_regulation of Cacna1c 1 0.06 0 0
107 INT249375 Phosphorylation of Stx1a 1 0.33 0.07 0
108 INT217840 Regulation of PPP3CB 1 0.00 0.74 0
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